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Atlas / Gene / LRCH1

LRCH1

gene
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Also known as KIAA1016

Summary

LRCH1 (leucine rich repeats and calponin homology domain containing 1, HGNC:20309) is a protein-coding gene on chromosome 13q14.13-q14.2, encoding Leucine-rich repeat and calponin homology domain-containing protein 1 (Q9Y2L9). Acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8.

This gene encodes a protein with a leucine-rich repeat and a calponin homology domain. Polymorphism in this gene may be associated with susceptibililty to knee osteoarthritis. Alternative splicing results in multiple transcript variants encoding different isoforms.

Source: NCBI Gene 23143 — RefSeq curated summary.

At a glance

  • GWAS associations: 20
  • Clinical variants (ClinVar): 147 total
  • MANE Select transcript: NM_001164211

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:20309
Approved symbolLRCH1
Nameleucine rich repeats and calponin homology domain containing 1
Location13q14.13-q14.2
Locus typegene with protein product
StatusApproved
AliasesKIAA1016
Ensembl geneENSG00000136141
Ensembl biotypeprotein_coding
OMIM610368
Entrez23143

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 5 protein_coding, 1 retained_intron

ENST00000311191, ENST00000389797, ENST00000389798, ENST00000443945, ENST00000463929, ENST00000478412

RefSeq mRNA: 3 — MANE Select: NM_001164211 NM_001164211, NM_001164213, NM_015116

CCDS: CCDS31972, CCDS53865, CCDS53866

Canonical transcript exons

ENST00000389797 — 20 exons

ExonStartEnd
ENSE000004629194673392146733998
ENSE000008367924671179146711844
ENSE000008367934671252546712597
ENSE000008367944672322146723330
ENSE000009234254670526846705304
ENSE000009234264672884746728984
ENSE000015334324671556046715664
ENSE000018221144655317046553703
ENSE000019435874674164246744898
ENSE000034682044668590546686041
ENSE000034692584668174146681846
ENSE000035036304668913346689196
ENSE000035142314669489346695017
ENSE000035372214665020146650345
ENSE000035796104669253646692641
ENSE000035912074670506846705157
ENSE000036040414668785246687979
ENSE000036449934666903046669156
ENSE000036620604670112146701207
ENSE000036724464669933646699403

Expression profiles

Bgee: expression breadth ubiquitous, 247 present calls, max score 91.34.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 17.9978 / max 252.0935, expressed in 1795 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter IDTPM avgSamples expressed
13501410.78461757
1350175.07781589
1350151.4983824
1350160.3261150
1350180.3111137

Top tissues by expression

288 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
cerebellar cortexUBERON:000212991.34gold quality
cerebellar hemisphereUBERON:000224591.33gold quality
right hemisphere of cerebellumUBERON:001489090.91gold quality
cerebellumUBERON:000203790.71gold quality
cauda epididymisUBERON:000436090.05gold quality
secondary oocyteCL:000065590.04gold quality
urethraUBERON:000005789.19gold quality
visceral pleuraUBERON:000240189.11gold quality
oocyteCL:000002389.01gold quality
saphenous veinUBERON:000731888.99gold quality
cerebellar vermisUBERON:000472088.98gold quality
upper leg skinUBERON:000426288.48gold quality
mucosa of stomachUBERON:000119988.19gold quality
calcaneal tendonUBERON:000370188.04gold quality
popliteal arteryUBERON:000225087.93gold quality
tibial arteryUBERON:000761087.93gold quality
cortical plateUBERON:000534387.62gold quality
sural nerveUBERON:001548887.39gold quality
seminal vesicleUBERON:000099887.31gold quality
aortaUBERON:000094786.97gold quality
penisUBERON:000098986.94gold quality
synovial jointUBERON:000221786.94gold quality
renal medullaUBERON:000036286.76gold quality
descending thoracic aortaUBERON:000234586.74gold quality
colonic epitheliumUBERON:000039786.46gold quality
esophagogastric junction muscularis propriaUBERON:003584186.12gold quality
lower esophagus muscularis layerUBERON:003583386.09gold quality
right lungUBERON:000216786.08gold quality
lower esophagusUBERON:001347386.05gold quality
skin of legUBERON:000151185.95gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

