MAGI2-AS3

Summary

MAGI2-AS3 (MAGI2 antisense RNA 3, HGNC:40862) is a long non-coding RNA gene on chromosome 7q21.11.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40862
Approved symbol	MAGI2-AS3
Name	MAGI2 antisense RNA 3
Location	7q21.11
Locus type	RNA, long non-coding
Status	Approved
Aliases	ENST00000414797
Ensembl gene	ENSG00000234456
Ensembl biotype	lncRNA
Entrez	100505881
RNAcentral	URS0000759965 — lncRNA, 8498 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 62 — 52 lncRNA, 10 retained_intron

ENST00000414797, ENST00000422093, ENST00000424477, ENST00000426835, ENST00000429408, ENST00000435749, ENST00000442765, ENST00000446159, ENST00000448195, ENST00000448636, ENST00000451809, ENST00000452320, ENST00000611793, ENST00000612203, ENST00000612949, ENST00000613867, ENST00000613892, ENST00000614953, ENST00000616192, ENST00000616796, ENST00000617955, ENST00000618186, ENST00000618603, ENST00000619135, ENST00000621901, ENST00000629211, ENST00000653779, ENST00000654732, ENST00000655337, ENST00000655795, ENST00000657546, ENST00000660878, ENST00000661940, ENST00000663422, ENST00000663669, ENST00000664666, ENST00000666657, ENST00000667103, ENST00000667729, ENST00000667881, ENST00000667887, ENST00000667893, ENST00000668474, ENST00000668746, ENST00000669576, ENST00000682311, ENST00000683157, ENST00000683943, ENST00000849244, ENST00000849245, ENST00000849246, ENST00000849247, ENST00000849248, ENST00000849249, ENST00000849250, ENST00000849251, ENST00000849252, ENST00000849253, ENST00000849254, ENST00000849255, ENST00000849256, ENST00000849257

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000414797 — 5 exons

Exon	Start	End
ENSE00001681309	79458847	79458999
ENSE00001708938	79470594	79470679
ENSE00001770052	79454886	79455007
ENSE00003987725	79470783	79471208
ENSE00004279537	79453930	79454244

Expression profiles

Bgee: expression breadth ubiquitous, 248 present calls, max score 98.32.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 11.6479 / max 125.2706, expressed in 1334 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
79233	5.5841	1211
79234	5.5217	1113
204501	0.3876	222
79232	0.1546	68

Top tissues by expression

254 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	98.32	gold quality
cerebellar hemisphere	UBERON:0002245	96.30	gold quality
right hemisphere of cerebellum	UBERON:0014890	96.20	gold quality
cerebellar cortex	UBERON:0002129	96.04	gold quality
right atrium auricular region	UBERON:0006631	95.14	gold quality
cardiac muscle of right atrium	UBERON:0003379	95.01	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	94.92	gold quality
cardiac atrium	UBERON:0002081	94.87	gold quality
left ovary	UBERON:0002119	94.69	gold quality
kidney epithelium	UBERON:0004819	94.68	gold quality
cerebellum	UBERON:0002037	94.65	gold quality
right ovary	UBERON:0002118	94.44	gold quality
lower esophagus muscularis layer	UBERON:0035833	94.44	gold quality
right coronary artery	UBERON:0001625	94.41	gold quality
lower esophagus	UBERON:0013473	94.40	gold quality
left coronary artery	UBERON:0001626	94.28	gold quality
descending thoracic aorta	UBERON:0002345	94.11	gold quality
stromal cell of endometrium	CL:0002255	94.02	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	93.93	gold quality
tibial artery	UBERON:0007610	93.78	gold quality
popliteal artery	UBERON:0002250	93.77	gold quality
tibial nerve	UBERON:0001323	93.73	gold quality
thoracic aorta	UBERON:0001515	93.64	gold quality
aorta	UBERON:0000947	93.63	gold quality
ascending aorta	UBERON:0001496	93.62	gold quality
spinal cord	UBERON:0002240	93.61	gold quality
oocyte	CL:0000023	93.60	gold quality
omental fat pad	UBERON:0010414	93.59	gold quality
peritoneum	UBERON:0002358	93.56	gold quality
mucosa of stomach	UBERON:0001199	93.54	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-CURD-119	yes	33.60
E-ANND-3	yes	13.83

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 27)

