MANCR

Summary

MANCR (mitotically associated long non coding RNA, HGNC:44678) is a long non-coding RNA gene on chromosome 10p15.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44678
Approved symbol	MANCR
Name	mitotically associated long non coding RNA
Location	10p15.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	CR749391
Ensembl gene	ENSG00000231298
Ensembl biotype	lncRNA
Entrez	100216001
RNAcentral	URS000075AF3D — lncRNA, 1394 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 25 — 25 lncRNA

ENST00000430998, ENST00000443994, ENST00000449712, ENST00000659646, ENST00000665967, ENST00000667425, ENST00000700874, ENST00000737867, ENST00000737868, ENST00000737869, ENST00000737870, ENST00000737871, ENST00000737872, ENST00000737873, ENST00000737874, ENST00000737875, ENST00000737876, ENST00000737877, ENST00000737878, ENST00000737879, ENST00000737880, ENST00000737881, ENST00000737882, ENST00000737883, ENST00000737884

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000430998 — 4 exons

Exon	Start	End
ENSE00001657354	4678049	4678177
ENSE00001760517	4659453	4659680
ENSE00004072607	4650149	4651203
ENSE00004072608	4657601	4657725

Expression profiles

Bgee: expression breadth ubiquitous, 110 present calls, max score 79.86.

FANTOM5 (CAGE): breadth broad, TPM avg 1.1570 / max 82.3753, expressed in 321 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
108040	0.5212	169
108039	0.2074	89
108038	0.1819	75
108037	0.1357	54
108036	0.1108	46

Top tissues by expression

110 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stromal cell of endometrium	CL:0002255	79.86	gold quality
bone marrow cell	CL:0002092	70.79	silver quality
spleen	UBERON:0002106	70.16	gold quality
adrenal tissue	UBERON:0018303	68.45	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	67.16	gold quality
rectum	UBERON:0001052	64.54	gold quality
endometrium	UBERON:0001295	62.18	gold quality
islet of Langerhans	UBERON:0000006	61.75	gold quality
skeletal muscle tissue	UBERON:0001134	61.63	gold quality
gall bladder	UBERON:0002110	60.92	gold quality
hindlimb stylopod muscle	UBERON:0004252	59.71	gold quality
transverse colon	UBERON:0001157	58.48	gold quality
left coronary artery	UBERON:0001626	57.65	gold quality
heart left ventricle	UBERON:0002084	57.58	gold quality
duodenum	UBERON:0002114	57.47	gold quality
vagina	UBERON:0000996	57.35	gold quality
esophagus mucosa	UBERON:0002469	57.05	gold quality
muscle of leg	UBERON:0001383	56.98	gold quality
gastrocnemius	UBERON:0001388	56.86	gold quality
right coronary artery	UBERON:0001625	56.67	gold quality
bone marrow	UBERON:0002371	56.67	silver quality
ascending aorta	UBERON:0001496	56.34	gold quality
thoracic aorta	UBERON:0001515	56.33	gold quality
vermiform appendix	UBERON:0001154	56.32	gold quality
heart	UBERON:0000948	56.25	gold quality
colon	UBERON:0001155	56.03	gold quality
descending thoracic aorta	UBERON:0002345	55.94	gold quality
intestine	UBERON:0000160	55.93	gold quality
liver	UBERON:0002107	55.70	gold quality
urinary bladder	UBERON:0001255	55.50	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.06

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• Results show that MANCR (LINC00704), is upregulated in breast cancer and is functionally linked with cell proliferation, viability, and genomic stability. (PMID:29378907)
• The authors found that MANCR may regulate mantle cell lymphoma cell proliferation possibly by interacting with RUNX2. (PMID:31650163)
• Long non-coding RNA MANCR is a target of BET bromodomain protein BRD4 and plays a critical role in cellular migration and invasion abilities of prostate cancer. (PMID:32199616)
• Upregulation of the long noncoding RNAs DSCAM-AS1 and MANCR is a potential diagnostic marker for breast carcinoma. (PMID:33012018)
• LncRNA MANCR positively affects the malignant progression of lung adenocarcinoma. (PMID:34418982)
• MANCR lncRNA Modulates Cell-Cycle Progression and Metastasis by Cis-Regulation of Nuclear Rho-GEF. (PMID:39133105)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.