MACO1

Summary

MACO1 (macoilin 1, HGNC:25572) is a protein-coding gene on chromosome 1p36.11, encoding Macoilin (Q8N5G2). Plays a role in the regulation of neuronal activity.

Predicted to enable microtubule binding activity. Involved in neuronal signal transduction. Located in rough endoplasmic reticulum membrane.

Source: NCBI Gene 55219 — RefSeq curated summary.

At a glance

• GWAS associations: 22
• Clinical variants (ClinVar): 65 total
• Druggable target: yes
• MANE Select transcript: NM_018202

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25572
Approved symbol	MACO1
Name	macoilin 1
Location	1p36.11
Locus type	gene with protein product
Status	Approved
Aliases	FLJ10747
Ensembl gene	ENSG00000204178
Ensembl biotype	protein_coding
OMIM	610301
Entrez	55219

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 8 protein_coding, 1 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay

ENST00000374343, ENST00000399766, ENST00000470035, ENST00000647928, ENST00000897263, ENST00000897264, ENST00000897265, ENST00000897266, ENST00000897267, ENST00000897268

RefSeq mRNA: 2 — MANE Select: NM_018202 NM_001282564, NM_018202

CCDS: CCDS30638, CCDS60034

Canonical transcript exons

ENST00000374343 — 11 exons

Exon	Start	End
ENSE00001463214	25498264	25500209
ENSE00001463216	25491410	25491584
ENSE00001463217	25489173	25489293
ENSE00001463219	25485613	25485795
ENSE00001463220	25484116	25484274
ENSE00001463223	25458391	25458892
ENSE00001463224	25456653	25456831
ENSE00001463228	25448808	25448934
ENSE00001463230	25446762	25446903
ENSE00001938711	25430897	25431178
ENSE00003573767	25454259	25454382

Expression profiles

Bgee: expression breadth ubiquitous, 269 present calls, max score 94.82.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 17.2602 / max 314.7606, expressed in 1810 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
1502	11.1401	1788
1503	4.6435	1636
1504	0.7432	383
1505	0.5981	265
1501	0.1352	27

Top tissues by expression

283 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	94.82	gold quality
tendon of biceps brachii	UBERON:0008188	93.63	gold quality
lower esophagus mucosa	UBERON:0035834	92.57	gold quality
ganglionic eminence	UBERON:0004023	92.27	gold quality
buccal mucosa cell	CL:0002336	92.14	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	90.98	gold quality
body of pancreas	UBERON:0001150	90.62	gold quality
gastrocnemius	UBERON:0001388	89.97	gold quality
tendon	UBERON:0000043	89.87	gold quality
islet of Langerhans	UBERON:0000006	89.86	gold quality
muscle of leg	UBERON:0001383	89.63	gold quality
hindlimb stylopod muscle	UBERON:0004252	89.42	gold quality
calcaneal tendon	UBERON:0003701	89.16	gold quality
biceps brachii	UBERON:0001507	88.96	gold quality
pancreas	UBERON:0001264	88.84	gold quality
liver	UBERON:0002107	88.39	gold quality
cerebellar cortex	UBERON:0002129	88.13	gold quality
cerebellar hemisphere	UBERON:0002245	88.11	gold quality
right lobe of liver	UBERON:0001114	88.08	gold quality
muscle organ	UBERON:0001630	87.69	gold quality
cerebellum	UBERON:0002037	87.63	gold quality
right adrenal gland cortex	UBERON:0035827	86.96	gold quality
right hemisphere of cerebellum	UBERON:0014890	86.79	gold quality
adrenal tissue	UBERON:0018303	86.73	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.60	gold quality
left adrenal gland	UBERON:0001234	86.51	gold quality
adrenal gland	UBERON:0002369	86.16	gold quality
right adrenal gland	UBERON:0001233	86.05	gold quality
left adrenal gland cortex	UBERON:0035825	86.01	gold quality
esophagus mucosa	UBERON:0002469	85.90	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.45

