LSM6

Summary

LSM6 (LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated, HGNC:17017) is a protein-coding gene on chromosome 4q31.22, encoding U6 snRNA-associated Sm-like protein LSm6 (P62312). Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). It is a common-essential gene (DepMap: required in 93.9% of cancer cell lines).

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.

Source: NCBI Gene 11157 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 11 total
• Cancer dependency (DepMap): dependent in 93.9% of screened cell lines (common-essential)
• MANE Select transcript: NM_007080

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:17017
Approved symbol	LSM6
Name	LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
Location	4q31.22
Locus type	gene with protein product
Status	Approved
Aliases	YDR378C
Ensembl gene	ENSG00000164167
Ensembl biotype	protein_coding
OMIM	607286
Entrez	11157

Gene structure

Transcript identifiers

Ensembl transcripts: 27 — 21 protein_coding, 3 nonsense_mediated_decay, 2 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000296581, ENST00000502781, ENST00000503982, ENST00000504181, ENST00000507449, ENST00000510331, ENST00000515311, ENST00000649747, ENST00000850848, ENST00000871396, ENST00000871397, ENST00000871398, ENST00000871399, ENST00000871400, ENST00000871401, ENST00000871402, ENST00000871403, ENST00000871404, ENST00000871405, ENST00000937836, ENST00000937837, ENST00000937838, ENST00000937839, ENST00000937840, ENST00000937841, ENST00000946380, ENST00000946381

RefSeq mRNA: 1 — MANE Select: NM_007080 NM_007080

CCDS: CCDS3767

Canonical transcript exons

ENST00000296581 — 4 exons

Exon	Start	End
ENSE00001082009	146182912	146183015
ENSE00001082010	146187274	146187387
ENSE00001678867	146175718	146175811
ENSE00002023645	146189622	146191535

Expression profiles

Bgee: expression breadth ubiquitous, 290 present calls, max score 97.93.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 37.7543 / max 465.2137, expressed in 1819 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
49921	37.7543	1819

Top tissues by expression

296 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	97.93	gold quality
mononuclear cell	CL:0000842	97.67	gold quality
leukocyte	CL:0000738	97.54	gold quality
granulocyte	CL:0000094	94.99	gold quality
vermiform appendix	UBERON:0001154	93.89	gold quality
lymph node	UBERON:0000029	93.63	gold quality
calcaneal tendon	UBERON:0003701	93.50	gold quality
adipose tissue of abdominal region	UBERON:0007808	93.49	gold quality
caecum	UBERON:0001153	93.47	gold quality
peritoneum	UBERON:0002358	93.45	gold quality
omental fat pad	UBERON:0010414	93.45	gold quality
ganglionic eminence	UBERON:0004023	93.26	gold quality
mucosa of transverse colon	UBERON:0004991	92.95	gold quality
right lung	UBERON:0002167	92.85	gold quality
islet of Langerhans	UBERON:0000006	92.81	gold quality
adult organism	UBERON:0007023	92.73	gold quality
adipose tissue	UBERON:0001013	92.67	gold quality
connective tissue	UBERON:0002384	92.54	gold quality
colonic epithelium	UBERON:0000397	92.50	gold quality
spleen	UBERON:0002106	92.41	gold quality
bone marrow	UBERON:0002371	92.25	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	92.23	gold quality
ventricular zone	UBERON:0003053	92.05	gold quality
embryo	UBERON:0000922	91.86	gold quality
oocyte	CL:0000023	91.76	gold quality
subcutaneous adipose tissue	UBERON:0002190	91.57	gold quality
tendon	UBERON:0000043	91.46	gold quality
left ovary	UBERON:0002119	91.43	gold quality
upper lobe of left lung	UBERON:0008952	91.32	gold quality
right ovary	UBERON:0002118	91.29	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-HCAD-1	yes	18.48
E-ANND-3	yes	8.48
E-CURD-88	yes	8.36

