MALINC1

Summary

MALINC1 (mitosis associated long intergenic non-coding RNA 1, HGNC:49009) is a long non-coding RNA gene on chromosome 5q31.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49009
Approved symbol	MALINC1
Name	mitosis associated long intergenic non-coding RNA 1
Location	5q31.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	MA-linc1
Ensembl gene	ENSG00000245146
Ensembl biotype	lncRNA
Entrez	100505636
RNAcentral	URS000075EBBA — lncRNA, 3153 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 38 — 38 lncRNA

ENST00000499203, ENST00000518790, ENST00000520928, ENST00000521133, ENST00000521563, ENST00000522747, ENST00000523452, ENST00000653092, ENST00000654348, ENST00000656599, ENST00000659306, ENST00000659960, ENST00000660071, ENST00000663778, ENST00000668151, ENST00000671132, ENST00000671248, ENST00000719579, ENST00000719580, ENST00000719581, ENST00000719582, ENST00000719583, ENST00000719584, ENST00000719585, ENST00000719586, ENST00000719587, ENST00000719588, ENST00000719589, ENST00000719590, ENST00000719591, ENST00000719592, ENST00000719593, ENST00000719594, ENST00000719595, ENST00000719596, ENST00000719597, ENST00000719598, ENST00000719599

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000499203 — 3 exons

Exon	Start	End
ENSE00001974752	140105587	140105762
ENSE00004037466	140102225	140104166
ENSE00004037469	140106296	140107831

Expression profiles

Bgee: expression breadth ubiquitous, 135 present calls, max score 79.23.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2981 / max 20.8486, expressed in 130 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
63780	0.2129	103
63781	0.0852	25

Top tissues by expression

138 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right testis	UBERON:0004534	79.23	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.17	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.78	gold quality
left testis	UBERON:0004533	78.75	gold quality
testis	UBERON:0000473	78.70	gold quality
calcaneal tendon	UBERON:0003701	77.45	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	75.02	gold quality
spinal cord	UBERON:0002240	75.00	gold quality
pituitary gland	UBERON:0000007	73.79	gold quality
substantia nigra	UBERON:0002038	72.89	gold quality
adenohypophysis	UBERON:0002196	72.67	gold quality
colonic epithelium	UBERON:0000397	72.52	gold quality
body of pancreas	UBERON:0001150	71.61	gold quality
tibial artery	UBERON:0007610	71.58	gold quality
popliteal artery	UBERON:0002250	71.57	gold quality
cerebellar hemisphere	UBERON:0002245	71.54	gold quality
cerebellar cortex	UBERON:0002129	71.48	gold quality
cerebellum	UBERON:0002037	71.42	gold quality
left ovary	UBERON:0002119	71.40	gold quality
pancreas	UBERON:0001264	71.33	gold quality
right hemisphere of cerebellum	UBERON:0014890	71.27	gold quality
hypothalamus	UBERON:0001898	71.13	gold quality
ovary	UBERON:0000992	71.11	gold quality
thyroid gland	UBERON:0002046	71.07	gold quality
cortex of kidney	UBERON:0001225	70.95	gold quality
metanephros cortex	UBERON:0010533	70.88	gold quality
bone marrow cell	CL:0002092	70.75	gold quality
left lobe of thyroid gland	UBERON:0001120	70.73	gold quality
islet of Langerhans	UBERON:0000006	70.65	gold quality
right lobe of thyroid gland	UBERON:0001119	70.51	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.20

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• our data identify MA-linc1 as a novel lncRNA regulator of cell cycle and demonstrate its potential role in cancer progression and treatment. (PMID:26337085)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.