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

106 targeting MACO1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-507	99.97	70.11	1915
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-548AN	99.97	70.91	2817
HSA-MIR-557	99.96	70.01	1640
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-545-3P	99.95	70.74	2783
HSA-MIR-548J-3P	99.94	72.61	4881
HSA-MIR-548AE-3P	99.93	72.66	4867
HSA-MIR-548AH-3P	99.93	72.54	4872
HSA-MIR-548AM-3P	99.93	72.54	4872
HSA-MIR-548AQ-3P	99.93	72.66	4867
HSA-MIR-450B-5P	99.92	71.48	3175
HSA-MIR-3686	99.90	70.53	2432
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-4496	99.88	68.89	2236
HSA-MIR-548D-3P	99.87	70.67	4362

Literature-anchored findings (GeneRIF, showing 1)

• these results indicate that PAK4 confers CDDP resistance via the activation of MEK/ERK and PI3K/Akt pathways. PAK4 and PI3K/Akt pathways can reciprocally activate each other. (PMID:27919029)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	si:dkey-12h9.6	ENSDARG00000056092
mus_musculus	Maco1	ENSMUSG00000028826
rattus_norvegicus	Maco1	ENSRNOG00000056156
drosophila_melanogaster	bif	FBGN0014133
drosophila_melanogaster	CG30389	FBGN0050389
caenorhabditis_elegans	maco-1	WBGENE00017066

Protein

Protein identifiers

Macoilin — Q8N5G2 (reviewed: Q8N5G2)

Alternative names: Macoilin-1, Transmembrane protein 57

All UniProt accessions (2): A0A3B3ITD2, Q8N5G2

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role in the regulation of neuronal activity.

Subcellular location. Nucleus membrane. Cell projection. Axon. Rough endoplasmic reticulum membrane.

Similarity. Belongs to the macoilin family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q8N5G2-1	1	yes
Q8N5G2-2	2
Q8N5G2-3	3

RefSeq proteins (2): NP_001269493, NP_060672* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR019130	Macoilin	Family

Pfam: PF09726

UniProt features (22 total): transmembrane region 4, modified residue 4, glycosylation site 4, splice variant 3, region of interest 3, compositionally biased region 2, chain 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N5G2-F1	66.84	0.30

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (4): 305, 332, 631, 634

Glycosylation sites (4): 324, 340, 452, 655

Function

Pathways and Gene Ontology

Reactome pathways

6 pathways

ID	Pathway
R-HSA-8980692	RHOA GTPase cycle
R-HSA-9013106	RHOC GTPase cycle
R-HSA-162582	Signal Transduction
R-HSA-194315	Signaling by Rho GTPases
R-HSA-9012999	RHO GTPase cycle
R-HSA-9716542	Signaling by Rho GTPases, Miro GTPases and RHOBTB3

MSigDB gene sets: 206 (showing top): FREAC2_01, MAZ_Q6, MEF2_02, GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLUE_UP, GOBP_TAXIS, CATRRAGC_UNKNOWN, SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN, SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_5, HIF1_Q3, NRF2_Q4, GOBP_HEAD_DEVELOPMENT, ATF4_Q2, AACTTT_UNKNOWN, P300_01

GO Biological Process (3): chemotaxis (GO:0006935), brain development (GO:0007420), neuronal signal transduction (GO:0023041)

GO Molecular Function (3): microtubule binding (GO:0008017), molecular_function (GO:0003674), protein binding (GO:0005515)

GO Cellular Component (10): nucleus (GO:0005634), axon (GO:0030424), rough endoplasmic reticulum membrane (GO:0030867), nuclear membrane (GO:0031965), neuron projection terminus (GO:0044306), synapse (GO:0045202), endoplasmic reticulum (GO:0005783), membrane (GO:0016020), cell projection (GO:0042995), neuron projection (GO:0043005)

Reactome top-level categories

Rollup of top-4 pathways:

Category	Pathways
RHO GTPase cycle	2
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	1
Signaling by Rho GTPases	1
Signal Transduction	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
intracellular membrane-bounded organelle	2
neuron projection	2
response to chemical	1
taxis	1
central nervous system development	1
animal organ development	1
head development	1
signal transduction	1
tubulin binding	1
binding	1
endoplasmic reticulum membrane	1
rough endoplasmic reticulum	1
bounding membrane of organelle	1
nucleus	1
nuclear envelope	1
organelle membrane	1
cell junction	1
cytoplasm	1
endomembrane system	1
plasma membrane bounded cell projection	1