ExperimentMarker?Max mean expression
E-CURD-119yes48.48
E-ANND-3yes5.68
E-GEOD-99795no5.94

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

131 targeting LRCH1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-126-5P100.0072.713180
HSA-MIR-29A-3P100.0073.111835
HSA-MIR-29B-3P100.0073.181833
HSA-MIR-29C-3P100.0073.151833
HSA-MIR-3163100.0077.238605
HSA-MIR-3613-3P100.0076.367965
HSA-MIR-4795-3P100.0074.624024
HSA-MIR-3646100.0073.565283
HSA-MIR-4533100.0069.482758
HSA-MIR-453199.9969.703181
HSA-MIR-428299.9975.366408
HSA-MIR-548C-3P99.9974.017587
HSA-MIR-477599.9875.006394
HSA-MIR-520D-5P99.9873.344883
HSA-MIR-524-5P99.9873.434882
HSA-MIR-4715-3P99.9866.03670
HSA-MIR-60799.9773.625593
HSA-MIR-6793-5P99.9765.95758
HSA-MIR-314899.9775.066478
HSA-MIR-146A-5P99.9668.93988
HSA-MIR-146B-5P99.9669.13977
HSA-MIR-590-3P99.9674.346478
HSA-MIR-448799.9664.581252
HSA-MIR-548AJ-3P99.9673.385345
HSA-MIR-548X-3P99.9673.385345
HSA-MIR-7153-5P99.9468.891006
HSA-MIR-218-5P99.9372.222103
HSA-MIR-4778-3P99.9370.401818
HSA-MIR-205-3P99.9269.923165
HSA-MIR-367199.9073.043897

Literature-anchored findings (GeneRIF, showing 7)

  • A genetic variant in LRCH1 was consistently associated with knee osteoarthritis in 3 samples from 2 populations. (PMID:16447229)
  • results suggest that there is no association between LRCH1 and knee osteoarthritis susceptibility (PMID:18049793)
  • Letter: Did not observe an association between LRCH-1 SNPs and knee osteoarthritis. (PMID:22325041)
  • In the analysis of hip osteoarthritis cases with superior maximum joint space narrowing (JSN) versus cases with non-superior maximum JSN we detected association with a variant in the LRCH1 gene. (PMID:27974301)
  • found a significant association between the four LRCH1 polymorphisms and delayed encephalopathy after acute carbon monoxide poisoning (DEACMP). The allelic A of rs9534475 polymorphism in LRCH1 might be a risk factor for DEACMP (PMID:31842790)
  • LRCH1 suppresses migration of CD4(+) T cells and refers to disease activity in ulcerative colitis. (PMID:32210709)
  • LRCH1 deficiency enhances LAT signalosome formation and CD8(+) T cell responses against tumors and pathogens. (PMID:32727906)

Cross-species orthologs

3 orthologs

OrganismSymbolGene ID
danio_reriolrch1ENSDARG00000078778
mus_musculusLrch1ENSMUSG00000068015
rattus_norvegicusLrch1ENSRNOG00000009412

