M1AP

Summary

M1AP (meiosis 1 associated protein, HGNC:25183) is a protein-coding gene on chromosome 2p13.1, encoding Meiosis 1 arrest protein (Q8TC57). Required for meiosis I progression during spermatogenesis.

This gene encodes a protein that is likely to function in progression of meiosis. A similar protein in mouse plays a role in gametogenesis in both sexes. Alternate splicing results in multiple transcript variants encoding different isoforms.

Source: NCBI Gene 130951 — RefSeq curated summary.

At a glance

• Gene–disease (curated): spermatogenic failure 48 (Strong, GenCC)
• GWAS associations: 1
• Clinical variants (ClinVar): 105 total — 2 pathogenic, 2 likely-pathogenic
• Phenotypes (HPO): 6
• MANE Select transcript: NM_001321739

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25183
Approved symbol	M1AP
Name	meiosis 1 associated protein
Location	2p13.1
Locus type	gene with protein product
Status	Approved
Aliases	D6Mm5e, SPATA37
Ensembl gene	ENSG00000159374
Ensembl biotype	protein_coding
OMIM	619098
Entrez	130951

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 6 protein_coding, 4 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay

ENST00000290536, ENST00000409585, ENST00000421985, ENST00000422394, ENST00000438226, ENST00000464686, ENST00000478437, ENST00000485997, ENST00000536235, ENST00000924975, ENST00000924976

RefSeq mRNA: 4 — MANE Select: NM_001321739 NM_001281295, NM_001281296, NM_001321739, NM_138804

CCDS: CCDS33229, CCDS62941

Canonical transcript exons

ENST00000421985 — 11 exons

Exon	Start	End
ENSE00001806226	74648265	74648330
ENSE00001913757	74557883	74558874
ENSE00002532889	74559698	74559709
ENSE00003478137	74575438	74575579
ENSE00003481248	74576456	74576618
ENSE00003503235	74562217	74562423
ENSE00003556498	74560151	74560291
ENSE00003560321	74607055	74607223
ENSE00003652436	74640036	74640327
ENSE00003669716	74581674	74581847
ENSE00003787018	74614964	74615149

Expression profiles

Bgee: expression breadth ubiquitous, 154 present calls, max score 85.51.

FANTOM5 (CAGE): breadth broad, TPM avg 0.5860 / max 31.7260, expressed in 259 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
29255	0.3331	122
29257	0.1895	110
29256	0.0634	26

Top tissues by expression

243 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.51	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.41	gold quality
bone marrow cell	CL:0002092	76.12	gold quality
monocyte	CL:0000576	71.74	gold quality
leukocyte	CL:0000738	71.61	gold quality
right testis	UBERON:0004534	71.00	gold quality
left testis	UBERON:0004533	70.63	gold quality
testis	UBERON:0000473	70.54	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	68.44	gold quality
granulocyte	CL:0000094	67.22	gold quality
islet of Langerhans	UBERON:0000006	66.68	gold quality
prefrontal cortex	UBERON:0000451	66.11	gold quality
right uterine tube	UBERON:0001302	65.56	gold quality
adenohypophysis	UBERON:0002196	65.12	gold quality
right lobe of thyroid gland	UBERON:0001119	64.35	gold quality
bone marrow	UBERON:0002371	62.82	gold quality
subcutaneous adipose tissue	UBERON:0002190	62.61	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	62.28	gold quality
pituitary gland	UBERON:0000007	61.91	gold quality
right lung	UBERON:0002167	61.88	gold quality
left lobe of thyroid gland	UBERON:0001120	61.27	gold quality
amygdala	UBERON:0001876	61.18	gold quality
sural nerve	UBERON:0015488	61.15	silver quality
thyroid gland	UBERON:0002046	61.14	gold quality
smooth muscle tissue	UBERON:0001135	60.82	gold quality
blood	UBERON:0000178	60.72	gold quality
Brodmann (1909) area 9	UBERON:0013540	60.66	gold quality
omental fat pad	UBERON:0010414	60.59	gold quality
peritoneum	UBERON:0002358	60.54	gold quality
spinal cord	UBERON:0002240	60.32	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.18

