LSM3

Summary

LSM3 (LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated, HGNC:17874) is a protein-coding gene on chromosome 3p25.1, encoding U6 snRNA-associated Sm-like protein LSm3 (P62310). Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). It is a common-essential gene (DepMap: required in 99.3% of cancer cell lines).

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.

Source: NCBI Gene 27258 — RefSeq curated summary.

At a glance

• GWAS associations: 13
• Clinical variants (ClinVar): 21 total — 4 pathogenic
• Cancer dependency (DepMap): dependent in 99.3% of screened cell lines (common-essential)
• MANE Select transcript: NM_014463

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:17874
Approved symbol	LSM3
Name	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
Location	3p25.1
Locus type	gene with protein product
Status	Approved
Aliases	YLR438C, SMX4, USS2
Ensembl gene	ENSG00000170860
Ensembl biotype	protein_coding
OMIM	607283
Entrez	27258

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 protein_coding

ENST00000306024, ENST00000907170, ENST00000907171

RefSeq mRNA: 1 — MANE Select: NM_014463 NM_014463

CCDS: CCDS2619

Canonical transcript exons

ENST00000306024 — 4 exons

Exon	Start	End
ENSE00001132721	14198036	14201122
ENSE00001132728	14181560	14181670
ENSE00001160195	14183937	14184032
ENSE00001160202	14178817	14178881

Expression profiles

Bgee: expression breadth ubiquitous, 294 present calls, max score 97.65.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 30.8277 / max 731.2733, expressed in 1804 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
35445	27.2916	1803
35444	2.7126	1347
35443	0.8234	434

Top tissues by expression

294 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
biceps brachii	UBERON:0001507	97.65	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	97.49	gold quality
diaphragm	UBERON:0001103	97.47	gold quality
heart right ventricle	UBERON:0002080	97.43	gold quality
type B pancreatic cell	CL:0000169	97.01	gold quality
oral cavity	UBERON:0000167	96.94	gold quality
triceps brachii	UBERON:0001509	96.57	gold quality
mucosa of sigmoid colon	UBERON:0004993	96.48	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	96.42	gold quality
adult organism	UBERON:0007023	96.32	gold quality
trabecular bone tissue	UBERON:0002483	96.25	gold quality
gluteal muscle	UBERON:0002000	96.04	gold quality
body of tongue	UBERON:0011876	96.03	gold quality
corpus epididymis	UBERON:0004359	95.91	gold quality
colonic mucosa	UBERON:0000317	95.76	gold quality
pharyngeal mucosa	UBERON:0000355	95.69	gold quality
seminal vesicle	UBERON:0000998	95.31	gold quality
tongue	UBERON:0001723	95.28	gold quality
synovial joint	UBERON:0002217	95.27	gold quality
penis	UBERON:0000989	95.19	gold quality
olfactory bulb	UBERON:0002264	95.18	gold quality
male germ cell	CL:0000015	95.17	gold quality
vena cava	UBERON:0004087	95.07	gold quality
pigmented layer of retina	UBERON:0001782	95.04	gold quality
renal medulla	UBERON:0000362	94.98	gold quality
sperm	CL:0000019	94.96	gold quality
tendon of biceps brachii	UBERON:0008188	94.90	gold quality
mammalian vulva	UBERON:0000997	94.88	gold quality
jejunum	UBERON:0002115	94.88	gold quality
superior surface of tongue	UBERON:0007371	94.86	gold quality

Single-cell (SCXA)

Detected in 6 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-HCAD-1	yes	41.79
E-ANND-3	yes	12.93
E-GEOD-93593	yes	8.92
E-MTAB-10485	no	760.43
E-MTAB-9388	no	727.55
E-MTAB-6386	no	206.22

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

21 targeting LSM3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-6758-5P	100.00	66.21	1470
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-6809-3P	99.91	71.45	3814
HSA-MIR-4698	99.84	71.41	4303
HSA-MIR-587	99.64	70.86	2611
HSA-MIR-889-3P	99.40	69.76	2103
HSA-MIR-5000-3P	98.79	65.63	1251
HSA-MIR-876-3P	98.76	68.23	945
HSA-MIR-323A-5P	98.59	65.13	651
HSA-MIR-4720-3P	98.50	68.88	988
HSA-MIR-6838-3P	98.40	65.88	559
HSA-MIR-4436A	98.05	64.83	1140
HSA-MIR-1279	97.83	67.50	1898
HSA-MIR-4700-3P	97.74	68.64	1014
HSA-MIR-5579-3P	97.00	68.81	1111
HSA-MIR-675-3P	95.77	69.27	675
HSA-MIR-6763-3P	90.80	64.32	80

