LRRC47
gene geneOn this page
Also known as KIAA1185RP1-286D6.3
Summary
LRRC47 (leucine rich repeat containing 47, HGNC:29207) is a protein-coding gene on chromosome 1p36.32, encoding Leucine-rich repeat-containing protein 47 (Q8N1G4).
Enables RNA binding activity. Predicted to be involved in phenylalanyl-tRNA aminoacylation.
Source: NCBI Gene 57470 — RefSeq curated summary.
At a glance
- GWAS associations: 6
- Clinical variants (ClinVar): 81 total
- Druggable target: yes
- MANE Select transcript:
NM_020710
Identifiers
Gene identifiers
| Field | Value |
|---|---|
| HGNC ID | HGNC:29207 |
| Approved symbol | LRRC47 |
| Name | leucine rich repeat containing 47 |
| Location | 1p36.32 |
| Locus type | gene with protein product |
| Status | Approved |
| Aliases | KIAA1185, RP1-286D6.3 |
| Ensembl gene | ENSG00000130764 |
| Ensembl biotype | protein_coding |
| OMIM | 619154 |
| Entrez | 57470 |
Gene structure
Transcript identifiers
Ensembl transcripts: 11 — 9 protein_coding, 1 retained_intron, 1 nonsense_mediated_decay
ENST00000378251, ENST00000462356, ENST00000479239, ENST00000855510, ENST00000855511, ENST00000855512, ENST00000931368, ENST00000931369, ENST00000931370, ENST00000931371, ENST00000971585
RefSeq mRNA: 1 — MANE Select: NM_020710
NM_020710
CCDS: CCDS51
Canonical transcript exons
ENST00000378251 — 7 exons
| Exon | Start | End |
|---|---|---|
| ENSE00000896208 | 3783996 | 3784111 |
| ENSE00000896210 | 3785087 | 3785203 |
| ENSE00000896213 | 3786849 | 3787310 |
| ENSE00001122552 | 3778559 | 3781336 |
| ENSE00001476853 | 3795862 | 3796498 |
| ENSE00003638046 | 3782661 | 3782763 |
| ENSE00003691484 | 3781512 | 3781601 |
Expression profiles
Bgee: expression breadth ubiquitous, 287 present calls, max score 98.55.
FANTOM5 (CAGE): breadth ubiquitous, TPM avg 32.3468 / max 189.5829, expressed in 1816 samples.
FANTOM5 promoters (1 alternative TSS)
| Promoter ID | TPM avg | Samples expressed |
|---|---|---|
| 9963 | 32.3468 | 1816 |
Top tissues by expression
288 total, by Bgee expression score (0-100, higher = more expressed):
| Tissue | Anatomy ID | Expression score | Quality |
|---|---|---|---|
| middle temporal gyrus | UBERON:0002771 | 98.55 | gold quality |
| skeletal muscle tissue of rectus abdominis | UBERON:0004511 | 97.90 | gold quality |
| endothelial cell | CL:0000115 | 97.89 | gold quality |
| gluteal muscle | UBERON:0002000 | 97.70 | gold quality |
| Brodmann (1909) area 23 | UBERON:0013554 | 97.69 | gold quality |
| quadriceps femoris | UBERON:0001377 | 97.66 | gold quality |
| tibialis anterior | UBERON:0001385 | 97.66 | gold quality |
| vastus lateralis | UBERON:0001379 | 97.65 | gold quality |
| gingival epithelium | UBERON:0001949 | 97.43 | gold quality |
| deltoid | UBERON:0001476 | 97.13 | gold quality |
| triceps brachii | UBERON:0001509 | 97.07 | gold quality |
| gingiva | UBERON:0001828 | 97.03 | gold quality |
| skeletal muscle tissue of biceps brachii | UBERON:0004502 | 96.89 | gold quality |
| skeletal muscle tissue | UBERON:0001134 | 96.82 | gold quality |
| gastrocnemius | UBERON:0001388 | 96.73 | gold quality |
| cerebellar vermis | UBERON:0004720 | 96.72 | gold quality |
| body of tongue | UBERON:0011876 | 96.72 | gold quality |
| muscle organ | UBERON:0001630 | 96.57 | gold quality |
| metanephric glomerulus | UBERON:0004736 | 96.54 | gold quality |
| palpebral conjunctiva | UBERON:0001812 | 96.36 | gold quality |
| muscle of leg | UBERON:0001383 | 96.34 | gold quality |
| muscle tissue | UBERON:0002385 | 96.24 | gold quality |
| esophagus squamous epithelium | UBERON:0006920 | 96.24 | gold quality |
| tibia | UBERON:0000979 | 96.22 | gold quality |
| renal glomerulus | UBERON:0000074 | 96.19 | gold quality |
| mammalian vulva | UBERON:0000997 | 96.17 | gold quality |
| biceps brachii | UBERON:0001507 | 96.17 | gold quality |
| seminal vesicle | UBERON:0000998 | 96.01 | gold quality |
| tongue | UBERON:0001723 | 95.97 | gold quality |
| nipple | UBERON:0002030 | 95.97 | gold quality |
Single-cell (SCXA)
Detected in 1 experiment(s), a significant marker in 1.