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

45 targeting M1AP, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-4682	100.00	68.89	1258
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-4425	100.00	67.59	1049
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-3934-3P	99.76	65.51	1351
HSA-MIR-4666B	99.64	68.69	1282
HSA-MIR-150-3P	99.43	70.51	920
HSA-MIR-580-5P	99.28	70.94	1776
HSA-MIR-491-5P	99.13	65.98	1468
HSA-MIR-4744	99.01	69.91	1581
HSA-MIR-511-5P	98.97	70.94	2268
HSA-MIR-520G-3P	98.91	67.38	1914
HSA-MIR-520H	98.91	67.38	1914
HSA-MIR-224-3P	98.91	68.42	1815
HSA-MIR-522-3P	98.91	68.56	1817
HSA-MIR-412-3P	98.86	66.89	712
HSA-MIR-6754-3P	98.84	66.60	889
HSA-MIR-760	98.81	66.65	1392
HSA-MIR-3135B	98.61	65.33	1470
HSA-MIR-3188	98.58	65.60	878
HSA-MIR-6818-3P	98.56	68.23	1307
HSA-MIR-3668	98.52	68.76	951
HSA-MIR-5089-5P	98.45	66.06	1388
HSA-MIR-484	98.16	66.92	1074
HSA-MIR-3155A	98.16	66.09	965

Literature-anchored findings (GeneRIF, showing 2)

• An M1AP homozygous splice-site mutation associated with severe oligozoospermia in a consanguineous family. (PMID:32017041)
• Structural analysis of M1AP variants associated with severely impaired spermatogenesis causing male infertility. (PMID:35341049)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	m1ap	ENSDARG00000099485
mus_musculus	M1ap	ENSMUSG00000030041
rattus_norvegicus	M1ap	ENSRNOG00000007288

Protein

Protein identifiers

Meiosis 1 arrest protein — Q8TC57 (reviewed: Q8TC57)

Alternative names: Meiosis 1-arresting protein, Meiosis 1-associated protein, Spermatogenesis-associated protein 37

All UniProt accessions (3): Q8TC57, C9JPR9, F8WEA5

UniProt curated annotations — full annotation on UniProt →

Function. Required for meiosis I progression during spermatogenesis.

Subcellular location. Cytoplasm.

Disease relevance. Spermatogenic failure 48 (SPGF48) [MIM:619108] An autosomal recessive infertility disorder caused by spermatogenesis defects resulting in non-obstructive azoospermia. The disease may be caused by variants affecting the gene represented in this entry.

Isoforms (4)

UniProt ID	Names	Canonical?
Q8TC57-1	1	yes
Q8TC57-2	2
Q8TC57-3	3
Q8TC57-4	4

RefSeq proteins (4): NP_001268224, NP_001268225, NP_001308668, NP_620159 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR033587	M1AP	Family

UniProt features (16 total): sequence variant 7, splice variant 5, chain 1, region of interest 1, sequence conflict 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8TC57-F1	74.03	0.44

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 79 (showing top): GSE45365_NK_CELL_VS_CD8A_DC_DN, GSE45365_NK_CELL_VS_CD11B_DC_UP, GOBP_MEIOTIC_CHROMOSOME_SEGREGATION, MODULE_511, IVANOVA_HEMATOPOIESIS_MATURE_CELL, GOBP_CHROMOSOME_SEPARATION, GOBP_MALE_GAMETE_GENERATION, GOBP_ORGANELLE_FISSION, GOBP_MEIOTIC_CHROMOSOME_SEPARATION, GOBP_FEMALE_GAMETE_GENERATION, GOBP_DEVELOPMENTAL_PROCESS_INVOLVED_IN_REPRODUCTION, GOBP_MEIOTIC_CELL_CYCLE_PROCESS, GOBP_NUCLEAR_CHROMOSOME_SEGREGATION, GOBP_MEIOTIC_CELL_CYCLE, MARSON_BOUND_BY_FOXP3_STIMULATED

GO Biological Process (7): chromatin organization (GO:0006325), RNA processing (GO:0006396), meiosis I (GO:0007127), spermatogenesis (GO:0007283), female gamete generation (GO:0007292), cell differentiation (GO:0030154), male meiosis chromosome separation (GO:0051308)

GO Molecular Function (2): identical protein binding (GO:0042802), protein binding (GO:0005515)

GO Cellular Component (2): cytoplasm (GO:0005737), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
cellular component organization	1
gene expression	1
RNA biosynthetic process	1
primary metabolic process	1
meiotic telophase I	1
meiosis I cell cycle process	1
meiotic nuclear division	1
developmental process involved in reproduction	1
male gamete generation	1
gamete generation	1
cellular developmental process	1
male meiosis chromosome segregation	1
male meiotic nuclear division	1
meiotic chromosome separation	1
protein binding	1
binding	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

