LRP8-DT

Summary

LRP8-DT (LRP8 divergent transcript, HGNC:52561) is a long non-coding RNA gene on chromosome 1p32.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:52561
Approved symbol	LRP8-DT
Name	LRP8 divergent transcript
Location	1p32.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000225675
Ensembl biotype	lncRNA
Entrez	105378732
RNAcentral	URS0000247A85 — lncRNA, 567 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000445039, ENST00000792371, ENST00000792372

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000445039 — 4 exons

Exon	Start	End
ENSE00001666598	53331168	53331251
ENSE00001688882	53328233	53328375
ENSE00004174282	53337937	53338107
ENSE00004174284	53336170	53337225

Expression profiles

Bgee: expression breadth ubiquitous, 118 present calls, max score 70.01.

FANTOM5 (CAGE): breadth broad, TPM avg 0.9173 / max 28.7072, expressed in 414 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
2917	0.9173	414

Top tissues by expression

118 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	70.01	gold quality
superior frontal gyrus	UBERON:0002661	68.70	gold quality
skeletal muscle tissue	UBERON:0001134	67.48	gold quality
hypothalamus	UBERON:0001898	67.17	gold quality
ventricular zone	UBERON:0003053	66.44	gold quality
tonsil	UBERON:0002372	66.24	gold quality
ganglionic eminence	UBERON:0004023	66.14	gold quality
lymph node	UBERON:0000029	65.58	gold quality
frontal cortex	UBERON:0001870	65.50	gold quality
right frontal lobe	UBERON:0002810	65.45	gold quality
Brodmann (1909) area 9	UBERON:0013540	65.30	gold quality
prefrontal cortex	UBERON:0000451	65.21	gold quality
primary visual cortex	UBERON:0002436	64.67	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	64.19	gold quality
anterior cingulate cortex	UBERON:0009835	63.40	gold quality
cerebral cortex	UBERON:0000956	63.10	gold quality
hindlimb stylopod muscle	UBERON:0004252	61.82	gold quality
monocyte	CL:0000576	61.40	gold quality
calcaneal tendon	UBERON:0003701	60.27	gold quality
bone marrow	UBERON:0002371	58.81	gold quality
placenta	UBERON:0001987	58.39	gold quality
vermiform appendix	UBERON:0001154	58.29	gold quality
brain	UBERON:0000955	58.12	gold quality
gall bladder	UBERON:0002110	57.92	gold quality
temporal lobe	UBERON:0001871	57.55	gold quality
amygdala	UBERON:0001876	57.42	gold quality
right testis	UBERON:0004534	57.35	gold quality
granulocyte	CL:0000094	56.75	gold quality
substantia nigra	UBERON:0002038	56.57	gold quality
testis	UBERON:0000473	56.40	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.63

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.