MAL-AS1

Summary

MAL-AS1 (MAL antisense RNA 1, HGNC:40355) is a long non-coding RNA gene on chromosome 2q11.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40355
Approved symbol	MAL-AS1
Name	MAL antisense RNA 1
Location	2q11.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	AC103563.8
Ensembl gene	ENSG00000233850
Ensembl biotype	lncRNA
Entrez	124906046
RNAcentral	URS0002A654B2 — lncRNA, 897 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 13 lncRNA

ENST00000448734, ENST00000730443, ENST00000730444, ENST00000730445, ENST00000730446, ENST00000730447, ENST00000730448, ENST00000730449, ENST00000730450, ENST00000730451, ENST00000730452, ENST00000730453, ENST00000730454

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000448734 — 3 exons

Exon	Start	End
ENSE00001756325	95026340	95026433
ENSE00004058988	95024823	95025425
ENSE00004058995	95026559	95026732

Expression profiles

Bgee: expression breadth ubiquitous, 116 present calls, max score 98.18.

Top tissues by expression

118 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
thymus	UBERON:0002370	98.18	gold quality
metanephros cortex	UBERON:0010533	80.45	gold quality
lower esophagus mucosa	UBERON:0035834	80.12	gold quality
esophagus mucosa	UBERON:0002469	77.71	gold quality
spinal cord	UBERON:0002240	77.42	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	77.37	gold quality
adult mammalian kidney	UBERON:0000082	74.12	gold quality
kidney	UBERON:0002113	73.38	gold quality
substantia nigra	UBERON:0002038	73.17	gold quality
cortex of kidney	UBERON:0001225	71.31	gold quality
putamen	UBERON:0001874	71.00	gold quality
amygdala	UBERON:0001876	70.91	gold quality
Ammon’s horn	UBERON:0001954	70.16	gold quality
granulocyte	CL:0000094	70.02	gold quality
blood	UBERON:0000178	69.59	gold quality
nucleus accumbens	UBERON:0001882	69.13	gold quality
tibial nerve	UBERON:0001323	68.83	gold quality
vagina	UBERON:0000996	67.47	gold quality
esophagus	UBERON:0001043	67.44	gold quality
caudate nucleus	UBERON:0001873	66.88	gold quality
prefrontal cortex	UBERON:0000451	66.27	gold quality
Brodmann (1909) area 9	UBERON:0013540	66.20	gold quality
hypothalamus	UBERON:0001898	66.19	gold quality
cerebral cortex	UBERON:0000956	66.14	gold quality
right frontal lobe	UBERON:0002810	66.10	gold quality
frontal cortex	UBERON:0001870	65.87	gold quality
quadriceps femoris	UBERON:0001377	65.49	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.42	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	65.14	gold quality
brain	UBERON:0000955	64.72	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.03

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.