Protein interactions and networks

STRING

662 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MACO1	SYN1	P17600	744
MACO1	RSRP1	Q9BUV0	659
MACO1	TMEM50A	O95807	547
MACO1	RHCE	P18577	545
MACO1	YPEL4	Q96NS1	499
MACO1	SYF2	O95926	493
MACO1	RIC3	Q7Z5B4	484
MACO1	MEMO1	Q9Y316	446
MACO1	DEDD2	Q8WXF8	439
MACO1	MYBPHL	A2RUH7	422
MACO1	CTCF	P49711	417
MACO1	GALNT5	Q7Z7M9	414
MACO1	UBL4B	Q8N7F7	412
MACO1	RANBP10	Q6VN20	411
MACO1	TBC1D15	Q8TC07	401

IntAct

173 interactions, top by confidence:

A	B	Type	Score
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
MACO1	CCN3	psi-mi:“MI:0915”(physical association)	0.560
MACO1	POTEB3	psi-mi:“MI:0915”(physical association)	0.560
MACO1	MEI4	psi-mi:“MI:0915”(physical association)	0.560
LCE2C	MACO1	psi-mi:“MI:0915”(physical association)	0.560
CCN3	MACO1	psi-mi:“MI:0915”(physical association)	0.560
KRTAP5-7	MACO1	psi-mi:“MI:0915”(physical association)	0.560
MACO1	CRCT1	psi-mi:“MI:0915”(physical association)	0.560
LCE1D	MACO1	psi-mi:“MI:0915”(physical association)	0.560
KRTAP5-2	MACO1	psi-mi:“MI:0915”(physical association)	0.560
NOTCH2NLC	MACO1	psi-mi:“MI:0915”(physical association)	0.560
LCE1E	MACO1	psi-mi:“MI:0915”(physical association)	0.560
MEOX2	MACO1	psi-mi:“MI:0915”(physical association)	0.560
LCE1F	MACO1	psi-mi:“MI:0915”(physical association)	0.560
LCE3A	MACO1	psi-mi:“MI:0915”(physical association)	0.560
MACO1	TMEM190	psi-mi:“MI:0915”(physical association)	0.560
LCE3E	MACO1	psi-mi:“MI:0915”(physical association)	0.560
HOXA1	MACO1	psi-mi:“MI:0915”(physical association)	0.560
MACO1	LINGO1	psi-mi:“MI:0915”(physical association)	0.560
SMCP	MACO1	psi-mi:“MI:0915”(physical association)	0.560
LCE1C	MACO1	psi-mi:“MI:0915”(physical association)	0.560
POTEB3	MACO1	psi-mi:“MI:0915”(physical association)	0.560
MACO1	ZNF655	psi-mi:“MI:0915”(physical association)	0.560
MACO1	NR4A3	psi-mi:“MI:0915”(physical association)	0.560
MEI4	MACO1	psi-mi:“MI:0915”(physical association)	0.560
PCDHAC2	TMEM223	psi-mi:“MI:0914”(association)	0.530

BioGRID (250): TMEM57 (Affinity Capture-MS), TMEM57 (Affinity Capture-MS), TMEM57 (Affinity Capture-MS), TMEM57 (Biochemical Activity), TMEM57 (Proximity Label-MS), TMEM57 (Proximity Label-MS), TMEM57 (Proximity Label-MS), TMEM57 (Affinity Capture-MS), TMEM57 (Affinity Capture-MS), TMEM57 (Affinity Capture-MS), TMEM57 (Affinity Capture-MS), TMEM57 (Affinity Capture-MS), TMEM57 (Affinity Capture-MS), TMEM57 (Proximity Label-MS), TMEM57 (Affinity Capture-MS)

ESM2 similar proteins: A1Z7Z9, A9UM82, G5EEK3, O14490, P11929, P97836, Q15007, Q2KN93, Q2KN94, Q2KN95, Q2KN96, Q2KN97, Q2KN98, Q2KN99, Q2KNA0, Q2KNA1, Q2TLY1, Q2TLY2, Q2TLZ1, Q2TLZ2, Q2TLZ3, Q2TLZ4, Q2TLZ5, Q3UIJ9, Q4KLT6, Q4V7D3, Q5EB94, Q5M775, Q5NVC2, Q5SXY1, Q60JJ0, Q60MF5, Q69YQ0, Q6P4K5, Q7SXL7, Q7TQE6, Q7YZA2, Q86W92, Q8C8U0, Q8N5G2

