LRRC8C-DT

Summary

LRRC8C-DT (LRRC8C divergent transcript, HGNC:53731) is a long non-coding RNA gene on chromosome 1p22.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53731
Approved symbol	LRRC8C-DT
Name	LRRC8C divergent transcript
Location	1p22.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ27354
Ensembl gene	ENSG00000231999
Ensembl biotype	lncRNA
Entrez	400761
RNAcentral	URS000075C18D — lncRNA, 789 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 22 — 22 lncRNA

ENST00000415584, ENST00000443562, ENST00000526694, ENST00000528692, ENST00000655657, ENST00000655898, ENST00000660266, ENST00000660444, ENST00000666079, ENST00000666228, ENST00000666432, ENST00000689648, ENST00000702838, ENST00000734607, ENST00000734608, ENST00000734609, ENST00000734610, ENST00000734611, ENST00000734612, ENST00000734613, ENST00000734614, ENST00000734615

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000415584 — 3 exons

Exon	Start	End
ENSE00001775044	89632016	89632209
ENSE00004066788	89632657	89632936
ENSE00004066832	89624752	89625205

Expression profiles

Bgee: expression breadth ubiquitous, 164 present calls, max score 90.65.

FANTOM5 (CAGE): breadth broad, TPM avg 1.7809 / max 36.9686, expressed in 710 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
13193	1.7809	710

Top tissues by expression

248 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	90.65	silver quality
right testis	UBERON:0004534	88.87	gold quality
left testis	UBERON:0004533	88.69	gold quality
testis	UBERON:0000473	84.93	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	83.87	gold quality
tibial nerve	UBERON:0001323	81.59	gold quality
sural nerve	UBERON:0015488	81.31	gold quality
spinal cord	UBERON:0002240	80.26	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.23	gold quality
right atrium auricular region	UBERON:0006631	77.58	gold quality
apex of heart	UBERON:0002098	77.16	gold quality
Brodmann (1909) area 9	UBERON:0013540	76.83	gold quality
amygdala	UBERON:0001876	76.60	gold quality
prefrontal cortex	UBERON:0000451	76.58	gold quality
cardiac atrium	UBERON:0002081	75.96	gold quality
leukocyte	CL:0000738	75.72	gold quality
monocyte	CL:0000576	75.61	gold quality
anterior cingulate cortex	UBERON:0009835	75.58	gold quality
putamen	UBERON:0001874	75.49	gold quality
medial globus pallidus	UBERON:0002477	75.40	gold quality
right frontal lobe	UBERON:0002810	75.39	gold quality
heart left ventricle	UBERON:0002084	75.20	gold quality
right coronary artery	UBERON:0001625	74.79	gold quality
hypothalamus	UBERON:0001898	74.64	gold quality
adenohypophysis	UBERON:0002196	74.47	gold quality
popliteal artery	UBERON:0002250	74.32	gold quality
tibial artery	UBERON:0007610	74.30	gold quality
nucleus accumbens	UBERON:0001882	74.24	gold quality
cardiac ventricle	UBERON:0002082	74.22	gold quality
left coronary artery	UBERON:0001626	73.72	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.22

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.