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

30 targeting LSM6, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-3912-5P	99.95	66.11	925
HSA-MIR-4760-3P	99.93	70.50	2385
HSA-MIR-338-5P	99.92	72.34	2951
HSA-MIR-10527-5P	99.91	72.28	3754
HSA-MIR-4697-3P	99.89	67.09	1123
HSA-MIR-4307	99.82	70.45	3374
HSA-MIR-944	99.82	70.85	3042
HSA-MIR-4719	99.73	72.10	3329
HSA-MIR-5004-5P	99.68	66.63	1294
HSA-MIR-4276	99.56	67.66	2514
HSA-MIR-410-3P	99.27	69.98	2457
HSA-MIR-8065	99.19	70.38	1289
HSA-MIR-6749-3P	99.00	65.73	1443
HSA-MIR-4738-3P	98.98	67.98	1846
HSA-MIR-511-5P	98.97	70.94	2268
HSA-MIR-583	98.71	67.44	1791
HSA-MIR-3136-5P	98.53	67.68	793
HSA-MIR-4439	98.53	67.53	793
HSA-MIR-4691-5P	98.41	66.77	1343
HSA-MIR-6792-3P	98.41	66.86	1359
HSA-MIR-224-5P	98.33	70.12	1256
HSA-MIR-6834-3P	98.16	65.77	551
HSA-MIR-1287-5P	96.80	65.30	743
HSA-MIR-550B-3P	95.43	67.73	599

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 93.9% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 1)

• LSm1-7 proteins colocalize with DCP1,DCP2 and Xrn1 in cytoplasmic foci (PMID:12515382)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	lsm6	ENSDARG00000036995
mus_musculus	Lsm6	ENSMUSG00000031683
rattus_norvegicus	Lsm6	ENSRNOG00000030374
drosophila_melanogaster	CG9344	FBGN0034564
caenorhabditis_elegans	lsm-6	WBGENE00003080

Paralogs (1): SNRPF (ENSG00000139343)

Protein

Protein identifiers

U6 snRNA-associated Sm-like protein LSm6 — P62312 (reviewed: P62312)

All UniProt accessions (1): P62312

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3’-terminal U-tract of U6 snRNA. Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5’-to-3’ mRNA decay pathway.

Subunit / interactions. Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome. Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7.

Subcellular location. Cytoplasm. Nucleus.

Similarity. Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.

RefSeq proteins (1): NP_009011* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001163	Sm_dom_euk/arc	Domain
IPR010920	LSM_dom_sf	Homologous_superfamily
IPR016487	Lsm6/sSmF	Family
IPR047575	Sm	Domain

Pfam: PF01423

UniProt features (3 total): chain 1, domain 1, modified residue 1

Structure

Experimental structures (PDB)

20 structures.

PDB	Method	Resolution (Å)
8H6L	ELECTRON MICROSCOPY	2.6
8H6K	ELECTRON MICROSCOPY	2.7
6QW6	ELECTRON MICROSCOPY	2.92
8H6E	ELECTRON MICROSCOPY	3.2
8H6J	ELECTRON MICROSCOPY	3.25
6QX9	ELECTRON MICROSCOPY	3.28
6AHD	ELECTRON MICROSCOPY	3.8
8QZS	ELECTRON MICROSCOPY	4.1
8R09	ELECTRON MICROSCOPY	4.3
8R0B	ELECTRON MICROSCOPY	4.4
5O9Z	ELECTRON MICROSCOPY	4.5
8QO9	ELECTRON MICROSCOPY	5.29
6AH0	ELECTRON MICROSCOPY	5.7
8R0A	ELECTRON MICROSCOPY	5.8
8R08	ELECTRON MICROSCOPY	6.1
8RM5	ELECTRON MICROSCOPY	6.9
3JCR	ELECTRON MICROSCOPY	7
7ABG	ELECTRON MICROSCOPY	7.8
9R8V	ELECTRON MICROSCOPY	8.5
8QXD	ELECTRON MICROSCOPY	9.6

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P62312-F1	91.51	0.76

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 59

Function

Pathways and Gene Ontology

Reactome pathways

6 pathways

ID	Pathway
R-HSA-430039	mRNA decay by 5’ to 3’ exoribonuclease
R-HSA-72163	mRNA Splicing - Major Pathway
R-HSA-429914	Deadenylation-dependent mRNA decay
R-HSA-72172	mRNA Splicing
R-HSA-72203	Processing of Capped Intron-Containing Pre-mRNA
R-HSA-8953854	Metabolism of RNA