Diamond homologs: P91193, Q2TLY1, Q2TLY2, Q2TLZ1, Q2TLZ2, Q2TLZ3, Q2TLZ4, Q2TLZ5, Q4V7D3, Q7TQE6, Q8N5G2

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 165 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Formation of the cornified envelope	7	6.8×	9e-03
Keratinization	9	5.5×	6e-03

GO biological processes:

GO term	Partners	Fold	FDR
keratinization	7	12.6×	1e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

65 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	48
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2004 predictions. Top by Δscore:

Variant	Effect	Δscore
1:25431176:CAGGT:C	donor_loss	1.0000
1:25431177:AGGT:A	donor_loss	1.0000
1:25431179:G:GC	donor_loss	1.0000
1:25431180:T:G	donor_loss	1.0000
1:25446760:A:AG	acceptor_gain	1.0000
1:25446761:G:GG	acceptor_gain	1.0000
1:25446761:GT:G	acceptor_gain	1.0000
1:25446761:GTAC:G	acceptor_gain	1.0000
1:25454257:A:AG	acceptor_gain	1.0000
1:25454258:G:GG	acceptor_gain	1.0000
1:25454258:GAAA:G	acceptor_gain	1.0000
1:25456651:A:AG	acceptor_gain	1.0000
1:25456652:G:GG	acceptor_gain	1.0000
1:25456652:GT:G	acceptor_gain	1.0000
1:25456652:GTAT:G	acceptor_gain	1.0000
1:25456652:GTATT:G	acceptor_gain	1.0000
1:25484112:CTA:C	acceptor_loss	1.0000
1:25484114:A:AC	acceptor_loss	1.0000
1:25484114:A:AG	acceptor_gain	1.0000
1:25484114:AGGCT:A	acceptor_gain	1.0000
1:25484115:G:GA	acceptor_loss	1.0000
1:25484115:G:GG	acceptor_gain	1.0000
1:25484115:GGCTG:G	acceptor_gain	1.0000
1:25484270:AACAA:A	donor_gain	1.0000
1:25484271:ACAA:A	donor_gain	1.0000
1:25484272:CAA:C	donor_gain	1.0000
1:25484273:AA:A	donor_gain	1.0000
1:25484274:AG:A	donor_loss	1.0000
1:25484275:G:C	donor_loss	1.0000
1:25484275:G:GG	donor_gain	1.0000

AlphaMissense

4409 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:25431135:C:A	R13S	1.000
1:25446793:T:A	W38R	1.000
1:25446793:T:C	W38R	1.000
1:25446814:G:C	D45H	1.000
1:25446833:G:C	R51T	1.000
1:25446833:G:T	R51I	1.000
1:25446847:T:A	W56R	1.000
1:25446847:T:C	W56R	1.000
1:25446860:T:C	L60P	1.000
1:25448880:T:A	W99R	1.000
1:25448880:T:C	W99R	1.000
1:25448893:C:A	A103D	1.000
1:25448896:C:A	A104D	1.000
1:25448898:A:C	S105R	1.000
1:25448900:C:A	S105R	1.000
1:25448900:C:G	S105R	1.000
1:25448910:T:A	W109R	1.000
1:25448910:T:C	W109R	1.000
1:25454291:T:A	W128R	1.000
1:25454291:T:C	W128R	1.000
1:25454373:C:A	A155D	1.000
1:25454376:C:A	A156D	1.000
1:25456657:G:A	G160R	1.000
1:25456657:G:C	G160R	1.000
1:25456657:G:T	G160W	1.000
1:25456658:G:A	G160E	1.000
1:25456749:C:A	N190K	1.000
1:25456749:C:G	N190K	1.000
1:25456766:T:C	L196P	1.000
1:25456769:T:C	L197P	1.000

dbSNP variants (sampled 300 via entrez): RS1000027457 (1:25473387 T>C), RS1000035283 (1:25453247 C>T), RS1000119056 (1:25487758 C>G,T), RS1000136193 (1:25453771 T>A), RS1000141693 (1:25466704 A>G), RS1000178436 (1:25477810 C>T), RS1000188058 (1:25435334 A>G), RS1000204440 (1:25487430 G>A), RS1000251887 (1:25478061 A>T), RS1000280780 (1:25494142 G>A,T), RS1000298179 (1:25439253 A>G), RS1000357654 (1:25479796 T>A), RS1000392691 (1:25439419 A>G), RS1000415051 (1:25484631 A>G), RS1000481582 (1:25435779 G>A)

