MAILR

Summary

MAILR (macrophage interferon regulatory lncRNA, HGNC:51558) is a long non-coding RNA gene on chromosome 8q22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51558
Approved symbol	MAILR
Name	macrophage interferon regulatory lncRNA
Location	8q22.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	MAIL1, H22954
Ensembl gene	ENSG00000253320
Ensembl biotype	lncRNA
Entrez	100506753
RNAcentral	URS00007E44DE — lncRNA, 884 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 51 — 51 lncRNA

ENST00000517389, ENST00000517512, ENST00000517983, ENST00000517996, ENST00000517999, ENST00000518518, ENST00000518978, ENST00000519181, ENST00000519257, ENST00000519648, ENST00000519979, ENST00000520455, ENST00000520538, ENST00000520750, ENST00000522850, ENST00000522939, ENST00000524007, ENST00000659614, ENST00000726336, ENST00000726337, ENST00000726338, ENST00000726339, ENST00000726340, ENST00000726341, ENST00000726342, ENST00000726343, ENST00000726344, ENST00000726345, ENST00000726346, ENST00000726348, ENST00000726349, ENST00000726350, ENST00000726351, ENST00000726352, ENST00000726353, ENST00000726354, ENST00000726355, ENST00000726356, ENST00000726357, ENST00000726358, ENST00000726359, ENST00000726360, ENST00000726361, ENST00000726362, ENST00000726363, ENST00000726364, ENST00000726365, ENST00000726366, ENST00000726367, ENST00000726368, ENST00000849071

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000517389 — 4 exons

Exon	Start	End
ENSE00002094806	102941921	102942053
ENSE00002097801	102937624	102937757
ENSE00002125379	102977587	102977786
ENSE00002134836	102925032	102925123

Expression profiles

Bgee: expression breadth ubiquitous, 218 present calls, max score 93.86.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 11.2561 / max 1497.0442, expressed in 1526 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
90075	7.3735	196
90071	2.2758	1140
90072	1.0290	544
205278	0.4551	241
90074	0.1226	59

Top tissues by expression

268 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	93.86	gold quality
left testis	UBERON:0004533	93.47	gold quality
right testis	UBERON:0004534	92.66	gold quality
body of pancreas	UBERON:0001150	90.48	gold quality
tendon of biceps brachii	UBERON:0008188	90.39	silver quality
testis	UBERON:0000473	89.41	gold quality
sural nerve	UBERON:0015488	87.98	gold quality
tendon	UBERON:0000043	86.57	gold quality
calcaneal tendon	UBERON:0003701	85.86	gold quality
secondary oocyte	CL:0000655	85.73	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	85.30	gold quality
pancreas	UBERON:0001264	83.97	gold quality
adenohypophysis	UBERON:0002196	83.46	gold quality
buccal mucosa cell	CL:0002336	83.20	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.22	gold quality
pituitary gland	UBERON:0000007	81.79	gold quality
bronchial epithelial cell	CL:0002328	80.93	gold quality
left lobe of thyroid gland	UBERON:0001120	80.37	gold quality
thyroid gland	UBERON:0002046	79.58	gold quality
right lobe of thyroid gland	UBERON:0001119	79.18	gold quality
hindlimb stylopod muscle	UBERON:0004252	78.24	gold quality
muscle of leg	UBERON:0001383	77.87	gold quality
gastrocnemius	UBERON:0001388	77.74	gold quality
ganglionic eminence	UBERON:0004023	77.74	gold quality
tibial nerve	UBERON:0001323	77.70	gold quality
metanephros cortex	UBERON:0010533	77.70	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	77.68	gold quality
stromal cell of endometrium	CL:0002255	77.60	gold quality
prefrontal cortex	UBERON:0000451	77.50	gold quality
mucosa of stomach	UBERON:0001199	77.44	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• MaIL1 binds TLR4 signal transduction protein and ubiquitin-adapter OPTN. MaIL1 stabilizes OPTN and is essential for OPTN aggregation and OPTN-TBK1 kinase-dependent IRF3 transcription factor phosphorylation. Knockout or knockdown of MaIL1 blunted TLR4-TRIF-IRF3-mediated IFN expression and antibacterial defense. MaIL1 levels is predictive of IFN expression in patients with bronchopulmonary infection. (PMID:32241891)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.