| Experiment | Marker? | Max mean expression |
|---|---|---|
| E-ANND-3 | yes | 8.32 |
Regulation
Is transcription factor: no
miRNA regulators (miRDB)
43 targeting LRRC47, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):
| miRNA | Max score | Avg score | miRNA target_count |
|---|---|---|---|
| HSA-MIR-3613-3P | 100.00 | 76.36 | 7965 |
| HSA-MIR-371B-5P | 99.99 | 75.34 | 4759 |
| HSA-MIR-373-5P | 99.98 | 75.36 | 4753 |
| HSA-MIR-616-5P | 99.98 | 75.58 | 4775 |
| HSA-MIR-548AA | 99.96 | 70.64 | 3753 |
| HSA-MIR-548AP-3P | 99.96 | 70.64 | 3753 |
| HSA-MIR-548T-3P | 99.96 | 70.64 | 3753 |
| HSA-MIR-589-3P | 99.91 | 69.62 | 2088 |
| HSA-MIR-6780A-5P | 99.88 | 66.69 | 2776 |
| HSA-MIR-548D-3P | 99.87 | 70.67 | 4362 |
| HSA-MIR-548BB-3P | 99.86 | 70.58 | 4354 |
| HSA-MIR-383-3P | 99.85 | 65.84 | 1359 |
| HSA-MIR-629-3P | 99.85 | 67.99 | 1875 |
| HSA-MIR-4728-5P | 99.85 | 69.39 | 4718 |
| HSA-MIR-548AC | 99.84 | 70.77 | 4351 |
| HSA-MIR-548H-3P | 99.84 | 70.80 | 4349 |
| HSA-MIR-548Z | 99.84 | 70.80 | 4349 |
| HSA-MIR-6785-5P | 99.82 | 68.68 | 4428 |
| HSA-MIR-4713-5P | 99.78 | 67.80 | 1794 |
| HSA-MIR-1299 | 99.77 | 71.24 | 2389 |
| HSA-MIR-1273H-5P | 99.77 | 66.32 | 2471 |
| HSA-MIR-2116-3P | 99.74 | 64.32 | 889 |
| HSA-MIR-30B-3P | 99.70 | 65.76 | 2325 |
| HSA-MIR-3689A-3P | 99.70 | 65.73 | 2306 |
| HSA-MIR-3689B-3P | 99.70 | 65.71 | 2311 |
| HSA-MIR-3689C | 99.70 | 65.71 | 2311 |
| HSA-MIR-6779-5P | 99.70 | 65.76 | 2363 |
| HSA-MIR-875-3P | 99.63 | 69.47 | 2548 |
| HSA-MIR-6134 | 99.63 | 65.68 | 1537 |
| HSA-MIR-7106-5P | 99.53 | 67.47 | 3574 |
Cross-species orthologs
4 orthologs
| Organism | Symbol | Gene ID |
|---|---|---|
| danio_rerio | lrrc47 | ENSDARG00000053138 |
| mus_musculus | Lrrc47 | ENSMUSG00000029028 |
| rattus_norvegicus | Lrrc47 | ENSRNOG00000024796 |
| caenorhabditis_elegans | Y54E10A.6 | WBGENE00021828 |
Paralogs (1): FARSB (ENSG00000116120)
Protein
Protein identifiers
Leucine-rich repeat-containing protein 47 — Q8N1G4 (reviewed: Q8N1G4)
All UniProt accessions (2): Q8N1G4, J3KRP5
RefSeq proteins (1): NP_065761* (*=MANE)
Domains & families (InterPro)
| ID | Name | Type |
|---|---|---|
| IPR001611 | Leu-rich_rpt | Repeat |
| IPR003591 | Leu-rich_rpt_typical-subtyp | Repeat |
| IPR005146 | B3/B4_tRNA-bd | Domain |
| IPR020825 | Phe-tRNA_synthase-like_B3/B4 | Homologous_superfamily |
| IPR025875 | Leu-rich_rpt_4 | Repeat |
| IPR032675 | LRR_dom_sf | Homologous_superfamily |
| IPR045060 | Phe-tRNA-ligase_IIc_bsu | Family |
Pfam: PF12799, PF13855