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 99.3% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 1)

• LSm1-7 proteins colocalize with DCP1,DCP2 and Xrn1 in cytoplasmic foci (PMID:12515382)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	lsm3	ENSDARG00000089663
mus_musculus	Lsm3	ENSMUSG00000034192
rattus_norvegicus	Lsm3	ENSRNOG00000008733
drosophila_melanogaster	LSm3	FBGN0051184
caenorhabditis_elegans		WBGENE00003077

Protein

Protein identifiers

U6 snRNA-associated Sm-like protein LSm3 — P62310 (reviewed: P62310)

All UniProt accessions (1): P62310

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3’-terminal U-tract of U6 snRNA.

Subunit / interactions. Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome.

Subcellular location. Nucleus.

Similarity. Belongs to the snRNP Sm proteins family.

RefSeq proteins (1): NP_055278* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001163	Sm_dom_euk/arc	Domain
IPR010920	LSM_dom_sf	Homologous_superfamily
IPR034105	Lsm3	Domain
IPR040002	Sm-like_LSM3	Family
IPR047575	Sm	Domain

Pfam: PF01423

UniProt features (4 total): initiator methionine 1, chain 1, domain 1, modified residue 1

Structure

Experimental structures (PDB)

20 structures.

PDB	Method	Resolution (Å)
8H6L	ELECTRON MICROSCOPY	2.6
8H6K	ELECTRON MICROSCOPY	2.7
6QW6	ELECTRON MICROSCOPY	2.92
8H6E	ELECTRON MICROSCOPY	3.2
8H6J	ELECTRON MICROSCOPY	3.25
6QX9	ELECTRON MICROSCOPY	3.28
6AHD	ELECTRON MICROSCOPY	3.8
8QZS	ELECTRON MICROSCOPY	4.1
8R09	ELECTRON MICROSCOPY	4.3
8R0B	ELECTRON MICROSCOPY	4.4
5O9Z	ELECTRON MICROSCOPY	4.5
8QO9	ELECTRON MICROSCOPY	5.29
6AH0	ELECTRON MICROSCOPY	5.7
8R0A	ELECTRON MICROSCOPY	5.8
8R08	ELECTRON MICROSCOPY	6.1
8RM5	ELECTRON MICROSCOPY	6.9
3JCR	ELECTRON MICROSCOPY	7
7ABG	ELECTRON MICROSCOPY	7.8
9R8V	ELECTRON MICROSCOPY	8.5
8QXD	ELECTRON MICROSCOPY	9.6

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P62310-F1	89.49	0.71

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 2

Function

Pathways and Gene Ontology

Reactome pathways

6 pathways

ID	Pathway
R-HSA-430039	mRNA decay by 5’ to 3’ exoribonuclease
R-HSA-72163	mRNA Splicing - Major Pathway
R-HSA-429914	Deadenylation-dependent mRNA decay
R-HSA-72172	mRNA Splicing
R-HSA-72203	Processing of Capped Intron-Containing Pre-mRNA
R-HSA-8953854	Metabolism of RNA

MSigDB gene sets: 203 (showing top): GOBP_P_BODY_ASSEMBLY, GOBP_REGULATION_OF_MRNA_CATABOLIC_PROCESS, BASSO_B_LYMPHOCYTE_NETWORK, PAL_PRMT5_TARGETS_UP, MODULE_151, REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, MORF_RAD21, MODULE_16, PUJANA_CHEK2_PCC_NETWORK, GOBP_POST_TRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION, MORF_SKP1A, MUELLER_PLURINET, GOBP_SPLICEOSOMAL_TRI_SNRNP_COMPLEX_ASSEMBLY, GOBP_REGULATION_OF_CATABOLIC_PROCESS

GO Biological Process (4): mRNA splicing, via spliceosome (GO:0000398), mRNA processing (GO:0006397), P-body assembly (GO:0033962), RNA splicing (GO:0008380)