MSigDB gene sets: 156 (showing top): GOBP_RIBOSOME_BIOGENESIS, GOBP_REGULATION_OF_MRNA_CATABOLIC_PROCESS, GOBP_MATURATION_OF_SSU_RRNA, GOBP_TRNA_METABOLIC_PROCESS, REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, EFC_Q6, PUJANA_CHEK2_PCC_NETWORK, WEI_MYCN_TARGETS_WITH_E_BOX, GOBP_POST_TRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION, IRF7_01, MUELLER_PLURINET, GOBP_SPLICEOSOMAL_TRI_SNRNP_COMPLEX_ASSEMBLY, GOBP_REGULATION_OF_CATABOLIC_PROCESS, GOBP_POSITIVE_REGULATION_OF_CATABOLIC_PROCESS

GO Biological Process (7): mRNA splicing, via spliceosome (GO:0000398), mRNA catabolic process (GO:0006402), tRNA processing (GO:0008033), RNA splicing (GO:0008380), maturation of SSU-rRNA (GO:0030490), rRNA processing (GO:0006364), mRNA processing (GO:0006397)

GO Molecular Function (3): RNA binding (GO:0003723), protein heterodimerization activity (GO:0046982), protein binding (GO:0005515)

GO Cellular Component (14): P-body (GO:0000932), nucleus (GO:0005634), nucleoplasm (GO:0005654), spliceosomal complex (GO:0005681), U6 snRNP (GO:0005688), nucleolus (GO:0005730), sno(s)RNA-containing ribonucleoprotein complex (GO:0005732), cytoplasm (GO:0005737), cytosol (GO:0005829), small nuclear ribonucleoprotein complex (GO:0030532), U4/U6 x U5 tri-snRNP complex (GO:0046540), U2-type precatalytic spliceosome (GO:0071005), Lsm2-8 complex (GO:0120115), ribonucleoprotein complex (GO:1990904)

Reactome top-level categories

Rollup of top-4 pathways:

Category	Pathways
Metabolism of RNA	2
Deadenylation-dependent mRNA decay	1
mRNA Splicing	1
Processing of Capped Intron-Containing Pre-mRNA	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA processing	4
cellular anatomical structure	3
ribonucleoprotein complex	3
mRNA metabolic process	2
nuclear lumen	2
nuclear protein-containing complex	2
Sm-like protein family complex	2
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	1
mRNA processing	1
RNA catabolic process	1
negative regulation of gene expression	1
tRNA metabolic process	1
rRNA processing	1
ribosomal small subunit biogenesis	1
rRNA metabolic process	1
ribosome biogenesis	1
nucleic acid binding	1
protein dimerization activity	1
binding	1
cytoplasmic ribonucleoprotein granule	1
intracellular membrane-bounded organelle	1
spliceosomal snRNP complex	1
Lsm2-8 complex	1
intracellular membraneless organelle	1
intracellular anatomical structure	1
cytoplasm	1
U5 snRNP	1
U4/U6 snRNP	1
spliceosomal tri-snRNP complex	1
U2-type spliceosomal complex	1
U1 snRNP	1
U2 snRNP	1
U4/U6 x U5 tri-snRNP complex	1
precatalytic spliceosome	1
protein-containing complex	1

Protein interactions and networks

STRING

1990 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
LSM6	LSM7	Q9UK45	998
LSM6	LSM3	P62310	997
LSM6	LSM2	Q9Y333	996
LSM6	LSM5	Q9Y4Y9	996
LSM6	LSM4	Q9Y4Z0	994
LSM6	LSM8	O95777	986
LSM6	LSM1	O15116	981
LSM6	XRN1	Q8IZH2	951
LSM6	SNRPD2	P43330	914
LSM6	SNRPE	P08578	756
LSM6	SNRPG	P62308	671
LSM6	SNRPD1	P13641	667
LSM6	SNRPD3	P43331	666
LSM6	NHP2	Q9NX24	661
LSM6	LSM12	Q3MHD2	637

IntAct

126 interactions, top by confidence:

A	B	Type	Score
LSM1	LSM3	psi-mi:“MI:0915”(physical association)	0.950
LSM3	LSM1	psi-mi:“MI:0914”(association)	0.950
CLNS1A	LSM6	psi-mi:“MI:0915”(physical association)	0.930
LSM6	CLNS1A	psi-mi:“MI:0915”(physical association)	0.930
SNRPF	GEMIN2	psi-mi:“MI:0914”(association)	0.910
LSM6	LSM5	psi-mi:“MI:0915”(physical association)	0.900
LSM5	LSM6	psi-mi:“MI:0915”(physical association)	0.900
LSM3	LSM6	psi-mi:“MI:0915”(physical association)	0.870
LSM6	LSM3	psi-mi:“MI:0915”(physical association)	0.870
LSM6	LSM2	psi-mi:“MI:0915”(physical association)	0.870
LSM2	LSM6	psi-mi:“MI:0915”(physical association)	0.870
LSM1	LSM6	psi-mi:“MI:0914”(association)	0.840
LSM6	LSM1	psi-mi:“MI:0914”(association)	0.840
SNRPD2	LSM6	psi-mi:“MI:0915”(physical association)	0.800
LSM7	LSM6	psi-mi:“MI:0915”(physical association)	0.800
LSM2	LSM8	psi-mi:“MI:0915”(physical association)	0.790
PATL1	LSM6	psi-mi:“MI:0915”(physical association)	0.740

BioGRID (203): LSM6 (Two-hybrid), LSM6 (Two-hybrid), LSM5 (Two-hybrid), LSM3 (Two-hybrid), HERC4 (Co-fractionation), LSM6 (Co-fractionation), LSM6 (Co-fractionation), LSM6 (Co-fractionation), LSM6 (Co-fractionation), LSM6 (Co-fractionation), LSM6 (Co-fractionation), LSM6 (Co-fractionation), LSM6 (Co-fractionation), LSM6 (Co-fractionation), LSM7 (Co-fractionation)

ESM2 similar proteins: A1CE19, A1DM27, A4RQ29, A5DRQ6, A6R363, A6S5C9, A7F5M4, A7TK72, A7UXE4, A8NHT8, B0DWN3, C5A1H1, C6A1T2, O22823, O26745, O43080, O59734, O74966, O82221, P0CR24, P0CR25, P24715, P34659, P54999, P57670, P57743, P62312, P62313, Q06406, Q0UWI9, Q0W8R9, Q12U30, Q1DRN0, Q24297, Q2HAN0, Q465S1, Q4PG71, Q4WNI0, Q54RX0, Q54XP2

Diamond homologs: A1CE19, A1DM27, A4RQ29, A5DRQ6, A6R363, A6S5C9, A6ZYX7, A7F5M4, A7TK72, A7UXE4, A8NHT8, B0DWN3, C6A1T2, O22823, O26745, O59734, P0CR24, P0CR25, P34659, P54999, P62306, P62307, P62312, P62313, P62321, Q06406, Q0UWI9, Q0W8R9, Q1DRN0, Q1H595, Q24297, Q2HAN0, Q3T0Z8, Q465S1, Q4PG71, Q4WNI0, Q54TF6, Q54XP2, Q552U1, Q6BR90

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
LSM6	“form complex”	“U4/U6.U5 snRNP complex”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 67 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
mRNA decay by 5’ to 3’ exoribonuclease	7	91.9×	2e-11
Metabolism of non-coding RNA	5	54.7×	7e-07
mRNA Splicing	15	28.4×	3e-16
snRNP Assembly	7	25.5×	3e-07
mRNA Splicing - Major Pathway	26	24.5×	5e-28
mRNA Splicing - Minor Pathway	6	23.2×	5e-06
SARS-CoV-2 modulates host translation machinery	6	23.2×	5e-06
Processing of Capped Intron-Containing Pre-mRNA	15	21.2×	1e-14

GO biological processes:

GO term	Partners	Fold	FDR
spliceosomal snRNP assembly	12	107.3×	3e-20
spliceosomal tri-snRNP complex assembly	6	103.7×	1e-09
RNA splicing, via transesterification reactions	5	48.0×	3e-06
U2-type prespliceosome assembly	5	48.0×	3e-06
mRNA splicing, via spliceosome	27	38.0×	5e-34
RNA splicing	13	17.6×	4e-11
mRNA processing	9	10.9×	5e-06

