LSG1

Summary

LSG1 (large 60S subunit nuclear export GTPase 1, HGNC:25652) is a protein-coding gene on chromosome 3q29, encoding Large subunit GTPase 1 homolog (Q9H089). Functions as a GTPase. It is a common-essential gene (DepMap: required in 96.2% of cancer cell lines).

This gene encodes a protein related to the yeast large subunit GTPase 1. The encoded protein is necessary for cell viability and may localize in the endoplasmic reticulum, nucleus and cytoplasm.

Source: NCBI Gene 55341 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 153 total
• Druggable target: yes
• Cancer dependency (DepMap): dependent in 96.2% of screened cell lines (common-essential)
• MANE Select transcript: NM_018385

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25652
Approved symbol	LSG1
Name	large 60S subunit nuclear export GTPase 1
Location	3q29
Locus type	gene with protein product
Status	Approved
Aliases	FLJ11301
Ensembl gene	ENSG00000041802
Ensembl biotype	protein_coding
OMIM	610780
Entrez	55341

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 4 protein_coding, 4 retained_intron, 1 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000265245, ENST00000427461, ENST00000437613, ENST00000460584, ENST00000461343, ENST00000466391, ENST00000475763, ENST00000480853, ENST00000906595, ENST00000917674

RefSeq mRNA: 1 — MANE Select: NM_018385 NM_018385

CCDS: CCDS33922

Canonical transcript exons

ENST00000265245 — 14 exons

Exon	Start	End
ENSE00000333025	194670009	194670135
ENSE00001057052	194658957	194659133
ENSE00001057057	194666203	194666289
ENSE00001057061	194665557	194665643
ENSE00001057062	194652729	194653142
ENSE00001057064	194666452	194666572
ENSE00001415869	194640791	194642247
ENSE00001507461	194648681	194648804
ENSE00001507463	194650881	194651024
ENSE00001644822	194672064	194672191
ENSE00003463351	194646164	194646243
ENSE00003493342	194644573	194644746
ENSE00003631729	194651115	194651216
ENSE00003687959	194660073	194660133

Expression profiles

Bgee: expression breadth ubiquitous, 291 present calls, max score 93.38.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 23.6961 / max 224.5924, expressed in 1814 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
46252	23.6961	1814

Top tissues by expression

292 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	93.38	gold quality
rectum	UBERON:0001052	92.14	gold quality
right lobe of liver	UBERON:0001114	91.96	gold quality
calcaneal tendon	UBERON:0003701	91.87	gold quality
body of pancreas	UBERON:0001150	91.85	gold quality
skin of abdomen	UBERON:0001416	91.85	gold quality
skin of leg	UBERON:0001511	91.73	gold quality
metanephros cortex	UBERON:0010533	91.01	gold quality
upper lobe of left lung	UBERON:0008952	90.99	gold quality
lymph node	UBERON:0000029	90.97	gold quality
right ovary	UBERON:0002118	90.82	gold quality
zone of skin	UBERON:0000014	90.78	gold quality
pancreas	UBERON:0001264	90.75	gold quality
small intestine Peyer’s patch	UBERON:0003454	90.72	gold quality
adrenal tissue	UBERON:0018303	90.55	gold quality
left uterine tube	UBERON:0001303	90.54	gold quality
upper lobe of lung	UBERON:0008948	90.53	gold quality
nipple	UBERON:0002030	90.52	gold quality
islet of Langerhans	UBERON:0000006	90.48	gold quality
vermiform appendix	UBERON:0001154	90.42	gold quality
right lobe of thyroid gland	UBERON:0001119	90.32	gold quality
mucosa of stomach	UBERON:0001199	90.27	gold quality
body of stomach	UBERON:0001161	90.24	gold quality
transverse colon	UBERON:0001157	90.21	gold quality
monocyte	CL:0000576	90.20	gold quality
mononuclear cell	CL:0000842	90.16	gold quality
leukocyte	CL:0000738	90.14	gold quality
body of uterus	UBERON:0009853	90.14	gold quality
ventricular zone	UBERON:0003053	90.10	gold quality
gastrocnemius	UBERON:0001388	90.04	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.55

