LRRC4B

Summary

LRRC4B (leucine rich repeat containing 4B, HGNC:25042) is a protein-coding gene on chromosome 19q13.33, encoding Leucine-rich repeat-containing protein 4B (Q9NT99). Synaptic adhesion protein.

Predicted to enable signaling receptor binding activity. Predicted to be involved in regulation of synapse assembly and synaptic membrane adhesion. Predicted to be located in cerebellar mossy fiber and presynaptic membrane. Predicted to be active in glutamatergic synapse and postsynaptic density membrane.

Source: NCBI Gene 94030 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 75 total
• MANE Select transcript: NM_001080457

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25042
Approved symbol	LRRC4B
Name	leucine rich repeat containing 4B
Location	19q13.33
Locus type	gene with protein product
Status	Approved
Aliases	DKFZp761A179, HSM, NGL-3
Ensembl gene	ENSG00000131409
Ensembl biotype	protein_coding
Entrez	94030

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 9 protein_coding

ENST00000389201, ENST00000599957, ENST00000600381, ENST00000652263, ENST00000903737, ENST00000903738, ENST00000903739, ENST00000940244, ENST00000940245

RefSeq mRNA: 2 — MANE Select: NM_001080457 NM_001080457, NM_001348568

CCDS: CCDS42595

Canonical transcript exons

ENST00000652263 — 3 exons

Exon	Start	End
ENSE00003850161	50567944	50568435
ENSE00003890031	50548542	50548873
ENSE00003894562	50516892	50519415

Expression profiles

Bgee: expression breadth ubiquitous, 164 present calls, max score 96.66.

FANTOM5 (CAGE): breadth broad, TPM avg 7.0232 / max 223.0532, expressed in 450 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
182236	5.7187	424
182237	1.1268	327
182230	0.1719	68
182228	0.0059	1

Top tissues by expression

251 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	96.66	gold quality
right frontal lobe	UBERON:0002810	96.31	gold quality
ventricular zone	UBERON:0003053	96.07	gold quality
Brodmann (1909) area 9	UBERON:0013540	95.79	gold quality
anterior cingulate cortex	UBERON:0009835	95.51	gold quality
ganglionic eminence	UBERON:0004023	95.43	gold quality
prefrontal cortex	UBERON:0000451	95.19	gold quality
amygdala	UBERON:0001876	95.06	gold quality
right hemisphere of cerebellum	UBERON:0014890	94.88	gold quality
hypothalamus	UBERON:0001898	94.78	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	94.33	gold quality
nucleus accumbens	UBERON:0001882	94.28	gold quality
cerebellar hemisphere	UBERON:0002245	94.09	gold quality
cerebellar cortex	UBERON:0002129	94.03	gold quality
putamen	UBERON:0001874	93.68	gold quality
caudate nucleus	UBERON:0001873	93.04	gold quality
cerebellum	UBERON:0002037	92.72	gold quality
frontal cortex	UBERON:0001870	92.21	gold quality
spinal cord	UBERON:0002240	92.11	gold quality
neocortex	UBERON:0001950	92.06	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	92.01	gold quality
endocervix	UBERON:0000458	89.96	gold quality
forebrain	UBERON:0001890	89.68	gold quality
brain	UBERON:0000955	89.46	gold quality
cerebral cortex	UBERON:0000956	89.46	gold quality
Ammon’s horn	UBERON:0001954	88.28	gold quality
substantia nigra	UBERON:0002038	87.98	gold quality
adenohypophysis	UBERON:0002196	87.92	gold quality
pituitary gland	UBERON:0000007	86.00	gold quality
midbrain	UBERON:0001891	85.75	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.78

