LUC7L

Summary

LUC7L (LUC7 like, HGNC:6723) is a protein-coding gene on chromosome 16p13.3, encoding Putative RNA-binding protein Luc7-like 1 (Q9NQ29). May bind to RNA via its Arg/Ser-rich domain.

The LUC7L gene may represent a mammalian heterochromatic gene, encoding a putative RNA-binding protein similar to the yeast Luc7p subunit of the U1 snRNP splicing complex that is normally required for 5-prime splice site selection (Tufarelli et al., 2001 [PubMed 11170747]).

Source: NCBI Gene 55692 — RefSeq curated summary.

At a glance

• GWAS associations: 28
• Clinical variants (ClinVar): 72 total — 1 pathogenic
• MANE Select transcript: NM_201412

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:6723
Approved symbol	LUC7L
Name	LUC7 like
Location	16p13.3
Locus type	gene with protein product
Status	Approved
Aliases	LUC7B1, hLuc7B1, Luc7
Ensembl gene	ENSG00000007392
Ensembl biotype	protein_coding
OMIM	607782
Entrez	55692

Gene structure

Transcript identifiers

Ensembl transcripts: 30 — 19 protein_coding, 7 retained_intron, 3 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000293872, ENST00000337351, ENST00000397780, ENST00000397783, ENST00000418978, ENST00000419516, ENST00000426094, ENST00000428363, ENST00000429378, ENST00000430864, ENST00000442701, ENST00000443357, ENST00000464711, ENST00000467552, ENST00000468732, ENST00000469109, ENST00000490762, ENST00000494366, ENST00000494545, ENST00000495349, ENST00000629543, ENST00000862883, ENST00000862884, ENST00000920887, ENST00000920888, ENST00000920889, ENST00000920890, ENST00000920891, ENST00000949701, ENST00000949702

RefSeq mRNA: 4 — MANE Select: NM_201412 NM_001320226, NM_001330420, NM_018032, NM_201412

CCDS: CCDS10401, CCDS32348, CCDS81921

Canonical transcript exons

ENST00000293872 — 10 exons

Exon	Start	End
ENSE00003464528	188990	189339
ENSE00003469522	199062	199238
ENSE00003527983	208078	208188
ENSE00003529172	192927	193015
ENSE00003602151	189968	190135
ENSE00003643311	220649	220747
ENSE00003681185	227242	227336
ENSE00003784923	190541	190570
ENSE00003787006	206004	206147
ENSE00003902541	229279	229449

Expression profiles

Bgee: expression breadth ubiquitous, 280 present calls, max score 98.92.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 52.2463 / max 380.4320, expressed in 1822 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
155711	50.2728	1822
155710	1.1053	640
207685	0.8682	551

Top tissues by expression

290 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tendon of biceps brachii	UBERON:0008188	98.92	gold quality
sural nerve	UBERON:0015488	98.43	gold quality
adenohypophysis	UBERON:0002196	98.35	gold quality
left lobe of thyroid gland	UBERON:0001120	98.25	gold quality
right lobe of thyroid gland	UBERON:0001119	98.14	gold quality
cerebellar hemisphere	UBERON:0002245	97.90	gold quality
pituitary gland	UBERON:0000007	97.89	gold quality
right uterine tube	UBERON:0001302	97.88	gold quality
right hemisphere of cerebellum	UBERON:0014890	97.88	gold quality
lower esophagus mucosa	UBERON:0035834	97.77	gold quality
cerebellar cortex	UBERON:0002129	97.76	gold quality
thyroid gland	UBERON:0002046	97.69	gold quality
endocervix	UBERON:0000458	97.66	gold quality
body of uterus	UBERON:0009853	97.54	gold quality
left ovary	UBERON:0002119	97.43	gold quality
right ovary	UBERON:0002118	97.41	gold quality
body of pancreas	UBERON:0001150	97.32	gold quality
right frontal lobe	UBERON:0002810	97.12	gold quality
granulocyte	CL:0000094	96.95	gold quality
metanephros cortex	UBERON:0010533	96.91	gold quality
cerebellum	UBERON:0002037	96.90	gold quality
muscle layer of sigmoid colon	UBERON:0035805	96.88	gold quality
ganglionic eminence	UBERON:0004023	96.87	gold quality
cortical plate	UBERON:0005343	96.86	gold quality
anterior cingulate cortex	UBERON:0009835	96.72	gold quality
cingulate cortex	UBERON:0003027	96.69	gold quality
adrenal tissue	UBERON:0018303	96.69	gold quality
left uterine tube	UBERON:0001303	96.64	gold quality
small intestine Peyer’s patch	UBERON:0003454	96.55	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	96.54	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): E2F4

miRNA regulators (miRDB)

