MAP10

Summary

MAP10 (microtubule associated protein 10, HGNC:29265) is a protein-coding gene on chromosome 1q42.2, encoding Microtubule-associated protein 10 (Q9P2G4). Microtubule-associated protein (MAP) that plays a role in the regulation of cell division; promotes microtubule stability and participates in the organization of the spindle midzone and normal progress of cytokinesis.

Enables microtubule binding activity. Involved in microtubule cytoskeleton organization; positive regulation of cytokinesis; and regulation of microtubule-based process. Located in microtubule cytoskeleton and midbody.

Source: NCBI Gene 54627 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 179 total
• MANE Select transcript: NM_019090

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29265
Approved symbol	MAP10
Name	microtubule associated protein 10
Location	1q42.2
Locus type	gene with protein product
Status	Approved
Aliases	MTR120
Ensembl gene	ENSG00000212916
Ensembl biotype	protein_coding
OMIM	618551
Entrez	54627

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000418460

RefSeq mRNA: 1 — MANE Select: NM_019090 NM_019090

CCDS: CCDS44334

Canonical transcript exons

ENST00000418460 — 1 exons

Exon	Start	End
ENSE00001623286	232805416	232809929

Expression profiles

Bgee: expression breadth ubiquitous, 130 present calls, max score 80.74.

FANTOM5 (CAGE): breadth broad, TPM avg 1.6708 / max 59.4992, expressed in 871 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
9071	1.0778	623
9070	0.5930	335

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.74	gold quality
islet of Langerhans	UBERON:0000006	73.74	gold quality
cortical plate	UBERON:0005343	73.33	gold quality
calcaneal tendon	UBERON:0003701	70.39	gold quality
skeletal muscle tissue	UBERON:0001134	69.71	gold quality
leukocyte	CL:0000738	69.57	gold quality
monocyte	CL:0000576	69.56	gold quality
hindlimb stylopod muscle	UBERON:0004252	68.69	gold quality
muscle tissue	UBERON:0002385	68.34	gold quality
ganglionic eminence	UBERON:0004023	67.91	gold quality
endometrium	UBERON:0001295	67.88	gold quality
pancreas	UBERON:0001264	67.17	gold quality
muscle of leg	UBERON:0001383	66.92	gold quality
prefrontal cortex	UBERON:0000451	66.83	gold quality
smooth muscle tissue	UBERON:0001135	66.79	gold quality
superior frontal gyrus	UBERON:0002661	66.56	gold quality
ventricular zone	UBERON:0003053	66.54	gold quality
lymph node	UBERON:0000029	66.43	gold quality
gastrocnemius	UBERON:0001388	66.14	gold quality
heart left ventricle	UBERON:0002084	65.47	gold quality
apex of heart	UBERON:0002098	64.80	gold quality
duodenum	UBERON:0002114	64.63	gold quality
primary visual cortex	UBERON:0002436	64.51	gold quality
granulocyte	CL:0000094	64.24	gold quality
body of pancreas	UBERON:0001150	64.19	gold quality
right lobe of liver	UBERON:0001114	63.86	gold quality
gall bladder	UBERON:0002110	63.75	gold quality
frontal cortex	UBERON:0001870	63.68	gold quality
heart	UBERON:0000948	63.56	gold quality
liver	UBERON:0002107	63.10	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-MTAB-6386	no	142.15
E-ANND-3	no	2.19

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

116 targeting MAP10, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-518D-5P	100.00	67.51	979
HSA-MIR-518E-5P	100.00	67.66	954
HSA-MIR-518F-5P	100.00	67.51	979
HSA-MIR-519A-5P	100.00	67.66	954
HSA-MIR-519B-5P	100.00	67.66	954
HSA-MIR-519C-5P	100.00	67.66	954
HSA-MIR-520C-5P	100.00	67.51	979
HSA-MIR-522-5P	100.00	67.66	954
HSA-MIR-523-5P	100.00	67.66	954
HSA-MIR-526A-5P	100.00	67.51	979
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-1236-3P	99.94	68.04	1695

