LRRC49

Summary

LRRC49 (leucine rich repeat containing 49, HGNC:25965) is a protein-coding gene on chromosome 15q23, encoding Leucine-rich repeat-containing protein 49 (Q8IUZ0). Subunit of the tubulin polyglutamylase complex (TPGC).

Located in centriolar satellite.

Source: NCBI Gene 54839 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 138 total
• MANE Select transcript: NM_017691

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25965
Approved symbol	LRRC49
Name	leucine rich repeat containing 49
Location	15q23
Locus type	gene with protein product
Status	Approved
Aliases	FLJ20156, CSTPP2, PGs4
Ensembl gene	ENSG00000137821
Ensembl biotype	protein_coding
OMIM	620497
Entrez	54839

Gene structure

Transcript identifiers

Ensembl transcripts: 30 — 14 protein_coding, 6 protein_coding_CDS_not_defined, 6 nonsense_mediated_decay, 4 retained_intron

ENST00000260382, ENST00000436542, ENST00000443425, ENST00000544974, ENST00000557977, ENST00000558032, ENST00000558137, ENST00000558204, ENST00000558271, ENST00000558456, ENST00000558546, ENST00000558799, ENST00000558808, ENST00000559069, ENST00000559201, ENST00000559422, ENST00000559469, ENST00000559670, ENST00000559685, ENST00000559806, ENST00000560107, ENST00000560158, ENST00000560369, ENST00000560691, ENST00000560755, ENST00000560980, ENST00000561081, ENST00000561131, ENST00000561285, ENST00000906574

RefSeq mRNA: 5 — MANE Select: NM_017691 NM_001199017, NM_001199018, NM_001284357, NM_001363732, NM_017691

CCDS: CCDS32282, CCDS55971, CCDS58376, CCDS61694, CCDS86472

Canonical transcript exons

ENST00000260382 — 16 exons

Exon	Start	End
ENSE00000931728	70892826	70892942
ENSE00003465211	70911532	70911598
ENSE00003471920	70904552	70904755
ENSE00003491496	70936761	70936822
ENSE00003498654	71009807	71009992
ENSE00003498965	71037179	71037332
ENSE00003504587	70984094	70984257
ENSE00003515698	71012804	71012913
ENSE00003558368	70980101	70980184
ENSE00003574713	70893584	70893640
ENSE00003602743	71008379	71008616
ENSE00003662018	70919050	70919193
ENSE00003664256	70895849	70895936
ENSE00003682275	70963785	70963932
ENSE00003686304	70900922	70901024
ENSE00003902217	71049409	71053658

Expression profiles

Bgee: expression breadth ubiquitous, 252 present calls, max score 96.41.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 11.3480 / max 406.6553, expressed in 1326 samples.

FANTOM5 promoters (10 alternative TSS)

Promoter ID	TPM avg	Samples expressed
147500	6.7738	973
147497	1.3805	398
147499	1.0863	611
147496	0.8281	312
147498	0.8122	423
147503	0.1421	56
147501	0.1217	39
147504	0.0958	34
147507	0.0860	39
147502	0.0215	9

Top tissues by expression

284 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	96.41	gold quality
lateral nuclear group of thalamus	UBERON:0002736	95.50	gold quality
left ventricle myocardium	UBERON:0006566	95.42	gold quality
heart right ventricle	UBERON:0002080	95.14	gold quality
bronchial epithelial cell	CL:0002328	94.15	gold quality
myocardium	UBERON:0002349	94.02	gold quality
ganglionic eminence	UBERON:0004023	93.80	gold quality
ventricular zone	UBERON:0003053	93.74	gold quality
apex of heart	UBERON:0002098	93.56	gold quality
cardiac ventricle	UBERON:0002082	93.21	gold quality
heart left ventricle	UBERON:0002084	93.18	gold quality
epithelium of bronchus	UBERON:0002031	92.86	gold quality
Brodmann (1909) area 23	UBERON:0013554	92.81	gold quality
primary visual cortex	UBERON:0002436	92.29	gold quality
calcaneal tendon	UBERON:0003701	92.11	gold quality
bronchus	UBERON:0002185	91.95	gold quality
middle temporal gyrus	UBERON:0002771	91.93	gold quality
cartilage tissue	UBERON:0002418	91.78	gold quality
caudate nucleus	UBERON:0001873	90.96	gold quality
heart	UBERON:0000948	90.86	gold quality
endothelial cell	CL:0000115	90.69	gold quality
cerebellar cortex	UBERON:0002129	90.68	gold quality
cerebellar hemisphere	UBERON:0002245	90.65	gold quality
right hemisphere of cerebellum	UBERON:0014890	90.45	gold quality
right atrium auricular region	UBERON:0006631	90.37	gold quality
cardiac atrium	UBERON:0002081	90.31	gold quality
secondary oocyte	CL:0000655	90.26	gold quality
right uterine tube	UBERON:0001302	90.13	gold quality
nucleus accumbens	UBERON:0001882	89.93	gold quality
putamen	UBERON:0001874	89.89	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.93

