LRRC8B

Summary

LRRC8B (leucine rich repeat containing 8 VRAC subunit B, HGNC:30692) is a protein-coding gene on chromosome 1p22.2, encoding Volume-regulated anion channel subunit LRRC8B (Q6P9F7). Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes.

Contributes to volume-sensitive anion channel activity. Involved in monoatomic anion transmembrane transport. Located in cytoplasm and plasma membrane. Part of monoatomic ion channel complex.

Source: NCBI Gene 23507 — RefSeq curated summary.

At a glance

• GWAS associations: 6
• Clinical variants (ClinVar): 78 total
• MANE Select transcript: NM_001369817

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30692
Approved symbol	LRRC8B
Name	leucine rich repeat containing 8 VRAC subunit B
Location	1p22.2
Locus type	gene with protein product
Status	Approved
Aliases	TA-LRRP, KIAA0231
Ensembl gene	ENSG00000197147
Ensembl biotype	protein_coding
OMIM	612888
Entrez	23507

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 6 protein_coding

ENST00000330947, ENST00000439853, ENST00000449440, ENST00000639264, ENST00000640258, ENST00000882796

RefSeq mRNA: 4 — MANE Select: NM_001369817 NM_001134476, NM_001369817, NM_001369819, NM_015350

CCDS: CCDS724

Canonical transcript exons

ENST00000330947 — 6 exons

Exon	Start	End
ENSE00001067376	89582625	89584789
ENSE00001369564	89568247	89568307
ENSE00001381649	89579591	89579688
ENSE00001390451	89568439	89568493
ENSE00001452759	89592771	89597861
ENSE00003898998	89524829	89525022

Expression profiles

Bgee: expression breadth ubiquitous, 260 present calls, max score 97.29.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 12.4378 / max 488.7921, expressed in 1527 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
3962	6.9758	1272
3961	5.1990	1354
3960	0.2631	105

Top tissues by expression

284 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
Brodmann (1909) area 23	UBERON:0013554	97.29	gold quality
middle temporal gyrus	UBERON:0002771	95.65	gold quality
endothelial cell	CL:0000115	95.11	gold quality
oocyte	CL:0000023	93.80	gold quality
secondary oocyte	CL:0000655	92.96	gold quality
orbitofrontal cortex	UBERON:0004167	92.23	gold quality
superior frontal gyrus	UBERON:0002661	92.16	gold quality
Brodmann (1909) area 46	UBERON:0006483	92.02	gold quality
primary visual cortex	UBERON:0002436	91.82	gold quality
postcentral gyrus	UBERON:0002581	91.58	gold quality
entorhinal cortex	UBERON:0002728	90.90	gold quality
parietal lobe	UBERON:0001872	90.87	gold quality
adrenal tissue	UBERON:0018303	90.12	gold quality
occipital lobe	UBERON:0002021	89.42	gold quality
prefrontal cortex	UBERON:0000451	89.28	gold quality
bronchial epithelial cell	CL:0002328	87.08	gold quality
Brodmann (1909) area 9	UBERON:0013540	86.75	gold quality
epithelium of nasopharynx	UBERON:0001951	86.65	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	86.65	gold quality
frontal cortex	UBERON:0001870	86.59	gold quality
epithelium of bronchus	UBERON:0002031	86.34	gold quality
cerebral cortex	UBERON:0000956	86.06	gold quality
neocortex	UBERON:0001950	85.80	gold quality
bronchus	UBERON:0002185	85.77	gold quality
gingival epithelium	UBERON:0001949	85.16	gold quality
corpus callosum	UBERON:0002336	85.14	gold quality
CA1 field of hippocampus	UBERON:0003881	85.11	gold quality
nasal cavity epithelium	UBERON:0005384	84.35	silver quality
gingiva	UBERON:0001828	84.34	gold quality
Ammon’s horn	UBERON:0001954	84.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.73

