MAD2L1-DT

Summary

MAD2L1-DT (MAD2L1 divergent transcript, HGNC:55546) is a long non-coding RNA gene on chromosome 4q27.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55546
Approved symbol	MAD2L1-DT
Name	MAD2L1 divergent transcript
Location	4q27
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000250938
Ensembl biotype	lncRNA
Entrez	121009649
RNAcentral	URS00026A20C0 — lncRNA, 1885 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 82 — 82 lncRNA

ENST00000503073, ENST00000504106, ENST00000508362, ENST00000511064, ENST00000653046, ENST00000686551, ENST00000691548, ENST00000693125, ENST00000693300, ENST00000700800, ENST00000701263, ENST00000701838, ENST00000740075, ENST00000740573, ENST00000740574, ENST00000740575, ENST00000740576, ENST00000740577, ENST00000740578, ENST00000740579, ENST00000740580, ENST00000740581, ENST00000740582, ENST00000740583, ENST00000740584, ENST00000740585, ENST00000740586, ENST00000740587, ENST00000740588, ENST00000740589, ENST00000740590, ENST00000740591, ENST00000740592, ENST00000740593, ENST00000740594, ENST00000740595, ENST00000740596, ENST00000740597, ENST00000740598, ENST00000740599, ENST00000740600, ENST00000740601, ENST00000740602, ENST00000740603, ENST00000740604, ENST00000740605, ENST00000740606, ENST00000740607, ENST00000740608, ENST00000740609, ENST00000740610, ENST00000740611, ENST00000740612, ENST00000740613, ENST00000740614, ENST00000740615, ENST00000740616, ENST00000740617, ENST00000740618, ENST00000740619, ENST00000740620, ENST00000740621, ENST00000740622, ENST00000740623, ENST00000740624, ENST00000740625, ENST00000740626, ENST00000740627, ENST00000740628, ENST00000740629, ENST00000740630, ENST00000740631, ENST00000740632, ENST00000740633, ENST00000740634, ENST00000740635, ENST00000740636, ENST00000740637, ENST00000740638, ENST00000740639, ENST00000740640, ENST00000740641

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000503073 — 2 exons

Exon	Start	End
ENSE00002019084	120066958	120067001
ENSE00002075449	120083285	120085579

Expression profiles

Bgee: expression breadth ubiquitous, 129 present calls, max score 83.94.

Top tissues by expression

129 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.94	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.99	gold quality
skeletal muscle tissue	UBERON:0001134	71.82	gold quality
muscle of leg	UBERON:0001383	70.79	gold quality
gastrocnemius	UBERON:0001388	70.61	gold quality
hindlimb stylopod muscle	UBERON:0004252	70.02	gold quality
calcaneal tendon	UBERON:0003701	69.10	gold quality
cortical plate	UBERON:0005343	68.14	gold quality
corpus callosum	UBERON:0002336	67.20	gold quality
ganglionic eminence	UBERON:0004023	66.85	gold quality
bone marrow cell	CL:0002092	66.79	silver quality
heart left ventricle	UBERON:0002084	66.61	gold quality
right atrium auricular region	UBERON:0006631	66.22	gold quality
heart	UBERON:0000948	66.08	gold quality
right coronary artery	UBERON:0001625	65.48	gold quality
smooth muscle tissue	UBERON:0001135	65.24	gold quality
lymph node	UBERON:0000029	64.73	gold quality
popliteal artery	UBERON:0002250	63.87	gold quality
tibial artery	UBERON:0007610	63.85	gold quality
right uterine tube	UBERON:0001302	63.47	gold quality
islet of Langerhans	UBERON:0000006	63.41	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	63.41	gold quality
tonsil	UBERON:0002372	63.00	gold quality
stromal cell of endometrium	CL:0002255	62.81	gold quality
endometrium	UBERON:0001295	62.61	gold quality
ventricular zone	UBERON:0003053	62.06	gold quality
left coronary artery	UBERON:0001626	61.74	gold quality
primary visual cortex	UBERON:0002436	61.63	gold quality
lower esophagus muscularis layer	UBERON:0035833	61.39	gold quality
lower esophagus	UBERON:0013473	61.32	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.61

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.