LRRK1-AS1

Summary

LRRK1-AS1 (LRRK1 antisense RNA 1, HGNC:58299) is a long non-coding RNA gene on chromosome 15q26.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:58299
Approved symbol	LRRK1-AS1
Name	LRRK1 antisense RNA 1
Location	15q26.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000259755
Ensembl biotype	lncRNA
Entrez	105371026
RNAcentral	URS0002A3C846 — lncRNA, 2298 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 8 lncRNA

ENST00000558979, ENST00000559857, ENST00000715977, ENST00000724428, ENST00000724429, ENST00000724430, ENST00000724431, ENST00000724432

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000558979 — 3 exons

Exon	Start	End
ENSE00002549515	101049389	101049664
ENSE00002559792	101042267	101044138
ENSE00004028503	101050634	101050650

Expression profiles

Bgee: expression breadth ubiquitous, 124 present calls, max score 89.56.

Top tissues by expression

124 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	89.56	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.09	gold quality
placenta	UBERON:0001987	66.60	gold quality
bone marrow cell	CL:0002092	65.69	silver quality
pituitary gland	UBERON:0000007	65.59	gold quality
ventricular zone	UBERON:0003053	63.09	gold quality
skeletal muscle tissue	UBERON:0001134	62.85	gold quality
prefrontal cortex	UBERON:0000451	62.69	gold quality
adenohypophysis	UBERON:0002196	62.37	gold quality
cortical plate	UBERON:0005343	62.03	gold quality
frontal cortex	UBERON:0001870	61.52	gold quality
ganglionic eminence	UBERON:0004023	61.21	gold quality
blood	UBERON:0000178	60.58	gold quality
right frontal lobe	UBERON:0002810	60.41	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	58.99	gold quality
cerebral cortex	UBERON:0000956	58.28	gold quality
Brodmann (1909) area 9	UBERON:0013540	57.99	gold quality
primary visual cortex	UBERON:0002436	57.57	gold quality
bone marrow	UBERON:0002371	56.46	gold quality
brain	UBERON:0000955	56.00	gold quality
superior frontal gyrus	UBERON:0002661	55.08	gold quality
stromal cell of endometrium	CL:0002255	54.74	silver quality
putamen	UBERON:0001874	54.52	gold quality
anterior cingulate cortex	UBERON:0009835	54.42	gold quality
right hemisphere of cerebellum	UBERON:0014890	53.88	gold quality
monocyte	CL:0000576	53.86	silver quality
lower esophagus mucosa	UBERON:0035834	53.42	gold quality
ascending aorta	UBERON:0001496	53.32	gold quality
thoracic aorta	UBERON:0001515	53.27	gold quality
cerebellum	UBERON:0002037	53.09	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.63

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.