MAB21L1

Summary

MAB21L1 (mab-21 like 1, HGNC:6757) is a protein-coding gene on chromosome 13q13.3, encoding Putative nucleotidyltransferase MAB21L1 (Q13394). Putative nucleotidyltransferase required for several aspects of embryonic development including normal development of the eye.

This gene is similar to the MAB-21 cell fate-determining gene found in C. elegans. It may be involved in eye and cerebellum development, and it has been proposed that expansion of a trinucleotide repeat region in the 5’ UTR may play a role in a variety of psychiatric disorders.

Source: NCBI Gene 4081 — RefSeq curated summary.

At a glance

• Gene–disease (curated): cerebellar, ocular, craniofacial, and genital syndrome (Strong, ClinGen)
• Clinical variants (ClinVar): 52 total — 8 pathogenic, 4 likely-pathogenic
• Phenotypes (HPO): 64
• MANE Select transcript: NM_005584

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:6757
Approved symbol	MAB21L1
Name	mab-21 like 1
Location	13q13.3
Locus type	gene with protein product
Status	Approved
Aliases	CAGR1
Ensembl gene	ENSG00000180660
Ensembl biotype	protein_coding
OMIM	601280
Entrez	4081

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 protein_coding

ENST00000379919, ENST00000707125, ENST00000951518

RefSeq mRNA: 1 — MANE Select: NM_005584 NM_005584

CCDS: CCDS9353

Canonical transcript exons

ENST00000379919 — 1 exons

Exon	Start	End
ENSE00003998268	35473789	35476689

Expression profiles

Bgee: expression breadth ubiquitous, 165 present calls, max score 96.58.

FANTOM5 (CAGE): breadth broad, TPM avg 3.4174 / max 613.0897, expressed in 537 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
136749	3.1132	491
136746	0.2865	135
136747	0.0177	7

Top tissues by expression

275 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pigmented layer of retina	UBERON:0001782	96.58	gold quality
cerebellar vermis	UBERON:0004720	93.82	gold quality
paraflocculus	UBERON:0005351	91.89	gold quality
cerebellum	UBERON:0002037	89.10	gold quality
cerebellar cortex	UBERON:0002129	88.63	gold quality
cerebellar hemisphere	UBERON:0002245	88.55	gold quality
right hemisphere of cerebellum	UBERON:0014890	87.15	gold quality
urethra	UBERON:0000057	80.56	gold quality
secondary oocyte	CL:0000655	80.24	gold quality
calcaneal tendon	UBERON:0003701	78.09	gold quality
nipple	UBERON:0002030	76.74	gold quality
thoracic mammary gland	UBERON:0005200	74.63	gold quality
penis	UBERON:0000989	74.55	gold quality
mammary gland	UBERON:0001911	74.07	gold quality
muscle of leg	UBERON:0001383	72.16	gold quality
popliteal artery	UBERON:0002250	71.86	gold quality
tibial artery	UBERON:0007610	71.84	gold quality
tibial nerve	UBERON:0001323	71.65	gold quality
gastrocnemius	UBERON:0001388	71.48	gold quality
mammalian vulva	UBERON:0000997	69.87	gold quality
muscle organ	UBERON:0001630	69.09	gold quality
pons	UBERON:0000988	68.85	gold quality
mammary duct	UBERON:0001765	68.59	gold quality
epithelium of mammary gland	UBERON:0003244	67.63	gold quality
oocyte	CL:0000023	67.62	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.30	gold quality
aorta	UBERON:0000947	66.47	gold quality
minor salivary gland	UBERON:0001830	65.69	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.50	gold quality
vastus lateralis	UBERON:0001379	64.80	silver quality

Single-cell (SCXA)

Detected in 5 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-HCAD-5	yes	828.40
E-HCAD-10	yes	485.83
E-GEOD-75140	yes	287.96
E-ANND-3	yes	3.10
E-MTAB-6108	no	284.75

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): DLX5, ELF4, PAX6

miRNA regulators (miRDB)

124 targeting MAB21L1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-6077	99.99	68.04	2299
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-485-3P	99.98	70.68	1585
HSA-MIR-539-3P	99.98	70.74	1616
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-507	99.97	70.11	1915
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-551B-5P	99.96	71.28	3493
HSA-MIR-557	99.96	70.01	1640
HSA-MIR-1-3P	99.93	72.35	1914
HSA-MIR-206	99.93	72.50	1893
HSA-MIR-4760-3P	99.93	70.50	2385
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-3143	99.93	71.96	3104
HSA-MIR-338-5P	99.92	72.34	2951

Literature-anchored findings (GeneRIF, showing 10)