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

45 targeting LRRC49, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-12118	100.00	65.88	1270
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-3667-3P	99.99	67.17	1636
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-3617-3P	99.98	67.86	918
HSA-MIR-6891-5P	99.98	66.53	1372
HSA-MIR-3173-3P	99.98	66.49	1217
HSA-MIR-302C-5P	99.97	72.56	3642
HSA-MIR-545-3P	99.95	70.74	2783
HSA-MIR-3119	99.92	71.34	2390
HSA-MIR-1305	99.91	71.43	3443
HSA-MIR-548AR-3P	99.85	71.26	3889
HSA-MIR-548AZ-3P	99.82	70.56	3549
HSA-MIR-548BC	99.82	70.61	3524
HSA-MIR-548E-3P	99.82	70.59	3514
HSA-MIR-548F-3P	99.82	70.59	3540
HSA-MIR-3133	99.81	70.92	3506
HSA-MIR-548A-3P	99.76	70.58	3524
HSA-MIR-1976	99.74	65.48	1127
HSA-MIR-4470	99.66	69.35	1767
HSA-MIR-186-3P	99.51	66.24	1685
HSA-MIR-203A-3P	99.49	70.56	2806
HSA-MIR-5584-5P	99.49	68.22	2814
HSA-MIR-3612	99.45	66.02	1333
HSA-MIR-650	99.45	65.77	1309
HSA-MIR-330-3P	99.41	69.95	2521
HSA-MIR-133A-3P	99.27	71.53	1270
HSA-MIR-133B	99.27	71.53	1270
HSA-MIR-6734-3P	99.15	66.27	1627

Literature-anchored findings (GeneRIF, showing 1)

• transcripts of LRRC49/THAP10 bidirectional gene pair are co-regulated by estrogen and that hypermethylation of the bidirectional promoter region simultaneously silences both genes. (PMID:18575747)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Lrrc49	ENSMUSG00000047766
rattus_norvegicus	Lrrc49	ENSRNOG00000012015
drosophila_melanogaster	CG13708	FBGN0035577

Paralogs (13): LRRC23 (ENSG00000010626), LRRC61 (ENSG00000127399), DNAAF11 (ENSG00000129295), LRRC9 (ENSG00000131951), LRRCC1 (ENSG00000133739), LRRC46 (ENSG00000141294), DNAAF1 (ENSG00000154099), LRGUK (ENSG00000155530), LRRC43 (ENSG00000158113), LRRIQ3 (ENSG00000162620), DRC3 (ENSG00000171962), PPP1R42 (ENSG00000178125), CEP97 (ENSG00000182504)

Protein

Protein identifiers

Leucine-rich repeat-containing protein 49 — Q8IUZ0 (reviewed: Q8IUZ0)

Alternative names: Centriolar satellite-associated tubulin polyglutamylase complex regulator 2, Tubulin polyglutamylase complex subunit 4

All UniProt accessions (14): Q8IUZ0, A0A0B4J283, H0YKE9, H0YKI5, H0YKQ0, H0YKS7, H0YLQ8, H0YLZ6, H0YM43, H0YMT2, H0YMZ6, H0YNI5, H0YNV5, H3BNA9

UniProt curated annotations — full annotation on UniProt →

Function. Subunit of the tubulin polyglutamylase complex (TPGC). The complex mediates cilia and flagella polyglutamylation which is essential for their biogenesis and motility.

Subunit / interactions. Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1. Interacts with PCM1; TTLL1, TPGS1, TPGS2 and LRRC49.

Subcellular location. Cytoplasm. Cytoskeleton. Microtubule organizing center. Centrosome. Centriolar satellite.

