LRRK2-DT

Summary

LRRK2-DT (LRRK2 divergent transcript, HGNC:40848) is a long non-coding RNA gene on chromosome 12q12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40848
Approved symbol	LRRK2-DT
Name	LRRK2 divergent transcript
Location	12q12
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000225342
Ensembl biotype	lncRNA
Entrez	107984474
RNAcentral	URS00026A2574 — lncRNA, 2194 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 6 lncRNA

ENST00000412812, ENST00000618127, ENST00000783202, ENST00000783203, ENST00000783204, ENST00000783205

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000412812 — 4 exons

Exon	Start	End
ENSE00001646779	40190253	40190394
ENSE00001675542	40189083	40189205
ENSE00004157030	40223659	40223895
ENSE00004157033	40184933	40186183

Expression profiles

Bgee: expression breadth ubiquitous, 166 present calls, max score 84.23.

FANTOM5 (CAGE): breadth broad, TPM avg 0.8144 / max 72.0794, expressed in 199 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
130467	0.4417	109
130468	0.2706	106
130466	0.1021	36

Top tissues by expression

244 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower lobe of lung	UBERON:0008949	84.23	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.41	gold quality
monocyte	CL:0000576	79.30	gold quality
leukocyte	CL:0000738	78.75	gold quality
blood	UBERON:0000178	77.61	gold quality
right lung	UBERON:0002167	76.89	gold quality
calcaneal tendon	UBERON:0003701	75.53	gold quality
metanephros cortex	UBERON:0010533	74.76	gold quality
kidney epithelium	UBERON:0004819	74.54	gold quality
lung	UBERON:0002048	74.48	gold quality
upper lobe of lung	UBERON:0008948	73.77	gold quality
upper lobe of left lung	UBERON:0008952	73.20	gold quality
adult mammalian kidney	UBERON:0000082	71.66	gold quality
vermiform appendix	UBERON:0001154	70.03	gold quality
kidney	UBERON:0002113	69.95	gold quality
granulocyte	CL:0000094	69.77	gold quality
bone marrow cell	CL:0002092	69.47	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	68.97	gold quality
cortex of kidney	UBERON:0001225	68.74	gold quality
mucosa of stomach	UBERON:0001199	66.76	gold quality
cortical plate	UBERON:0005343	65.36	gold quality
spleen	UBERON:0002106	65.35	gold quality
metanephros	UBERON:0000081	65.11	gold quality
descending thoracic aorta	UBERON:0002345	64.78	gold quality
prefrontal cortex	UBERON:0000451	64.65	gold quality
tibial artery	UBERON:0007610	64.37	gold quality
popliteal artery	UBERON:0002250	64.35	gold quality
right coronary artery	UBERON:0001625	64.28	gold quality
smooth muscle tissue	UBERON:0001135	64.19	gold quality
thoracic aorta	UBERON:0001515	64.18	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	16.84

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.