• MEF is involved in PTH suppression of osteoblasts through activating the MKK4/JNK1 pathway and subsequently up-regulating Mab21l1 expression. (PMID:21465527)
• We hypothesize that MAB21L1 haploinsufficiency cause a previously undescribed syndrome with scrotal agenesis, ophthalmological anomalies, facial dysmorphism and gross psychomotor delay as remarkable hallmarks. (PMID:27103078)
• offer a structure-based explanation for the effects of MAB21L2 mutations in patients with eye malformations (PMID:27271801)
• mab21 gene family members, mab21l1 and mab21l2, play important roles in regulating eye development. [review] (PMID:27558071)
• Mab21l1-/- osteoblasts also expressed higher levels of adipocyte genes and interferon-regulated genes at early stages of osteogenesis (PMID:29156428)
• This report defines an ultrarare but clinically recognisable Cerebello-Oculo-Facio-Genital syndrome associated with recessive MAB21L1 variants. Additionally, our findings further support the critical role of MAB21L1 in cerebellum, lens, genitalia and as craniofacial morphogenesis. (PMID:30487245)
• Identification of missense MAB21L1 variants in microphthalmia and aniridia. (PMID:33973683)
• Monoallelic variants resulting in substitutions of MAB21L1 Arg51 Cause Aniridia and microphthalmia. (PMID:36413568)
• Single amino acid variation in MAB21L1 is dominantly associated with congenital eye defects. (PMID:36446583)
• Missense Mutations in MAB21L1: Causation of Novel Autosomal Dominant Ocular BAMD Syndrome. (PMID:36892533)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	mab21l1	ENSDARG00000102047
mus_musculus	Mab21l1	ENSMUSG00000056947
rattus_norvegicus	Mab21l1	ENSRNOG00000032941
drosophila_melanogaster	CG4766	FBGN0027546
drosophila_melanogaster	mab-21	FBGN0029003
caenorhabditis_elegans		WBGENE00003112

Paralogs (9): ITPRIP (ENSG00000148841), CGAS (ENSG00000164430), MAB21L4 (ENSG00000172478), MAB21L3 (ENSG00000173212), MB21D2 (ENSG00000180611), TMEM102 (ENSG00000181284), MAB21L2 (ENSG00000181541), ITPRIPL1 (ENSG00000198885), ITPRIPL2 (ENSG00000205730)

Protein

Protein identifiers

Putative nucleotidyltransferase MAB21L1 — Q13394 (reviewed: Q13394)

Alternative names: Protein mab-21-like 1

All UniProt accessions (2): F1T0A2, Q13394

UniProt curated annotations — full annotation on UniProt →

Function. Putative nucleotidyltransferase required for several aspects of embryonic development including normal development of the eye. It is unclear whether it displays nucleotidyltransferase activity in vivo. Binds single-stranded RNA (ssRNA).

Subunit / interactions. Monomer. Homodecamer; composed of 2 back to back homopentamers. The protein may exist as monomer in solution and oiligomerizes upon ligand binding.

Subcellular location. Nucleus.

Tissue specificity. Expressed in brain, cerebellum and skeletal muscle.

Disease relevance. Cerebellar, ocular, craniofacial, and genital syndrome (COFG) [MIM:618479] An autosomal recessive syndrome characterized by moderate to severe developmental delay, intellectual disability, cerebellar hypoplasia with ataxia, variable microcephaly, ophthalmological anomalies, facial dysmorphism, absent or underdeveloped nipples, underdeveloped labioscrotal folds and scrotal agenesis. The disease is caused by variants affecting the gene represented in this entry.

Domain organisation. While it shares structure similarities with CGAS, it also features a number of differences. The crystal structure is in inactive conformation and the enzyme would require a conformational change to be active. The nucleotidyltransferase activity is therefore unclear.

Polymorphism. A CAG trinucleotide repeat occurs in the 5’-UTR of this gene. This repeat has been found to be highly polymorphic, although expanded alleles have not yet been definitely linked with any phenotypic abnormality.

Similarity. Belongs to the mab-21 family.