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

27 targeting LSG1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-196A-5P	100.00	68.16	684
HSA-MIR-196B-5P	100.00	68.16	681
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-1305	99.91	71.43	3443
HSA-MIR-3140-3P	99.88	68.47	2069
HSA-MIR-3133	99.81	70.92	3506
HSA-MIR-548AJ-5P	99.78	71.12	3085
HSA-MIR-548F-5P	99.78	71.02	3093
HSA-MIR-548G-5P	99.78	71.12	3085
HSA-MIR-548X-5P	99.78	71.12	3085
HSA-MIR-6885-3P	99.75	70.36	3187
HSA-MIR-1197	99.70	67.75	1027
HSA-MIR-5004-5P	99.68	66.63	1294
HSA-MIR-12117	99.50	67.57	868
HSA-MIR-892C-5P	99.16	70.56	2116
HSA-MIR-6780B-3P	99.13	67.18	622
HSA-MIR-3194-3P	98.83	66.22	1167
HSA-MIR-6846-5P	98.81	65.86	1121
HSA-MIR-6848-5P	98.81	65.49	1126
HSA-MIR-7158-3P	98.46	66.45	728
HSA-MIR-12127	97.93	66.67	793
HSA-MIR-4638-3P	97.90	65.75	905
HSA-MIR-665	97.60	65.64	1781
HSA-MIR-6890-3P	97.50	65.71	997
HSA-MIR-1913	97.07	66.20	1417
HSA-MIR-6070	86.37	66.56	59

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 96.2% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 3)

• hLsg1 is an essential GTPase predominantly located in the endoplasmic reticulum and, in some cells, in Cajal bodies in the nucleus. (PMID:16209721)
• Targeting of LSG1 resulted in amplification of the cholesterol/endoplasmic reticular signature and restoration of a robust cellular senescence response in transformed cells, suggesting potential therapeutic uses of LSG1 inhibition. (PMID:31148378)
• The Ribosome Assembly Factor LSG1 Interacts with Vesicle-Associated Membrane Protein-Associated Proteins (VAPs). (PMID:39133101)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	lsg1	ENSDARG00000015352
mus_musculus	Lsg1	ENSMUSG00000022538
rattus_norvegicus	Lsg1	ENSRNOG00000001727
drosophila_melanogaster	Ns3	FBGN0266284
caenorhabditis_elegans	C53H9.2	WBGENE00016907

Paralogs (6): NOA1 (ENSG00000084092), GNL3L (ENSG00000130119), GNL2 (ENSG00000134697), MTG1 (ENSG00000148824), GNL3 (ENSG00000163938), GNL1 (ENSG00000204590)

Protein

Protein identifiers

Large subunit GTPase 1 homolog — Q9H089 (reviewed: Q9H089)

All UniProt accessions (3): Q9H089, F8WFC6, H7C2X7

UniProt curated annotations — full annotation on UniProt →

Function. Functions as a GTPase. May act by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm during the 60S ribosomal subunit maturation.

Subcellular location. Cytoplasm. Endoplasmic reticulum. Nucleus. Cajal body.

Domain organisation. In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.

Similarity. Belongs to the TRAFAC class YlqF/YawG GTPase family. LSG1 subfamily.

RefSeq proteins (1): NP_060855* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR006073	GTP-bd	Domain
IPR027417	P-loop_NTPase	Homologous_superfamily
IPR030378	G_CP_dom	Domain
IPR043358	GNL1-like	Family

Pfam: PF01926

Catalyzed reactions (Rhea), 1 shown:

• GTP + H2O = GDP + phosphate + H(+) (RHEA:19669)

UniProt features (19 total): compositionally biased region 6, binding site 3, modified residue 3, region of interest 3, sequence variant 2, chain 1, domain 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
6LSR	ELECTRON MICROSCOPY	3.13

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H089-F1	69.85	0.29

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (3): 212–215; 393–400; 437–440

Post-translational modifications (3): 93, 97, 252

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 142 (showing top): GOBP_RIBOSOME_BIOGENESIS, GOBP_NUCLEAR_TRANSPORT, WEI_MYCN_TARGETS_WITH_E_BOX, GOBP_NUCLEAR_EXPORT, GOBP_ORGANELLE_LOCALIZATION, GOBP_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS, GOCC_CAJAL_BODY, BENPORATH_OCT4_TARGETS, GOCC_NUCLEAR_BODY, GOCC_RIBONUCLEOPROTEIN_GRANULE, PAX2_02, GOMF_GTPASE_ACTIVITY, ELVIDGE_HIF1A_TARGETS_UP, GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES, MEISSNER_ES_ICP_WITH_H3K4ME3

