MAGOHB

Summary

MAGOHB (mago homolog B, exon junction complex subunit, HGNC:25504) is a protein-coding gene on chromosome 12p13.2, encoding Protein mago nashi homolog 2 (Q96A72). Required for pre-mRNA splicing as component of the spliceosome.

Enables RNA binding activity. Involved in mRNA splicing, via spliceosome and nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Located in nucleus. Part of U2-type catalytic step 1 spliceosome; U2-type precatalytic spliceosome; and exon-exon junction subcomplex mago-y14.

Source: NCBI Gene 55110 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 35 total
• MANE Select transcript: NM_018048

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25504
Approved symbol	MAGOHB
Name	mago homolog B, exon junction complex subunit
Location	12p13.2
Locus type	gene with protein product
Status	Approved
Aliases	FLJ10292, MGN2
Ensembl gene	ENSG00000111196
Ensembl biotype	protein_coding
OMIM	619552
Entrez	55110

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 5 protein_coding, 5 nonsense_mediated_decay, 3 retained_intron

ENST00000320756, ENST00000398874, ENST00000537852, ENST00000539554, ENST00000540074, ENST00000543929, ENST00000544176, ENST00000544850, ENST00000545236, ENST00000546173, ENST00000625272, ENST00000903320, ENST00000939461

RefSeq mRNA: 3 — MANE Select: NM_018048 NM_001300739, NM_001319985, NM_018048

CCDS: CCDS76532, CCDS8628

Canonical transcript exons

ENST00000320756 — 5 exons

Exon	Start	End
ENSE00002290598	10613439	10613609
ENSE00003541466	10609831	10609941
ENSE00003551921	10607854	10607936
ENSE00003593392	10610622	10610680
ENSE00003751297	10604193	10606374

Expression profiles

Bgee: expression breadth ubiquitous, 210 present calls, max score 92.72.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 30.0767 / max 975.0310, expressed in 1810 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
129533	15.7584	1789
129534	14.3183	1792

Top tissues by expression

264 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	92.72	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	91.89	gold quality
ganglionic eminence	UBERON:0004023	90.91	gold quality
ventricular zone	UBERON:0003053	90.43	gold quality
stromal cell of endometrium	CL:0002255	89.61	gold quality
sural nerve	UBERON:0015488	89.49	gold quality
islet of Langerhans	UBERON:0000006	89.06	gold quality
cortical plate	UBERON:0005343	88.55	gold quality
monocyte	CL:0000576	88.32	gold quality
mononuclear cell	CL:0000842	88.10	gold quality
leukocyte	CL:0000738	88.02	gold quality
rectum	UBERON:0001052	87.70	gold quality
adenohypophysis	UBERON:0002196	87.03	gold quality
mucosa of transverse colon	UBERON:0004991	86.80	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	86.77	gold quality
right lobe of liver	UBERON:0001114	86.03	gold quality
body of pancreas	UBERON:0001150	86.01	gold quality
adrenal tissue	UBERON:0018303	85.39	gold quality
pancreas	UBERON:0001264	85.33	gold quality
ectocervix	UBERON:0012249	85.28	gold quality
left coronary artery	UBERON:0001626	85.23	gold quality
lower esophagus mucosa	UBERON:0035834	85.08	gold quality
body of uterus	UBERON:0009853	85.07	gold quality
colonic epithelium	UBERON:0000397	84.97	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	84.78	gold quality
endocervix	UBERON:0000458	84.76	gold quality
right adrenal gland	UBERON:0001233	84.73	gold quality
left ovary	UBERON:0002119	84.72	gold quality
left adrenal gland	UBERON:0001234	84.52	gold quality
pituitary gland	UBERON:0000007	84.51	gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-HCAD-13	yes	19.96
E-ANND-3	yes	6.42
E-MTAB-6379	no	705.81
E-GEOD-124858	no	169.23

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): KMT2A

miRNA regulators (miRDB)