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

221 targeting LRRC8B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-4776-3P	100.00	68.73	1340
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-6077	99.99	68.04	2299
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-6759-5P	99.99	66.54	785
HSA-MIR-223-3P	99.99	70.14	1140
HSA-MIR-513B-5P	99.99	69.96	2150
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-19A-3P	99.98	75.33	2762
HSA-MIR-19B-3P	99.98	75.44	2754
HSA-MIR-499A-5P	99.98	70.79	1323

Literature-anchored findings (GeneRIF, showing 2)

• identified four genes, named TA-LRRP, AD158, LRRC5, and FLJ23420, as unknown LRRC8-like genes (PMID:15094057)
• LRRC8B participates in intracellular Ca(2+) homeostasis by acting as a leak channel in the endoplasmic reticulum. (PMID:28972132)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Lrrc8b	ENSMUSG00000070639
rattus_norvegicus	Lrrc8b	ENSRNOG00000002129

Paralogs (31): LRRC7 (ENSG00000033122), PHLPP2 (ENSG00000040199), LRRC40 (ENSG00000066557), LRCH4 (ENSG00000077454), PHLPP1 (ENSG00000081913), SHOC2 (ENSG00000108061), ERBIN (ENSG00000112851), LRRC39 (ENSG00000122477), LRCH2 (ENSG00000130224), LRCH1 (ENSG00000136141), LRRC8A (ENSG00000136802), LRRC1 (ENSG00000137269), MFHAS1 (ENSG00000147324), LRRC27 (ENSG00000148814), LRRK1 (ENSG00000154237), LRRC58 (ENSG00000163428), LRRC2 (ENSG00000163827), LRRC18 (ENSG00000165383), LRRC28 (ENSG00000168904), LRRC8E (ENSG00000171017), LRRC8C (ENSG00000171488), LRRC8D (ENSG00000171492), PIDD1 (ENSG00000177595), SCRIB (ENSG00000180900), LRCH3 (ENSG00000186001), LRRIQ4 (ENSG00000188306), LRRC10 (ENSG00000198812), LRRC10B (ENSG00000204950), LRRC30 (ENSG00000206422), LRRC69 (ENSG00000214954), LRRD1 (ENSG00000240720)

Protein

Protein identifiers

Volume-regulated anion channel subunit LRRC8B — Q6P9F7 (reviewed: Q6P9F7)

Alternative names: Leucine-rich repeat-containing protein 8B, T-cell activation leucine repeat-rich protein

All UniProt accessions (4): A0A384N5V6, A0A7I2RK03, C9JGJ7, Q6P9F7

UniProt curated annotations — full annotation on UniProt →

Function. Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition.

Subunit / interactions. Heterohexamer; oligomerizes with other LRRC8 proteins (LRRC8A, LRRC8C, LRRC8D and/or LRRC8E) to form a heterohexamer. In vivo, the subunit composition may depend primarily on expression levels, and heterooligomeric channels containing various proportions of the different LRRC8 proteins may coexist.

Subcellular location. Cell membrane. Endoplasmic reticulum membrane.

Domain organisation. The volume-regulated anion channel (VRAC) channel forms a trimer of dimers, with symmetry mismatch between the pore-forming domain and the cytosolic LRR repeats, a topology similar to gap junction proteins.

Similarity. Belongs to the LRRC8 family.

RefSeq proteins (4): NP_001127948, NP_001356746, NP_001356748, NP_056165 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001611	Leu-rich_rpt	Repeat
IPR003591	Leu-rich_rpt_typical-subtyp	Repeat
IPR021040	LRRC8_Pannexin-like	Domain
IPR026906	LRR_5	Repeat
IPR032675	LRR_dom_sf	Homologous_superfamily
IPR052595	LRRC69/RLP	Family

Pfam: PF12534, PF13306, PF13855

Catalyzed reactions (Rhea), 3 shown:

• chloride(in) = chloride(out) (RHEA:29823)
• iodide(out) = iodide(in) (RHEA:66324)
• taurine(out) = taurine(in) (RHEA:66328)

UniProt features (34 total): repeat 13, topological domain 5, transmembrane region 4, sequence variant 4, modified residue 2, disulfide bond 2, sequence conflict 2, chain 1, glycosylation site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6P9F7-F1	81.76	0.36