Disease & clinical

Clinical variants and AI predictions

ClinVar

11 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	6
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1060 predictions. Top by Δscore:

Variant	Effect	Δscore
4:146182898:A:AG	acceptor_gain	1.0000
4:146182899:T:G	acceptor_gain	1.0000
4:146182900:A:AG	acceptor_gain	1.0000
4:146182900:ATTTT:A	acceptor_gain	1.0000
4:146182901:T:G	acceptor_gain	1.0000
4:146182908:TTAGG:T	acceptor_loss	1.0000
4:146182909:TA:T	acceptor_loss	1.0000
4:146182910:A:T	acceptor_loss	1.0000
4:146182910:AG:A	acceptor_gain	1.0000
4:146182911:GG:G	acceptor_gain	1.0000
4:146182911:GGATT:G	acceptor_gain	1.0000
4:146183012:CGAG:C	donor_loss	1.0000
4:146183013:GAGGT:G	donor_loss	1.0000
4:146183014:AGGTA:A	donor_loss	1.0000
4:146183015:GGTAA:G	donor_loss	1.0000
4:146183016:G:GC	donor_loss	1.0000
4:146187255:T:A	acceptor_gain	1.0000
4:146187263:T:G	acceptor_gain	1.0000
4:146187264:A:AG	acceptor_gain	1.0000
4:146187265:T:G	acceptor_gain	1.0000
4:146187350:GAA:G	donor_gain	1.0000
4:146187352:A:AG	donor_gain	1.0000
4:146187352:A:G	donor_gain	1.0000
4:146187356:G:GG	donor_gain	1.0000
4:146187423:A:AG	donor_gain	1.0000
4:146189620:A:AG	acceptor_gain	1.0000
4:146189621:G:GC	acceptor_gain	1.0000
4:146189621:GT:G	acceptor_gain	1.0000
4:146189621:GTGT:G	acceptor_gain	1.0000
4:146189621:GTGTT:G	acceptor_gain	1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000093972 (4:146184829 T>C), RS1000228689 (4:146191054 G>A), RS1000478913 (4:146174037 T>C,G), RS1000577964 (4:146181951 TGTTA>T), RS1000696327 (4:146174312 A>G), RS1000710351 (4:146181683 A>G), RS1001052965 (4:146180263 T>C,G), RS1001157993 (4:146186618 A>T), RS1001226215 (4:146178477 G>C), RS1001351746 (4:146192006 T>C), RS1001379050 (4:146184811 AT>A), RS1001381277 (4:146175802 C>T), RS10015395 (4:146174229 A>C), RS1001586253 (4:146173918 T>C), RS1001736358 (4:146190807 C>T)

Disease associations

OMIM: gene MIM:607286 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST003807_2	Systolic blood pressure response to hydrochlorothiazide in hypertension	5.000000e-06
GCST010725_4	Malaria	4.000000e-10
GCST010725_84	Malaria	7.000000e-11
GCST010725_89	Malaria	7.000000e-11

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0006944	systolic blood pressure change measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

33 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	increases expression, decreases expression	4
bisphenol A	affects cotreatment, decreases methylation, decreases expression	2
Benzo(a)pyrene	decreases expression, decreases methylation, increases methylation	2
Tretinoin	decreases expression	2
beta-lapachone	decreases expression, increases expression	1
arsenite	affects binding, increases reaction	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
epigallocatechin gallate	decreases expression, affects cotreatment	1
pinosylvin	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
K 7174	decreases expression	1
pyrimidifen	increases expression	1
ICG 001	decreases expression	1
Grape Seed Proanthocyanidins	affects cotreatment, increases expression	1
jinfukang	affects cotreatment, decreases expression	1
Resveratrol	increases expression, affects cotreatment	1
Fulvestrant	affects cotreatment, decreases methylation	1
Air Pollutants	affects expression, increases abundance	1
Catechin	affects cotreatment, increases expression	1
Cisplatin	affects cotreatment, decreases expression	1
Gold	decreases expression	1
Hydrogen Peroxide	increases expression	1
Ozone	affects expression, increases abundance	1
Plant Extracts	affects cotreatment, increases expression	1
Urethane	decreases expression	1
Valproic Acid	decreases methylation	1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	1
Cyclosporine	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.