764 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
M1AP	STAG3	Q9UJ98	584
M1AP	FBXO47	Q5MNV8	578
M1AP	MEIOC	A2RUB1	558
M1AP	MEI1	Q5TIA1	558
M1AP	STPG2	Q8N412	557
M1AP	SHOC1	Q5VXU9	545
M1AP	ADAD2	Q8NCV1	516
M1AP	PRDM9	Q9NQV7	465
M1AP	RAD21L1	Q9H4I0	464
M1AP	CCDC142	Q17RM4	460
M1AP	OR5K3	A6NET4	447
M1AP	HAUS8	Q9BT25	437
M1AP	SMC1B	Q8NDV3	429
M1AP	TEX38	Q6PEX7	420
M1AP	LRRC42	Q9Y546	416

IntAct

56 interactions, top by confidence:

A	B	Type	Score
M1AP	M1AP	psi-mi:“MI:0915”(physical association)	0.670
CRX	M1AP	psi-mi:“MI:0915”(physical association)	0.670
M1AP	TRIP13	psi-mi:“MI:0915”(physical association)	0.560
M1AP	POLR3GL	psi-mi:“MI:0915”(physical association)	0.560
M1AP	PLEKHA2	psi-mi:“MI:0915”(physical association)	0.560
BAHD1	M1AP	psi-mi:“MI:0915”(physical association)	0.560
SIAH1	M1AP	psi-mi:“MI:0915”(physical association)	0.560
GOLGA6L9	M1AP	psi-mi:“MI:0915”(physical association)	0.560
CWF19L2	M1AP	psi-mi:“MI:0915”(physical association)	0.560
OTX2	M1AP	psi-mi:“MI:0915”(physical association)	0.560
LMNB1	M1AP	psi-mi:“MI:0915”(physical association)	0.560
OTX1	M1AP	psi-mi:“MI:0915”(physical association)	0.560
ZNF740	M1AP	psi-mi:“MI:0915”(physical association)	0.560
UBL3	M1AP	psi-mi:“MI:0915”(physical association)	0.560
DES	M1AP	psi-mi:“MI:0915”(physical association)	0.560
NP	KPNA6	psi-mi:“MI:0914”(association)	0.350
ATG16L1	ESYT2	psi-mi:“MI:0914”(association)	0.350
KLHL34	IFT56	psi-mi:“MI:0914”(association)	0.350
AMZ1	IFT56	psi-mi:“MI:0914”(association)	0.350
POLR3GL	M1AP	psi-mi:“MI:0915”(physical association)	0.000
M1AP	PLEKHA2	psi-mi:“MI:0915”(physical association)	0.000
M1AP	M1AP	psi-mi:“MI:0915”(physical association)	0.000
M1AP	BAHD1	psi-mi:“MI:0915”(physical association)	0.000
M1AP	SIAH1	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (19): M1AP (Two-hybrid), M1AP (Two-hybrid), M1AP (Two-hybrid), M1AP (Two-hybrid), M1AP (Two-hybrid), M1AP (Two-hybrid), M1AP (Two-hybrid), M1AP (Two-hybrid), M1AP (Two-hybrid), M1AP (Two-hybrid), M1AP (Two-hybrid), M1AP (Two-hybrid), OTX2 (Two-hybrid), PLEKHA2 (Two-hybrid), DES (Two-hybrid)

ESM2 similar proteins: A1A4J7, A2A9C3, A2BID5, B1WC10, E7FAW3, E7FCN8, O02696, O15360, O75153, O75800, O95248, Q08D69, Q1JPG0, Q3U6Q4, Q499Q5, Q5BLE2, Q5SW28, Q5SW45, Q5T011, Q5U1Z0, Q5U249, Q5UE93, Q5ZIB8, Q6AXZ5, Q6GLY5, Q6GR21, Q6PGF3, Q6ZNJ1, Q6ZQA0, Q7L4E1, Q8BK03, Q8BM55, Q8BMG7, Q8C3S2, Q8CJF7, Q8ND04, Q8QZV7, Q8TC57, Q8VDR9, Q8VE18

Diamond homologs: Q8TC57, Q9Z0E1

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

105 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	2
Likely pathogenic	2
Uncertain significance	82
Likely benign	9
Benign	1

Top pathogenic / likely-pathogenic (4)

Variant ID	HGVS	Classification
3061751	NM_001321739.2(M1AP):c.1073_1074+10del	Pathogenic
870128	NM_001321739.2(M1AP):c.1435-1G>A	Pathogenic
4845729	NM_001321739.2(M1AP):c.932+1G>A	Likely pathogenic
4845843	NM_001321739.2(M1AP):c.13C>T (p.Arg5Ter)	Likely pathogenic

SpliceAI

1695 predictions. Top by Δscore:

Variant	Effect	Δscore
2:74560288:TGCT:T	acceptor_gain	1.0000
2:74560290:CT:C	acceptor_gain	1.0000
2:74560292:C:CC	acceptor_gain	1.0000
2:74576442:C:A	donor_gain	1.0000
2:74576454:A:AC	donor_gain	1.0000
2:74576455:C:CC	donor_gain	1.0000
2:74576615:CACA:C	acceptor_gain	1.0000
2:74576616:ACACT:A	acceptor_loss	1.0000
2:74576617:CA:C	acceptor_gain	1.0000
2:74576618:ACT:A	acceptor_loss	1.0000
2:74576619:C:CC	acceptor_gain	1.0000
2:74576620:T:C	acceptor_loss	1.0000
2:74581672:A:AC	donor_gain	1.0000
2:74581673:C:CC	donor_gain	1.0000
2:74640031:CTTA:C	donor_loss	1.0000
2:74640032:TTACC:T	donor_loss	1.0000
2:74640033:TAC:T	donor_loss	1.0000
2:74640325:CAC:C	acceptor_gain	1.0000
2:74560145:CGGTA:C	donor_loss	0.9900
2:74560146:GGTAC:G	donor_loss	0.9900
2:74560147:GTA:G	donor_loss	0.9900
2:74560148:TACC:T	donor_loss	0.9900
2:74560149:A:AG	donor_loss	0.9900
2:74560287:ATGCT:A	acceptor_gain	0.9900
2:74560291:TC:T	acceptor_loss	0.9900
2:74560293:T:A	acceptor_loss	0.9900
2:74575576:AGCCC:A	acceptor_gain	0.9900
2:74575577:GCCCT:G	acceptor_gain	0.9900
2:74575578:CC:C	acceptor_gain	0.9900
2:74575579:CC:C	acceptor_gain	0.9900

AlphaMissense

916 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:74640081:A:C	S65R	0.996
2:74640081:A:T	S65R	0.996
2:74640083:T:G	S65R	0.996
2:74640142:A:G	L45P	0.986
2:74615035:C:G	G119R	0.977
2:74615035:C:T	G119R	0.977
2:74640202:A:G	L25P	0.976
2:74615034:C:T	G119E	0.974
2:74615035:C:A	G119W	0.972
2:74640046:A:G	L77P	0.972
2:74640146:C:G	A44P	0.968
2:74640154:A:G	L41P	0.968
2:74640205:A:G	L24P	0.964
2:74640082:C:A	S65I	0.961
2:74615124:A:G	L89S	0.960
2:74640040:A:G	F79S	0.960
2:74615046:G:T	A115E	0.959
2:74640176:A:G	W34R	0.959
2:74640176:A:T	W34R	0.959
2:74640051:G:C	C75W	0.958
2:74640202:A:C	L25R	0.957
2:74615103:A:G	L96P	0.956
2:74640053:A:G	C75R	0.954
2:74615031:A:G	L120P	0.953
2:74640145:G:T	A44D	0.949
2:74640077:A:C	Y67D	0.947
2:74640085:A:G	F64S	0.947
2:74640082:C:T	S65N	0.945
2:74615043:A:T	V116E	0.944
2:74640202:A:T	L25H	0.944

dbSNP variants (sampled 300 via entrez): RS1000039060 (2:74603320 T>G), RS1000053489 (2:74623927 T>C), RS1000059030 (2:74585966 CTTG>C), RS1000127390 (2:74584666 A>G), RS1000221941 (2:74584811 T>A), RS1000223025 (2:74637427 A>T), RS1000233625 (2:74638830 G>T), RS1000236398 (2:74630359 T>C), RS1000239173 (2:74578830 G>A), RS1000240289 (2:74616558 A>G), RS1000319307 (2:74563965 C>G), RS1000356694 (2:74591382 T>C), RS1000406904 (2:74577414 A>C), RS1000422956 (2:74598317 G>T), RS1000482834 (2:74630502 G>T)

Disease associations

OMIM: gene MIM:619098 | disease phenotypes: MIM:619108

GenCC curated gene-disease

Disease	Classification	Inheritance
spermatogenic failure 48	Strong	Autosomal recessive

Mondo (2): spermatogenic failure 48 (MONDO:0030846), male infertility (MONDO:0005372)

Orphanet (1): Male infertility with azoospermia or oligozoospermia due to single gene mutation (Orphanet:399805)

HPO phenotypes

6 total (6 of 6 shown, HPO-id order):

HPO	Term
HP:0000007	Autosomal recessive inheritance
HP:0000027	Azoospermia
HP:0000798	Oligozoospermia
HP:0003251	Male infertility
HP:0003581	Adult onset
HP:0031038	Spermatogenesis maturation arrest

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST010002_394	Refractive error	2.000000e-11