110 targeting MAGOHB, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-29A-3P	100.00	73.11	1835
HSA-MIR-29B-3P	100.00	73.18	1833
HSA-MIR-29C-3P	100.00	73.15	1833
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-539-3P	99.98	70.74	1616
HSA-MIR-485-3P	99.98	70.68	1585
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-23A-3P	99.95	74.24	3163
HSA-MIR-23B-3P	99.95	74.24	3163
HSA-MIR-23C	99.95	73.92	3192
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-144-3P	99.94	73.98	2698
HSA-MIR-539-5P	99.93	70.30	2855

Literature-anchored findings (GeneRIF, showing 2)

• findings show 2 genes MAGOH and MAGOHB are expressed in mammals; in macrophages, expression of MAGOHB but not MAGOH mRNA increases after LPS stimulation; both MAGOH proteins interact with other exon junction complex (EJC) components, incorporate into mRNA-bound EJCs and activate nonsense-mediated decay (PMID:23917022)
• MAGOH and MAGOHB Knockdown in Melanoma Cells Decreases Nonsense-Mediated Decay Activity and Promotes Apoptosis via Upregulation of GADD45A. (PMID:36497117)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	magoh	ENSDARG00000038635
mus_musculus	Magohb	ENSMUSG00000030188
rattus_norvegicus	Magohb	ENSRNOG00000010316
drosophila_melanogaster	mago	FBGN0002736
caenorhabditis_elegans	mag-1	WBGENE00003123

Paralogs (1): MAGOH (ENSG00000162385)

Protein

Protein identifiers

Protein mago nashi homolog 2 — Q96A72 (reviewed: Q96A72)

All UniProt accessions (6): Q96A72, A0A023T6R1, F5H124, F5H3U9, F5H6N1, F5H6P7

UniProt curated annotations — full annotation on UniProt →

Function. Required for pre-mRNA splicing as component of the spliceosome. Plays a redundant role with MAGOH in the exon junction complex and in the nonsense-mediated decay (NMD) pathway.

Subunit / interactions. Component of the pre-catalytic, catalytic and post-catalytic spliceosome complexes. Heterodimer with RBM8A. Core component of the mRNA splicing-dependent exon junction complex (EJC); the core complex contains CASC3, EIF4A3, MAGOH or MAGOHB, and RBM8A.

Subcellular location. Nucleus.

Tissue specificity. Ubiquitous.

Similarity. Belongs to the mago nashi family.

RefSeq proteins (3): NP_001287668, NP_001306914, NP_060518* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR004023	Mago_nashi	Family
IPR036605	Mago_nashi_sf	Homologous_superfamily

Pfam: PF02792

UniProt features (16 total): strand 7, helix 5, initiator methionine 1, chain 1, modified residue 1, sequence variant 1

Structure

Experimental structures (PDB)

4 structures.

PDB	Method	Resolution (Å)
6ICZ	ELECTRON MICROSCOPY	3
6QDV	ELECTRON MICROSCOPY	3.3
5XJC	ELECTRON MICROSCOPY	3.6
5YZG	ELECTRON MICROSCOPY	4.1

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96A72-F1	93.61	0.86

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 2

Function

Pathways and Gene Ontology

Reactome pathways

17 pathways

ID	Pathway
R-HSA-159236	Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72163	mRNA Splicing - Major Pathway
R-HSA-72187	mRNA 3’-end processing
R-HSA-9010553	Regulation of expression of SLITs and ROBOs
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
R-HSA-73856	RNA Polymerase II Transcription Termination
R-HSA-1266738	Developmental Biology
R-HSA-376176	Signaling by ROBO receptors
R-HSA-422475	Axon guidance
R-HSA-72172	mRNA Splicing
R-HSA-72202	Transport of Mature Transcript to Cytoplasm
R-HSA-72203	Processing of Capped Intron-Containing Pre-mRNA
R-HSA-73857	RNA Polymerase II Transcription
R-HSA-74160	Gene expression (Transcription)
R-HSA-8953854	Metabolism of RNA
R-HSA-927802	Nonsense-Mediated Decay (NMD)
R-HSA-9675108	Nervous system development