Paralogs (31): LRRC7 (ENSG00000033122), PHLPP2 (ENSG00000040199), LRRC40 (ENSG00000066557), LRCH4 (ENSG00000077454), PHLPP1 (ENSG00000081913), SHOC2 (ENSG00000108061), ERBIN (ENSG00000112851), LRRC39 (ENSG00000122477), LRCH2 (ENSG00000130224), LRRC8A (ENSG00000136802), LRRC1 (ENSG00000137269), MFHAS1 (ENSG00000147324), LRRC27 (ENSG00000148814), LRRK1 (ENSG00000154237), LRRC58 (ENSG00000163428), LRRC2 (ENSG00000163827), LRRC18 (ENSG00000165383), LRRC28 (ENSG00000168904), LRRC8E (ENSG00000171017), LRRC8C (ENSG00000171488), LRRC8D (ENSG00000171492), PIDD1 (ENSG00000177595), SCRIB (ENSG00000180900), LRCH3 (ENSG00000186001), LRRIQ4 (ENSG00000188306), LRRC8B (ENSG00000197147), LRRC10 (ENSG00000198812), LRRC10B (ENSG00000204950), LRRC30 (ENSG00000206422), LRRC69 (ENSG00000214954), LRRD1 (ENSG00000240720)

Protein

Protein identifiers

Leucine-rich repeat and calponin homology domain-containing protein 1 — Q9Y2L9 (reviewed: Q9Y2L9)

Alternative names: Calponin homology domain-containing protein 1, Neuronal protein 81

All UniProt accessions (3): C9J5B8, C9JWE0, Q9Y2L9

UniProt curated annotations — full annotation on UniProt →

Function. Acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. Probably by preventing CDC42 activation, negatively regulates CD4(+) T-cell migration.

Subunit / interactions. Interacts (via LRR repeats) with unphosphorylated DOCK8 (via DHR-2 domain); the interaction prevents the interaction between DOCK8 and CDC42.

Subcellular location. Cytoplasm.

Isoforms (3)

UniProt IDNamesCanonical?
Q9Y2L9-11, b, NP81byes
Q9Y2L9-22, a, NP81a
Q9Y2L9-33

RefSeq proteins (3): NP_001157683, NP_001157685, NP_055931 (=MANE)

Domains & families (InterPro)

IDNameType
IPR001611Leu-rich_rptRepeat
IPR001715CH_domDomain
IPR003591Leu-rich_rpt_typical-subtypRepeat
IPR032675LRR_dom_sfHomologous_superfamily
IPR036872CH_dom_sfHomologous_superfamily
IPR050216LRR_domain-containingFamily

Pfam: PF00307, PF13855

UniProt features (31 total): repeat 9, compositionally biased region 5, modified residue 5, region of interest 4, splice variant 3, sequence variant 2, chain 1, domain 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q9Y2L9-F163.180.14

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (5): 370, 409, 532, 536, 568

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 174 (showing top): CREL_01, GOBP_RESPONSE_TO_PEPTIDE, GOBP_NEGATIVE_REGULATION_OF_HYDROLASE_ACTIVITY, GOZGIT_ESR1_TARGETS_DN, GAUSSMANN_MLL_AF4_FUSION_TARGETS_C_UP, GOBP_REGULATION_OF_GTPASE_ACTIVITY, CAGCTG_AP4_Q5, GOBP_REGULATION_OF_LEUKOCYTE_MIGRATION, GOBP_REGULATION_OF_MONONUCLEAR_CELL_MIGRATION, NFKB_C, GOBP_LEUKOCYTE_MIGRATION, CCANNAGRKGGC_UNKNOWN, GOBP_REGULATION_OF_HYDROLASE_ACTIVITY, FOSTER_TOLERANT_MACROPHAGE_UP, GOBP_NEGATIVE_REGULATION_OF_LEUKOCYTE_MIGRATION

GO Biological Process (3): negative regulation of GTPase activity (GO:0034260), cellular response to chemokine (GO:1990869), negative regulation of T cell migration (GO:2000405)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (1): cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
GTPase activity1
regulation of GTPase activity1
negative regulation of biological process1
negative regulation of hydrolase activity1
cellular response to cytokine stimulus1
response to chemokine1
T cell migration1
negative regulation of lymphocyte migration1
regulation of T cell migration1
binding1
intracellular anatomical structure1
cellular anatomical structure1