GO Molecular Function (3): RNA binding (GO:0003723), U6 snRNA 3’-end binding (GO:0030629), protein binding (GO:0005515)

GO Cellular Component (13): P-body (GO:0000932), nucleus (GO:0005634), nucleoplasm (GO:0005654), spliceosomal complex (GO:0005681), U6 snRNP (GO:0005688), cytosol (GO:0005829), U4/U6 x U5 tri-snRNP complex (GO:0046540), U2-type precatalytic spliceosome (GO:0071005), precatalytic spliceosome (GO:0071011), catalytic step 2 spliceosome (GO:0071013), Lsm2-8 complex (GO:0120115), Lsm1-7-Pat1 complex (GO:1990726), ribonucleoprotein complex (GO:1990904)

Reactome top-level categories

Rollup of top-4 pathways:

Category	Pathways
Metabolism of RNA	2
Deadenylation-dependent mRNA decay	1
mRNA Splicing	1
Processing of Capped Intron-Containing Pre-mRNA	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA processing	2
cellular anatomical structure	2
U5 snRNP	2
spliceosomal complex	2
Sm-like protein family complex	2
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	1
mRNA processing	1
mRNA metabolic process	1
membraneless organelle assembly	1
nucleic acid binding	1
U6 snRNA binding	1
binding	1
cytoplasmic ribonucleoprotein granule	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
nuclear protein-containing complex	1
ribonucleoprotein complex	1
spliceosomal snRNP complex	1
Lsm2-8 complex	1
cytoplasm	1
U4/U6 snRNP	1
spliceosomal tri-snRNP complex	1
U2-type spliceosomal complex	1
U1 snRNP	1
U2 snRNP	1
U4/U6 x U5 tri-snRNP complex	1
precatalytic spliceosome	1
Prp19 complex	1
catalytic complex	1
protein-containing complex	1

Protein interactions and networks

STRING

2162 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
LSM3	LSM2	Q9Y333	999
LSM3	LSM4	Q9Y4Z0	998
LSM3	LSM6	P62312	997
LSM3	LSM7	Q9UK45	996
LSM3	LSM8	O95777	993
LSM3	LSM5	Q9Y4Y9	991
LSM3	LSM1	O15116	986
LSM3	XRN1	Q8IZH2	921
LSM3	SNRPF	P62306	715
LSM3	SNRPD1	P13641	665
LSM3	SNRPE	P08578	665
LSM3	SNRPD3	P43331	625
LSM3	EDC3	Q96F86	619
LSM3	LSM12	Q3MHD2	616
LSM3	DCP2	Q8IU60	561

IntAct

246 interactions, top by confidence:

A	B	Type	Score
LSM2	LSM3	psi-mi:“MI:0915”(physical association)	0.980
LSM3	LSM2	psi-mi:“MI:0915”(physical association)	0.980
LSM3	LSM2	psi-mi:“MI:2364”(proximity)	0.980

BioGRID (217): LSM3 (Two-hybrid), LSM3 (Two-hybrid), LSM3 (Two-hybrid), LSM3 (Two-hybrid), LSM3 (Two-hybrid), LSM2 (Two-hybrid), LSM3 (Two-hybrid), LSM2 (Two-hybrid), LSM10 (Two-hybrid), LSM3 (Two-hybrid), LSM1 (Co-fractionation), LSM3 (Co-fractionation), LSM3 (Co-fractionation), LSM3 (Co-fractionation), LSM3 (Co-fractionation)

ESM2 similar proteins: A5GFZ5, A8MWD9, C9WPN6, O35900, O60762, O70152, P02362, P50894, P62084, P62306, P62307, P62308, P62309, P62310, P62311, P62314, P62315, P62318, P62320, P62321, P62323, P62487, P62488, P62489, P82931, Q16576, Q1JQ93, Q24572, Q2TBV5, Q2VIR3, Q32PE9, Q3SWX8, Q3T0Z8, Q3ZBL0, Q3ZC10, Q4R304, Q4R5F6, Q5E9B8, Q5ZMS3, Q60973