UniProt features (62 total): strand 20, helix 13, repeat 7, turn 7, modified residue 6, sequence variant 3, region of interest 2, initiator methionine 1, chain 1, coiled-coil region 1, compositionally biased region 1
Structure
Experimental structures (PDB)
5 structures.
| PDB | Method | Resolution (Å) |
|---|---|---|
| 6ZXG | ELECTRON MICROSCOPY | 2.6 |
| 6ZXE | ELECTRON MICROSCOPY | 3 |
| 6ZXD | ELECTRON MICROSCOPY | 3.2 |
| 8XP3 | ELECTRON MICROSCOPY | 3.4 |
| 6ZXF | ELECTRON MICROSCOPY | 3.7 |
Predicted structure (AlphaFold)
| Model | pLDDT | Fraction very-high |
|---|---|---|
| AF-Q8N1G4-F1 | 77.50 | 0.27 |
Functional residue map
Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.
Post-translational modifications (6): 2, 315, 431, 509, 518, 520
Function
Pathways and Gene Ontology
Reactome pathways
0 pathways
MSigDB gene sets: 67 (showing top):
GOBP_AMINO_ACID_ACTIVATION, GOBP_TRNA_METABOLIC_PROCESS, GOBP_TRANSLATION, LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN, TIEN_INTESTINE_PROBIOTICS_24HR_UP, HAN_SATB1_TARGETS_DN, SENESE_HDAC3_TARGETS_DN, GOMF_LIGASE_ACTIVITY_FORMING_CARBON_OXYGEN_BONDS, chr1p36, KRIEG_KDM3A_TARGETS_NOT_HYPOXIA, GOMF_CATALYTIC_ACTIVITY_ACTING_ON_RNA, GOMF_CATALYTIC_ACTIVITY_ACTING_ON_A_TRNA, CEBPZ_TARGET_GENES, DACH1_TARGET_GENES, MAFG_TARGET_GENES
GO Biological Process (1): phenylalanyl-tRNA aminoacylation (GO:0006432)
GO Molecular Function (3): RNA binding (GO:0003723), phenylalanine-tRNA ligase activity (GO:0004826), protein binding (GO:0005515)
GO Cellular Component (0):
GO top-level categories
Rollup of top GO terms by namespace:
| Category | Terms |
|---|---|
| tRNA aminoacylation for protein translation | 1 |
| nucleic acid binding | 1 |
| aminoacyl-tRNA ligase activity | 1 |
| binding | 1 |
Protein interactions and networks
STRING
2752 interactions, top by confidence (×1000):
| Protein A | Protein B | Partner UniProt | Score |
|---|---|---|---|
| LRRC47 | RIOK1 | Q9BRS2 | 612 |
| LRRC47 | EIF1AD | Q8N9N8 | 549 |
| LRRC47 | CCDC27 | Q2M243 | 520 |
| LRRC47 | PJA2 | O43164 | 487 |
| LRRC47 | C1orf54 | Q8WWF1 | 465 |
| LRRC47 | EIF3CL | B5ME19 | 449 |
| LRRC47 | C1orf174 | Q8IYL3 | 447 |
| LRRC47 | CEP104 | O60308 | 445 |
| LRRC47 | RIOK2 | Q9BVS4 | 440 |
| LRRC47 | SPRYD3 | Q8NCJ5 | 412 |
| LRRC47 | RBMS2 | Q15434 | 406 |
| LRRC47 | XPO1 | O14980 | 404 |
| LRRC47 | KCNH2 | Q12809 | 403 |
| LRRC47 | MICU2 | Q8IYU8 | 403 |
| LRRC47 | OLA1 | Q9NTK5 | 402 |
| LRRC47 | CPSF2 | Q9P2I0 | 402 |
IntAct
70 interactions, top by confidence:
| A | B | Type | Score |
|---|---|---|---|
| MED4 | MED19 | psi-mi:“MI:0914”(association) | 0.900 |
| MED20 | MED19 | psi-mi:“MI:0914”(association) | 0.840 |
| CUL4B | COPS2 | psi-mi:“MI:0914”(association) | 0.790 |