Isoforms (4)

UniProt ID	Names	Canonical?
Q8IUZ0-1	1	yes
Q8IUZ0-2	2
Q8IUZ0-3	3
Q8IUZ0-4	4

RefSeq proteins (5): NP_001185946, NP_001185947, NP_001271286, NP_001350661, NP_060161* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001611	Leu-rich_rpt	Repeat
IPR003591	Leu-rich_rpt_typical-subtyp	Repeat
IPR025875	Leu-rich_rpt_4	Repeat
IPR032675	LRR_dom_sf	Homologous_superfamily
IPR050576	Cilia_flagella_integrity	Family

Pfam: PF12799, PF14580

UniProt features (19 total): repeat 7, sequence conflict 5, splice variant 3, chain 1, coiled-coil region 1, domain 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8IUZ0-F1	75.69	0.33

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-8955332	Carboxyterminal post-translational modifications of tubulin
R-HSA-392499	Metabolism of proteins
R-HSA-597592	Post-translational protein modification

MSigDB gene sets: 118 (showing top): GOCC_MICROTUBULE_ORGANIZING_CENTER, MODULE_205, GOCC_CENTROSOME, NRF2_01, RFX1_02, chr15q23, PTF1BETA_Q6, CETS1P54_01, TTCNRGNNNNTTC_HSF_Q6, MARSON_BOUND_BY_E2F4_UNSTIMULATED, GOCC_CENTRIOLAR_SATELLITE, SCGGAAGY_ELK1_02, GAUSSMANN_MLL_AF4_FUSION_TARGETS_G_UP, REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN

GO Biological Process (3): microtubule cytoskeleton organization (GO:0000226), microtubule polymerization (GO:0046785), cilium disassembly (GO:0061523)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (4): microtubule (GO:0005874), centriolar satellite (GO:0034451), cytoplasm (GO:0005737), cytoskeleton (GO:0005856)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Post-translational protein modification	1
Metabolism of proteins	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
cytoskeleton organization	1
microtubule-based process	1
microtubule nucleation	1
microtubule polymerization or depolymerization	1
protein polymerization	1
supramolecular fiber organization	1
cilium organization	1
organelle disassembly	1
binding	1
microtubule cytoskeleton	1
polymeric cytoskeletal fiber	1
centrosome	1
intracellular anatomical structure	1
intracellular membraneless organelle	1

Protein interactions and networks

STRING

1181 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
LRRC49	TPGS1	Q6ZTW0	732
LRRC49	THAP10	Q9P2Z0	603
LRRC49	TTLL1	O95922	595
LRRC49	NICN1	Q9BSH3	589
LRRC49	CCDC148	Q8NFR7	516
LRRC49	CSTPP1	Q9H6J7	448
LRRC49	REDIC1	Q86WS4	447
LRRC49	C3orf80	F5H4A9	444
LRRC49	E5RHQ9	E5RHQ9	419
LRRC49	LARP6	Q9BRS8	418
LRRC49	TPGS2	Q68CL5	401
LRRC49	SPACA6	W5XKT8	386
LRRC49	CLEC5A	Q9NY25	375
LRRC49	TEX9	Q8N6V9	374
LRRC49	TMEM234	Q8WY98	354

IntAct

68 interactions, top by confidence:

A	B	Type	Score
CEP290	CCP110	psi-mi:“MI:2364”(proximity)	0.890
EIF3F	EIF3CL	psi-mi:“MI:0914”(association)	0.640
NICN1	TTLL1	psi-mi:“MI:0914”(association)	0.640
TTLL1	CDC27	psi-mi:“MI:0914”(association)	0.640
NICN1	TPGS2	psi-mi:“MI:0914”(association)	0.640
LRRC49	EIF3F	psi-mi:“MI:0914”(association)	0.640
INSR	PIK3R2	psi-mi:“MI:2364”(proximity)	0.570
CEP104	CCDC66	psi-mi:“MI:2364”(proximity)	0.540
LRRC49	SNAP29	psi-mi:“MI:0914”(association)	0.530
CSTPP1	TPGS2	psi-mi:“MI:0914”(association)	0.530
AHI1	OFD1	psi-mi:“MI:2364”(proximity)	0.420
GSK3B	SEC16A	psi-mi:“MI:2364”(proximity)	0.420
	LRRC49	psi-mi:“MI:0915”(physical association)	0.400
LRRC49		psi-mi:“MI:0915”(physical association)	0.370
SPATA1	ANKHD1	psi-mi:“MI:0914”(association)	0.350
LRRC49	PCM1	psi-mi:“MI:0914”(association)	0.350
SMG8	HSP90AA4P	psi-mi:“MI:0914”(association)	0.350
CSTPP1	TPGS2	psi-mi:“MI:0914”(association)	0.350
ROS1	ODAD3	psi-mi:“MI:0914”(association)	0.350
HCN1	USP27X	psi-mi:“MI:0914”(association)	0.350
TPGS1	PIK3R2	psi-mi:“MI:0914”(association)	0.350
CSTPP1	PEX5	psi-mi:“MI:0914”(association)	0.350
TTLL1	CAMK2B	psi-mi:“MI:0914”(association)	0.350
LRRC49	ASS1	psi-mi:“MI:0914”(association)	0.350
MAGEA10	KANSL1L	psi-mi:“MI:0914”(association)	0.350
NICN1	PLEKHG3	psi-mi:“MI:0914”(association)	0.350