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

59 targeting LRRC4B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4283	100.00	66.42	2097
HSA-MIR-559	99.95	72.28	3609
HSA-MIR-548AB	99.95	71.31	3488
HSA-MIR-185-3P	99.95	67.01	1743
HSA-MIR-548A-5P	99.94	71.27	3482
HSA-MIR-548AD-5P	99.94	71.23	3502
HSA-MIR-548AE-5P	99.94	71.23	3502
HSA-MIR-548AK	99.94	71.24	3488
HSA-MIR-548AM-5P	99.94	71.24	3488
HSA-MIR-548AP-5P	99.94	71.14	3489
HSA-MIR-548AQ-5P	99.94	71.34	3426
HSA-MIR-548AR-5P	99.94	71.28	3515
HSA-MIR-548AS-5P	99.94	71.22	3482
HSA-MIR-548AU-5P	99.94	71.24	3488
HSA-MIR-548AY-5P	99.94	71.23	3502
HSA-MIR-548B-5P	99.94	71.23	3502
HSA-MIR-548BB-5P	99.94	71.27	3509
HSA-MIR-548C-5P	99.94	71.24	3488
HSA-MIR-548D-5P	99.94	71.23	3502
HSA-MIR-548H-5P	99.94	71.24	3488
HSA-MIR-548I	99.94	71.25	3481
HSA-MIR-548J-5P	99.94	71.14	3489
HSA-MIR-548O-5P	99.94	71.24	3488
HSA-MIR-548W	99.94	71.24	3488
HSA-MIR-548Y	99.94	71.28	3514
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-3151-5P	99.86	63.83	1069
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-4447	99.85	67.81	2900
HSA-MIR-6785-5P	99.82	68.68	4428

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	lrrc4ba	ENSDARG00000004597
danio_rerio	lrrc4bb	ENSDARG00000014792
mus_musculus	Lrrc4b	ENSMUSG00000047085
rattus_norvegicus	Lrrc4b	ENSRNOG00000019418

Paralogs (22): DCN (ENSG00000011465), RTN4R (ENSG00000040608), ASPN (ENSG00000106819), FLRT3 (ENSG00000125848), FLRT1 (ENSG00000126500), LRRC4 (ENSG00000128594), PODNL1 (ENSG00000132000), LRTM1 (ENSG00000144771), LRRC4C (ENSG00000148948), LRRTM1 (ENSG00000162951), LRRC15 (ENSG00000172061), PODN (ENSG00000174348), LRRTM4 (ENSG00000176204), BGN (ENSG00000182492), LRRC19 (ENSG00000184434), FLRT2 (ENSG00000185070), GP1BA (ENSG00000185245), RTN4RL1 (ENSG00000185924), RTN4RL2 (ENSG00000186907), NYX (ENSG00000188937), LRRC66 (ENSG00000188993), LRRTM3 (ENSG00000198739)

Protein

Protein identifiers

Leucine-rich repeat-containing protein 4B — Q9NT99 (reviewed: Q9NT99)

Alternative names: Netrin-G3 ligand

All UniProt accessions (2): Q9NT99, M0R2G0

UniProt curated annotations — full annotation on UniProt →

Function. Synaptic adhesion protein. Regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner.

Subunit / interactions. Interacts with PTPRF. Interacts with DLG4.

Subcellular location. Membrane. Presynaptic cell membrane.

Post-translational modifications. N-glycosylated. O-glycosylated; contains sialic acid.

Domain organisation. The last 4 C-terminal residues bind to the first 2 PDZ domains of DLG4.

RefSeq proteins (2): NP_001073926, NP_001335497 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000372	LRRNT	Domain
IPR000483	Cys-rich_flank_reg_C	Domain
IPR001611	Leu-rich_rpt	Repeat
IPR003591	Leu-rich_rpt_typical-subtyp	Repeat
IPR003598	Ig_sub2	Domain
IPR003599	Ig_sub	Domain
IPR007110	Ig-like_dom	Domain
IPR013098	Ig_I-set	Domain
IPR013783	Ig-like_fold	Homologous_superfamily
IPR032675	LRR_dom_sf	Homologous_superfamily
IPR036179	Ig-like_dom_sf	Homologous_superfamily
IPR050541	LRR_TM_domain-containing	Family

Pfam: PF00560, PF07679, PF13855

UniProt features (33 total): repeat 9, glycosylation site 9, domain 3, region of interest 2, compositionally biased region 2, topological domain 2, signal peptide 1, chain 1, modified residue 1, transmembrane region 1, disulfide bond 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NT99-F1	73.36	0.54

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 693

Disulfide bonds (1): 385–436

Glycosylation sites (9): 224, 283, 333, 374, 400, 422, 425, 444, 452

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-388844	Receptor-type tyrosine-protein phosphatases
R-HSA-112316	Neuronal System
R-HSA-6794362	Protein-protein interactions at synapses

