LUCAT1

Summary

LUCAT1 (lung cancer associated transcript 1, HGNC:48498) is a long non-coding RNA gene on chromosome 5q14.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48498
Approved symbol	LUCAT1
Name	lung cancer associated transcript 1
Location	5q14.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	SCAL1, SCAT5
Ensembl gene	ENSG00000248323
Ensembl biotype	lncRNA
OMIM	618190
Entrez	100505994
RNAcentral	URS000075A1E7 — lncRNA, 890 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 141 — 141 lncRNA

ENST00000511918, ENST00000513492, ENST00000513626, ENST00000607854, ENST00000647745, ENST00000647759, ENST00000647761, ENST00000647807, ENST00000648015, ENST00000648031, ENST00000648075, ENST00000648137, ENST00000648199, ENST00000648310, ENST00000648385, ENST00000648439, ENST00000648457, ENST00000648597, ENST00000648636, ENST00000648683, ENST00000648751, ENST00000648773, ENST00000648811, ENST00000648822, ENST00000648905, ENST00000648923, ENST00000649138, ENST00000649304, ENST00000649322, ENST00000649392, ENST00000649405, ENST00000649424, ENST00000649447, ENST00000649467, ENST00000649539, ENST00000649654, ENST00000649702, ENST00000649968, ENST00000649969, ENST00000649976, ENST00000650003, ENST00000650004, ENST00000650008, ENST00000650017, ENST00000650047, ENST00000650067, ENST00000650098, ENST00000650100, ENST00000650150, ENST00000650261, ENST00000650273, ENST00000650321, ENST00000650381, ENST00000650529, ENST00000650583, ENST00000653155, ENST00000654784, ENST00000660484, ENST00000664701, ENST00000668775, ENST00000670581, ENST00000685632, ENST00000687742, ENST00000690504, ENST00000690915, ENST00000730024, ENST00000730025, ENST00000730026, ENST00000730027, ENST00000730028, ENST00000730029, ENST00000730030, ENST00000730031, ENST00000730032, ENST00000730033, ENST00000730034, ENST00000730035, ENST00000730036, ENST00000730037, ENST00000730038, ENST00000730039, ENST00000730040, ENST00000730041, ENST00000730042, ENST00000730043, ENST00000730044, ENST00000730045, ENST00000730046, ENST00000730047, ENST00000730048, ENST00000730049, ENST00000730050, ENST00000730051, ENST00000730052, ENST00000730053, ENST00000730054, ENST00000730055, ENST00000730056, ENST00000730057, ENST00000730058, ENST00000730059, ENST00000730060, ENST00000730061, ENST00000730062, ENST00000730063, ENST00000730064, ENST00000730065, ENST00000730066, ENST00000730067, ENST00000730068, ENST00000730069, ENST00000730070, ENST00000730071, ENST00000730072, ENST00000730073, ENST00000730074, ENST00000730075, ENST00000730076, ENST00000730077, ENST00000730078, ENST00000730079, ENST00000730080, ENST00000730081, ENST00000730082, ENST00000730083, ENST00000730084, ENST00000730085, ENST00000730086, ENST00000730087, ENST00000730088, ENST00000730089, ENST00000730090, ENST00000730091, ENST00000730092, ENST00000730093, ENST00000730094, ENST00000730095, ENST00000730096, ENST00000730097, ENST00000730098, ENST00000730099

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000511918 — 4 exons

Exon	Start	End
ENSE00002019863	91314080	91314391
ENSE00002035458	91303029	91303161
ENSE00002054060	91313078	91313229
ENSE00003700613	91313638	91313777

Expression profiles

Bgee: expression breadth ubiquitous, 133 present calls, max score 96.10.

FANTOM5 (CAGE): breadth broad, TPM avg 17.3819 / max 1777.5225, expressed in 811 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
62546	16.5854	797
62544	0.5067	84
62545	0.2899	59

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	96.10	gold quality
bone marrow cell	CL:0002092	89.57	gold quality
gastrocnemius	UBERON:0001388	87.02	gold quality
bone marrow	UBERON:0002371	86.20	gold quality
muscle of leg	UBERON:0001383	85.60	gold quality
right lobe of thyroid gland	UBERON:0001119	84.37	gold quality
right atrium auricular region	UBERON:0006631	84.21	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.64	gold quality
islet of Langerhans	UBERON:0000006	83.15	gold quality
hindlimb stylopod muscle	UBERON:0004252	83.10	gold quality
skeletal muscle tissue	UBERON:0001134	82.44	gold quality
leukocyte	CL:0000738	82.23	gold quality
monocyte	CL:0000576	82.17	gold quality
left adrenal gland	UBERON:0001234	82.14	gold quality
left lobe of thyroid gland	UBERON:0001120	82.01	gold quality
left adrenal gland cortex	UBERON:0035825	81.81	gold quality
vermiform appendix	UBERON:0001154	81.76	gold quality
right adrenal gland cortex	UBERON:0035827	80.92	gold quality
adrenal gland	UBERON:0002369	80.78	gold quality
colonic epithelium	UBERON:0000397	80.42	gold quality
thyroid gland	UBERON:0002046	80.32	gold quality
spleen	UBERON:0002106	80.26	gold quality
right adrenal gland	UBERON:0001233	80.13	gold quality
granulocyte	CL:0000094	79.81	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	79.78	gold quality
sural nerve	UBERON:0015488	79.12	gold quality
muscle tissue	UBERON:0002385	78.89	gold quality
upper lobe of left lung	UBERON:0008952	77.13	gold quality
adrenal tissue	UBERON:0018303	77.03	gold quality
heart	UBERON:0000948	76.89	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): NFE2L2

Literature-anchored findings (GeneRIF, showing 40)

• these results identify a novel and intriguing new noncoding RNA that may act downstream of NRF2 to regulate gene expression and mediate oxidative stress protection in airway epithelial cells. (PMID:23672216)
• lncRNA LUCAT1 expression is significantly up-regulated in NSCLC tissues and cell lines. Its abnormal expression can predict a poor prognosis of NSCLC patients, and it may be an independent prognostic marker. (PMID:28423699)
• lncRNA LUCAT1 could act as an oncogenic lncRNA that promotes glioma tumorigenesis via regulating miR-375. (PMID:29089067)
• Data show that long noncoding RNA LUCAT1 activated DNA methyltransferase 1 (DNMT1), a major DNA methylation protein, to repress the expression of tumor-suppressor genes, leading to the development and progression of esophageal squamous cell carcinoma (ESCC). (PMID:29247823)
• Results indicate that highly expressed LUCAT1 acts as an oncogenic lncRNA that promotes the tumorigenesis and progression of clear cell renal cell carcinoma (ccRCC) through the miR-495-3p-SATB1 axis, indicating that LUCAT1 could be a useful marker for ccRCC. (PMID:29932248)
• LUCAT1 promoted proliferation and invasion in ccRCC cells partly through inducing the phosphorylation of AKT and suppressing the phosphorylation of GSK-3beta. (PMID:30032137)
• it was found that LUCAT1 was activated by STAT3 and promoted cell proliferation, migration, and invasion in HB through modulation of the miR-301b/STAT3 axis. (PMID:30479162)
• LUCAT1 inhibited the phosphorylation of Annexin A2 (ANXA2) to reduce the degradation of ANXA2-S100A10 heterotetramer (AIIt). (PMID:30588744)
• our findings indicate that suppression of LUCAT1 induces CRC cell cycle arrest and apoptosis by binding UBA52 and activating the RPL40-MDM2-p53 pathway. These results implicate LUCAT1 as a potential prognostic biomarker and therapeutic target for CRC. (PMID:30690837)
• SP1-induced up-regulation of lncRNA LUCAT1 promotes proliferation, migration and invasion of cervical cancer by sponging miR-181a (PMID:30831032)
• LUCAT1 might be a significant biomarker to evaluate prognosis in breast cancer survivors. LUCAT1 increased BCCs stem-like properties and BCSCs stemness by competitively binding miR-5582-3p with TCF7L2 and enhancing the Wnt/beta-catenin signaling pathway. (PMID:31300015)
• LncRNA LUCAT1 facilitates tumorigenesis and metastasis of triple-negative breast cancer through modulating miR-5702. (PMID:31399501)
• Up-regulation of LUCAT1 was significantly related to worse overall survival in clear cell renal cell carcinoma (PMID:31577719)
• LncRNA LUCAT1 as a novel prognostic biomarker for patients with papillary thyroid cancer. (PMID:31591432)
• the expression of lnc-LUCAT1 was highly up-regulated in breast cancer tissues and cell lines. Over-expression of lnc-LUCAT1 enhanced cell proliferation, migration and invasion in breast cancer cell lines. (PMID:31635802)
• LUCAT1 contributes to MYRF-dependent smooth muscle cell apoptosis and may facilitate aneurysm formation via the sequestration of miR-199a-5p. (PMID:31769911)
• LncRNA LUCAT1 contributes to cell proliferation and migration in human pancreatic ductal adenocarcinoma via sponging miR-539. (PMID:31789465)
• Downregulated long noncoding RNA LUCAT1 inhibited proliferation and promoted apoptosis of cardiomyocyte via miR-612/HOXA13 pathway in chronic heart failure. (PMID:31957853)
• Hypoxia induced LUCAT1/PTBP1 axis modulates cancer cell viability and chemotherapy response. (PMID:31964396)
• ELF1-mediated LUCAT1 promotes choroidal melanoma by modulating RBX1 expression. (PMID:31968402)
• LncRNA LUCAT1 promotes proliferation of ovarian cancer cells by regulating miR-199a-5p expression. (PMID:32141534)
• Long Noncoding RNA LUCAT1 Promotes Multiple Myeloma Cell Growth by Regulating the TGF-beta Signaling Pathway. (PMID:32812490)
• Serum LUCAT1 implicates the pathogenesis of muscle-invasive bladder cancer via targeting miR-199a-5p and miR-199b-5p. (PMID:32844284)
• Long noncoding RNA LUCAT1 contributes to cisplatin resistance by regulating the miR514a3p/ULK1 axis in human nonsmall cell lung cancer. (PMID:32945379)
• LncRNA LUCAT1/miR-181a-5p axis promotes proliferation and invasion of breast cancer via targeting KLF6 and KLF15. (PMID:32998707)
• The long noncoding RNA LUCAT1 promotes colorectal cancer cell proliferation by antagonizing Nucleolin to regulate MYC expression. (PMID:33097685)
• Lung cancerassociated transcript 1 facilitates tumorigenesis in laryngeal squamous cell carcinoma through the targeted inhibition of miR493. (PMID:33215214)
• The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans. (PMID:33311506)
• Knockdown of the Long Noncoding RNA LUCAT1 Inhibits High-Glucose-Induced Epithelial-Mesenchymal Transition through the miR-199a-5p-ZEB1 Axis in Human Renal Tubular Epithelial Cells. (PMID:33426083)
• MiR-133b inhibits colorectal cancer metastasis via lncRNA-LUCAT1. (PMID:33541136)
• The progression of pancreatic cancer cells is promoted by a long non-coding RNA LUCAT1 by activating AKT phosphorylation. (PMID:33577028)
• LUCAT1 as an oncogene in tongue squamous cell carcinoma by targeting miR-375 expression. (PMID:33787082)
• Expression of long non-coding RNA LUCAT1 in patients with chronic obstructive pulmonary disease and its potential functions in regulating cigarette smoke extract-induced 16HBE cell proliferation and apoptosis. (PMID:34125980)
• Knockdown of lncRNA LUCAT1 attenuates sepsisinduced myocardial cell injury by sponging miR-642a. (PMID:34272987)
• IncRNA LUCAT1 acts as a Potential Biomarker and Demonstrates Malignant Biological Behaviors in Gastric Cancer. (PMID:34383427)
• Long non-coding RNA LUCAT1 inhibits myocardial oxidative stress and apoptosis after myocardial infarction via targeting microRNA-181a-5p. (PMID:34414854)
• Concomitant and decoupled effects of cigarette smoke and SCAL1 upregulation on oncogenic phenotypes and ROS detoxification in lung adenocarcinoma cells. (PMID:34526564)
• LncRNA PVT1 is increased in renal cell carcinoma and affects viability and migration in vitro. (PMID:35441392)
• lncRNA LUCAT1/ELAVL1/LIN28B/SOX2 Positive Feedback Loop Promotes Cell Stemness in Triple-Negative Breast Cancer. (PMID:35711895)
• The lncRNA LUCAT1 is elevated in inflammatory disease and restrains inflammation by regulating the splicing and stability of NR4A2. (PMID:36577072)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.