Protein interactions and networks

STRING

1320 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
LRCH1NME8Q8N427685
LRCH1TM2D3Q9BRN9648
LRCH1ZFAND4Q86XD8626
LRCH1A0A590UK56A0A590UK56611
LRCH1DOCK8Q8NF50604
LRCH1TNFAIP6P98066599
LRCH1DOCK6Q96HP0563
LRCH1RHOBP01121554
LRCH1FRZBQ92765549
LRCH1LPAR1P78351549
LRCH1DIRAS1O95057535
LRCH1PDP2Q9P2J9477
LRCH1UBL4BQ8N7F7477
LRCH1CTIFO43310447
LRCH1EPAS1Q99814429
LRCH1ITGA6P23229429

IntAct

49 interactions, top by confidence:

ABTypeScore
LRCH1DOCK7psi-mi:“MI:0915”(physical association)0.800
DOCK8LRCH1psi-mi:“MI:0915”(physical association)0.740
DOCK8LRCH2psi-mi:“MI:0914”(association)0.740
MYO6GIPC1psi-mi:“MI:0914”(association)0.690
MOB1ALATS1psi-mi:“MI:0914”(association)0.670
DOCK8LRCH1psi-mi:“MI:0915”(physical association)0.560
LRCH1DOCK8psi-mi:“MI:0915”(physical association)0.560
YWHAESRSF10psi-mi:“MI:0914”(association)0.560
YWHAZBLTP3Bpsi-mi:“MI:0914”(association)0.530
PSME1POLR3Apsi-mi:“MI:0914”(association)0.530
LRCH3LRCH2psi-mi:“MI:0914”(association)0.530
DOCK7LRCH2psi-mi:“MI:0914”(association)0.530
MOB1BPPP6Cpsi-mi:“MI:2364”(proximity)0.480
MOB1BANKRD28psi-mi:“MI:0914”(association)0.420
MOB1APPP6Cpsi-mi:“MI:2364”(proximity)0.420
MOB1APPP6Cpsi-mi:“MI:0914”(association)0.420
LRCH1DOCK7psi-mi:“MI:0915”(physical association)0.400
LRCH1psi-mi:“MI:0915”(physical association)0.400
Xpo1IFT56psi-mi:“MI:0914”(association)0.350
EGLN3FAM168Bpsi-mi:“MI:0914”(association)0.350
NOTCH1CNOT1psi-mi:“MI:0914”(association)0.350
DOCK6PSMD12psi-mi:“MI:0914”(association)0.350
DOCK8IPO5psi-mi:“MI:0914”(association)0.350

BioGRID (89): DOCK8 (Two-hybrid), LRCH1 (Affinity Capture-MS), LRCH1 (Affinity Capture-MS), LRCH1 (Affinity Capture-MS), LRCH1 (Affinity Capture-MS), LRCH1 (Affinity Capture-MS), LRCH1 (Affinity Capture-MS), LRCH1 (Affinity Capture-MS), LRCH1 (Affinity Capture-MS), LRCH1 (Affinity Capture-MS), LRCH1 (Proximity Label-MS), LRCH1 (Proximity Label-MS), DOCK7 (Affinity Capture-Western), LRCH1 (Affinity Capture-MS), LRCH1 (Affinity Capture-MS)

ESM2 similar proteins: A0JM56, A2RRS8, A6H759, A6NJI9, A6PVS8, B0FXQ5, B1ANS9, B7FF12, D3ZXS4, D4A039, E9QA62, F1MCA7, O00522, P62046, P70587, Q0V9Y8, Q0VAK6, Q14DL3, Q3U3V8, Q3UMG5, Q3V0L5, Q4KLV2, Q5JTW2, Q5PPX0, Q5SUS0, Q5VUJ6, Q6AXZ2, Q6AYL8, Q6GQN5, Q6IRU7, Q6P5J6, Q7Z3E5, Q7ZV84, Q80TE7, Q80TM9, Q8BGI7, Q8BVU0, Q8C008, Q8C0Q4, Q8C5W4