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
D007248	Infertility, Male	C12.100.500.430; C12.100.750.700; C12.200.294.430

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

13 total (human), top 13 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
potassium chromate(VI)	increases expression, affects cotreatment, decreases expression	2
triphenyl phosphate	affects expression	1
bisphenol A	increases expression	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
di-n-butylphosphoric acid	affects expression	1
chromium hexavalent ion	affects expression	1
bisphenol S	increases methylation	1
Benzo(a)pyrene	decreases methylation	1
Formaldehyde	affects response to substance	1
Phthalic Acids	decreases methylation	1
Vanadates	decreases expression	1
Cadmium Chloride	decreases expression	1
Genistein	decreases expression	1

Clinical trials (associated diseases)

125 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT02202382	PHASE4	COMPLETED	Effects of Korean Red Ginseng on Male Infertility
NCT02204826	PHASE4	COMPLETED	Effects of Korean Red Ginseng on Semen Parameters in Male Infertility Patients: a Randomized, Placebo-controlled, Double-blind Clinical Study
NCT03802864	PHASE4	COMPLETED	Post-operative Pain Control of Testicular Sperm Extraction Using Liposomal Bupivacaine
NCT06100432	PHASE4	ACTIVE_NOT_RECRUITING	Effect of Eurycoma Longifolia (DLBS5055) and Multivitamins (Vitamin C+Vitamin E+ β-carotene) for Infertile Males
NCT07523022	PHASE4	ENROLLING_BY_INVITATION	Comparison of the Effect of Gonadotropin and Clomiphene Citrate Treatment on Sperm Parameters and the Outcome of Assisted Reproductive Procedures in Subfertile Men Based on the APHRODITE Groups
NCT00975117	PHASE3	COMPLETED	Spermotrend in the Treatment of Male Infertility
NCT01407432	PHASE3	COMPLETED	Impact of Folates in the Care of the Male Infertility
NCT01895816	PHASE3	COMPLETED	Herbal Tonic Fertile Supplement(ZO2C5)
NCT02605070	PHASE3	TERMINATED	Pilot Study on the Effects of FSH Treatment on the Epigenetic Characteristics of Spermatozoa in Infertile Patients With Severe Oligozoospermia
NCT07402759	PHASE3	ACTIVE_NOT_RECRUITING	Impact of tdrd9 Gene Mutations in the Therapeutic Response to L-carnitine in Oligoasthenozoospermic Men
NCT01880086	PHASE2	COMPLETED	Clomiphene Citrate for the Treatment of Low Testosterone Associated With Chronic Opioid Pain Medication Administration
NCT02061384	PHASE2	COMPLETED	RA-2 13-cis Retinoic Acid (Isotretinoin)
NCT02421887	PHASE2	COMPLETED	Males, Antioxidants, and Infertility Trial
NCT05200663	PHASE2	UNKNOWN	Efficacy Comparison of Tamoxifen and Tamoxifen With Antioxidants on Semen Quality of Male With Idiopathic Infertility
NCT05290558	PHASE2	ACTIVE_NOT_RECRUITING	The Therapeutic Effects of Bu Shen Yi Jing Pill on Semen Quality in Sub Fertile Males: a Randomized Controlled Trial
NCT06091969	PHASE2	NOT_YET_RECRUITING	Supplementation for Male Subfertility
NCT01595308	PHASE1	COMPLETED	A Pilot Study to Evaluate the Effect of Pomegranate Juice on Semen Parameters in Healthy Male Volunteers
NCT02122211	PHASE1	COMPLETED	Choline Dehydrogenase and Sperm Function: Effects of Betaine
NCT02575924	PHASE1	UNKNOWN	Influence of Culture Media on Clinical Outcomes in Poor Responders or Severe Male Infertility
NCT01304927	PHASE2/PHASE3	COMPLETED	Vitamin D Supplementation and Male Infertility: The CBG-study a Randomized Clinical Trial
NCT02349945	PHASE2/PHASE3	COMPLETED	FSH Receptor Polymorphism p.N680S and Efficacy of FSH Therapy
NCT05222841	PHASE2/PHASE3	COMPLETED	The Effectiveness of Spermotrend Food Supplement in the Treatment of Male Infertility
NCT05616598	PHASE2/PHASE3	COMPLETED	Effect of New Oral Treatment for Hepatitis C Virus on Seminal Parameters
NCT02025270	PHASE1/PHASE2	COMPLETED	MSCs For Treatment of Azoospermic Patients
NCT04541459	EARLY_PHASE1	UNKNOWN	Validation of New Devices Against Ambient Electromagnetic Radiation
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