MSigDB gene sets: 244 (showing top): GOBP_REGULATION_OF_MRNA_CATABOLIC_PROCESS, SHEPARD_CRASH_AND_BURN_MUTANT_UP, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, GOBP_NUCLEAR_TRANSPORT, KESHELAVA_MULTIPLE_DRUG_RESISTANCE, MARTINEZ_RB1_TARGETS_DN, GOBP_REGULATION_OF_CATABOLIC_PROCESS, KORKOLA_EMBRYONAL_CARCINOMA_UP, REACTOME_MRNA_3_END_PROCESSING, REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA, RAHMAN_TP53_TARGETS_PHOSPHORYLATED, GOBP_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT, GOBP_RNA_SPLICING

GO Biological Process (8): nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184), mRNA splicing, via spliceosome (GO:0000398), mRNA export from nucleus (GO:0006406), RNA splicing (GO:0008380), regulation of mRNA processing (GO:0050684), regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:2000622), mRNA processing (GO:0006397), mRNA transport (GO:0051028)

GO Molecular Function (2): RNA binding (GO:0003723), protein binding (GO:0005515)

GO Cellular Component (10): nucleus (GO:0005634), nucleoplasm (GO:0005654), cytosol (GO:0005829), exon-exon junction complex (GO:0035145), neuronal cell body (GO:0043025), U2-type precatalytic spliceosome (GO:0071005), U2-type catalytic step 1 spliceosome (GO:0071006), catalytic step 2 spliceosome (GO:0071013), exon-exon junction subcomplex mago-y14 (GO:1990501), spliceosomal complex (GO:0005681)

Reactome top-level categories

Rollup of top-11 pathways:

Category	Pathways
Processing of Capped Intron-Containing Pre-mRNA	3
Metabolism of RNA	2
Transport of Mature Transcript to Cytoplasm	1
mRNA Splicing	1
Signaling by ROBO receptors	1
Nonsense-Mediated Decay (NMD)	1
RNA Polymerase II Transcription	1
Axon guidance	1
Nervous system development	1
Gene expression (Transcription)	1
Developmental Biology	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
mRNA processing	2
RNA processing	2
cellular anatomical structure	2
nuclear protein-containing complex	2
U2-type spliceosomal complex	2
U2 snRNP	2
nuclear-transcribed mRNA catabolic process	1
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	1
RNA export from nucleus	1
gene expression	1
mRNA transport	1
regulation of mRNA metabolic process	1
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	1
regulation of mRNA catabolic process	1
mRNA metabolic process	1
RNA transport	1
nucleic acid binding	1
binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
cytoplasm	1
somatodendritic compartment	1
cell body	1
U1 snRNP	1
U4/U6 x U5 tri-snRNP complex	1
precatalytic spliceosome	1
U6 snRNP	1
catalytic step 1 spliceosome	1
Prp19 complex	1
spliceosomal complex	1
U5 snRNP	1
catalytic complex	1
exon-exon junction complex	1
ATPase inhibitor complex	1
ribonucleoprotein complex	1

Protein interactions and networks

STRING

1914 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MAGOHB	CASC3	O15234	999
MAGOHB	EIF4A3	P38919	999
MAGOHB	RBM8A	Q9Y5S9	999
MAGOHB	UPF3A	Q9H1J1	969
MAGOHB	PYM1	Q9BRP8	964
MAGOHB	UPF3B	Q9BZI7	962
MAGOHB	RNPS1	Q15287	960
MAGOHB	ALYREF	Q86V81	894
MAGOHB	EIF4A1	P04765	868
MAGOHB	UPF1	Q92900	846
MAGOHB	SRRM1	Q8IYB3	813
MAGOHB	UPF2	Q9HAU5	808
MAGOHB	EIF4A2	Q14240	801
MAGOHB	DDX39B	Q13838	771
MAGOHB	NCBP1	Q09161	752

IntAct

290 interactions, top by confidence:

A	B	Type	Score
MAGOHB	RBM8A	psi-mi:“MI:0915”(physical association)	0.890
IKZF3	MAGOHB	psi-mi:“MI:0915”(physical association)	0.780
MAGOHB	IKZF3	psi-mi:“MI:0915”(physical association)	0.780
MAGOHB	CCDC102B	psi-mi:“MI:0915”(physical association)	0.720
MAGOHB	GOLGA2	psi-mi:“MI:0915”(physical association)	0.720
CALCOCO2	MAGOHB	psi-mi:“MI:0915”(physical association)	0.720
ZNF398	MAGOHB	psi-mi:“MI:0915”(physical association)	0.720
CCDC102B	MAGOHB	psi-mi:“MI:0915”(physical association)	0.720
MAGOHB	CALCOCO2	psi-mi:“MI:0915”(physical association)	0.720
MAGOHB	ZNF398	psi-mi:“MI:0915”(physical association)	0.720
GOLGA2	MAGOHB	psi-mi:“MI:0915”(physical association)	0.720
MAGOHB	AMOTL2	psi-mi:“MI:0915”(physical association)	0.670
MAGOHB	HMG20A	psi-mi:“MI:0915”(physical association)	0.670
MAGOHB	TRIM42	psi-mi:“MI:0915”(physical association)	0.560
MAGOHB	ZNF250	psi-mi:“MI:0915”(physical association)	0.560
MAGOHB	TCF4	psi-mi:“MI:0915”(physical association)	0.560
MAGOHB	RBMX	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (201): MAGOHB (Two-hybrid), MAGOHB (Two-hybrid), MAGOHB (Two-hybrid), MAGOHB (Two-hybrid), MAGOHB (Two-hybrid), MAGOHB (Two-hybrid), MAGOHB (Two-hybrid), MAGOHB (Two-hybrid), MAGOHB (Two-hybrid), MAGOHB (Two-hybrid), ZNF398 (Two-hybrid), ZNF250 (Two-hybrid), CCDC102B (Two-hybrid), KRT40 (Two-hybrid), TRIM42 (Two-hybrid)

ESM2 similar proteins: A0A0P0XB70, A3DGF9, A5VPY5, A6X1N2, A9CJB1, A9MAI1, B0CLD1, B2J6S5, B2S545, B9ENE7, B9JVE7, C0RIE1, F1SVL1, O23676, O28269, O34834, O42149, O43037, O65806, P40207, P41063, P49028, P49029, P49030, P50594, P59327, P61326, P61327, Q0VC92, Q10YT5, Q11JK4, Q163Q2, Q27W02, Q2YNC7, Q39QA9, Q3ZBV3, Q55E21, Q566Y8, Q57DU9, Q5LPR5

Diamond homologs: A0A0P0XB70, B9ENE7, O23676, O42149, O43037, O65806, P49028, P49029, P49030, P50594, P61326, P61327, Q0VC92, Q27W02, Q3ZBV3, Q55E21, Q566Y8, Q96A72, Q9CQL1

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 87 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Processing of Capped Intron-Containing Pre-mRNA	6	10.7×	3e-03
mRNA Splicing - Major Pathway	6	7.1×	9e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

35 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	16
Likely benign	0
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

993 predictions. Top by Δscore:

Variant	Effect	Δscore
12:10607852:A:AC	donor_gain	1.0000
12:10607853:C:CC	donor_gain	1.0000
12:10609827:AAACC:A	donor_loss	1.0000
12:10609828:AAC:A	donor_loss	1.0000
12:10609829:A:AC	donor_gain	1.0000
12:10609830:C:CC	donor_gain	1.0000
12:10609830:C:G	donor_loss	1.0000
12:10609937:TAAGC:T	acceptor_gain	1.0000
12:10609938:AAGC:A	acceptor_gain	1.0000
12:10609939:AGC:A	acceptor_gain	1.0000
12:10609940:GCC:G	acceptor_loss	1.0000
12:10609942:C:CC	acceptor_gain	1.0000
12:10609942:CTA:C	acceptor_loss	1.0000
12:10609943:T:A	acceptor_loss	1.0000
12:10610617:CTTA:C	donor_loss	1.0000
12:10610618:TTA:T	donor_loss	1.0000
12:10610619:TA:T	donor_loss	1.0000
12:10610620:A:AC	donor_gain	1.0000
12:10610620:A:T	donor_loss	1.0000
12:10610620:ACCT:A	donor_gain	1.0000
12:10610621:C:CA	donor_loss	1.0000
12:10610621:C:CC	donor_gain	1.0000
12:10610621:CCT:C	donor_gain	1.0000
12:10610621:CCTC:C	donor_gain	1.0000
12:10610676:CTTTC:C	acceptor_gain	1.0000
12:10610677:TTTC:T	acceptor_gain	1.0000
12:10610679:TCC:T	acceptor_loss	1.0000
12:10610681:C:CC	acceptor_gain	1.0000
12:10610690:G:GC	acceptor_gain	1.0000
12:10613401:C:A	donor_gain	1.0000