| RIOK1 | PRMT5 | psi-mi:“MI:0914”(association) | 0.710 |
| LRRC47 | gag | psi-mi:“MI:0915”(physical association) | 0.500 |
| LRRC47 | PLOD1 | psi-mi:“MI:0915”(physical association) | 0.400 |
| GNAT3 | psi-mi:“MI:0915”(physical association) | 0.400 | |
| JUN | psi-mi:“MI:0914”(association) | 0.350 | |
| JUN | TPM3 | psi-mi:“MI:0914”(association) | 0.350 |
| MAPT | C11orf98 | psi-mi:“MI:0914”(association) | 0.350 |
| MAPT | POTEF | psi-mi:“MI:0914”(association) | 0.350 |
| TNFRSF10A | NAP1L4 | psi-mi:“MI:0914”(association) | 0.350 |
| COPS5 | FBLL1 | psi-mi:“MI:0914”(association) | 0.350 |
| COPS6 | DDX3X | psi-mi:“MI:0914”(association) | 0.350 |
| LRRK2 | psi-mi:“MI:0914”(association) | 0.350 | |
| TNIP3 | RNH1 | psi-mi:“MI:0914”(association) | 0.350 |
| USP32 | psi-mi:“MI:0914”(association) | 0.350 | |
| USP42 | KPNA3 | psi-mi:“MI:0914”(association) | 0.350 |
| BABAM1 | PYCR3 | psi-mi:“MI:0914”(association) | 0.350 |
| ORF4 | CTDNEP1 | psi-mi:“MI:0914”(association) | 0.350 |
| SHTN1 | psi-mi:“MI:0914”(association) | 0.350 | |
| TNFRSF10A | psi-mi:“MI:0914”(association) | 0.350 | |
| RIN3 | psi-mi:“MI:0914”(association) | 0.350 | |
| PAK4 | SNRPE | psi-mi:“MI:0914”(association) | 0.350 |
| PAK4 | MCM5 | psi-mi:“MI:0914”(association) | 0.350 |
| MAP1LC3A | psi-mi:“MI:0914”(association) | 0.350 | |
| MAP1LC3B | psi-mi:“MI:0914”(association) | 0.350 | |
| MAPT | SHTN1 | psi-mi:“MI:0914”(association) | 0.350 |
BioGRID (150): EIF2A (Co-fractionation), LRRC47 (Co-fractionation), LRRC47 (Co-fractionation), LRRC47 (Co-fractionation), LRRC47 (Co-fractionation), NAPRT (Co-fractionation), PSMB6 (Co-fractionation), LRRC47 (Affinity Capture-MS), LRRC47 (Proximity Label-MS), LRRC47 (Affinity Capture-MS), LRRC47 (Affinity Capture-MS), LRRC47 (Proximity Label-MS), LRRC47 (Proximity Label-MS), LRRC47 (Affinity Capture-MS), LRRC47 (Affinity Capture-MS)
ESM2 similar proteins: A0A8P0N4K0, A2AB59, B4F7F3, D3YZU1, D3ZD05, O35681, O75427, O95382, P22455, P22607, P40748, P55144, P70218, Q06418, Q14160, Q1LZH7, Q2PS20, Q32P44, Q495M9, Q4ACU6, Q4H4B6, Q505F5, Q5F488, Q61851, Q63ZY3, Q6P9K8, Q6TLK4, Q6ZUM4, Q7KRY7, Q80T11, Q80U72, Q8BH60, Q8BX02, Q8N1G4, Q8TE68, Q8VC03, Q8VHK1, Q8VHK2, Q8WXD9, Q8WXE0
Diamond homologs: A0B993, A1QZU9, A1RYS1, A2ST82, A3CT77, A4FWS3, A4YIL0, A6UPQ4, A6UWT1, A6VGJ4, A7I615, A9AA58, B0R807, B1L7C0, B2S0L6, B5RM71, B5RPL7, B6YTJ3, B7J278, B8GEX4, B9LU47, C3MJ88, C3MYY0, C3N028, C3N8B1, C3NMS5, C4KJ68, C5A5Z0, C6A237, O26864, O28848, O42849, O73984, P57694, P94283, P95960, Q0W0X4, Q12YP2, Q19713, Q2FLL1
SIGNOR signaling
0 interactions.