Diamond homologs: A5DRQ6, A8NHT8, B0DWN3, B6YUU5, C5A1H1, C6A1T2, O22823, O26745, O29386, O42978, O59734, O74016, O74966, P34659, P40089, P57670, P62306, P62307, P62310, P62311, P62312, P62313, P62321, Q0W8R9, Q12U30, Q1DRN0, Q1ZXK3, Q24297, Q32PE9, Q3T0Z8, Q465S1, Q4PG71, Q552U1, Q5JIE0, Q6BR90, Q8PZZ9, Q8TL47, Q8U0P4, Q97BU5, Q9C6K5

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
LSM3	“form complex”	“U4/U6.U5 snRNP complex”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 58 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
mRNA decay by 5’ to 3’ exoribonuclease	5	95.2×	7e-08
snRNP Assembly	5	26.4×	4e-05
mRNA Splicing	9	24.7×	1e-08
Processing of Capped Intron-Containing Pre-mRNA	9	18.5×	6e-08
mRNA Splicing - Major Pathway	11	15.0×	1e-08
Metabolism of RNA	14	14.6×	7e-11
Viral Infection Pathways	7	5.4×	7e-03

GO biological processes:

GO term	Partners	Fold	FDR
spliceosomal snRNP assembly	6	68.4×	5e-08
mRNA splicing, via spliceosome	13	23.4×	3e-12
RNA splicing	8	13.8×	1e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

21 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	4
Likely pathogenic	0
Uncertain significance	11
Likely benign	0
Benign	2

Top pathogenic / likely-pathogenic (4)

Variant ID	HGVS	Classification
1071711	NC_000003.11:g.(?14166684)(14220439_?)del	Pathogenic
1458454	NC_000003.11:g.(?14206303)(14220439_?)del	Pathogenic
2425188	NC_000003.11:g.(?14214357)(14220439_?)del	Pathogenic
831828	NC_000003.12:g.(?14170428)(14178939_?)del	Pathogenic

SpliceAI

355 predictions. Top by Δscore:

Variant	Effect	Δscore
3:14181555:A:AG	acceptor_gain	1.0000
3:14181557:CAGC:C	acceptor_loss	1.0000
3:14181558:A:AG	acceptor_gain	1.0000
3:14181559:G:A	acceptor_loss	1.0000
3:14181559:G:GA	acceptor_gain	1.0000
3:14181559:GC:G	acceptor_gain	1.0000
3:14181559:GCA:G	acceptor_gain	1.0000
3:14181559:GCAA:G	acceptor_gain	1.0000
3:14181559:GCAAC:G	acceptor_gain	1.0000
3:14181666:TACAT:T	donor_gain	1.0000
3:14181667:ACAT:A	donor_gain	1.0000
3:14181668:CAT:C	donor_gain	1.0000
3:14181669:AT:A	donor_gain	1.0000
3:14181669:ATG:A	donor_loss	1.0000
3:14181670:TG:T	donor_loss	1.0000
3:14181671:G:GA	donor_loss	1.0000
3:14181671:G:GG	donor_gain	1.0000
3:14181672:TAAG:T	donor_loss	1.0000
3:14181675:G:GG	donor_gain	1.0000
3:14183930:A:AG	acceptor_gain	1.0000
3:14183931:C:G	acceptor_gain	1.0000
3:14183931:CTTTA:C	acceptor_loss	1.0000
3:14183932:TTTA:T	acceptor_loss	1.0000
3:14183933:TTAGG:T	acceptor_loss	1.0000
3:14183934:TAGG:T	acceptor_loss	1.0000
3:14183935:A:AG	acceptor_gain	1.0000
3:14183935:AG:A	acceptor_gain	1.0000
3:14183935:AGG:A	acceptor_loss	1.0000
3:14183936:G:A	acceptor_loss	1.0000
3:14183936:G:GA	acceptor_gain	1.0000