RefSeq proteins (1): NP_005575* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR024810	MAB21L/cGLR	Family
IPR046903	Mab-21-like_nuc_Trfase	Domain
IPR046906	Mab-21_HhH/H2TH-like	Domain

Pfam: PF03281, PF20266

UniProt features (40 total): helix 14, strand 10, binding site 6, turn 3, sequence variant 3, mutagenesis site 2, chain 1, sequence conflict 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
5EOM	X-RAY DIFFRACTION	2.55
5EOG	X-RAY DIFFRACTION	3.05

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q13394-F1	94.18	0.87

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (6): 23–24; 63–66; 73; 75; 248; 252–255

Mutagenesis-validated functional residues (2):

Position	Phenotype
51	decreased protein stability.
247	decreased protein stability.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 315 (showing top): GSE45365_CD8A_DC_VS_CD11B_DC_IFNAR_KO_MCMV_INFECTION_UP, BENPORATH_ES_WITH_H3K27ME3, TGCACTT_MIR519C_MIR519B_MIR519A, AREB6_03, chr13q13, NKX62_Q2, IRF1_Q6, ACATTCC_MIR1_MIR206, AACTTT_UNKNOWN, GOBP_SENSORY_ORGAN_DEVELOPMENT, ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN, CONCANNON_APOPTOSIS_BY_EPOXOMICIN_DN, PITX2_Q2, TGGAAA_NFAT_Q4_01, TAATTA_CHX10_01

GO Biological Process (5): eye development (GO:0001654), cell population proliferation (GO:0008283), positive regulation of cell population proliferation (GO:0008284), anatomical structure morphogenesis (GO:0009653), camera-type eye development (GO:0043010)

GO Molecular Function (7): ATP binding (GO:0005524), GTP binding (GO:0005525), nucleotidyltransferase activity (GO:0016779), metal ion binding (GO:0046872), nucleotide binding (GO:0000166), protein binding (GO:0005515), transferase activity (GO:0016740)

GO Cellular Component (1): nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
purine ribonucleoside triphosphate binding	2
sensory organ development	1
visual system development	1
cellular process	1
cell population proliferation	1
regulation of cell population proliferation	1
positive regulation of cellular process	1
developmental process	1
anatomical structure development	1
eye development	1
adenyl ribonucleotide binding	1
guanyl ribonucleotide binding	1
transferase activity, transferring phosphorus-containing groups	1
cation binding	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
binding	1
catalytic activity	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

864 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MAB21L1	NBEA	Q8NFP9	898
MAB21L1	DCLK1	O15075	764
MAB21L1	SMAD9	O15198	662
MAB21L1	HTR2A	P28223	573
MAB21L1	FOXE3	Q13461	552
MAB21L1	CCDC169	A6NNP5	471
MAB21L1	SIX3	O95343	459
MAB21L1	TGFB1	P01137	445
MAB21L1	CDX1	P47902	423
MAB21L1	PAX6	P26367	418
MAB21L1	S100A16	Q96FQ6	397
MAB21L1	RBM39	Q14498	389
MAB21L1	AMOT	Q4VCS5	389
MAB21L1	PITX3	O75364	382
MAB21L1	BFSP1	Q12934	381

IntAct

13 interactions, top by confidence:

A	B	Type	Score
MAB21L1	PBX2	psi-mi:“MI:0915”(physical association)	0.620
SIAH1	MAB21L1	psi-mi:“MI:0915”(physical association)	0.560
MAB21L1	SIAH1	psi-mi:“MI:0915”(physical association)	0.560
MAB21L1	MEIS1	psi-mi:“MI:0914”(association)	0.530
FAM222A	MEIS1	psi-mi:“MI:0914”(association)	0.530
TSHZ3	MAB21L1	psi-mi:“MI:0915”(physical association)	0.400
LMX1B	POTEF	psi-mi:“MI:0914”(association)	0.350

BioGRID (31): SIAH1 (Two-hybrid), MAB21L1 (Affinity Capture-MS), UBAC1 (Affinity Capture-MS), EDRF1 (Affinity Capture-MS), MEIS1 (Affinity Capture-MS), MEIS2 (Affinity Capture-MS), AMY1C (Affinity Capture-MS), PBX1 (Affinity Capture-MS), PBX2 (Affinity Capture-MS), PBX3 (Affinity Capture-MS), MEIS2 (Affinity Capture-MS), MEIS1 (Affinity Capture-MS), PBX2 (Affinity Capture-MS), PBX3 (Affinity Capture-MS), MAB21L1 (Affinity Capture-MS)

ESM2 similar proteins: A0A2B4RP11, A0A3M6TIF0, A0A482WD11, A0A6J1SUS3, A0A8B6XWW9, A0A913XCT1, A1ZA55, A4FV14, A4IIW0, A7SFB5, A8DYP7, A8E4S7, B3NQ14, B4QGZ2, D6WI29, D7Y2H2, O70299, P0DV11, P0DV12, P0DX69, P0DX77, P0DXB4, P0DXB5, P0DXB6, P0DXB7, P0DXB8, P0DXC0, Q0IES7, Q0IES8, Q0V9X7, Q13394, Q20054, Q29H55, Q29H56, Q5BKD0, Q5MYT9, Q5TW90, Q60856, Q6DCQ5, Q6GQD9