Diamond homologs: O75427, P26932, P41737, P52735, P62046, Q3UMG5, Q5S006, Q5VUJ6, Q60992, Q6Z8P4, Q8BVU0, Q921G6, Q96II8, Q9R0C8, Q9Y2L9, B9EUM5, O14185, O14188, P14318, P19966, P31232, P37397, P37802, P37803, P37804, P37805, P46940, P51911, Q01995, Q08091, Q08092, Q08093, Q08094, Q08290, Q08873, Q12280, Q15052, Q15417, Q24799, Q2HJ38

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

147 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance111
Likely benign0
Benign2

Top pathogenic / likely-pathogenic (0)

SpliceAI

4403 predictions. Top by Δscore:

VariantEffectΔscore
13:46553700:GCAG:Gdonor_gain1.0000
13:46553704:G:GGdonor_gain1.0000
13:46650196:TATA:Tacceptor_loss1.0000
13:46650197:ATAG:Aacceptor_loss1.0000
13:46650198:TA:Tacceptor_loss1.0000
13:46650199:A:AGacceptor_gain1.0000
13:46650199:A:ATacceptor_loss1.0000
13:46650200:G:GCacceptor_gain1.0000
13:46650200:GA:Gacceptor_gain1.0000
13:46650200:GAC:Gacceptor_gain1.0000
13:46650200:GACT:Gacceptor_gain1.0000
13:46650200:GACTT:Gacceptor_gain1.0000
13:46650343:GAG:Gdonor_gain1.0000
13:46650344:AGGTA:Adonor_loss1.0000
13:46650346:G:GGdonor_gain1.0000
13:46650346:GTA:Gdonor_loss1.0000
13:46669153:GCTG:Gdonor_gain1.0000
13:46681733:T:TAacceptor_gain1.0000
13:46689100:A:AGacceptor_gain1.0000
13:46689110:A:AGacceptor_gain1.0000
13:46689113:A:AGacceptor_gain1.0000
13:46689113:ATT:Aacceptor_gain1.0000
13:46689115:T:Aacceptor_gain1.0000
13:46699400:GCAT:Gdonor_gain1.0000
13:46699404:G:GGdonor_gain1.0000
13:46701208:GTGT:Gdonor_gain1.0000
13:46705155:G:GTdonor_gain1.0000
13:46705158:G:GGdonor_gain1.0000
13:46705266:A:AGacceptor_gain1.0000
13:46705267:G:GGacceptor_gain1.0000

AlphaMissense

5018 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
13:46650214:C:AN107K1.000
13:46650214:C:GN107K1.000
13:46650283:C:AN130K1.000
13:46650283:C:GN130K1.000
13:46650336:T:CL148P1.000
13:46669155:T:CL193P1.000
13:46681808:T:CL216P1.000
13:46686031:C:AP271H1.000
13:46728907:G:CG609R1.000
13:46728908:G:AG609D1.000
13:46728919:T:CC613R1.000
13:46728921:C:GC613W1.000
13:46728926:T:CL615P1.000
13:46728953:T:AV624D1.000
13:46728962:T:AI627N1.000
13:46728964:C:GH628D1.000
13:46728968:T:AV629D1.000
13:46733928:T:AL637H1.000
13:46733951:A:GN645D1.000
13:46733953:T:AN645K1.000
13:46733953:T:GN645K1.000
13:46553623:T:CL76P0.999
13:46553629:T:CL78P0.999
13:46553638:G:CR81T0.999
13:46553638:G:TR81M0.999
13:46553639:G:CR81S0.999
13:46553639:G:TR81S0.999
13:46553700:G:CA102P0.999
13:46650207:C:TS105F0.999
13:46650212:A:GN107D0.999

dbSNP variants (sampled 300 via entrez): RS1000021568 (13:46552795 C>A), RS1000031111 (13:46587448 A>C,G), RS1000047792 (13:46594122 A>C,G), RS1000078406 (13:46574351 A>T), RS1000088849 (13:46722915 G>A), RS1000089534 (13:46577431 G>T), RS1000117289 (13:46677583 A>C), RS1000119393 (13:46709499 C>T), RS1000131891 (13:46635709 G>T), RS1000139157 (13:46716379 A>G), RS1000142703 (13:46722612 G>A), RS1000160109 (13:46663374 A>G), RS1000169059 (13:46571061 T>G), RS1000175117 (13:46630533 C>A,T), RS1000178504 (13:46581110 G>A,C)