17 targeting LUC7L, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-545-3P	99.95	70.74	2783
HSA-MIR-6508-5P	99.92	70.67	2465
HSA-MIR-8067	99.86	69.59	2260
HSA-MIR-1283	99.69	72.42	3009
HSA-MIR-7844-5P	99.55	68.56	1428
HSA-MIR-519D-5P	99.41	69.30	2057
HSA-MIR-4291	99.20	68.88	2969
HSA-MIR-892C-5P	99.16	70.56	2116
HSA-MIR-7702	99.06	65.95	698
HSA-MIR-361-5P	98.95	70.16	1340
HSA-MIR-4711-5P	98.89	68.00	965
HSA-MIR-374A-3P	98.87	67.82	1531
HSA-MIR-10395-3P	98.10	66.70	1726
HSA-MIR-506-5P	98.02	67.41	1065
HSA-MIR-151A-3P	95.52	65.29	516
HSA-MIR-1247-3P	83.69	63.18	99

Literature-anchored findings (GeneRIF, showing 1)

• Functional analyses of human LUC7-like proteins involved in splicing regulation and myeloid neoplasms. (PMID:33852859)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	luc7l	ENSDARG00000055903
mus_musculus	Luc7l	ENSMUSG00000024188
rattus_norvegicus	Luc7l	ENSRNOG00000020488
drosophila_melanogaster	CG7564	FBGN0036734
caenorhabditis_elegans		WBGENE00015207

Paralogs (2): LUC7L3 (ENSG00000108848), LUC7L2 (ENSG00000146963)

Protein

Protein identifiers

Putative RNA-binding protein Luc7-like 1 — Q9NQ29 (reviewed: Q9NQ29)

Alternative names: Putative SR protein LUC7B1, SR+89

All UniProt accessions (10): Q9NQ29, A8MYV2, B8ZZ08, B8ZZ09, B8ZZ10, B8ZZ12, F2Z322, F8WBC1, H7C2U4, Q1W6G4

UniProt curated annotations — full annotation on UniProt →

Function. May bind to RNA via its Arg/Ser-rich domain.

Tissue specificity. Ubiquitous.

Miscellaneous. May be due to an intron retention.

Similarity. Belongs to the Luc7 family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9NQ29-1	1	yes
Q9NQ29-2	2
Q9NQ29-3	3

RefSeq proteins (4): NP_001307155, NP_001317349, NP_060502, NP_958815* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR004882	Luc7-rel	Family

Pfam: PF03194

UniProt features (14 total): compositionally biased region 4, modified residue 3, splice variant 2, coiled-coil region 2, chain 1, region of interest 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NQ29-F1	68.18	0.08

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 363, 332, 336

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 200 (showing top): RRAGTTGT_UNKNOWN, AP1_01, GOBP_MUSCLE_TISSUE_DEVELOPMENT, HNF3ALPHA_Q6, TTTGTAG_MIR520D, RACCACAR_AML_Q6, GGGTGGRR_PAX4_03, CAGCTG_AP4_Q5, EVI1_05, GOBP_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS, GOBP_MUSCLE_STRUCTURE_DEVELOPMENT, MYOD_01, AML_Q6, BACH2_01, WTGAAAT_UNKNOWN

GO Biological Process (4): mRNA splice site recognition (GO:0006376), negative regulation of striated muscle tissue development (GO:0045843), mRNA processing (GO:0006397), RNA splicing (GO:0008380)

GO Molecular Function (4): mRNA binding (GO:0003729), identical protein binding (GO:0042802), RS domain binding (GO:0050733), protein binding (GO:0005515)

GO Cellular Component (3): U1 snRNP (GO:0005685), U2-type prespliceosome (GO:0071004), nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA processing	2
spliceosomal complex assembly	1
protein-RNA complex assembly	1
striated muscle tissue development	1
regulation of striated muscle tissue development	1
negative regulation of muscle organ development	1
negative regulation of muscle tissue development	1
mRNA metabolic process	1
RNA binding	1
protein binding	1
protein domain specific binding	1
binding	1
spliceosomal snRNP complex	1
U2-type spliceosomal complex	1
U1 snRNP	1
U2 snRNP	1
prespliceosome	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