Enriched among interaction partners
Reactome pathways and GO biological processes over-represented among this gene’s 96 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.
Reactome pathways:
| Pathway | Partners | Fold | FDR |
|---|---|---|---|
| SARS-CoV-2 modulates host translation machinery | 5 | 16.2× | 8e-04 |
| Influenza Infection | 5 | 12.7× | 2e-03 |
| SARS-CoV-1 Infection | 6 | 12.4× | 7e-04 |
| Signaling by ROBO receptors | 6 | 10.8× | 9e-04 |
| SARS-CoV-2-host interactions | 6 | 10.3× | 9e-04 |
| SARS-CoV-2 Infection | 7 | 8.2× | 9e-04 |
| Major pathway of rRNA processing in the nucleolus and cytosol | 9 | 8.1× | 4e-04 |
| SARS-CoV Infections | 7 | 5.6× | 5e-03 |
GO biological processes:
| GO term | Partners | Fold | FDR |
|---|---|---|---|
| cytoplasmic translation | 6 | 12.9× | 1e-03 |
| positive regulation of cell growth | 5 | 10.7× | 6e-03 |
| positive regulation of canonical Wnt signaling pathway | 5 | 9.0× | 1e-02 |
Disease & clinical
Clinical variants and AI predictions
ClinVar
81 variants total. Per-class counts are floors (≥ shown; pagination cap):
| Classification | Count (floor) |
|---|---|
| Pathogenic | 0 |
| Likely pathogenic | 0 |
| Uncertain significance | 65 |
| Likely benign | 1 |
| Benign | 0 |
Top pathogenic / likely-pathogenic (0)
SpliceAI
1343 predictions. Top by Δscore:
| Variant | Effect | Δscore |
|---|---|---|
| 1:3781600:ACC:A | acceptor_loss | 1.0000 |
| 1:3781601:CCT:C | acceptor_gain | 1.0000 |
| 1:3781602:C:CC | acceptor_gain | 1.0000 |
| 1:3781602:C:T | acceptor_gain | 1.0000 |
| 1:3781603:T:C | acceptor_gain | 1.0000 |
| 1:3781603:T:TC | acceptor_gain | 1.0000 |
| 1:3782656:CCTA:C | donor_loss | 1.0000 |
| 1:3782657:CTACC:C | donor_loss | 1.0000 |
| 1:3782660:C:A | donor_loss | 1.0000 |
| 1:3782673:A:AC | donor_gain | 1.0000 |
| 1:3782674:C:CC | donor_gain | 1.0000 |
| 1:3782759:GGTAT:G | acceptor_gain | 1.0000 |
| 1:3782760:GTAT:G | acceptor_gain | 1.0000 |
| 1:3782761:TAT:T | acceptor_gain | 1.0000 |
| 1:3782762:AT:A | acceptor_gain | 1.0000 |
| 1:3782763:TCTG:T | acceptor_loss | 1.0000 |
| 1:3782764:C:CA | acceptor_loss | 1.0000 |
| 1:3782764:C:CC | acceptor_gain | 1.0000 |
| 1:3782765:T:A | acceptor_loss | 1.0000 |
| 1:3782766:G:C | acceptor_gain | 1.0000 |
| 1:3784108:CAAT:C | acceptor_gain | 1.0000 |
| 1:3784112:C:CC | acceptor_gain | 1.0000 |
| 1:3787064:T:TA | donor_gain | 1.0000 |
| 1:3787070:C:CA | donor_gain | 1.0000 |
| 1:3787073:T:TA | donor_gain | 1.0000 |
| 1:3787079:T:TA | donor_gain | 1.0000 |
| 1:3787093:T:TA | donor_gain | 1.0000 |
| 1:3787160:C:CA | donor_gain | 1.0000 |
| 1:3787306:AACGT:A | acceptor_gain | 1.0000 |
| 1:3787307:ACGT:A | acceptor_gain | 1.0000 |
AlphaMissense
3707 scored. Top likely-pathogenic:
| Variant | Protein change | am_pathogenicity |
|---|---|---|
| 1:3781560:A:C | S485R | 0.998 |
| 1:3781560:A:T | S485R | 0.998 |
| 1:3781562:T:G | S485R | 0.998 |
| 1:3787290:G:C | N212K | 0.998 |
| 1:3787290:G:T | N212K | 0.998 |
| 1:3795910:G:C | N189K | 0.998 |
| 1:3795910:G:T | N189K | 0.998 |
| 1:3795988:A:C | N163K | 0.998 |
| 1:3795988:A:T | N163K | 0.998 |
| 1:3796150:G:C | N109K | 0.998 |
| 1:3796150:G:T | N109K | 0.998 |
| 1:3796151:T:A | N109I | 0.998 |
| 1:3796313:A:G | L55S | 0.998 |
| 1:3781144:A:C | Y566D | 0.997 |
| 1:3781539:G:C | C492W | 0.997 |
| 1:3795866:A:T | L204H | 0.997 |
| 1:3796060:G:C | N139K | 0.997 |
| 1:3796060:G:T | N139K | 0.997 |
| 1:3796061:T:A | N139I | 0.997 |
| 1:3796175:A:T | L101H | 0.997 |
| 1:3796222:G:C | N85K | 0.997 |
| 1:3796222:G:T | N85K | 0.997 |
| 1:3796238:A:T | L80H | 0.997 |
| 1:3781540:C:T | C492Y | 0.996 |
| 1:3785163:G:T | A373D | 0.996 |
| 1:3787221:G:C | N235K | 0.996 |
| 1:3787221:G:T | N235K | 0.996 |
| 1:3787291:T:A | N212I | 0.996 |
| 1:3795989:T:A | N163I | 0.996 |
| 1:3796062:T:C | N139D | 0.996 |
dbSNP variants (sampled 300 via entrez): RS1000010436 (1:3784824 C>T), RS1000388489 (1:3794820 C>G), RS1000488149 (1:3789941 G>A), RS1000515827 (1:3790105 G>A), RS1000625061 (1:3786066 C>T), RS1000671680 (1:3781231 T>C), RS1000915190 (1:3795211 T>C), RS1000916168 (1:3780943 T>G), RS1000960846 (1:3785781 A>G), RS1001101341 (1:3786245 C>T), RS1001566744 (1:3782182 A>G), RS1001819343 (1:3780719 C>T), RS1001985844 (1:3796662 C>G,T), RS1002032431 (1:3784909 C>A,T), RS1002094263 (1:3791171 G>A,C,T)
Disease associations
OMIM: gene MIM:619154 | disease phenotypes:
GenCC curated gene-disease
Mondo (0):
Orphanet (0):
HPO phenotypes
0 total (0 of 0 shown, HPO-id order):
GWAS associations
6 associations (top):
| Study | Trait | p-value |
|---|---|---|
| GCST001524_16 | Visceral adipose tissue/subcutaneous adipose tissue ratio | 2.000000e-06 |
| GCST001525_13 | Visceral fat | 2.000000e-06 |
| GCST001525_2 | Visceral fat | 2.000000e-06 |
| GCST002041_1 | Blood trace element (Cu levels) | 5.000000e-10 |
| GCST004621_2 | Red cell distribution width | 7.000000e-21 |
| GCST90002383_142 | Hematocrit | 9.000000e-10 |
EFO canonical traits (4, from GWAS)
| EFO ID | Trait name |
|---|---|
| EFO:0004767 | visceral:subcutaneous adipose tissue ratio |
| EFO:0005267 | serum copper measurement |
| EFO:0009188 | Red cell distribution width |
| EFO:0004348 | hematocrit |
Drugs & pharmacology
Drug and pharmacology data
Is drug target: yes
ChEMBL targets (1): CHEMBL6066357 (SINGLE PROTEIN)
PharmGKB: 1 entry (VIP=true, CPIC=false)
ChEMBL bioactivities
4 potent at pChembl≥5 of 4 total, top 4 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).