BioGRID (137): LRRC49 (Affinity Capture-MS), LRRC49 (Affinity Capture-MS), LRRC49 (Affinity Capture-MS), LRRC49 (Affinity Capture-MS), LRRC49 (Proximity Label-MS), LRRC49 (Proximity Label-MS), LRRC49 (Proximity Label-MS), LRRC49 (Proximity Label-MS), LRRC49 (Proximity Label-MS), LRRC49 (Proximity Label-MS), LRRC49 (Proximity Label-MS), LRRC49 (Proximity Label-MS), LRRC49 (Proximity Label-MS), LRRC49 (Proximity Label-MS), LRRC49 (Proximity Label-MS)

ESM2 similar proteins: A2VE78, B1H1X1, B4F7C5, E1C3P4, O94898, O95170, P55265, P97432, Q14596, Q1L994, Q2HJ90, Q2TBA3, Q3UGM2, Q496Y0, Q4KM95, Q52KR2, Q5F3F2, Q5KSL6, Q5Q9Z2, Q5R6E1, Q641K1, Q69ZK0, Q6NTL4, Q7TPQ3, Q80TL0, Q80XG9, Q80Z30, Q86VH4, Q8C2S5, Q8IUZ0, Q8K2I9, Q8N4P6, Q8NA31, Q8NEE8, Q8NFZ0, Q8R2U7, Q8WY54, Q91YK0, Q95LZ5, Q96EK7

Diamond homologs: Q8IUZ0, Q91YK0

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
LRRC49	“form complex”	“Tubulin polyglutamylase complex”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 87 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Loss of Nlp from mitotic centrosomes	8	23.5×	2e-07
Loss of proteins required for interphase microtubule organization from the centrosome	8	23.5×	2e-07
Anchoring of the basal body to the plasma membrane	11	23.0×	4e-10
AURKA Activation by TPX2	8	22.6×	2e-07
Recruitment of mitotic centrosome proteins and complexes	8	20.1×	4e-07
Regulation of PLK1 Activity at G2/M Transition	8	18.8×	6e-07
Recruitment of NuMA to mitotic centrosomes	8	17.3×	1e-06
Cilium Assembly	5	10.1×	5e-03

GO biological processes:

GO term	Partners	Fold	FDR
centriole replication	8	79.2×	3e-11
centrosome cycle	5	22.8×	4e-04
cell surface receptor protein tyrosine kinase signaling pathway	6	14.1×	5e-04
cilium assembly	11	10.9×	2e-06
protein autophosphorylation	5	9.8×	7e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

138 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	124
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

3518 predictions. Top by Δscore:

Variant	Effect	Δscore
15:70882648:TAC:T	acceptor_gain	1.0000
15:70882648:TACC:T	acceptor_loss	1.0000
15:70882651:C:CC	acceptor_gain	1.0000
15:70882651:CTGA:C	acceptor_loss	1.0000
15:70882759:AC:A	donor_gain	1.0000
15:70882760:CC:C	donor_gain	1.0000
15:70882760:CCCA:C	donor_gain	1.0000
15:70892938:ACAAC:A	donor_gain	1.0000
15:70892939:CAAC:C	donor_gain	1.0000
15:70892940:AAC:A	donor_gain	1.0000
15:70892941:AC:A	donor_gain	1.0000
15:70892943:G:GA	donor_loss	1.0000
15:70892943:G:GG	donor_gain	1.0000
15:70892944:T:A	donor_loss	1.0000
15:70893641:G:GG	donor_gain	1.0000
15:70895987:T:TG	donor_gain	1.0000
15:70904550:A:AG	acceptor_gain	1.0000
15:70904551:G:GG	acceptor_gain	1.0000
15:70919191:GTG:G	donor_gain	1.0000
15:70919194:G:A	donor_loss	1.0000
15:70919195:TGAGT:T	donor_loss	1.0000
15:70919196:G:GT	donor_loss	1.0000
15:70919197:AGTAT:A	donor_loss	1.0000
15:70936755:TTCCA:T	acceptor_loss	1.0000
15:70936756:TCCA:T	acceptor_loss	1.0000
15:70936758:CA:C	acceptor_loss	1.0000
15:70936759:A:AG	acceptor_gain	1.0000
15:70936759:A:AT	acceptor_loss	1.0000
15:70936760:G:GG	acceptor_gain	1.0000
15:70936760:GA:G	acceptor_gain	1.0000

