MACORIS

Summary

MACORIS (macrophage enriched lincRNA repressor of IFN-gamma signaling, HGNC:53963) is a long non-coding RNA gene on chromosome 10p11.22.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53963
Approved symbol	MACORIS
Name	macrophage enriched lincRNA repressor of IFN-gamma signaling
Location	10p11.22
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000237797
Ensembl biotype	lncRNA
Entrez	101929951
RNAcentral	URS00025EFA2B — lncRNA, 408 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 lncRNA

ENST00000433770, ENST00000702488, ENST00000775191, ENST00000775192, ENST00000775193

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000433770 — 2 exons

Exon	Start	End
ENSE00004141744	31707306	31707601
ENSE00004141748	31693027	31693347

Expression profiles

Bgee: expression breadth ubiquitous, 122 present calls, max score 82.07.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1815 / max 14.3536, expressed in 99 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
108967	0.1569	83
108968	0.0246	9

Top tissues by expression

122 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	82.07	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.06	gold quality
monocyte	CL:0000576	77.28	gold quality
leukocyte	CL:0000738	76.74	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	75.93	gold quality
substantia nigra	UBERON:0002038	75.43	gold quality
amygdala	UBERON:0001876	74.87	gold quality
Ammon’s horn	UBERON:0001954	73.37	gold quality
hypothalamus	UBERON:0001898	71.41	gold quality
anterior cingulate cortex	UBERON:0009835	71.40	gold quality
Brodmann (1909) area 9	UBERON:0013540	70.12	gold quality
duodenum	UBERON:0002114	69.92	gold quality
gall bladder	UBERON:0002110	69.82	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	69.58	gold quality
granulocyte	CL:0000094	69.46	gold quality
cerebral cortex	UBERON:0000956	69.45	gold quality
nucleus accumbens	UBERON:0001882	69.24	gold quality
lymph node	UBERON:0000029	68.75	gold quality
putamen	UBERON:0001874	68.72	gold quality
caudate nucleus	UBERON:0001873	68.48	gold quality
prefrontal cortex	UBERON:0000451	68.18	gold quality
frontal cortex	UBERON:0001870	67.24	gold quality
right frontal lobe	UBERON:0002810	66.90	gold quality
brain	UBERON:0000955	66.57	gold quality
bone marrow	UBERON:0002371	66.21	gold quality
urinary bladder	UBERON:0001255	64.62	gold quality
vermiform appendix	UBERON:0001154	63.87	gold quality
corpus callosum	UBERON:0002336	63.64	gold quality
muscle tissue	UBERON:0002385	63.28	gold quality
blood	UBERON:0000178	63.05	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.10

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.