MAFTRR

Summary

MAFTRR (MAF transcriptional regulator RNA, HGNC:51525) is a long non-coding RNA gene on chromosome 16q23.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51525
Approved symbol	MAFTRR
Name	MAF transcriptional regulator RNA
Location	16q23.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	linc-MAF-4
Ensembl gene	ENSG00000261390
Ensembl biotype	lncRNA
OMIM	616264
Entrez	102467146
RNAcentral	URS00003CD6E9 — lncRNA, 685 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 68 — 68 lncRNA

ENST00000562921, ENST00000566729, ENST00000567993, ENST00000568389, ENST00000654454, ENST00000657613, ENST00000658463, ENST00000662553, ENST00000668946, ENST00000669528, ENST00000670969, ENST00000685222, ENST00000689799, ENST00000691736, ENST00000692854, ENST00000693525, ENST00000700877, ENST00000701022, ENST00000701820, ENST00000702060, ENST00000766536, ENST00000766537, ENST00000766538, ENST00000766539, ENST00000766540, ENST00000766541, ENST00000766542, ENST00000766543, ENST00000766544, ENST00000766545, ENST00000766546, ENST00000766547, ENST00000766548, ENST00000766549, ENST00000766550, ENST00000766551, ENST00000766552, ENST00000766553, ENST00000766554, ENST00000766555, ENST00000766556, ENST00000766557, ENST00000766558, ENST00000766559, ENST00000766560, ENST00000766561, ENST00000766562, ENST00000766563, ENST00000766564, ENST00000766565, ENST00000766566, ENST00000766567, ENST00000766568, ENST00000766569, ENST00000766570, ENST00000766571, ENST00000766572, ENST00000766573, ENST00000766574, ENST00000766575, ENST00000766576, ENST00000766577, ENST00000766578, ENST00000766579, ENST00000766580, ENST00000766581, ENST00000766582, ENST00000766583

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000562921 — 4 exons

Exon	Start	End
ENSE00002589383	79770447	79770566
ENSE00002604150	79751214	79751276
ENSE00002625947	79769153	79769222
ENSE00003865362	79715220	79716840

Expression profiles

Bgee: expression breadth ubiquitous, 127 present calls, max score 86.02.

FANTOM5 (CAGE): breadth broad, TPM avg 1.7374 / max 43.0608, expressed in 713 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
158236	0.7087	389
158234	0.6098	297
158235	0.4190	247

Top tissues by expression

127 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.02	gold quality
sural nerve	UBERON:0015488	80.18	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	70.36	gold quality
skeletal muscle tissue	UBERON:0001134	70.33	gold quality
left adrenal gland cortex	UBERON:0035825	67.96	gold quality
skin of leg	UBERON:0001511	67.95	gold quality
right adrenal gland cortex	UBERON:0035827	67.93	gold quality
zone of skin	UBERON:0000014	67.50	gold quality
muscle tissue	UBERON:0002385	67.36	gold quality
left adrenal gland	UBERON:0001234	67.26	gold quality
left ovary	UBERON:0002119	66.66	gold quality
duodenum	UBERON:0002114	66.62	gold quality
skin of abdomen	UBERON:0001416	66.48	gold quality
ovary	UBERON:0000992	66.45	gold quality
mucosa of transverse colon	UBERON:0004991	66.29	gold quality
right adrenal gland	UBERON:0001233	66.13	gold quality
adrenal gland	UBERON:0002369	65.46	gold quality
liver	UBERON:0002107	64.44	gold quality
right ovary	UBERON:0002118	64.32	gold quality
lower esophagus mucosa	UBERON:0035834	63.59	gold quality
tibial nerve	UBERON:0001323	63.19	gold quality
smooth muscle tissue	UBERON:0001135	62.45	gold quality
body of uterus	UBERON:0009853	62.43	gold quality
tibial artery	UBERON:0007610	62.03	gold quality
popliteal artery	UBERON:0002250	62.02	gold quality
lymph node	UBERON:0000029	61.97	gold quality
right lobe of liver	UBERON:0001114	61.51	gold quality
myometrium	UBERON:0001296	61.34	gold quality
monocyte	CL:0000576	61.29	gold quality
urinary bladder	UBERON:0001255	61.22	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.98

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Investigation of Linc-MAF-4 expression as an effective marker in brucellosis. (PMID:32417631)
• Elevated Expression of the Long Noncoding RNA MAFTRR in Patients with Hashimoto’s Thyroiditis. (PMID:34869781)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.