GO Biological Process (3): ribosomal subunit export from nucleus (GO:0000054), protein transport (GO:0015031), nuclear export (GO:0051168)

GO Molecular Function (4): GTPase activity (GO:0003924), GTP binding (GO:0005525), nucleotide binding (GO:0000166), hydrolase activity (GO:0016787)

GO Cellular Component (8): nucleoplasm (GO:0005654), endoplasmic reticulum (GO:0005783), cytosol (GO:0005829), Cajal body (GO:0015030), membrane (GO:0016020), nuclear body (GO:0016604), nucleus (GO:0005634), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
cytoplasm	2
intracellular membrane-bounded organelle	2
ribosome localization	1
ribosome biogenesis	1
nuclear export	1
establishment of organelle localization	1
transport	1
intracellular protein localization	1
establishment of protein localization	1
nucleocytoplasmic transport	1
intercellular transport	1
ribonucleoside triphosphate phosphatase activity	1
guanyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
catalytic activity	1
nuclear lumen	1
endomembrane system	1
nuclear ribonucleoprotein granule	1
nucleoplasm	1
intracellular membraneless organelle	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

3285 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
LSG1	NMD3	Q96D46	872
LSG1	RSL24D1	Q9UHA3	775
LSG1	XPO1	O14980	771
LSG1	MRTO4	Q9UKD2	723
LSG1	GTPBP4	Q9BZE4	716
LSG1	NSA2	O95478	706
LSG1	MDN1	Q9NU22	686
LSG1	RIOK2	Q9BVS4	658
LSG1	RRP12	Q5JTH9	648
LSG1	WDR74	Q6RFH5	627
LSG1	SBDS	Q9Y3A5	607
LSG1	EFL1	Q7Z2Z2	594
LSG1	RPF2	Q9H7B2	584
LSG1	WDR12	Q9GZL7	580
LSG1	FAM43A	Q8N2R8	579

IntAct

86 interactions, top by confidence:

A	B	Type	Score
VAPB	FAM83G	psi-mi:“MI:0914”(association)	0.730
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
VAPA	FAM83G	psi-mi:“MI:0914”(association)	0.640
VAPA	PITPNM1	psi-mi:“MI:0914”(association)	0.640
FGL1	LCMT2	psi-mi:“MI:0914”(association)	0.640
YWHAH	BLTP3B	psi-mi:“MI:2364”(proximity)	0.570
PLPPR1	STXBP3	psi-mi:“MI:0914”(association)	0.530
LSG1	SPARC	psi-mi:“MI:0915”(physical association)	0.400
LSG1	KRT8	psi-mi:“MI:0915”(physical association)	0.400
Rpl35	RPS6	psi-mi:“MI:0914”(association)	0.350
Prkci	LLGL2	psi-mi:“MI:0914”(association)	0.350
RPL10	RPS6	psi-mi:“MI:0914”(association)	0.350
Emc3	EMC8	psi-mi:“MI:0914”(association)	0.350
NOP56	C12orf43	psi-mi:“MI:0914”(association)	0.350
VAPA		psi-mi:“MI:0914”(association)	0.350
Eif3e	RPSA	psi-mi:“MI:0914”(association)	0.350
JUN	TPM3	psi-mi:“MI:0914”(association)	0.350
ESR1	ESYT2	psi-mi:“MI:0914”(association)	0.350
VAPA	FAM83G	psi-mi:“MI:0914”(association)	0.350
TTC29	DHX16	psi-mi:“MI:0914”(association)	0.350
FGL1	DNM1L	psi-mi:“MI:0914”(association)	0.350

BioGRID (242): LSG1 (Affinity Capture-RNA), LSG1 (Affinity Capture-RNA), LSG1 (Affinity Capture-MS), LSG1 (Affinity Capture-MS), LSG1 (Affinity Capture-MS), LSG1 (Affinity Capture-MS), LSG1 (Affinity Capture-MS), LSG1 (Affinity Capture-MS), LSG1 (Affinity Capture-MS), LSG1 (Proximity Label-MS), LSG1 (Affinity Capture-MS), LSG1 (Affinity Capture-MS), LSG1 (Affinity Capture-MS), LSG1 (Affinity Capture-MS), LSG1 (Affinity Capture-MS)

