LY86-AS1

Summary

LY86-AS1 (LY86 antisense RNA 1, HGNC:26593) is a long non-coding RNA gene on chromosome 6p25.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26593
Approved symbol	LY86-AS1
Name	LY86 antisense RNA 1
Location	6p25.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ33708
Ensembl gene	ENSG00000216863
Ensembl biotype	lncRNA
Entrez	285780
RNAcentral	URS000075AC6F — lncRNA, 2037 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 35 — 35 lncRNA

ENST00000429345, ENST00000435641, ENST00000447858, ENST00000606044, ENST00000606992, ENST00000607278, ENST00000653438, ENST00000655679, ENST00000658580, ENST00000661991, ENST00000665459, ENST00000669477, ENST00000701209, ENST00000753058, ENST00000753059, ENST00000753060, ENST00000753061, ENST00000753062, ENST00000753063, ENST00000753064, ENST00000753065, ENST00000753066, ENST00000753067, ENST00000753068, ENST00000753069, ENST00000753070, ENST00000753071, ENST00000753072, ENST00000753073, ENST00000753074, ENST00000753075, ENST00000753076, ENST00000753077, ENST00000753078, ENST00000753079

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000429345 — 8 exons

Exon	Start	End
ENSE00001612985	6346465	6347420
ENSE00001617804	6569418	6569489
ENSE00001624325	6366355	6366609
ENSE00001631439	6622632	6622744
ENSE00001679673	6369002	6369155
ENSE00001701595	6438576	6438732
ENSE00001733971	6348611	6348750
ENSE00001974277	6564295	6564388

Expression profiles

Bgee: expression breadth ubiquitous, 154 present calls, max score 86.78.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.5737 / max 157.8898, expressed in 98 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
71576	0.3746	63
71575	0.0940	35
71570	0.0683	27
71571	0.0272	13
71569	0.0095	5

Top tissues by expression

236 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	86.78	gold quality
colonic epithelium	UBERON:0000397	81.69	gold quality
Brodmann (1909) area 9	UBERON:0013540	81.00	gold quality
right frontal lobe	UBERON:0002810	80.44	gold quality
prefrontal cortex	UBERON:0000451	80.05	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.01	gold quality
anterior cingulate cortex	UBERON:0009835	78.93	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	77.10	gold quality
neocortex	UBERON:0001950	74.67	gold quality
frontal cortex	UBERON:0001870	74.51	gold quality
monocyte	CL:0000576	74.24	gold quality
spleen	UBERON:0002106	74.06	gold quality
leukocyte	CL:0000738	73.47	gold quality
bone marrow cell	CL:0002092	71.79	silver quality
cerebral cortex	UBERON:0000956	70.16	gold quality
amygdala	UBERON:0001876	67.20	gold quality
lymph node	UBERON:0000029	65.73	gold quality
cortical plate	UBERON:0005343	65.25	gold quality
vermiform appendix	UBERON:0001154	65.05	gold quality
granulocyte	CL:0000094	63.73	gold quality
corpus callosum	UBERON:0002336	61.51	gold quality
primary visual cortex	UBERON:0002436	61.14	gold quality
hindlimb stylopod muscle	UBERON:0004252	60.84	gold quality
tonsil	UBERON:0002372	60.58	gold quality
forebrain	UBERON:0001890	60.17	gold quality
small intestine Peyer’s patch	UBERON:0003454	59.69	gold quality
caecum	UBERON:0001153	59.66	gold quality
Ammon’s horn	UBERON:0001954	59.51	gold quality
brain	UBERON:0000955	58.78	gold quality
temporal lobe	UBERON:0001871	58.18	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-HCAD-35	yes	96.37
E-CURD-119	yes	37.97
E-ANND-3	yes	6.20

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Authors found that the expression of LY86-AS1 and HCG27_201 were down regulated in the T2DM group compared with the control group. We further identify that the expression of both lncRNAs was negatively correlated with fasting blood sugar (FBS) levels. (PMID:30328000)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.