• our data revealed that lncRNA MAGI2-AS3 is involved in breast cancer cell progression by regulating the miR-374a-PTEN axis. (PMID:30883342)
• a functional MAGI2-AS3/miR-374b-5p/SMG1 axis that suppresses hepatocellular cancer progression, is reported. (PMID:30924168)
• Expression of long non-coding RNA MAGI2AS3 in human gliomas and its prognostic significance. (PMID:31081100)
• LncRNA MAGI2-AS3 suppresses the proliferation and invasion of non-small cell lung carcinoma through miRNA-23a-3p/PTEN axis. (PMID:31539127)
• Long noncoding MAGI2-AS3 promotes colorectal cancer progression through regulating miR-3163/TMEM106B axis. (PMID:31709544)
• LncRNA MAGI2-AS3 Upregulates Cytokine Signaling 1 by Sponging miR-155 in Non-Small Cell Lung Cancer. (PMID:31910343)
• LncRNA MAGI2-AS3 is down-regulated in intervertebral disc degeneration and participates in the regulation of FasL expression in nucleus pulposus cells. (PMID:32143617)
• LncRNA MAGI2-AS3 inhibits the self-renewal of leukaemic stem cells by promoting TET2-dependent DNA demethylation of the LRIG1 promoter in acute myeloid leukaemia. (PMID:32174258)
• MAGI2-AS3 rs7783388 polymorphism contributes to colorectal cancer risk through altering the binding affinity of the transcription factor GR to the MAGI2-AS3 promoter. (PMID:32533587)
• LncRNA MAGI2-AS3 is downregulated in the distant recurrence of hepatocellular carcinoma after surgical resection and affects migration and invasion via ROCK2. (PMID:32546442)
• MAGI2-AS3 suppresses MYC signaling to inhibit cell proliferation and migration in ovarian cancer through targeting miR-525-5p/MXD1 axis. (PMID:32681706)
• MAGI2-AS3 inhibits breast cancer by downregulating DNA methylation of MAGI2. (PMID:32730644)
• Long noncoding RNA MAGI2-AS3 inhibits bladder cancer progression through MAGI2/PTEN/epithelial-mesenchymal transition (EMT) axis. (PMID:33104021)
• LncRNA MAGI2-AS3 inhibits bladder cancer progression by targeting the miR-31-5p/TNS1 axis. (PMID:33231563)
• LncRNA MAGI2-AS3 inhibits tumor progression and angiogenesis by regulating ACY1 via interacting with transcription factor HEY1 in clear cell renal cell carcinoma. (PMID:34002044)
• Roles of lncRNA MAGI2-AS3 in human cancers. (PMID:34126355)
• MicroRNA MiR-490-5p suppresses pancreatic cancer through regulating epithelial-mesenchymal transition via targeting MAGI2 antisense RNA 3. (PMID:35043728)
• Long noncoding RNA MAGI2-AS3 regulates the H2O2 level and cell senescence via HSPA8. (PMID:35797800)
• LncRNA MAGI2-AS3 Inhibits Prostate Cancer Progression by Targeting the miR-142-3p. (PMID:35944561)
• Hypermethylation-Mediated lncRNA MAGI2-AS3 Downregulation Facilitates Malignant Progression of Laryngeal Squamous Cell Carcinoma via Interacting With SPT6. (PMID:36852700)
• MAGI2-AS3 and miR-374b-5p as Putative Regulators of Multiple Sclerosis via Modulating the PTEN/AKT/IRF-3/IFN-beta Axis: New Clinical Insights. (PMID:36878000)
• lncRNA MAGI2-AS3 suppresses castration-resistant prostate cancer proliferation and migration via the miR-106a-5p/RAB31 axis. (PMID:36889366)
• Role of lncRNA MAGI2-AS3 in lipopolysaccharide-induced nucleus pulposus cells injury by regulating miR-374b-5p/interleukin-10 axis. (PMID:37102649)
• Role of MAGI2-AS3 in malignant and non-malignant disorders. (PMID:37196468)
• Long Noncoding RNA MAGI2-AS3 Represses Cell Progression in Clear Cell Renal Cell Carcinoma by Modulating the miR-629-5p/PRDM16 Axis. (PMID:37602452)
• Long non-coding RNAs PTENP1, GNG12-AS1, MAGI2-AS3 and MEG3 as tumor suppressors in breast cancer and their associations with clinicopathological parameters. (PMID:38277283)
• LncRNA MAGI2-AS3 promotes fracture healing through downregulation of miR-223-3p. (PMID:38907263)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.