ESM2 similar proteins: A0A1L8G016, A1A5Q0, B3DH20, D3Z8X7, D4A1F2, E1BTG2, F1MF74, F1RA39, O14730, O60308, O88978, O94851, O95801, P51432, P70566, Q1RMR5, Q1RMT7, Q28FY0, Q2YDM7, Q3UHZ5, Q3UM18, Q4KLT3, Q4R3F0, Q4R8L2, Q5BJT6, Q5EA11, Q5ZJD3, Q6AZN0, Q6P5Q4, Q7Z569, Q80V31, Q863A4, Q863A5, Q863A6, Q863A7, Q86X45, Q8BML1, Q8CCP0, Q8R368, Q8R3H9

Diamond homologs: A4SCU1, A5IMB8, A5N2K5, A6LT31, A6TM67, A7Z7A9, A8EXG4, A8FFV6, A8GM60, A8GQS1, A8GUK6, A9BHV0, B1LBK5, B1YJV8, B2TPB6, B2UX10, B3EGV8, B3QQY9, B4S596, B5EEM1, B5XL04, B8I8N7, B8J030, B9E746, C0MA50, C0MEW6, C1F4C3, C3PMD9, C4K1B9, C4Z1T3, C6E8C5, O67679, P0DA92, P0DA93, P36915, P36916, P38424, P53145, Q026Q1, Q0A4P0

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 109 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
SRP-dependent cotranslational protein targeting to membrane	16	20.0×	3e-14
Peptide chain elongation	11	17.4×	3e-09
Viral mRNA Translation	11	17.4×	3e-09
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	11	17.3×	3e-09
Selenocysteine synthesis	11	16.5×	3e-09
Eukaryotic Translation Termination	11	16.5×	3e-09
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	11	16.2×	3e-09
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	11	16.2×	3e-09

GO biological processes:

GO term	Partners	Fold	FDR
cytoplasmic translation	12	22.7×	1e-10
ribosomal small subunit biogenesis	6	13.9×	1e-03
translation	11	11.5×	1e-06

Disease & clinical

Clinical variants and AI predictions

ClinVar

153 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	119
Likely benign	7
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

2224 predictions. Top by Δscore:

Variant	Effect	Δscore
3:194644566:AACTT:A	donor_loss	1.0000
3:194644567:ACTT:A	donor_loss	1.0000
3:194644568:CTT:C	donor_loss	1.0000
3:194644569:TTA:T	donor_loss	1.0000
3:194644570:TA:T	donor_loss	1.0000
3:194644571:A:AC	donor_gain	1.0000
3:194644571:AC:A	donor_loss	1.0000
3:194644572:C:CC	donor_gain	1.0000
3:194646159:CTTA:C	donor_loss	1.0000
3:194646160:TTA:T	donor_gain	1.0000
3:194646161:T:TG	donor_loss	1.0000
3:194646161:TAC:T	donor_gain	1.0000
3:194646162:A:AC	donor_gain	1.0000
3:194646162:A:C	donor_loss	1.0000
3:194646162:ACA:A	donor_gain	1.0000
3:194646163:C:CA	donor_gain	1.0000
3:194646163:CA:C	donor_gain	1.0000
3:194646163:CAC:C	donor_gain	1.0000
3:194646163:CACT:C	donor_gain	1.0000
3:194646163:CACTG:C	donor_gain	1.0000
3:194646172:AGT:A	donor_gain	1.0000
3:194646239:CATGT:C	acceptor_gain	1.0000
3:194646240:ATGT:A	acceptor_gain	1.0000
3:194646241:TGT:T	acceptor_gain	1.0000
3:194646242:GT:G	acceptor_gain	1.0000
3:194646242:GTC:G	acceptor_loss	1.0000
3:194646244:C:CA	acceptor_loss	1.0000
3:194646244:C:CC	acceptor_gain	1.0000
3:194646246:G:C	acceptor_gain	1.0000
3:194650910:T:C	donor_gain	1.0000