Diamond homologs: A4FV14, A4IIW0, O70299, Q0IES7, Q0IES8, Q0V9X7, Q13394, Q20054, Q29H55, Q29H56, Q5TW90, Q6DCQ5, Q6GQD9, Q6NYB4, Q7QHX4, Q8AY65, Q8BPP1, Q8UUZ1, Q9GQ38, Q9I9K2, Q9U3W6, Q9Y106, Q9Y586, A0A3M6TIF0, A2ASA8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

52 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	8
Likely pathogenic	4
Uncertain significance	34
Likely benign	6
Benign	0

Top pathogenic / likely-pathogenic (12)

Variant ID	HGVS	Classification
2175962	NM_005584.5(MAB21L1):c.152G>A (p.Arg51Gln)	Pathogenic
2685461	GRCh37/hg19 13q13.3(chr13:35778509-36259617)x1	Pathogenic
4536806	NC_000013.10:g.(35517252_35615069)_(36180716_36202217)del	Pathogenic
634926	NM_005584.5(MAB21L1):c.735dup (p.Cys246fs)	Pathogenic
634927	NM_005584.5(MAB21L1):c.840C>G (p.Tyr280Ter)	Pathogenic
634928	NM_005584.5(MAB21L1):c.859del (p.Arg287fs)	Pathogenic
634929	NM_005584.5(MAB21L1):c.841del (p.Glu281fs)	Pathogenic
634930	NM_005584.5(MAB21L1):c.698A>C (p.Gln233Pro)	Pathogenic
1341245	GRCh37/hg19 13q13.3(chr13:35951031-36115573)x1	Likely pathogenic
2685462	GRCh37/hg19 13q13.3(chr13:36035608-36058874)x1	Likely pathogenic
4814017	NM_005584.5(MAB21L1):c.371C>T (p.Ser124Leu)	Likely pathogenic
666336	NM_005584.5(MAB21L1):c.737dup (p.Cys246fs)	Likely pathogenic

SpliceAI

210 predictions. Top by Δscore:

Variant	Effect	Δscore
13:35476909:G:C	donor_gain	0.9700
13:35476917:A:AC	donor_gain	0.9700
13:35477103:A:C	donor_gain	0.9700
13:35477112:AAT:A	donor_gain	0.9700
13:35477114:T:TA	donor_gain	0.9300
13:35477078:A:AC	donor_gain	0.9200
13:35477079:C:CC	donor_gain	0.9200
13:35477082:G:A	donor_gain	0.9100
13:35477106:T:TA	donor_gain	0.9100
13:35475030:A:AG	donor_gain	0.9000
13:35475436:C:CA	acceptor_gain	0.8300
13:35476922:T:C	donor_gain	0.8300
13:35477077:A:T	donor_gain	0.8300
13:35477104:CGT:C	donor_gain	0.8200
13:35477080:T:C	donor_gain	0.8100
13:35476920:A:AC	donor_gain	0.7900
13:35476921:C:CC	donor_gain	0.7900
13:35475031:T:G	donor_gain	0.6600
13:35475025:G:A	donor_gain	0.6500
13:35475415:G:GA	acceptor_gain	0.6500
13:35474946:A:AG	acceptor_gain	0.6400
13:35475014:GACTT:G	donor_gain	0.6400
13:35475025:GG:G	donor_gain	0.6400
13:35475026:GG:G	donor_gain	0.6400
13:35475081:G:A	acceptor_gain	0.6100
13:35475434:CGCGA:C	acceptor_gain	0.6100
13:35474947:A:G	acceptor_gain	0.6000
13:35475024:AG:A	donor_gain	0.6000
13:35477268:T:TA	donor_gain	0.6000
13:35477269:A:AA	donor_gain	0.6000

AlphaMissense

2348 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
13:35475207:A:G	L311P	1.000
13:35475219:A:G	L307P	1.000
13:35475243:C:G	R299P	1.000
13:35475266:C:A	W291C	1.000
13:35475266:C:G	W291C	1.000
13:35475267:C:G	W291S	1.000
13:35475268:A:G	W291R	1.000
13:35475268:A:T	W291R	1.000
13:35475449:C:A	W230C	1.000
13:35475449:C:G	W230C	1.000
13:35475451:A:G	W230R	1.000
13:35475451:A:T	W230R	1.000
13:35475510:A:G	L210P	1.000
13:35475520:C:G	G207R	1.000
13:35475559:A:G	W194R	1.000
13:35475559:A:T	W194R	1.000
13:35475578:C:A	W187C	1.000
13:35475578:C:G	W187C	1.000
13:35475580:A:G	W187R	1.000
13:35475580:A:T	W187R	1.000
13:35475588:G:T	A184D	1.000
13:35475599:C:A	W180C	1.000
13:35475599:C:G	W180C	1.000
13:35475601:A:G	W180R	1.000
13:35475601:A:T	W180R	1.000
13:35475611:G:C	C176W	1.000
13:35475613:A:G	C176R	1.000
13:35475617:A:C	F174L	1.000
13:35475617:A:T	F174L	1.000
13:35475618:A:G	F174S	1.000