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 186, 196

Disulfide bonds (2): 55–304, 109–289

Glycosylation sites (1): 78

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-5223345	Miscellaneous transport and binding events
R-HSA-382551	Transport of small molecules

MSigDB gene sets: 168 (showing top): GOBP_AMINO_ACID_TRANSMEMBRANE_TRANSPORT, GOBP_NUCLEOTIDE_TRANSPORT, GOBP_ORGANIC_ACID_TRANSPORT, GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT, GOBP_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORT, GOBP_AMINO_ACID_TRANSPORT, GOBP_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT, GOBP_ORGANIC_ANION_TRANSPORT, GOBP_DICARBOXYLIC_ACID_TRANSPORT, GOBP_PURINE_NUCLEOTIDE_TRANSPORT, GOBP_ACIDIC_AMINO_ACID_TRANSPORT, HAN_SATB1_TARGETS_DN, GOBP_IMPORT_INTO_CELL, chr1p22, GOBP_CARBOHYDRATE_DERIVATIVE_TRANSPORT

GO Biological Process (5): aspartate transmembrane transport (GO:0015810), monoatomic anion transmembrane transport (GO:0098656), cyclic-GMP-AMP transmembrane import across plasma membrane (GO:0140361), monoatomic ion transport (GO:0006811), monoatomic ion transmembrane transport (GO:0034220)

GO Molecular Function (2): volume-sensitive anion channel activity (GO:0005225), protein binding (GO:0005515)

GO Cellular Component (6): cytoplasm (GO:0005737), endoplasmic reticulum membrane (GO:0005789), plasma membrane (GO:0005886), monoatomic ion channel complex (GO:0034702), endoplasmic reticulum (GO:0005783), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Transport of small molecules	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
amino acid transmembrane transport	1
C4-dicarboxylate transport	1
acidic amino acid transport	1
nitrogen compound transport	1
carboxylic acid transmembrane transport	1
monoatomic anion transport	1
monoatomic ion transmembrane transport	1
purine ribonucleotide transport	1
adenine nucleotide transport	1
cyclic nucleotide transport	1
import across plasma membrane	1
guanine nucleotide transmembrane transport	1
transport	1
monoatomic ion transport	1
transmembrane transport	1
monoatomic anion channel activity	1
binding	1
intracellular anatomical structure	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
membrane	1
cell periphery	1
transmembrane transporter complex	1
cytoplasm	1
endomembrane system	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

1060 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
LRRC8B	LRRC8A	Q8IWT6	580
LRRC8B	BEST1	O76090	577
LRRC8B	TTYH2	Q9BSA4	570
LRRC8B	CLCA2	Q9UQC9	550
LRRC8B	CLCN3	P51790	541
LRRC8B	CLCA4	Q14CN2	514
LRRC8B	TTYH3	Q9C0H2	503
LRRC8B	TTYH1	Q9H313	494
LRRC8B	STK32C	Q86UX6	486
LRRC8B	SLC41A1	Q8IVJ1	471
LRRC8B	CFTR	P13569	461
LRRC8B	CLCA1	A8K7I4	461
LRRC8B	ANO1	Q5XXA6	456
LRRC8B	BEST3	Q8N1M1	450
LRRC8B	HEPACAM	Q14CZ8	447

IntAct

8 interactions, top by confidence:

A	B	Type	Score
LRRC8A	LRRC8B	psi-mi:“MI:0915”(physical association)	0.740
LRRC8B	SLC25A17	psi-mi:“MI:0914”(association)	0.530
	LRRC8B	psi-mi:“MI:0915”(physical association)	0.400
TTYH1	TMEM223	psi-mi:“MI:0914”(association)	0.350
LRRC8B	CDH2	psi-mi:“MI:0914”(association)	0.350