AlphaMissense

4379 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
3:194665576:A:G	W168R	1.000
3:194665576:A:T	W168R	1.000
3:194650990:T:A	D437V	0.999
3:194650990:T:C	D437G	0.999
3:194650990:T:G	D437A	0.999
3:194665588:A:G	W164R	0.999
3:194665588:A:T	W164R	0.999
3:194650986:A:C	C438W	0.998
3:194650989:G:C	D437E	0.998
3:194650989:G:T	D437E	0.998
3:194650991:C:G	D437H	0.998
3:194650996:A:G	L435P	0.998
3:194651190:A:C	S400R	0.998
3:194651190:A:T	S400R	0.998
3:194651192:T:G	S400R	0.998
3:194665578:A:G	L167P	0.998
3:194665584:C:G	R165P	0.998
3:194666222:A:G	W139R	0.998
3:194666222:A:T	W139R	0.998
3:194666254:A:G	L128P	0.998
3:194666289:T:A	R116S	0.998
3:194666289:T:G	R116S	0.998
3:194666452:C:G	R116T	0.998
3:194670016:A:C	F73L	0.998
3:194670016:A:T	F73L	0.998
3:194670018:A:G	F73L	0.998
3:194650988:A:G	C438R	0.997
3:194651119:A:G	F424S	0.997
3:194651195:T:G	K399Q	0.997
3:194652730:A:G	L391P	0.997

dbSNP variants (sampled 300 via entrez): RS1000021025 (3:194647258 T>C), RS1000044771 (3:194644331 C>T), RS1000075898 (3:194644034 T>TG), RS1000112815 (3:194671733 T>A), RS1000146158 (3:194666621 A>G), RS1000332597 (3:194656539 C>T), RS1000447251 (3:194656221 A>C,G), RS1000664965 (3:194654982 G>C), RS1000690195 (3:194647560 G>A,C), RS1000697081 (3:194661943 G>A,T), RS1000708282 (3:194650189 G>C), RS1000751998 (3:194654430 C>T), RS1000762729 (3:194660537 T>A), RS1000780355 (3:194654699 A>G), RS1000974238 (3:194648584 T>C)

Disease associations

OMIM: gene MIM:610780 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST004267_3	Blood osmolality (transformed sodium)	3.000000e-06
GCST005024_67	Pursuit maintenance gain	5.000000e-06
GCST009267_23	Dental caries (decayed, missing and filled teeth)	2.000000e-07
GCST009268_8	Dental caries (decayed, missing and filled tooth surfaces)	2.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0008433	pursuit maintenance gain measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067316 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
9.28	Kd	0.521	nM	CHEMBL3752910
9.28	ED50	0.521	nM	CHEMBL3752910

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(1-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2148669: Binding affinity to human LSG1 incubated for 45 mins by Kinobead based pull down assay	kd	0.0005	uM

CTD chemical–gene interactions

28 total (human), top 28 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	increases methylation, affects expression, increases expression	3
Benzo(a)pyrene	affects methylation	2
Cisplatin	affects cotreatment, decreases expression	2
FR900359	decreases phosphorylation	1
triphenyl phosphate	affects expression	1
alpha-pinene	affects cotreatment, increases oxidation, increases abundance	1
bisphenol A	affects cotreatment, increases expression	1
sodium arsenite	affects binding, increases reaction, increases activity	1
methacrylaldehyde	affects cotreatment, increases oxidation, increases abundance	1
jinfukang	affects cotreatment, decreases expression	1
Sunitinib	increases expression	1
Acrolein	affects cotreatment, increases oxidation, increases abundance	1
Air Pollutants	affects cotreatment, increases abundance, increases oxidation	1
Amphotericin B	decreases expression	1
Caffeine	decreases phosphorylation	1
Cyclophosphamide	decreases expression	1
Estradiol	increases expression	1
Gentamicins	decreases expression	1
Methotrexate	decreases expression	1
Ozone	affects cotreatment, increases oxidation, increases abundance	1
Phenolsulfonphthalein	affects cotreatment, increases expression	1
Ribonucleotides	affects binding, increases reaction	1
Tretinoin	decreases expression	1
Cyclosporine	increases expression	1
Aflatoxin B1	increases methylation	1
Copper Sulfate	increases expression	1
Lactic Acid	decreases expression	1
Volatile Organic Compounds	affects cotreatment, increases oxidation	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5651711	Binding	Binding affinity to human LSG1 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.