AlphaMissense

659 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
3:14181588:C:A	P17H	1.000
3:14181591:T:C	L18P	1.000
3:14181594:A:T	D19V	1.000
3:14181597:T:C	L20P	1.000
3:14181606:T:C	L23P	1.000
3:14181630:T:A	V31E	1.000
3:14181639:G:C	R34T	1.000
3:14181640:A:C	R34S	1.000
3:14181640:A:T	R34S	1.000
3:14181648:G:C	R37P	1.000
3:14181654:T:A	L39H	1.000
3:14181654:T:C	L39P	1.000
3:14181659:G:A	G41S	1.000
3:14181659:G:C	G41R	1.000
3:14181659:G:T	G41C	1.000
3:14181660:G:A	G41D	1.000
3:14181660:G:T	G41V	1.000
3:14181666:T:C	L43S	1.000
3:14183937:G:C	A45P	1.000
3:14183938:C:A	A45D	1.000
3:14183943:G:A	D47N	1.000
3:14183943:G:C	D47H	1.000
3:14183943:G:T	D47Y	1.000
3:14183944:A:C	D47A	1.000
3:14183944:A:G	D47G	1.000
3:14183944:A:T	D47V	1.000
3:14183945:T:A	D47E	1.000
3:14183945:T:G	D47E	1.000
3:14183949:C:G	H49D	1.000
3:14183950:A:G	H49R	1.000

dbSNP variants (sampled 300 via entrez): RS1000060401 (3:14197287 T>C,G), RS1000122809 (3:14192176 T>C), RS1000153986 (3:14192036 T>G), RS1000390228 (3:14197545 A>G), RS1000409652 (3:14179791 A>G), RS1000680819 (3:14198783 G>A,T), RS1000719173 (3:14197836 T>C), RS1000720435 (3:14192159 T>C), RS1000890686 (3:14181210 A>G), RS1001077457 (3:14187757 C>T), RS1001400761 (3:14188047 G>A,T), RS1001418324 (3:14181175 G>A,C), RS1001737149 (3:14200413 G>A), RS1001989049 (3:14196318 C>A), RS1002075069 (3:14185142 G>A)

Disease associations

OMIM: gene MIM:607283 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

13 associations (top):

Study	Trait	p-value
GCST007576_265	Chronotype	3.000000e-10
GCST008363_31	Offspring birth weight	2.000000e-10
GCST008839_424	Height	2.000000e-09
GCST010320_106	PR interval	2.000000e-17
GCST010321_199	PR interval	2.000000e-19
GCST010796_1637	Electrocardiogram morphology (amplitude at temporal datapoints)	2.000000e-15
GCST010796_1638	Electrocardiogram morphology (amplitude at temporal datapoints)	7.000000e-10
GCST010796_1639	Electrocardiogram morphology (amplitude at temporal datapoints)	6.000000e-12
GCST010796_1640	Electrocardiogram morphology (amplitude at temporal datapoints)	1.000000e-13
GCST010796_1641	Electrocardiogram morphology (amplitude at temporal datapoints)	3.000000e-15
GCST011202_5	Dilated cardiomyopathy (MTAG)	9.000000e-09
GCST012211_1	Dilated cardiomyopathy	5.000000e-13
GCST90002403_130	Red blood cell count	4.000000e-09

EFO canonical traits (6, from GWAS)

EFO ID	Trait name
EFO:0008328	chronotype measurement
EFO:0004344	birth weight
EFO:0005939	parental genotype effect measurement
EFO:0004462	PR interval
EFO:0004327	electrocardiography
EFO:0004305	erythrocyte count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB variants

1 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs1870134	LSM3, XPC		0.00	0

CTD chemical–gene interactions

30 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	increases abundance, increases expression	3
bisphenol A	affects expression, decreases expression	2
(+)-JQ1 compound	decreases expression	2
Air Pollutants	decreases expression, increases abundance	2
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
deoxynivalenol	increases expression	1
arsenite	affects binding, increases reaction	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
cobaltous chloride	decreases expression	1
M-VAC protocol	increases response to substance	1
yessotoxin	decreases expression	1
CGP 52608	affects binding, increases reaction	1
CD 437	decreases expression	1
K 7174	decreases expression	1
3-(4’-hydroxy-3’-adamantylbiphenyl-4-yl)acrylic acid	decreases expression	1
ICG 001	decreases expression	1
PP242	increases expression	1
Arsenic	increases abundance, increases expression	1
Benzo(a)pyrene	increases methylation	1
Coal	decreases expression, increases abundance	1
Ivermectin	decreases expression	1
Phenobarbital	affects expression	1
Ribonucleotides	affects binding	1
Smoke	decreases expression, increases abundance	1
Cyclosporine	affects expression	1
Copper Sulfate	decreases expression	1
Lactic Acid	decreases expression	1
Acrylamide	increases expression	1
Particulate Matter	increases abundance, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.