MACC1-OT1

Summary

MACC1-OT1 (MACC1 3’ UTR overlapping transcript 1, HGNC:58196) is a long non-coding RNA gene on chromosome 7p21.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:58196
Approved symbol	MACC1-OT1
Name	MACC1 3’ UTR overlapping transcript 1
Location	7p21.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000243004
Ensembl biotype	lncRNA
Entrez	101927668
RNAcentral	URS0000759F53 — lncRNA, 828 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 79 — 79 lncRNA

ENST00000415499, ENST00000418442, ENST00000424516, ENST00000428100, ENST00000435968, ENST00000437191, ENST00000449573, ENST00000457921, ENST00000656115, ENST00000691231, ENST00000737925, ENST00000737926, ENST00000737927, ENST00000737928, ENST00000737929, ENST00000737930, ENST00000737931, ENST00000737932, ENST00000737933, ENST00000737934, ENST00000737935, ENST00000737936, ENST00000737937, ENST00000737938, ENST00000737939, ENST00000737940, ENST00000737941, ENST00000737942, ENST00000737943, ENST00000737944, ENST00000737945, ENST00000737946, ENST00000737947, ENST00000737948, ENST00000737949, ENST00000737950, ENST00000737951, ENST00000737952, ENST00000737953, ENST00000737954, ENST00000737955, ENST00000737956, ENST00000737957, ENST00000737958, ENST00000737959, ENST00000737960, ENST00000737961, ENST00000737962, ENST00000737963, ENST00000737964, ENST00000737965, ENST00000737966, ENST00000737967, ENST00000737968, ENST00000737969, ENST00000737970, ENST00000737971, ENST00000737972, ENST00000737973, ENST00000737974, ENST00000737975, ENST00000737976, ENST00000737977, ENST00000737978, ENST00000737979, ENST00000737980, ENST00000737981, ENST00000737982, ENST00000737983, ENST00000737984, ENST00000737985, ENST00000737986, ENST00000737987, ENST00000737988, ENST00000737989, ENST00000737990, ENST00000737991, ENST00000737992, ENST00000737993

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000415499 — 6 exons

Exon	Start	End
ENSE00001614892	19960922	19960994
ENSE00001618512	20045503	20045561
ENSE00001642172	20028919	20028959
ENSE00001797218	19968137	19968395
ENSE00004072724	19931037	19931298
ENSE00004072728	20125080	20125190

Expression profiles

Bgee: expression breadth ubiquitous, 158 present calls, max score 85.75.

Top tissues by expression

249 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.75	gold quality
sperm	CL:0000019	81.64	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	79.13	gold quality
colonic epithelium	UBERON:0000397	77.64	gold quality
islet of Langerhans	UBERON:0000006	77.62	gold quality
left uterine tube	UBERON:0001303	77.27	gold quality
gall bladder	UBERON:0002110	74.66	gold quality
body of uterus	UBERON:0009853	74.51	gold quality
bone marrow cell	CL:0002092	71.72	silver quality
urinary bladder	UBERON:0001255	71.57	gold quality
stromal cell of endometrium	CL:0002255	71.42	gold quality
lower esophagus mucosa	UBERON:0035834	71.22	gold quality
decidua	UBERON:0002450	70.96	gold quality
buccal mucosa cell	CL:0002336	70.55	gold quality
vermiform appendix	UBERON:0001154	70.28	gold quality
endometrium	UBERON:0001295	70.10	gold quality
sural nerve	UBERON:0015488	69.13	gold quality
uterus	UBERON:0000995	68.99	gold quality
ectocervix	UBERON:0012249	67.60	gold quality
smooth muscle tissue	UBERON:0001135	66.81	gold quality
pancreas	UBERON:0001264	66.06	gold quality
left testis	UBERON:0004533	65.84	gold quality
esophagus mucosa	UBERON:0002469	65.70	gold quality
endocervix	UBERON:0000458	65.64	gold quality
right testis	UBERON:0004534	65.58	gold quality
uterine cervix	UBERON:0000002	65.57	gold quality
ganglionic eminence	UBERON:0004023	65.47	gold quality
right uterine tube	UBERON:0001302	65.35	gold quality
hindlimb stylopod muscle	UBERON:0004252	65.07	gold quality
testis	UBERON:0000473	64.99	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-9543	yes	35.78
E-ANND-3	yes	10.60

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.