MAFG-AS1

Summary

MAFG-AS1 (MAFG antisense RNA 1, HGNC:56705) is a long non-coding RNA gene on chromosome 17q25.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:56705
Approved symbol	MAFG-AS1
Name	MAFG antisense RNA 1
Location	17q25.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000264769
Ensembl biotype	lncRNA
Entrez	128385369
RNAcentral	URS000010288B — lncRNA, 563 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000580897

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580897 — 3 exons

Exon	Start	End
ENSE00002690201	81922899	81923232
ENSE00002700774	81924079	81924214
ENSE00002717405	81924419	81924511

Expression profiles

Bgee: expression breadth ubiquitous, 124 present calls, max score 83.29.

Top tissues by expression

124 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	83.29	gold quality
bone marrow	UBERON:0002371	74.05	gold quality
monocyte	CL:0000576	72.99	gold quality
leukocyte	CL:0000738	71.78	gold quality
bone marrow cell	CL:0002092	71.76	silver quality
mucosa of stomach	UBERON:0001199	69.69	gold quality
hindlimb stylopod muscle	UBERON:0004252	68.33	gold quality
duodenum	UBERON:0002114	66.95	gold quality
blood	UBERON:0000178	66.52	gold quality
skeletal muscle tissue	UBERON:0001134	66.27	gold quality
muscle of leg	UBERON:0001383	65.27	gold quality
gastrocnemius	UBERON:0001388	65.01	gold quality
gall bladder	UBERON:0002110	64.96	gold quality
vermiform appendix	UBERON:0001154	64.95	gold quality
esophagus mucosa	UBERON:0002469	62.69	gold quality
granulocyte	CL:0000094	62.09	gold quality
left adrenal gland cortex	UBERON:0035825	62.03	gold quality
left uterine tube	UBERON:0001303	61.74	gold quality
upper lobe of left lung	UBERON:0008952	61.69	gold quality
esophagus	UBERON:0001043	61.67	gold quality
body of stomach	UBERON:0001161	61.49	gold quality
left adrenal gland	UBERON:0001234	61.40	gold quality
stromal cell of endometrium	CL:0002255	61.35	gold quality
lymph node	UBERON:0000029	61.30	gold quality
lung	UBERON:0002048	61.16	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	61.15	gold quality
omental fat pad	UBERON:0010414	61.13	gold quality
urinary bladder	UBERON:0001255	61.05	gold quality
placenta	UBERON:0001987	60.94	gold quality
stomach	UBERON:0000945	60.92	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.13

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Carcinogenic roles of MAFG-AS1 in human cancers. (PMID:37351806)
• Transcription factor ETV1-induced lncRNA MAFG-AS1 promotes migration, invasion, and epithelial-mesenchymal transition of pancreatic cancer cells by recruiting IGF2BP2 to stabilize ETV1 expression. (PMID:37428861)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.