LY6E-DT

Summary

LY6E-DT (LY6E divergent transcript, HGNC:53728) is a long non-coding RNA gene on chromosome 8q24.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53728
Approved symbol	LY6E-DT
Name	LY6E divergent transcript
Location	8q24.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	LOC100133669
Ensembl gene	ENSG00000247317
Ensembl biotype	lncRNA
Entrez	100133669
RNAcentral	URS000075CA9F — lncRNA, 709 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 12 lncRNA

ENST00000502167, ENST00000517833, ENST00000518024, ENST00000518831, ENST00000522060, ENST00000690018, ENST00000702175, ENST00000808441, ENST00000808442, ENST00000808443, ENST00000808444, ENST00000808445

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000502167 — 3 exons

Exon	Start	End
ENSE00001959091	143007753	143009207
ENSE00001989713	143012485	143012572
ENSE00002126436	143018160	143018397

Expression profiles

Bgee: expression breadth ubiquitous, 158 present calls, max score 91.32.

FANTOM5 (CAGE): breadth broad, TPM avg 1.4751 / max 33.2673, expressed in 702 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
95438	1.3909	675
95436	0.0631	27
95437	0.0210	7

Top tissues by expression

242 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	91.32	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.38	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.84	silver quality
nucleus accumbens	UBERON:0001882	79.29	gold quality
Brodmann (1909) area 9	UBERON:0013540	78.07	gold quality
right frontal lobe	UBERON:0002810	77.99	gold quality
putamen	UBERON:0001874	77.62	gold quality
anterior cingulate cortex	UBERON:0009835	77.41	gold quality
prefrontal cortex	UBERON:0000451	77.12	gold quality
caudate nucleus	UBERON:0001873	76.39	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	75.25	gold quality
neocortex	UBERON:0001950	74.50	gold quality
frontal cortex	UBERON:0001870	74.32	gold quality
right lobe of liver	UBERON:0001114	73.35	gold quality
amygdala	UBERON:0001876	73.34	gold quality
cerebral cortex	UBERON:0000956	72.62	gold quality
cortical plate	UBERON:0005343	71.91	gold quality
forebrain	UBERON:0001890	71.89	gold quality
endocervix	UBERON:0000458	71.49	gold quality
brain	UBERON:0000955	70.93	gold quality
hypothalamus	UBERON:0001898	70.65	gold quality
stromal cell of endometrium	CL:0002255	70.59	gold quality
ectocervix	UBERON:0012249	70.22	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	70.17	gold quality
Ammon’s horn	UBERON:0001954	70.01	gold quality
right ovary	UBERON:0002118	69.61	gold quality
left adrenal gland cortex	UBERON:0035825	69.57	gold quality
adult mammalian kidney	UBERON:0000082	69.19	gold quality
uterine cervix	UBERON:0000002	69.18	gold quality
adrenal cortex	UBERON:0001235	68.97	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.86

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.