MSigDB gene sets: 104 (showing top): GOBP_SYNAPSE_ASSEMBLY, GOBP_POSITIVE_REGULATION_OF_SYNAPSE_ASSEMBLY, GOBP_REGULATION_OF_CELL_JUNCTION_ASSEMBLY, GOBP_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT, GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS, GOBP_POSITIVE_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT, GOBP_CELL_CELL_ADHESION, GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS, GOBP_CELL_JUNCTION_ORGANIZATION, GOBP_REGULATION_OF_SYNAPSE_ASSEMBLY, GOBP_POSITIVE_REGULATION_OF_CELL_JUNCTION_ASSEMBLY, GOBP_ORGANELLE_ASSEMBLY, GOBP_REGULATION_OF_SYNAPSE_STRUCTURE_OR_ACTIVITY, GOBP_CELL_JUNCTION_ASSEMBLY, GOCC_NEURON_PROJECTION

GO Biological Process (4): positive regulation of synapse assembly (GO:0051965), regulation of postsynaptic density assembly (GO:0099151), synaptic membrane adhesion (GO:0099560), regulation of presynapse assembly (GO:1905606)

GO Molecular Function (3): signaling receptor binding (GO:0005102), cell-cell adhesion mediator activity (GO:0098632), protein binding (GO:0005515)

GO Cellular Component (8): plasma membrane (GO:0005886), presynaptic membrane (GO:0042734), cerebellar mossy fiber (GO:0044300), postsynaptic density membrane (GO:0098839), glutamatergic synapse (GO:0098978), membrane (GO:0016020), cell projection (GO:0042995), synapse (GO:0045202)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Protein-protein interactions at synapses	1
Neuronal System	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of synapse assembly	2
cell-cell adhesion	2
cellular anatomical structure	2
synapse assembly	1
positive regulation of nervous system development	1
positive regulation of cell junction assembly	1
postsynaptic density assembly	1
regulation of postsynaptic specialization assembly	1
regulation of excitatory synapse assembly	1
regulation of postsynaptic density organization	1
synapse organization	1
presynapse assembly	1
regulation of presynapse organization	1
protein binding	1
cell adhesion mediator activity	1
binding	1
membrane	1
cell periphery	1
synaptic membrane	1
presynapse	1
axon	1
postsynaptic density	1
postsynaptic membrane	1
postsynaptic specialization membrane	1
synapse	1
cell junction	1

Protein interactions and networks

STRING

2096 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
LRRC4B	PTPRS	Q13332	978
LRRC4B	PTPRF	P10586	817
LRRC4B	NTNG2	Q96CW9	765
LRRC4B	NTNG1	Q9Y2I2	751
LRRC4B	IL1RAPL1	Q9NZN1	697
LRRC4B	DLG4	P78352	652
LRRC4B	NLGN1	Q8N2Q7	587
LRRC4B	IL1RAP	Q9NPH3	574
LRRC4B	NRXN2	Q9P2S2	557
LRRC4B	NRXN1	Q9ULB1	557
LRRC4B	NLGN2	Q8NFZ4	538
LRRC4B	FN1	P02751	481
LRRC4B	NLGN4X	Q8N0W4	456
LRRC4B	ZNF562	Q6V9R5	453
LRRC4B	PTPDC1	A2A3K4	452

IntAct

143 interactions, top by confidence:

A	B	Type	Score
KLRG2	GLRX3	psi-mi:“MI:0914”(association)	0.640
LRRC4B	SNTG1	psi-mi:“MI:0407”(direct interaction)	0.590
KLRG2	GXYLT2	psi-mi:“MI:0914”(association)	0.530
LRRC4C	DVL2	psi-mi:“MI:0914”(association)	0.530
TAFA4	NRP1	psi-mi:“MI:0914”(association)	0.530
LGALS1	PODXL	psi-mi:“MI:0914”(association)	0.530
CCT8L2	ACSL4	psi-mi:“MI:0914”(association)	0.530
CD53	FAM171A2	psi-mi:“MI:0914”(association)	0.530
LRRC4B	MAST2	psi-mi:“MI:0407”(direct interaction)	0.440
LRRC4B	SNX27	psi-mi:“MI:0407”(direct interaction)	0.440
LRRC4B	PDZD7	psi-mi:“MI:0407”(direct interaction)	0.440
LRRC4B	WHRN	psi-mi:“MI:0407”(direct interaction)	0.440
LRRC4B	RHPN1	psi-mi:“MI:0407”(direct interaction)	0.440
LRRC4B	SNTB1	psi-mi:“MI:0407”(direct interaction)	0.440
LRRC4B	PDZK1	psi-mi:“MI:0407”(direct interaction)	0.440
SCRIB	LRRC4B	psi-mi:“MI:0407”(direct interaction)	0.440
LRRC4B	SCRIB	psi-mi:“MI:0407”(direct interaction)	0.440
LRRC4B	SNTG2	psi-mi:“MI:0407”(direct interaction)	0.440
LRRC4B	PTPN3	psi-mi:“MI:0407”(direct interaction)	0.440
LRRC4B	SNTA1	psi-mi:“MI:0407”(direct interaction)	0.440
LRRC4B	DLG3	psi-mi:“MI:0407”(direct interaction)	0.440
LRRC4B	DLG1	psi-mi:“MI:0407”(direct interaction)	0.440
LRRC4B	SYNJ2BP	psi-mi:“MI:0407”(direct interaction)	0.440
LRRC4B	DLG4	psi-mi:“MI:0407”(direct interaction)	0.440
LRRC4B	DLG2	psi-mi:“MI:0407”(direct interaction)	0.440
LRRC4B	ARHGEF12	psi-mi:“MI:0407”(direct interaction)	0.440
MAGI3	LRRC4B	psi-mi:“MI:0407”(direct interaction)	0.440

