LUADT1

Summary

LUADT1 (lung adenocarcinoma associated transcript 1, HGNC:51845) is a long non-coding RNA gene on chromosome 6q24.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51845
Approved symbol	LUADT1
Name	lung adenocarcinoma associated transcript 1
Location	6q24.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000196634
Ensembl biotype	lncRNA
Entrez	106182249
RNAcentral	URS00001B3B08 — lncRNA, 453 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000359838

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000359838 — 3 exons

Exon	Start	End
ENSE00001432261	147180729	147180992
ENSE00001633101	147165731	147165859
ENSE00001795819	147158925	147158984

Expression profiles

Bgee: expression breadth broad, 98 present calls, max score 82.77.

Top tissues by expression

98 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.77	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	65.70	gold quality
leukocyte	CL:0000738	60.75	gold quality
monocyte	CL:0000576	59.46	gold quality
islet of Langerhans	UBERON:0000006	58.61	gold quality
lymph node	UBERON:0000029	58.35	gold quality
stromal cell of endometrium	CL:0002255	56.60	gold quality
bone marrow	UBERON:0002371	56.37	gold quality
cortex of kidney	UBERON:0001225	55.33	gold quality
prefrontal cortex	UBERON:0000451	54.42	gold quality
blood	UBERON:0000178	54.13	gold quality
calcaneal tendon	UBERON:0003701	54.05	gold quality
endometrium	UBERON:0001295	52.80	gold quality
superior frontal gyrus	UBERON:0002661	52.25	gold quality
descending thoracic aorta	UBERON:0002345	52.20	gold quality
pancreas	UBERON:0001264	50.93	gold quality
muscle of leg	UBERON:0001383	49.83	gold quality
adult mammalian kidney	UBERON:0000082	49.45	gold quality
primary visual cortex	UBERON:0002436	49.21	gold quality
body of pancreas	UBERON:0001150	49.20	gold quality
left uterine tube	UBERON:0001303	49.00	gold quality
gastrocnemius	UBERON:0001388	48.80	gold quality
vermiform appendix	UBERON:0001154	47.97	gold quality
putamen	UBERON:0001874	47.85	gold quality
left adrenal gland cortex	UBERON:0035825	47.50	gold quality
cerebellar hemisphere	UBERON:0002245	46.32	silver quality
tibial artery	UBERON:0007610	46.30	gold quality
popliteal artery	UBERON:0002250	46.27	gold quality
myometrium	UBERON:0001296	45.93	gold quality
right lobe of liver	UBERON:0001114	45.72	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.26

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• A novel lncRNA, LUADT1, promotes lung adenocarcinoma proliferation via the epigenetic suppression of p27. (PMID:26291312)
• LncRNA LUADT1 might contribute to the development of colorectal cancer. (PMID:29762830)
• The study found that LUADT1 and Twist1 were upregulated in small cell lung cancer (SCLC), while miR-15a-3p was downregulated in SCLC. (PMID:31842825)
• LncRNA LUADT1 inhibits cell apoptosis in diabetic retinopathy by regulating miR-383/peroxiredoxin 3 axis. (PMID:32125187)
• LncRNA LUADT1 sponges miR-195 to prevent cardiac endothelial cell apoptosis in sepsis. (PMID:33225891)
• LncRNA LUADT1 is Upregulated in Mantle Cell Lymphoma and Modulates TRIM11 by Sponging miR-24-3p to Inhibit Cell Apoptosis. (PMID:34591388)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.