AlphaMissense

986 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:10606282:G:T	P147Q	1.000
12:10606283:G:A	P147S	1.000
12:10606290:C:A	K144N	1.000
12:10606290:C:G	K144N	1.000
12:10606293:G:C	F143L	1.000
12:10606293:G:T	F143L	1.000
12:10606295:A:G	F143L	1.000
12:10606309:A:G	L138P	1.000
12:10606311:A:C	S137R	1.000
12:10606311:A:T	S137R	1.000
12:10606313:T:G	S137R	1.000
12:10606318:A:T	V135D	1.000
12:10606323:A:C	C133W	1.000
12:10606325:A:G	C133R	1.000
12:10606326:T:A	K132N	1.000
12:10606326:T:G	K132N	1.000
12:10606327:T:A	K132I	1.000
12:10606360:A:G	L121P	1.000
12:10606363:C:T	G120D	1.000
12:10606364:C:G	G120R	1.000
12:10607866:A:T	V112E	1.000
12:10607881:C:T	G107D	1.000
12:10607882:C:G	G107R	1.000
12:10607886:T:A	K105N	1.000
12:10607886:T:G	K105N	1.000
12:10607887:T:A	K105I	1.000
12:10607888:T:C	K105E	1.000
12:10607899:A:G	F101S	1.000
12:10607930:C:T	E91K	1.000
12:10607932:A:G	L90P	1.000

dbSNP variants (sampled 300 via entrez): RS1000139915 (12:10615058 C>G), RS1000323101 (12:10599727 T>C), RS1000426790 (12:10614576 G>A,T), RS1000609898 (12:10599499 G>A,C), RS1000835038 (12:10610146 C>T), RS1000990070 (12:10610454 G>A,T), RS1001078142 (12:10603531 C>A), RS1001184863 (12:10614828 G>A,C), RS1001467364 (12:10601319 C>G), RS1001493014 (12:10602667 A>T), RS1001659776 (12:10607221 G>A), RS1001700288 (12:10608609 A>AC), RS1002215849 (12:10613643 G>A), RS1002303093 (12:10610038 G>A), RS1002347273 (12:10602371 C>A,T)

Disease associations

OMIM: gene MIM:619552 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

32 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects splicing, decreases expression, increases expression	3
(+)-JQ1 compound	decreases expression	2
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
aristolochic acid I	decreases expression, increases expression	1
GSK-J4	decreases expression	1
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
arsenite	affects binding, increases reaction	1
mono-(2-ethylhexyl)phthalate	decreases expression	1
butyraldehyde	decreases expression	1
pentanal	decreases expression	1
yessotoxin	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
NSC 689534	affects binding, decreases expression	1
PP242	increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Sunitinib	decreases expression	1
Vorinostat	increases expression	1
Benzo(a)pyrene	decreases methylation	1
Copper	affects binding, decreases expression	1
Coumestrol	affects cotreatment, increases expression	1
Dichlorodiphenyl Dichloroethylene	increases expression	1
Doxorubicin	decreases expression	1
Ivermectin	decreases expression	1
Lead	increases expression	1
Nickel	increases expression	1
Thiram	decreases expression	1
Urethane	decreases expression	1
Valproic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.