MAL2-AS1

Summary

MAL2-AS1 (MAL2 antisense RNA 1, HGNC:53626) is a long non-coding RNA gene on chromosome 8q24.12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53626
Approved symbol	MAL2-AS1
Name	MAL2 antisense RNA 1
Location	8q24.12
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000253972
Ensembl biotype	lncRNA
Entrez	105375726
RNAcentral	URS0000BC45A1 — lncRNA, 1133 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 7 lncRNA

ENST00000521048, ENST00000522187, ENST00000522828, ENST00000523307, ENST00000524129, ENST00000655158, ENST00000756056

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000521048 — 5 exons

Exon	Start	End
ENSE00002098623	119224250	119224312
ENSE00002115818	119246730	119246843
ENSE00002130105	119223804	119223999
ENSE00002132355	119244295	119244330
ENSE00002139380	119244810	119244975

Expression profiles

Bgee: expression breadth ubiquitous, 124 present calls, max score 78.52.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0142 / max 12.1793, expressed in 3 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
94607	0.0142	3

Top tissues by expression

124 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.52	gold quality
sural nerve	UBERON:0015488	78.25	gold quality
left testis	UBERON:0004533	76.24	gold quality
testis	UBERON:0000473	75.84	gold quality
right testis	UBERON:0004534	74.89	gold quality
esophagus mucosa	UBERON:0002469	72.57	gold quality
lower esophagus mucosa	UBERON:0035834	70.97	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	69.87	gold quality
esophagus	UBERON:0001043	69.36	gold quality
skin of abdomen	UBERON:0001416	69.11	gold quality
colonic epithelium	UBERON:0000397	68.26	silver quality
zone of skin	UBERON:0000014	67.79	gold quality
vagina	UBERON:0000996	67.34	gold quality
ganglionic eminence	UBERON:0004023	66.83	gold quality
skin of leg	UBERON:0001511	66.47	gold quality
left lobe of thyroid gland	UBERON:0001120	66.30	gold quality
liver	UBERON:0002107	65.88	gold quality
thyroid gland	UBERON:0002046	65.51	gold quality
stomach	UBERON:0000945	65.45	gold quality
body of stomach	UBERON:0001161	65.20	gold quality
metanephros cortex	UBERON:0010533	64.49	gold quality
right lobe of thyroid gland	UBERON:0001119	64.33	gold quality
cortex of kidney	UBERON:0001225	63.90	gold quality
rectum	UBERON:0001052	63.48	gold quality
skeletal muscle tissue	UBERON:0001134	62.99	silver quality
tonsil	UBERON:0002372	62.96	gold quality
minor salivary gland	UBERON:0001830	62.46	gold quality
kidney	UBERON:0002113	62.30	gold quality
saliva-secreting gland	UBERON:0001044	62.21	gold quality
hindlimb stylopod muscle	UBERON:0004252	61.95	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.88

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.