Disease associations

OMIM: gene MIM:610301 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

22 associations (top):

Study	Trait	p-value
GCST000285_9	Cholesterol, total	5.000000e-10
GCST000759_33	LDL cholesterol	1.000000e-10
GCST000760_48	Cholesterol, total	4.000000e-11
GCST001120_4	Erythrocyte sedimentation rate	5.000000e-13
GCST006612_48	LDL cholesterol	6.000000e-12
GCST006614_112	Total cholesterol levels	6.000000e-11
GCST008077_22	LDL cholesterol levels	3.000000e-07
GCST008077_69	LDL cholesterol levels	3.000000e-09
GCST008078_10	LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df)	8.000000e-16
GCST008078_69	LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df)	9.000000e-21
GCST008079_144	LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df)	9.000000e-20
GCST008079_15	LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df)	3.000000e-16
GCST008086_41	LDL cholesterol levels in current drinkers	5.000000e-11
GCST008086_55	LDL cholesterol levels in current drinkers	8.000000e-13
GCST009366_56	LDL cholesterol levels x long total sleep time interaction (2df test)	1.000000e-12
GCST010204_95	Low density lipoprotein cholesterol levels	4.000000e-36
GCST010243_184	Apolipoprotein B levels	4.000000e-42
GCST010245_195	LDL cholesterol levels	2.000000e-35
GCST011347_1	Low density lipoprotein cholesterol levels	5.000000e-09
GCST90002387_193	Immature fraction of reticulocytes	1.000000e-55
GCST90002396_120	Mean reticulocyte volume	2.000000e-17
GCST90002397_620	Mean spheric corpuscular volume	7.000000e-24

EFO canonical traits (5, from GWAS)

EFO ID	Trait name
EFO:0004574	total cholesterol measurement
EFO:0004611	low density lipoprotein cholesterol measurement
EFO:0004329	alcohol drinking
EFO:0004615	apolipoprotein B measurement
EFO:0010701	mean reticulocyte volume

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067170 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB variants

1 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs10903129	MACO1		0.00	0

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
7.07	Kd	84.92	nM	CHEMBL3752910
7.04	ED50	91.96	nM	CHEMBL3752910

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(1-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2149955: Binding affinity to human TMEM57 incubated for 45 mins by Kinobead based pull down assay	kd	0.0849	uM

CTD chemical–gene interactions

37 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases expression	3
Valproic Acid	affects expression, decreases methylation	2
Cyclosporine	increases expression	2
GSK-J4	increases expression	1
FR900359	decreases phosphorylation	1
aminomethylphosphonic acid (AMPA)	increases expression	1
methylmercuric chloride	decreases expression	1
lasiocarpine	decreases expression	1
bisphenol A	affects cotreatment, increases methylation	1
beta-methylcholine	affects expression	1
perfluorooctane sulfonic acid	increases expression	1
(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	increases expression	1
Sunitinib	increases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Glyphosate	increases expression	1
Atrazine	increases expression	1
Vehicle Emissions	increases abundance, increases expression	1
Benzo(a)pyrene	increases methylation	1
Caffeine	affects phosphorylation	1
Calcitriol	increases expression	1
Demecolcine	increases expression	1
Drugs, Chinese Herbal	increases expression	1
Ethyl Methanesulfonate	increases expression	1
Formaldehyde	increases expression	1
Methyl Methanesulfonate	increases expression	1
Naled	affects expression	1
Naphthoquinones	increases expression	1
Thiram	increases expression	1
Tobacco Smoke Pollution	increases expression	1
Tunicamycin	increases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652997	Binding	Binding affinity to human TMEM57 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.