LUNAR1

Summary

LUNAR1 (leukemia-associated non-coding IGF1R activator RNA 1, HGNC:51199) is a long non-coding RNA gene on chromosome 15q26.3.

This gene is thought to produce a functional long non-coding RNA. It is regulated by Notch and is overexpressed in T cell acute lymphoblastic leukemia. The transcript acts as a positive regulator of cell division by promoting expression of the insulin-like growth factor type I receptor (IGF1R) gene.

Source: NCBI Gene 104564224 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51199
Approved symbol	LUNAR1
Name	leukemia-associated non-coding IGF1R activator RNA 1
Location	15q26.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000278090
Ensembl biotype	lncRNA
Entrez	104564224
RNAcentral	URS00007E45FA — lncRNA, 484 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 25 — 25 lncRNA

ENST00000611654, ENST00000651497, ENST00000651737, ENST00000657814, ENST00000663917, ENST00000665845, ENST00000667025, ENST00000669003, ENST00000671414, ENST00000762568, ENST00000762569, ENST00000762570, ENST00000762571, ENST00000762572, ENST00000762573, ENST00000762574, ENST00000762575, ENST00000762576, ENST00000762577, ENST00000762578, ENST00000762579, ENST00000762580, ENST00000762581, ENST00000762582, ENST00000762583

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000611654 — 1 exons

Exon	Start	End
ENSE00003738574	99028538	99031053

Expression profiles

Bgee: expression breadth ubiquitous, 135 present calls, max score 79.44.

Top tissues by expression

267 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	79.44	silver quality
cortical plate	UBERON:0005343	64.06	gold quality
olfactory bulb	UBERON:0002264	63.26	gold quality
thymus	UBERON:0002370	62.69	silver quality
blood	UBERON:0000178	62.39	gold quality
secondary oocyte	CL:0000655	60.97	gold quality
popliteal artery	UBERON:0002250	60.31	gold quality
tibial artery	UBERON:0007610	60.22	gold quality
right coronary artery	UBERON:0001625	59.40	gold quality
ganglionic eminence	UBERON:0004023	58.64	gold quality
pigmented layer of retina	UBERON:0001782	57.82	silver quality
left testis	UBERON:0004533	57.46	gold quality
right testis	UBERON:0004534	57.28	gold quality
testis	UBERON:0000473	57.19	gold quality
monocyte	CL:0000576	56.68	gold quality
aorta	UBERON:0000947	56.64	gold quality
mononuclear cell	CL:0000842	56.51	gold quality
right uterine tube	UBERON:0001302	56.43	gold quality
hindlimb stylopod muscle	UBERON:0004252	55.30	gold quality
right lobe of thyroid gland	UBERON:0001119	54.56	gold quality
oviduct epithelium	UBERON:0004804	54.50	gold quality
lower esophagus mucosa	UBERON:0035834	54.05	gold quality
tibialis anterior	UBERON:0001385	53.89	silver quality
thyroid gland	UBERON:0002046	53.67	gold quality
left lobe of thyroid gland	UBERON:0001120	53.50	gold quality
stromal cell of endometrium	CL:0002255	53.35	silver quality
muscle of leg	UBERON:0001383	53.29	gold quality
gastrocnemius	UBERON:0001388	52.91	gold quality
calcaneal tendon	UBERON:0003701	52.61	silver quality
muscle organ	UBERON:0001630	52.26	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.78

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• our results indicate that LUNAR1 may serve as a candidate prognostic biomarker through growth regulation in diffuse large b-cell lymphoma (PMID:26796267)
• LncRNA-LUNAR1 Levels Are Closely Related to Coronary Collaterals in Patients with Chronic Total Coronary Occlusion. (PMID:31997261)
• lncRNA LUNAR1 accelerates colorectal cancer progression by targeting the miR4953p/MYCBP axis. (PMID:33300052)
• Upregulation of leukemia-induced non-coding activator RNA (LUNAR1) predicts poor outcome in pediatric T-acute lymphoblastic leukemia. (PMID:34735923)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.