dbSNP variants (sampled 300 via entrez): RS1000300376 (13:35474166 T>C), RS1000567375 (13:35474511 T>A,C), RS1000602935 (13:35477587 C>A,G), RS1001676886 (13:35475592 T>C), RS1001822147 (13:35473755 C>T), RS1002191081 (13:35473444 A>T), RS1003314369 (13:35478513 G>C,T), RS1005220686 (13:35478196 C>G), RS1006487563 (13:35476978 A>C), RS1006867182 (13:35476641 G>A,T), RS1007304396 (13:35476658 A>G,T), RS1007336291 (13:35476624 G>A,C,T), RS1008195725 (13:35475437 G>A,T), RS1008302109 (13:35474514 T>C), RS1008981380 (13:35474625 T>A)

Disease associations

OMIM: gene MIM:601280 | disease phenotypes: MIM:619157, MIM:618479

GenCC curated gene-disease

Disease	Classification	Inheritance
cerebellar, ocular, craniofacial, and genital syndrome	Strong	Autosomal recessive

ClinGen Gene-Disease Validity (1)

Expert-panel classifications — Definitive > Strong > Moderate > Limited > Disputed > Refuted.

Disease	Classification	Inheritance
cerebellar, ocular, craniofacial, and genital syndrome	Strong	AR

Mondo (2): neurodevelopmental disorder with or without early-onset generalized epilepsy (MONDO:0030930), cerebellar, ocular, craniofacial, and genital syndrome (MONDO:0032774)

Orphanet (0):

HPO phenotypes

64 total (30 of 64 shown, HPO-id order):

HPO	Term
HP:0000007	Autosomal recessive inheritance
HP:0000028	Cryptorchidism
HP:0000047	Hypospadias
HP:0000064	Hypoplastic labia minora
HP:0000107	Renal cyst
HP:0000252	Microcephaly
HP:0000280	Coarse facial features
HP:0000294	Low anterior hairline
HP:0000319	Smooth philtrum
HP:0000343	Long philtrum
HP:0000347	Micrognathia
HP:0000350	Small forehead
HP:0000358	Posteriorly rotated ears
HP:0000369	Low-set ears
HP:0000411	Protruding ear
HP:0000455	Broad nasal tip
HP:0000463	Anteverted nares
HP:0000470	Short neck
HP:0000478	Abnormality of the eye
HP:0000486	Strabismus
HP:0000505	Visual impairment
HP:0000527	Long eyelashes
HP:0000546	Retinal degeneration
HP:0000557	Buphthalmos
HP:0000609	Optic nerve hypoplasia
HP:0000639	Nystagmus
HP:0000664	Synophrys
HP:0000666	Horizontal nystagmus
HP:0000718	Aggressive behavior
HP:0001007	Hirsutism

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

17 total (human), top 17 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	decreases expression, increases expression	3
bisphenol A	decreases expression	1
arsenite	decreases expression	1
sodium arsenite	affects methylation	1
CGP 52608	affects binding, increases reaction	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
bisphenol S	decreases expression, affects cotreatment	1
Vorinostat	affects cotreatment, increases expression, decreases expression	1
Benzo(a)pyrene	increases methylation	1
Dexamethasone	affects cotreatment, decreases expression	1
Diethylhexyl Phthalate	decreases expression	1
Indomethacin	affects cotreatment, decreases expression	1
Tretinoin	increases expression	1
1-Methyl-3-isobutylxanthine	affects cotreatment, decreases expression	1
Antirheumatic Agents	increases expression	1
tert-Butylhydroperoxide	decreases expression	1

Cellosaurus cell lines

3 cell lines: 3 embryonic stem cell

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_A3Y9	SEES3-1V human MAB21L1, clone1	Embryonic stem cell	Male
CVCL_A3Z0	SEES3-1V human MAB21L1, clone2	Embryonic stem cell	Male
CVCL_A3Z1	SEES3-1V human MAB21L1, clone3	Embryonic stem cell	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.