1282 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
LUC7L	RBM25	P49756	982
LUC7L	SNRNP70	P08621	924
LUC7L	RBM39	Q14498	890
LUC7L	PRPF40A	O75400	888
LUC7L	SNRPC	P09234	880
LUC7L	HBQ1	P09105	856
LUC7L	RSRC1	Q96IZ7	855
LUC7L	SRSF5	Q13243	761
LUC7L	SNRPA	P09012	747
LUC7L	HBA1	P01922	740
LUC7L	U2AF1	Q01081	698
LUC7L	NCBP2	P52298	653
LUC7L	PRPF39	Q86UA1	622
LUC7L	SF3B3	Q15393	619
LUC7L	SRSF1	Q07955	604

IntAct

122 interactions, top by confidence:

A	B	Type	Score
EAF1	ELL2	psi-mi:“MI:0914”(association)	0.840
SRPK2	LUC7L	psi-mi:“MI:0217”(phosphorylation reaction)	0.780
CSNK2B	RPS6KA5	psi-mi:“MI:0914”(association)	0.660
CHCHD10	CLPX	psi-mi:“MI:0914”(association)	0.640
LIN28A	IGF2BP3	psi-mi:“MI:0914”(association)	0.640
LUC7L	SRPK1	psi-mi:“MI:0217”(phosphorylation reaction)	0.640
ZRANB2	PIP4K2A	psi-mi:“MI:0914”(association)	0.610
NPM1	MPHOSPH10	psi-mi:“MI:0914”(association)	0.610
LUC7L	SPRED1	psi-mi:“MI:0915”(physical association)	0.560
YWHAG	SHTN1	psi-mi:“MI:0914”(association)	0.560
MAGEB2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
LUC7L2	ZNF593	psi-mi:“MI:0914”(association)	0.530
CHERP	LUC7L	psi-mi:“MI:0915”(physical association)	0.510
LUC7L	LUC7L	psi-mi:“MI:0915”(physical association)	0.510
RNASEH1	LUC7L	psi-mi:“MI:0915”(physical association)	0.500
LUC7L	TSC1	psi-mi:“MI:0915”(physical association)	0.370
LUC7L	PRDX1	psi-mi:“MI:0915”(physical association)	0.370
TCERG1	LUC7L	psi-mi:“MI:0915”(physical association)	0.370
GADD45G	LUC7L	psi-mi:“MI:0915”(physical association)	0.370
CTNNBL1	LUC7L	psi-mi:“MI:0915”(physical association)	0.370
LUC7L	PRMT5	psi-mi:“MI:0915”(physical association)	0.370
Dynlrb1	DYNC1LI2	psi-mi:“MI:0914”(association)	0.350
C1qbp		psi-mi:“MI:0914”(association)	0.350
NLRP3	PHRF1	psi-mi:“MI:0914”(association)	0.350
JUN	TPM3	psi-mi:“MI:0914”(association)	0.350
Xpo1	IFT56	psi-mi:“MI:0914”(association)	0.350

BioGRID (400): LUC7L (Affinity Capture-MS), LUC7L (Affinity Capture-MS), LUC7L (Affinity Capture-MS), LUC7L (Affinity Capture-MS), LUC7L (Affinity Capture-MS), LUC7L2 (Affinity Capture-MS), RBM27 (Affinity Capture-MS), RBM26 (Affinity Capture-MS), ZFP91 (Affinity Capture-MS), MRPL46 (Affinity Capture-MS), EIF2B1 (Affinity Capture-MS), ZC3H18 (Affinity Capture-MS), NKAP (Affinity Capture-MS), BCLAF1 (Affinity Capture-MS), THRAP3 (Affinity Capture-MS)

ESM2 similar proteins: A2AQ19, B2GV05, O54941, O55047, O95232, P08621, P09406, P23588, P50502, P52756, P97762, Q07866, Q08CW1, Q13123, Q1ECX4, Q1RMR2, Q1RMU5, Q32KT0, Q3SX41, Q56A18, Q5NVI3, Q5R8W6, Q5RAD5, Q5RF31, Q5SRX1, Q5SUF2, Q5U2T8, Q5U2U0, Q5ZI03, Q62376, Q66HG8, Q66II8, Q6PH81, Q7TNC4, Q86UE8, Q86X95, Q8BGD9, Q8C0V0, Q8TA86, Q90ZY6

Diamond homologs: O95232, Q07508, Q3SX41, Q54XQ8, Q5R8W6, Q5SUF2, Q7TNC4, Q9CYI4, Q9NQ29, Q9USM4, Q9VVI1, Q9Y383, Q09217