AlphaMissense

4560 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
15:70919162:T:C	L227P	1.000
15:70904621:T:A	N122K	0.999
15:70904621:T:G	N122K	0.999
15:70911585:T:A	L185H	0.999
15:70911585:T:C	L185P	0.999
15:70919087:T:G	L202W	0.999
15:70936795:T:C	L249P	0.999
15:70936801:T:C	L251P	0.999
15:70936811:C:A	N254K	0.999
15:70936811:C:G	N254K	0.999
15:70963848:T:A	N279K	0.999
15:70963848:T:G	N279K	0.999
15:71009811:T:C	L471P	0.999
15:71009817:T:C	F473S	0.999
15:71009913:T:A	V505D	0.999
15:71009930:T:A	W511R	0.999
15:71009930:T:C	W511R	0.999
15:71012828:G:C	A540P	0.999
15:71012829:C:A	A540D	0.999
15:71049533:T:A	V661D	0.999
15:70904568:T:C	C105R	0.998
15:70904687:C:A	N144K	0.998
15:70904687:C:G	N144K	0.998
15:70904737:T:A	L161H	0.998
15:70904737:T:C	L161P	0.998
15:70904753:C:A	N166K	0.998
15:70904753:C:G	N166K	0.998
15:70911579:T:C	L183S	0.998
15:70911579:T:G	L183W	0.998
15:70911585:T:G	L185R	0.998

dbSNP variants (sampled 300 via entrez): RS1000000734 (15:70903110 G>T), RS1000013170 (15:70960986 G>A), RS1000034631 (15:70952345 C>A,G,T), RS1000046296 (15:71005389 C>T), RS1000075561 (15:70961102 T>C), RS1000080846 (15:71003995 G>A), RS1000085281 (15:71032673 T>C), RS1000096085 (15:71034727 C>A,G), RS1000122051 (15:71051435 C>T), RS1000130470 (15:70934002 C>T), RS1000131307 (15:71003655 T>C), RS1000137025 (15:70882124 T>C), RS1000144106 (15:71044714 A>G), RS1000144874 (15:70855394 T>G), RS1000154534 (15:70860250 C>A)

Disease associations

OMIM: gene MIM:620497 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST004864_13	Perceived unattractiveness to mosquitoes	4.000000e-07

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0008380	perceived unattractiveness to mosquitos measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

28 total (human), top 28 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
trichostatin A	affects cotreatment, decreases expression	3
Benzo(a)pyrene	decreases expression, affects methylation	3
Valproic Acid	affects expression, decreases expression, increases expression	3
bisphenol A	affects cotreatment, increases methylation, increases expression	2
9-hydroxyoctadecadienoic acid	increases expression	1
methylmercuric chloride	decreases expression	1
perfluorooctanoic acid	increases expression	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
epigallocatechin gallate	decreases expression, affects cotreatment	1
2-palmitoylglycerol	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
ICG 001	increases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
bisphenol S	decreases methylation	1
jinfukang	decreases expression	1
NSC 689534	affects binding, increases expression	1
Resveratrol	decreases expression	1
Sunitinib	decreases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Air Pollutants	decreases expression, increases abundance	1
Copper	affects binding, increases expression	1
Diethylhexyl Phthalate	decreases expression	1
Doxorubicin	increases expression	1
Methyl Methanesulfonate	increases expression	1
Tobacco Smoke Pollution	decreases expression	1
Cyclosporine	increases expression	1
Aflatoxin B1	increases methylation	1
Particulate Matter	decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.