LRRC52-AS1

Summary

LRRC52-AS1 (LRRC52 antisense RNA 1, HGNC:54044) is a long non-coding RNA gene on chromosome 1q23.3-q24.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:54044
Approved symbol	LRRC52-AS1
Name	LRRC52 antisense RNA 1
Location	1q23.3-q24.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000237463
Ensembl biotype	lncRNA
Entrez	400794
RNAcentral	URS00008E3971 — lncRNA, 1803 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 56 — 56 lncRNA

ENST00000415000, ENST00000416424, ENST00000418925, ENST00000421273, ENST00000438275, ENST00000452283, ENST00000454251, ENST00000656941, ENST00000658987, ENST00000665666, ENST00000666433, ENST00000685058, ENST00000685245, ENST00000688379, ENST00000690583, ENST00000690611, ENST00000690955, ENST00000692705, ENST00000755460, ENST00000755461, ENST00000755462, ENST00000755463, ENST00000755464, ENST00000755465, ENST00000755466, ENST00000755467, ENST00000755468, ENST00000755469, ENST00000755470, ENST00000755471, ENST00000755472, ENST00000755473, ENST00000755474, ENST00000755475, ENST00000755476, ENST00000755477, ENST00000755478, ENST00000755479, ENST00000755480, ENST00000755481, ENST00000755482, ENST00000755483, ENST00000755484, ENST00000755485, ENST00000755486, ENST00000755487, ENST00000755488, ENST00000755489, ENST00000755490, ENST00000755491, ENST00000755492, ENST00000755493, ENST00000755494, ENST00000755495, ENST00000755496, ENST00000755497

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000415000 — 3 exons

Exon	Start	End
ENSE00001784365	165501431	165501627
ENSE00004104584	165527590	165527945
ENSE00004104618	165476832	165477115

Expression profiles

Bgee: expression breadth ubiquitous, 135 present calls, max score 83.23.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0127 / max 7.5983, expressed in 5 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
15731	0.0110	4
15732	0.0017	1

Top tissues by expression

223 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.23	gold quality
left testis	UBERON:0004533	82.50	gold quality
right testis	UBERON:0004534	82.32	gold quality
sperm	CL:0000019	81.22	gold quality
testis	UBERON:0000473	79.64	gold quality
apex of heart	UBERON:0002098	76.56	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	75.34	gold quality
mucosa of paranasal sinus	UBERON:0005030	71.39	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	69.29	gold quality
buccal mucosa cell	CL:0002336	66.45	gold quality
epithelium of nasopharynx	UBERON:0001951	66.36	gold quality
myocardium	UBERON:0002349	66.03	gold quality
vastus lateralis	UBERON:0001379	65.83	gold quality
quadriceps femoris	UBERON:0001377	65.61	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	64.84	gold quality
heart left ventricle	UBERON:0002084	64.49	gold quality
cardiac ventricle	UBERON:0002082	64.31	gold quality
nasal cavity epithelium	UBERON:0005384	64.21	gold quality
biceps brachii	UBERON:0001507	62.66	gold quality
skeletal muscle tissue	UBERON:0001134	61.86	gold quality
cortical plate	UBERON:0005343	61.21	gold quality
cardia of stomach	UBERON:0001162	61.20	gold quality
oocyte	CL:0000023	61.15	gold quality
endothelial cell	CL:0000115	60.77	gold quality
heart	UBERON:0000948	60.69	gold quality
substantia nigra pars reticulata	UBERON:0001966	60.67	silver quality
parotid gland	UBERON:0001831	60.00	gold quality
superficial temporal artery	UBERON:0001614	59.75	gold quality
germinal epithelium of ovary	UBERON:0001304	59.69	gold quality
vena cava	UBERON:0004087	59.65	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.40

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LRRC52-AS1 is associated with clinical progression and regulates cell migration and invasion in papillary thyroid cancer. (PMID:31855284)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.