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 147 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Transport of Mature Transcript to Cytoplasm	5	18.7×	1e-04
RNA Polymerase II Transcription Termination	8	17.2×	4e-07
mRNA 3’-end processing	8	15.4×	1e-06
Nonsense-Mediated Decay (NMD)	6	13.7×	1e-04
Peptide chain elongation	11	13.7×	4e-08
Viral mRNA Translation	11	13.7×	4e-08
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	11	13.5×	4e-08
Selenocysteine synthesis	11	13.0×	4e-08

GO biological processes:

GO term	Partners	Fold	FDR
negative regulation of mRNA splicing, via spliceosome	6	34.8×	4e-06
cytoplasmic translation	12	16.8×	5e-09
ribosomal small subunit biogenesis	7	12.1×	3e-04
RNA processing	7	11.6×	3e-04
regulation of alternative mRNA splicing, via spliceosome	6	11.1×	1e-03
translation	13	10.1×	2e-07
RNA splicing	12	8.0×	7e-06
mRNA splicing, via spliceosome	10	6.9×	3e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

72 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	53
Likely benign	3
Benign	1

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
15680	NC_000016.10:g.174045_192395del	Pathogenic

SpliceAI

2065 predictions. Top by Δscore:

Variant	Effect	Δscore
16:189929:A:AC	donor_gain	1.0000
16:189929:ACT:A	donor_gain	1.0000
16:189930:C:CC	donor_gain	1.0000
16:189930:CTC:C	donor_gain	1.0000
16:189966:A:AC	donor_gain	1.0000
16:189967:C:CC	donor_gain	1.0000
16:192925:ACCT:A	donor_gain	1.0000
16:192926:CCTC:C	donor_gain	1.0000
16:192928:T:TA	donor_gain	1.0000
16:193013:TTT:T	acceptor_gain	1.0000
16:199056:ACAT:A	donor_loss	1.0000
16:199057:CATA:C	donor_loss	1.0000
16:199060:A:T	donor_loss	1.0000
16:199060:AC:A	donor_gain	1.0000
16:199061:C:T	donor_loss	1.0000
16:199061:CC:C	donor_gain	1.0000
16:199067:A:C	donor_gain	1.0000
16:199111:TTGC:T	donor_gain	1.0000
16:199112:TGCC:T	donor_gain	1.0000
16:199235:CTTC:C	acceptor_gain	1.0000
16:199236:TTC:T	acceptor_gain	1.0000
16:199238:CCT:C	acceptor_loss	1.0000
16:199239:C:CA	acceptor_loss	1.0000
16:199239:C:CC	acceptor_gain	1.0000
16:205994:T:C	donor_gain	1.0000
16:206041:T:TA	donor_gain	1.0000
16:206144:CTGC:C	acceptor_gain	1.0000
16:206147:CCT:C	acceptor_loss	1.0000
16:206148:C:CC	acceptor_gain	1.0000
16:206148:CTGTG:C	acceptor_loss	1.0000

AlphaMissense

2417 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:199075:A:G	L225P	1.000
16:199084:C:G	R222P	1.000
16:199085:G:C	R222G	1.000
16:199095:G:C	F218L	1.000
16:199095:G:T	F218L	1.000
16:199096:A:G	F218S	1.000
16:199097:A:G	F218L	1.000
16:199099:C:T	G217E	1.000
16:199100:C:A	G217W	1.000
16:199100:C:G	G217R	1.000
16:199100:C:T	G217R	1.000
16:199104:G:C	H215Q	1.000
16:199104:G:T	H215Q	1.000
16:199105:T:C	H215R	1.000
16:199106:G:C	H215D	1.000
16:199106:G:T	H215N	1.000
16:199108:A:G	L214S	1.000
16:199110:C:A	K213N	1.000
16:199110:C:G	K213N	1.000
16:199112:T:C	K213E	1.000
16:199114:C:A	G212V	1.000
16:199114:C:G	G212A	1.000
16:199114:C:T	G212D	1.000
16:199115:C:A	G212C	1.000
16:199115:C:G	G212R	1.000
16:199115:C:T	G212S	1.000
16:199117:C:T	G211D	1.000
16:199119:G:C	F210L	1.000
16:199119:G:T	F210L	1.000
16:199120:A:C	F210C	1.000

dbSNP variants (sampled 300 via entrez): RS1000034731 (16:218416 G>T), RS1000191719 (16:200967 A>G), RS1000292110 (16:214091 G>GC), RS1000320242 (16:215584 T>C), RS1000344083 (16:208030 G>C), RS1000379162 (16:223272 CAG>C), RS1000379851 (16:210741 G>A), RS1000395119 (16:205908 A>T), RS1000576118 (16:215083 CTTTT>C,CTT,CTTT,CTTTTT), RS1000616026 (16:229092 C>A,G,T), RS1000691185 (16:229259 G>A,C,T), RS1000692070 (16:196135 C>T), RS1000729919 (16:209532 A>G), RS1000838907 (16:204491 G>A), RS1000856362 (16:215217 A>G)

Disease associations

OMIM: gene MIM:607782 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

28 associations (top):

Study	Trait	p-value
GCST000587_1	Mean corpuscular hemoglobin	3.000000e-09
GCST004334_13	Mean corpuscular hemoglobin	5.000000e-07
GCST004602_221	Mean corpuscular volume	4.000000e-38
GCST004605_11	Mean corpuscular hemoglobin concentration	2.000000e-11
GCST004615_103	Hemoglobin concentration	7.000000e-12
GCST004615_104	Hemoglobin concentration	4.000000e-10
GCST004621_82	Red cell distribution width	3.000000e-14
GCST004630_170	Mean corpuscular hemoglobin	6.000000e-68
GCST006804_150	Red cell distribution width	2.000000e-10
GCST006979_944	Heel bone mineral density	8.000000e-10
GCST90002385_68	High light scatter reticulocyte count	3.000000e-14
GCST90002385_69	High light scatter reticulocyte count	4.000000e-16
GCST90002386_277	High light scatter reticulocyte percentage of red cells	1.000000e-15
GCST90002390_631	Mean corpuscular hemoglobin	1.000000e-65
GCST90002390_632	Mean corpuscular hemoglobin	6.000000e-31
GCST90002391_162	Mean corpuscular hemoglobin concentration	3.000000e-39
GCST90002391_163	Mean corpuscular hemoglobin concentration	8.000000e-30
GCST90002391_164	Mean corpuscular hemoglobin concentration	1.000000e-09
GCST90002392_478	Mean corpuscular volume	9.000000e-53
GCST90002392_479	Mean corpuscular volume	2.000000e-26
GCST90002396_646	Mean reticulocyte volume	4.000000e-40
GCST90002397_274	Mean spheric corpuscular volume	3.000000e-24
GCST90002403_658	Red blood cell count	9.000000e-20
GCST90002403_659	Red blood cell count	3.000000e-11
GCST90002404_330	Red cell distribution width	1.000000e-34
GCST90002405_352	Reticulocyte count	4.000000e-21
GCST90002405_353	Reticulocyte count	4.000000e-14
GCST90002406_428	Reticulocyte fraction of red cells	2.000000e-13

EFO canonical traits (8, from GWAS)

EFO ID	Trait name
EFO:0004509	hemoglobin measurement
EFO:0004527	mean corpuscular hemoglobin
EFO:0004528	mean corpuscular hemoglobin concentration
EFO:0009188	Red cell distribution width
EFO:0009270	heel bone mineral density
EFO:0007986	reticulocyte count
EFO:0010701	mean reticulocyte volume
EFO:0004305	erythrocyte count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

51 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression, affects expression	6
bisphenol A	affects cotreatment, increases methylation, increases expression, decreases reaction, increases abundance	3
sodium arsenite	decreases expression	2
Hydrogen Peroxide	increases expression, affects expression	2
Tobacco Smoke Pollution	decreases expression, decreases methylation	2
FR900359	affects phosphorylation	1
bisphenol F	affects cotreatment, decreases expression	1
ginger extract	increases expression, decreases reaction, increases abundance	1
alpha-pinene	increases abundance, affects cotreatment, increases oxidation	1
deoxynivalenol	increases expression	1
beta-lapachone	decreases expression, increases expression	1
aflatoxin B2	increases methylation	1
coumarin	increases phosphorylation	1
methacrylaldehyde	affects cotreatment, increases oxidation, increases abundance	1
avobenzone	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
abrine	increases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
bisphenol S	affects cotreatment, decreases expression	1
PCI 5002	affects cotreatment, increases expression	1
3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol	decreases expression	1
Bortezomib	increases expression	1
Resveratrol	increases expression, affects cotreatment	1
Temozolomide	increases expression	1
Sunitinib	increases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Vorinostat	decreases expression	1
Acrolein	affects cotreatment, increases oxidation, increases abundance	1
Air Pollutants	increases oxidation, affects cotreatment, increases abundance	1
Benzo(a)pyrene	affects methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.