BioGRID (20): LRRC4B (Two-hybrid), LRRC4B (Affinity Capture-MS), LRRC4B (Affinity Capture-MS), LRRC4B (Affinity Capture-MS), LRRC4B (Affinity Capture-MS), LRRC4B (Proximity Label-MS), LRRC4B (Affinity Capture-MS), LRRC4B (Affinity Capture-MS), LRRC4B (Affinity Capture-MS), LRRC4B (Affinity Capture-MS), LRRC4B (Affinity Capture-MS), LRRC4B (Affinity Capture-MS), LRRC4B (Affinity Capture-MS), LRRC4B (Affinity Capture-MS), LRRC4B (Affinity Capture-MS)

ESM2 similar proteins: A1A5X2, A2RT62, A3KMV1, A4IIK1, B3FL73, F4HX15, P0C192, P0C5J9, P0CC10, Q09299, Q17R01, Q2T9W8, Q32KX5, Q32PG9, Q38SD2, Q3TX51, Q3UHC2, Q3V1N1, Q3ZBA7, Q4G017, Q570C0, Q5BJ29, Q5MJ12, Q65XV2, Q6GLE8, Q6P7W2, Q80TM9, Q86V97, Q86X40, Q8BFZ4, Q8BID8, Q8C4V4, Q8N1E6, Q8N461, Q8TBC3, Q8W104, Q8WVZ9, Q96ME1, Q9EPX5, Q9LW29

Diamond homologs: A1KZ92, A2AJ76, A2ASS6, A4IGL7, A4IIW9, A8WGA3, B0BNK7, B4JEF2, D2HFT7, D3YXG0, D4A1J9, D4ABX8, F1NY98, G5EG78, O01761, O42414, O55005, O88280, O89026, P0C192, P0C5E3, P0C6S8, P0C7J6, P0CC10, P11799, P12960, P14781, P20241, P32004, P82987, P97685, Q03696, Q0E9H9, Q12860, Q149C3, Q15746, Q1RMS4, Q28106, Q2WF71, Q3KNY0

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
PTPRF	“up-regulates activity”	LRRC4B	binding
LRRC4B	“up-regulates activity”	DLG4	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 113 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Ras activation upon Ca2+ influx through NMDA receptor	5	39.6×	8e-06
Unblocking of NMDA receptors, glutamate binding and activation	5	37.8×	8e-06
Negative regulation of NMDA receptor-mediated neuronal transmission	5	37.8×	8e-06
Long-term potentiation	5	33.0×	1e-05
Assembly and cell surface presentation of NMDA receptors	9	31.7×	9e-10
Neurexins and neuroligins	10	27.4×	6e-10
Protein-protein interactions at synapses	6	22.1×	1e-05

GO biological processes:

GO term	Partners	Fold	FDR
establishment or maintenance of epithelial cell apical/basal polarity	9	48.4×	8e-11
receptor clustering	8	46.2×	1e-09
protein localization to synapse	6	42.6×	7e-07
regulation of postsynaptic membrane neurotransmitter receptor levels	6	27.5×	8e-06
cell-cell adhesion	12	11.3×	2e-07
protein-containing complex assembly	7	7.4×	2e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

75 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	70
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

674 predictions. Top by Δscore:

Variant	Effect	Δscore
19:50519412:TCAC:T	acceptor_gain	1.0000
19:50519412:TCACC:T	acceptor_loss	1.0000
19:50519413:CAC:C	acceptor_gain	1.0000
19:50519413:CACC:C	acceptor_gain	1.0000
19:50519413:CACCT:C	acceptor_loss	1.0000
19:50519414:AC:A	acceptor_gain	1.0000
19:50519414:ACCTG:A	acceptor_loss	1.0000
19:50519415:CC:C	acceptor_gain	1.0000
19:50519416:C:A	acceptor_loss	1.0000
19:50519416:C:CC	acceptor_gain	1.0000
19:50519417:T:G	acceptor_loss	1.0000
19:50519411:ATCAC:A	acceptor_gain	0.9900
19:50548538:ATAC:A	donor_loss	0.9900
19:50548539:TA:T	donor_loss	0.9900
19:50548869:GGGGG:G	acceptor_gain	0.9900
19:50548870:GGGG:G	acceptor_gain	0.9900
19:50548871:GGG:G	acceptor_gain	0.9900
19:50548871:GGGC:G	acceptor_loss	0.9900
19:50548872:GG:G	acceptor_gain	0.9900
19:50548874:C:A	acceptor_loss	0.9900
19:50548874:C:CC	acceptor_gain	0.9900
19:50548880:G:C	acceptor_gain	0.9900
19:50548880:G:GC	acceptor_gain	0.9900
19:50548540:A:AC	donor_gain	0.9800
19:50548541:C:CC	donor_gain	0.9800
19:50548876:G:C	acceptor_gain	0.9800
19:50550879:CCT:C	donor_gain	0.9700
19:50548872:GGC:G	acceptor_gain	0.9600
19:50548873:GCT:G	acceptor_gain	0.9600
19:50519416:C:T	acceptor_gain	0.9500

AlphaMissense

4600 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:50517935:A:G	L593P	1.000
19:50517935:A:T	L593H	1.000
19:50517938:A:C	M592R	1.000
19:50517938:A:T	M592K	1.000
19:50517944:G:T	A590E	1.000
19:50517947:G:T	A589D	1.000
19:50517950:A:C	M588R	1.000
19:50517950:A:T	M588K	1.000
19:50517956:G:C	T586R	1.000
19:50517956:G:T	T586K	1.000
19:50517962:G:T	A584D	1.000
19:50517965:A:T	V583E	1.000
19:50517971:C:T	C581Y	1.000
19:50517972:A:G	C581R	1.000
19:50517974:C:T	G580D	1.000
19:50517975:C:G	G580R	1.000
19:50517977:A:T	I579N	1.000
19:50517980:A:T	I578N	1.000
19:50517983:A:C	I577S	1.000
19:50517983:A:G	I577T	1.000
19:50518361:A:G	L451P	1.000
19:50518361:A:T	L451H	1.000
19:50518367:G:T	A449D	1.000
19:50518368:C:G	A449P	1.000
19:50518374:C:G	A447P	1.000
19:50518385:C:A	G443V	1.000
19:50518385:C:T	G443D	1.000
19:50518386:C:A	G443C	1.000
19:50518386:C:G	G443R	1.000
19:50518393:G:C	N440K	1.000

dbSNP variants (sampled 300 via entrez): RS1000024028 (19:50561654 G>C), RS1000075005 (19:50536620 C>A), RS1000124730 (19:50520485 C>T), RS1000131747 (19:50556485 C>G,T), RS1000181976 (19:50551630 G>A), RS1000220391 (19:50566487 G>A), RS1000318862 (19:50525295 G>A), RS1000404449 (19:50559168 C>T), RS1000409930 (19:50547019 T>C), RS1000425406 (19:50523599 G>T), RS1000540291 (19:50541479 C>G,T), RS1000585413 (19:50556819 G>A,C), RS1000628535 (19:50517519 C>T), RS1000647807 (19:50535469 G>A), RS1000773274 (19:50530004 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST010796_4206	Electrocardiogram morphology (amplitude at temporal datapoints)	5.000000e-08

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004327	electrocardiography

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

13 total (human), top 13 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, increases methylation	2
bisphenol A	decreases methylation	1
benzo(e)pyrene	increases methylation	1
aflatoxin B2	increases methylation	1
pentanal	increases expression	1
(+)-JQ1 compound	decreases expression	1
Sunitinib	decreases expression	1
Allergens	increases expression	1
Doxorubicin	decreases expression	1
Estradiol	decreases expression	1
Methapyrilene	increases methylation	1
Rotenone	decreases expression	1
Silicon Dioxide	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.