MACC1-AS1

Summary

MACC1-AS1 (MACC1 antisense RNA 1, HGNC:41257) is a long non-coding RNA gene on chromosome 7p21.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41257
Approved symbol	MACC1-AS1
Name	MACC1 antisense RNA 1
Location	7p21.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000228598
Ensembl biotype	lncRNA
Entrez	100874041
RNAcentral	URS00005F5556 — lncRNA, 639 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 12 lncRNA

ENST00000439285, ENST00000738676, ENST00000738677, ENST00000738678, ENST00000738679, ENST00000738680, ENST00000738681, ENST00000738682, ENST00000738683, ENST00000738684, ENST00000738685, ENST00000738686

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000439285 — 4 exons

Exon	Start	End
ENSE00001604888	20141916	20142020
ENSE00001649144	20150435	20150589
ENSE00001677469	20147427	20147537
ENSE00001771539	20153264	20153531

Expression profiles

Bgee: expression breadth broad, 100 present calls, max score 80.21.

Top tissues by expression

103 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	80.21	silver quality
endometrium	UBERON:0001295	77.57	gold quality
thymus	UBERON:0002370	77.41	silver quality
bone marrow cell	CL:0002092	75.72	gold quality
quadriceps femoris	UBERON:0001377	73.01	gold quality
cerebellar vermis	UBERON:0004720	70.27	gold quality
bone marrow	UBERON:0002371	62.54	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	61.45	gold quality
calcaneal tendon	UBERON:0003701	61.40	gold quality
colonic epithelium	UBERON:0000397	60.57	silver quality
placenta	UBERON:0001987	58.11	gold quality
prefrontal cortex	UBERON:0000451	57.95	gold quality
tonsil	UBERON:0002372	57.65	gold quality
tibial nerve	UBERON:0001323	57.20	gold quality
lymph node	UBERON:0000029	57.07	gold quality
ectocervix	UBERON:0012249	55.12	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	54.94	gold quality
uterine cervix	UBERON:0000002	54.79	gold quality
kidney	UBERON:0002113	54.26	gold quality
lower esophagus mucosa	UBERON:0035834	54.26	gold quality
liver	UBERON:0002107	54.21	gold quality
adult mammalian kidney	UBERON:0000082	54.08	gold quality
right testis	UBERON:0004534	53.98	gold quality
cortex of kidney	UBERON:0001225	53.44	gold quality
left testis	UBERON:0004533	52.73	gold quality
monocyte	CL:0000576	52.62	silver quality
testis	UBERON:0000473	52.48	gold quality
metanephros cortex	UBERON:0010533	52.16	gold quality
sural nerve	UBERON:0015488	52.08	silver quality
right ovary	UBERON:0002118	52.06	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.59

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• expression of MACC1-AS1 in gastric cancer tissues is linked to poor prognosis and promotes malignant phenotype upon cancer cells. MACC1-AS1 is elevated under metabolic stress and facilitates metabolic plasticity by promoting MACC1 expression through mRNA stabilization. (PMID:29510730)
• LncRNA MACC-AS1 promotes stemness and chemoresistance in gastric cancer through fatty acid oxidation. (PMID:30742067)
• Long Non-Coding RNA MACC1-AS1 Is Involved in Distant Recurrence of Hepatocellular Carcinoma After Surgical Resection. (PMID:32267834)
• Long noncoding RNA MACC1-AS1 promotes the stemness of hepatocellular carcinoma cells by antagonizing miR-145. (PMID:32339066)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.