BioGRID (66): LRRC8D (Affinity Capture-MS), LRRC8C (Affinity Capture-MS), LRRC8A (Affinity Capture-MS), LRRC8E (Affinity Capture-MS), TSPAN3 (Affinity Capture-MS), ATP2A3 (Affinity Capture-MS), SLC44A1 (Affinity Capture-MS), ABCB9 (Affinity Capture-MS), TMEM164 (Affinity Capture-MS), ANO6 (Affinity Capture-MS), TM2D3 (Affinity Capture-MS), SLC25A17 (Affinity Capture-MS), ADCK2 (Affinity Capture-MS), LMBR1 (Affinity Capture-MS), CHPT1 (Affinity Capture-MS)

ESM2 similar proteins: A0JM56, A0JPI9, A2BFL2, A5PK13, A6H639, J9SQF3, O13066, P19686, P33402, Q02108, Q0VAA2, Q14BP6, Q15111, Q15813, Q3USB7, Q498T9, Q4R642, Q4V8D9, Q4ZHS0, Q5DU41, Q5FVQ9, Q5RAG3, Q5RBD9, Q5RJH2, Q5ZIJ9, Q5ZIU8, Q62688, Q68F79, Q6DN12, Q6GQN5, Q6NU09, Q6P9F7, Q6WRX3, Q7Z7L7, Q80ZJ6, Q8BG40, Q8CDU4, Q8CIR4, Q8CIV8, Q8HXA6

Diamond homologs: A5PK13, Q3KRC6, Q498T9, Q4V8I7, Q5DU41, Q5U308, Q66JT1, Q68F79, Q6NSJ5, Q6NU09, Q6P9F7, Q7L1W4, Q80WG5, Q8BGR2, Q8IWT6, Q8R502, Q8TDW0, D4AC13, O35103, O35367, O42235, O46378, O46379, O60938, O62702, O75093, O77742, P13605, P24014, P28654, P28675, P50608, P50609, P51884, P51885, P51886, P51887, P51888, P51890, P58681

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

78 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	66
Likely benign	2
Benign	5

Top pathogenic / likely-pathogenic (0)

SpliceAI

1714 predictions. Top by Δscore:

Variant	Effect	Δscore
1:89568308:G:GG	donor_gain	1.0000
1:89528327:T:G	donor_gain	0.9900
1:89568304:T:G	donor_gain	0.9900
1:89568304:TTAA:T	donor_loss	0.9900
1:89568305:TAAGT:T	donor_loss	0.9900
1:89568307:AGT:A	donor_loss	0.9900
1:89568308:GT:G	donor_loss	0.9900
1:89568309:T:TC	donor_loss	0.9900
1:89568492:GG:G	donor_gain	0.9900
1:89568493:GG:G	donor_gain	0.9900
1:89579684:CTGTA:C	donor_gain	0.9900
1:89579686:GTA:G	donor_gain	0.9900
1:89579689:G:GG	donor_gain	0.9900
1:89582623:A:AG	acceptor_gain	0.9900
1:89582624:G:GG	acceptor_gain	0.9900
1:89584790:G:GG	donor_gain	0.9900
1:89552842:G:GT	donor_gain	0.9800
1:89568241:CCCTA:C	acceptor_loss	0.9800
1:89568242:CCTA:C	acceptor_loss	0.9800
1:89568243:CTA:C	acceptor_loss	0.9800
1:89568245:A:G	acceptor_loss	0.9800
1:89568311:AGTTA:A	donor_loss	0.9800
1:89568433:CCTTA:C	acceptor_loss	0.9800
1:89568434:CTTAG:C	acceptor_loss	0.9800
1:89568435:TTA:T	acceptor_loss	0.9800
1:89568436:TAGGA:T	acceptor_loss	0.9800
1:89568437:A:T	acceptor_loss	0.9800
1:89568438:G:GT	acceptor_loss	0.9800
1:89582624:GTTT:G	acceptor_gain	0.9800
1:89592937:G:GT	donor_gain	0.9800

