MAMDC2-AS1

Summary

MAMDC2-AS1 (MAMDC2 antisense RNA 1, HGNC:48719) is a long non-coding RNA gene on chromosome 9q21.12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48719
Approved symbol	MAMDC2-AS1
Name	MAMDC2 antisense RNA 1
Location	9q21.12
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000204706
Ensembl biotype	lncRNA
Entrez	100507244
RNAcentral	URS000075DE3E — lncRNA, 1675 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 64 — 64 lncRNA

ENST00000377178, ENST00000414515, ENST00000420573, ENST00000448377, ENST00000451488, ENST00000585478, ENST00000590177, ENST00000591368, ENST00000594708, ENST00000610059, ENST00000625991, ENST00000626263, ENST00000626529, ENST00000626773, ENST00000627123, ENST00000627141, ENST00000627262, ENST00000628046, ENST00000628414, ENST00000628563, ENST00000628903, ENST00000629922, ENST00000630191, ENST00000630232, ENST00000656832, ENST00000664022, ENST00000670800, ENST00000685052, ENST00000715771, ENST00000727061, ENST00000727062, ENST00000727063, ENST00000727064, ENST00000727065, ENST00000727066, ENST00000727067, ENST00000727068, ENST00000727069, ENST00000727070, ENST00000727071, ENST00000727072, ENST00000727073, ENST00000727074, ENST00000727075, ENST00000727076, ENST00000727077, ENST00000727078, ENST00000727079, ENST00000727080, ENST00000727081, ENST00000727082, ENST00000727083, ENST00000727084, ENST00000727085, ENST00000727086, ENST00000727087, ENST00000727088, ENST00000727089, ENST00000727090, ENST00000727091, ENST00000727092, ENST00000727093, ENST00000727094, ENST00000727095

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000377178 — 4 exons

Exon	Start	End
ENSE00001537786	70153134	70154241
ENSE00001595421	70157512	70157742
ENSE00001649234	70171038	70171124
ENSE00002085232	70175755	70175832

Expression profiles

Bgee: expression breadth ubiquitous, 132 present calls, max score 90.42.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 3.8799 / max 87.7682, expressed in 1408 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
100834	2.7764	1318
100832	0.7543	310
100833	0.2214	111
100835	0.1277	41

Top tissues by expression

132 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	90.42	gold quality
colonic epithelium	UBERON:0000397	90.04	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.43	gold quality
mucosa of stomach	UBERON:0001199	79.87	gold quality
sural nerve	UBERON:0015488	78.63	gold quality
left ovary	UBERON:0002119	78.18	gold quality
ovary	UBERON:0000992	77.21	gold quality
right testis	UBERON:0004534	75.53	gold quality
left uterine tube	UBERON:0001303	75.24	gold quality
urinary bladder	UBERON:0001255	75.08	gold quality
right ovary	UBERON:0002118	74.97	gold quality
left testis	UBERON:0004533	74.53	gold quality
testis	UBERON:0000473	74.45	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	74.41	gold quality
body of uterus	UBERON:0009853	73.96	gold quality
pituitary gland	UBERON:0000007	73.93	gold quality
adenohypophysis	UBERON:0002196	73.67	gold quality
lower esophagus muscularis layer	UBERON:0035833	72.88	gold quality
lower esophagus	UBERON:0013473	72.87	gold quality
corpus callosum	UBERON:0002336	72.43	gold quality
left lobe of thyroid gland	UBERON:0001120	72.33	gold quality
thyroid gland	UBERON:0002046	72.30	gold quality
right lobe of thyroid gland	UBERON:0001119	72.27	gold quality
adrenal tissue	UBERON:0018303	71.87	gold quality
muscle layer of sigmoid colon	UBERON:0035805	71.78	gold quality
myometrium	UBERON:0001296	71.32	gold quality
bone marrow cell	CL:0002092	71.23	silver quality
right uterine tube	UBERON:0001302	70.84	gold quality
right lung	UBERON:0002167	70.80	gold quality
fallopian tube	UBERON:0003889	69.78	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.27

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Single-cell RNA-sequencing analysis identifies host long noncoding RNA MAMDC2-AS1 as a co-factor for HSV-1 nuclear transport. (PMID:32226304)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.