| pChembl | Type | Value | Unit | Molecule |
|---|---|---|---|---|
| 8.04 | Kd | 9.132 | nM | CHEMBL5653589 |
| 8.04 | ED50 | 9.132 | nM | CHEMBL5653589 |
| 7.68 | Kd | 20.68 | nM | CHEMBL3752910 |
| 7.68 | ED50 | 20.68 | nM | CHEMBL3752910 |
PubChem BioAssay actives
2 with measured affinity, of 4 total; 2 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.
| Compound | Assay | Type | Value | Unit |
|---|---|---|---|---|
| 4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide | 2148666: Binding affinity to human LRRC47 incubated for 45 mins by Kinobead based pull down assay | kd | 0.0091 | uM |
| 4-methyl-3-[(1-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide | 2148666: Binding affinity to human LRRC47 incubated for 45 mins by Kinobead based pull down assay | kd | 0.0207 | uM |
CTD chemical–gene interactions
48 total (human), top 30 by PubMed support.
| Chemical | Actions (top 5) | PubMed papers |
|---|---|---|
| Benzo(a)pyrene | affects methylation, decreases expression | 2 |
| aristolochic acid I | increases expression | 1 |
| FR900359 | affects phosphorylation | 1 |
| bisphenol A | increases expression | 1 |
| pyrogallol 1,3-dimethyl ether | affects cotreatment, affects localization, decreases expression | 1 |
| sodium arsenite | affects cotreatment, increases abundance, increases expression | 1 |
| cobaltous chloride | increases expression | 1 |
| perfluorooctanoic acid | decreases expression | 1 |
| manganese chloride | affects cotreatment, increases abundance, increases expression | 1 |
| coumarin | affects phosphorylation | 1 |
| di-n-butylphosphoric acid | affects expression | 1 |
| perfluorooctane sulfonic acid | decreases expression | 1 |
| CGP 52608 | affects binding, increases reaction | 1 |
| perfluoro-n-nonanoic acid | decreases expression | 1 |
| perfluorohexanesulfonic acid | decreases expression | 1 |
| bisphenol S | increases expression | 1 |
| bisphenol AF | increases expression | 1 |
| Resveratrol | affects cotreatment, increases expression | 1 |
| Temozolomide | increases expression | 1 |
| Sunitinib | increases expression | 1 |
| Adenine | decreases expression | 1 |
| Air Pollutants | decreases expression, increases abundance | 1 |
| Arsenic | affects cotreatment, increases abundance, increases expression | 1 |
| Atrazine | decreases expression | 1 |
| Cadmium | decreases expression | 1 |
| Caffeine | increases phosphorylation | 1 |
| Cisplatin | decreases expression | 1 |
| Colchicine | decreases expression | 1 |
| Doxorubicin | increases expression | 1 |
| Enzyme Inhibitors | decreases activity, increases O-linked glycosylation | 1 |
ChEMBL screening assays
1 unique, capped per target: 1 binding
Representative assays (with source publication via chembl_document):
| Assay ID | Type | Description | Source paper |
|---|---|---|---|
| CHEMBL5651708 | Binding | Binding affinity to human LRRC47 incubated for 45 mins by Kinobead based pull down assay | NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem |
Clinical trials (associated diseases)
0 trials via MONDO — disease-level, not drug-specific.
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.