AlphaMissense

5278 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:89583140:T:A	W164R	1.000
1:89583140:T:C	W164R	1.000
1:89583809:T:C	F387L	1.000
1:89583810:T:C	F387S	1.000
1:89583811:C:A	F387L	1.000
1:89583811:C:G	F387L	1.000
1:89582720:T:A	W24R	0.999
1:89582720:T:C	W24R	0.999
1:89582975:T:A	C109S	0.999
1:89582975:T:C	C109R	0.999
1:89582976:G:A	C109Y	0.999
1:89582976:G:C	C109S	0.999
1:89582977:T:G	C109W	0.999
1:89583117:T:C	L156P	0.999
1:89583125:T:C	C159R	0.999
1:89583127:C:G	C159W	0.999
1:89583142:G:C	W164C	0.999
1:89583142:G:T	W164C	0.999
1:89583362:T:C	F238L	0.999
1:89583364:T:A	F238L	0.999
1:89583364:T:G	F238L	0.999
1:89583384:G:C	R245P	0.999
1:89583560:T:A	C304S	0.999
1:89583560:T:C	C304R	0.999
1:89583561:G:C	C304S	0.999
1:89583562:T:G	C304W	0.999
1:89583689:T:C	F347L	0.999
1:89583691:T:A	F347L	0.999
1:89583691:T:G	F347L	0.999
1:89583743:G:C	D365H	0.999

dbSNP variants (sampled 300 via entrez): RS1000031664 (1:89549334 T>C), RS1000086693 (1:89548903 C>T), RS1000149310 (1:89587976 A>G), RS1000157978 (1:89542090 C>T), RS1000189578 (1:89522691 C>T), RS1000283792 (1:89555970 C>T), RS1000297940 (1:89561373 C>T), RS1000303972 (1:89593660 A>G), RS1000325431 (1:89542798 C>A,T), RS1000395392 (1:89555113 G>A), RS1000489626 (1:89563604 A>T), RS1000495194 (1:89571199 T>C), RS1000574343 (1:89567151 T>C), RS1000576940 (1:89525333 C>G,T), RS1000583047 (1:89560087 A>G)

Disease associations

OMIM: gene MIM:612888 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

6 associations (top):

Study	Trait	p-value
GCST001999_2	Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel)	9.000000e-07
GCST002006_5	Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin)	3.000000e-06
GCST009391_524	Metabolite levels	7.000000e-06
GCST012071_3	Response to selenium supplementation (change in plasma selenium concentration)	3.000000e-06
GCST90002393_35	Monocyte count	4.000000e-16
GCST90002394_142	Monocyte percentage of white cells	2.000000e-12

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0010117	pyruvate measurement
EFO:0600021	response to dietary selenium supplementation
EFO:0005091	monocyte count
EFO:0007989	monocyte percentage of leukocytes

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

45 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression, decreases methylation, increases expression	6
trichostatin A	affects cotreatment, decreases expression	3
Estradiol	affects cotreatment, decreases expression, increases expression	3
methacrylaldehyde	affects cotreatment, decreases expression, increases abundance	2
entinostat	affects cotreatment, decreases expression	2
Panobinostat	affects cotreatment, decreases expression	2
Acrolein	affects cotreatment, decreases expression, increases abundance	2
Arsenic	affects methylation, affects cotreatment, increases abundance, increases expression	2
Ozone	affects cotreatment, decreases expression, increases abundance	2
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
aristolochic acid I	decreases expression	1
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
testosterone enanthate	affects expression	1
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	affects cotreatment, decreases expression, increases abundance	1
bisphenol A	decreases methylation	1
2-methyl-4-isothiazolin-3-one	increases expression	1
tris(2-butoxyethyl) phosphate	affects expression	1
sodium arsenite	increases expression, affects cotreatment, increases abundance	1
butyraldehyde	decreases expression	1
manganese chloride	affects cotreatment, increases abundance, increases expression	1
CGP 52608	affects binding, increases reaction	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
abrine	decreases expression	1
dorsomorphin	decreases expression, affects cotreatment	1
bisphenol S	decreases methylation	1
jinfukang	decreases expression	1
incobotulinumtoxinA	decreases expression	1
Sunitinib	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.