Disease associations

OMIM: gene MIM:610368 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

20 associations (top):

StudyTraitp-value
GCST002456_8PR segment duration2.000000e-08
GCST003872_7QRS complex (12-leadsum)4.000000e-10
GCST004599_157Mean platelet volume3.000000e-13
GCST004616_100Platelet distribution width3.000000e-30
GCST004616_99Platelet distribution width2.000000e-30
GCST004863_67Mosquito bite size5.000000e-06
GCST006624_43Systolic blood pressure6.000000e-14
GCST007045_39PR interval1.000000e-19
GCST007226_4PR interval1.000000e-10
GCST007269_56Pulse pressure2.000000e-08
GCST009462_75Optic disc size1.000000e-16
GCST010321_146PR interval4.000000e-35
GCST010703_281Brain morphology (MOSTest)3.000000e-15
GCST010796_908Electrocardiogram morphology (amplitude at temporal datapoints)9.000000e-27
GCST010796_909Electrocardiogram morphology (amplitude at temporal datapoints)1.000000e-25
GCST90002387_134Immature fraction of reticulocytes2.000000e-11
GCST90002395_155Mean platelet volume3.000000e-35
GCST90002401_58Platelet distribution width6.000000e-175
GCST90002401_59Platelet distribution width3.000000e-09
GCST90002402_214Platelet count7.000000e-13

EFO canonical traits (11, from GWAS)

EFO IDTrait name
EFO:0005095PR segment
EFO:0005054QRS complex
EFO:0007742QRS amplitude
EFO:0007984platelet component distribution width
EFO:0008378mosquito bite reaction size measurement
EFO:0006335systolic blood pressure
EFO:0004462PR interval
EFO:0005763pulse pressure measurement
EFO:0004346neuroimaging measurement
EFO:0004327electrocardiography
EFO:0004309platelet count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

34 total (human), top 30 by PubMed support.

ChemicalActions (top 5)PubMed papers
Valproic Acidaffects cotreatment, increases expression, decreases methylation5
trichostatin Aaffects cotreatment, increases expression3
Phenylmercuric Acetateaffects cotreatment, increases expression2
Tretinoindecreases expression, increases expression2
aristolochic acid Idecreases expression1
FR900359affects phosphorylation1
triphenyl phosphateaffects expression1
pirinixic acidincreases activity, affects binding, decreases expression1
bisphenol Aaffects cotreatment, increases methylation1
arseniteaffects binding, decreases reaction1
tris(1,3-dichloro-2-propyl)phosphateincreases expression1
potassium chromate(VI)affects cotreatment, decreases expression1
coumarinaffects phosphorylation1
epigallocatechin gallateaffects cotreatment, decreases expression1
pentanaldecreases expression1
entinostatdecreases expression1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamideaffects cotreatment, increases expression1
dorsomorphinaffects cotreatment, increases expression1
jinfukangaffects cotreatment, decreases expression1
Fulvestrantaffects cotreatment, increases methylation1
Leflunomideincreases expression1
Benzo(a)pyreneaffects methylation1
Caffeineaffects phosphorylation1
Carbamazepineaffects expression1
Cisplatinaffects cotreatment, decreases expression1
Diethylhexyl Phthalateincreases expression1
Doxorubicindecreases expression1
Phthalic Acidsdecreases methylation1
Quercetinincreases expression1
Silicon Dioxideincreases expression1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
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Sources 74

This page pulls from 74 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomerefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot