LY6S-AS1

Summary

LY6S-AS1 (LY6S antisense RNA 1, HGNC:26731) is a long non-coding RNA gene on chromosome 8q24.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26731
Approved symbol	LY6S-AS1
Name	LY6S antisense RNA 1
Location	8q24.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ37131
Ensembl gene	ENSG00000177335
Ensembl biotype	lncRNA
Entrez	286122
RNAcentral	URS00009B592E — lncRNA, 2110 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 34 — 32 lncRNA, 2 retained_intron

ENST00000395172, ENST00000517653, ENST00000519775, ENST00000520786, ENST00000523099, ENST00000523766, ENST00000524181, ENST00000622366, ENST00000665431, ENST00000669519, ENST00000685395, ENST00000689572, ENST00000702010, ENST00000702083, ENST00000769720, ENST00000769721, ENST00000769722, ENST00000769723, ENST00000769724, ENST00000769725, ENST00000769726, ENST00000769727, ENST00000769728, ENST00000769729, ENST00000769730, ENST00000769731, ENST00000769732, ENST00000769733, ENST00000769734, ENST00000769735, ENST00000769736, ENST00000769737, ENST00000769738, ENST00000769739

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000395172 — 6 exons

Exon	Start	End
ENSE00001275647	143043163	143043262
ENSE00001520798	143053226	143054303
ENSE00001520799	143042958	143043087
ENSE00001520801	143039262	143039569
ENSE00003506923	143044649	143044817
ENSE00003759831	143049209	143049298

Expression profiles

Bgee: expression breadth ubiquitous, 133 present calls, max score 83.92.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 3.0983 / max 147.8870, expressed in 987 samples.

FANTOM5 promoters (9 alternative TSS)

Promoter ID	TPM avg	Samples expressed
91384	2.5873	939
91388	0.1981	40
91383	0.0889	29
91386	0.0887	34
91382	0.0551	25
91385	0.0550	18
91387	0.0188	6
91389	0.0043	3
91381	0.0021	1

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	83.92	gold quality
left adrenal gland cortex	UBERON:0035825	82.18	gold quality
left adrenal gland	UBERON:0001234	81.69	gold quality
right adrenal gland cortex	UBERON:0035827	81.19	gold quality
adrenal gland	UBERON:0002369	80.81	gold quality
right adrenal gland	UBERON:0001233	80.77	gold quality
thyroid gland	UBERON:0002046	79.85	gold quality
left lobe of thyroid gland	UBERON:0001120	79.68	gold quality
right lobe of thyroid gland	UBERON:0001119	79.05	gold quality
stromal cell of endometrium	CL:0002255	78.17	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.52	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	76.83	gold quality
endocervix	UBERON:0000458	75.64	gold quality
gall bladder	UBERON:0002110	75.42	gold quality
right hemisphere of cerebellum	UBERON:0014890	75.09	gold quality
left uterine tube	UBERON:0001303	75.04	gold quality
spleen	UBERON:0002106	74.98	gold quality
primary visual cortex	UBERON:0002436	74.80	gold quality
cerebellar hemisphere	UBERON:0002245	74.76	gold quality
right frontal lobe	UBERON:0002810	74.66	gold quality
cerebellar cortex	UBERON:0002129	74.61	gold quality
cerebellum	UBERON:0002037	74.59	gold quality
fallopian tube	UBERON:0003889	74.42	gold quality
anterior cingulate cortex	UBERON:0009835	74.29	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	74.10	gold quality
ventricular zone	UBERON:0003053	73.88	gold quality
metanephros cortex	UBERON:0010533	73.78	gold quality
pituitary gland	UBERON:0000007	73.75	gold quality
apex of heart	UBERON:0002098	73.62	gold quality
bone marrow cell	CL:0002092	73.43	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.56

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.