Literature-anchored findings (GeneRIF, showing 1)

• these data suggest that MTR120 is a novel microtubule (MT)-associated protein that directly stabilizes MTs and hence ensures the fidelity of cell division. (PMID:23264731)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	map10	ENSDARG00000100261
mus_musculus	Map10	ENSMUSG00000050930
rattus_norvegicus	Map10	ENSRNOG00000028652

Protein

Protein identifiers

Microtubule-associated protein 10 — Q9P2G4 (reviewed: Q9P2G4)

Alternative names: Microtubule regulator of 120 KDa

All UniProt accessions (1): Q9P2G4

UniProt curated annotations — full annotation on UniProt →

Function. Microtubule-associated protein (MAP) that plays a role in the regulation of cell division; promotes microtubule stability and participates in the organization of the spindle midzone and normal progress of cytokinesis.

Subunit / interactions. Interacts (via middle region) with microtubules.

Subcellular location. Cytoplasm. Cytoskeleton. Spindle pole. Microtubule organizing center. Centrosome. Midbody.

Tissue specificity. Expressed in different cell lines (at protein level).

RefSeq proteins (1): NP_061963* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR026679	MAP10_C-term	Domain
IPR039302	MAP10	Family

Pfam: PF14924, PF14925

UniProt features (16 total): compositionally biased region 8, region of interest 7, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9P2G4-F1	50.70	0.10

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 103 (showing top): GOBP_CHROMOSOME_ORGANIZATION, GOBP_CYTOPLASMIC_MICROTUBULE_ORGANIZATION, GOBP_REGULATION_OF_MICROTUBULE_BASED_PROCESS, BOYLAN_MULTIPLE_MYELOMA_D_DN, GOCC_MICROTUBULE_ORGANIZING_CENTER, GOBP_MITOTIC_SPINDLE_ASSEMBLY, MODULE_205, GOBP_ORGANELLE_FISSION, GOBP_CYTOKINESIS, GOBP_POSITIVE_REGULATION_OF_CELL_DIVISION, GOBP_REGULATION_OF_CELL_CYCLE, GOCC_CENTROSOME, GOBP_MITOTIC_NUCLEAR_DIVISION, GOBP_POSITIVE_REGULATION_OF_CELL_CYCLE_PROCESS, GOBP_REGULATION_OF_CYTOKINESIS

GO Biological Process (6): cytoplasmic microtubule organization (GO:0031122), positive regulation of cytokinesis (GO:0032467), regulation of microtubule-based process (GO:0032886), mitotic spindle midzone assembly (GO:0051256), cell division (GO:0051301), microtubule cytoskeleton organization (GO:0000226)

GO Molecular Function (1): microtubule binding (GO:0008017)

GO Cellular Component (8): centrosome (GO:0005813), cytoplasmic microtubule (GO:0005881), midbody (GO:0030496), mitotic spindle pole (GO:0097431), mitotic spindle midzone (GO:1990023), spindle pole (GO:0000922), cytoplasm (GO:0005737), cytoskeleton (GO:0005856)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
microtubule-based process	2
mitotic spindle	2
microtubule cytoskeleton organization	1
supramolecular fiber organization	1
cytokinesis	1
regulation of cytokinesis	1
positive regulation of cell division	1
positive regulation of cell cycle process	1
regulation of cellular process	1
mitotic spindle elongation	1
spindle midzone assembly	1
mitotic spindle assembly	1
mitotic nuclear division	1
mitotic cell cycle process	1
cellular process	1
cytoskeleton organization	1
tubulin binding	1
centriole	1
microtubule organizing center	1
cytoplasm	1
microtubule	1
spindle pole	1
spindle midzone	1
spindle	1
intracellular anatomical structure	1
intracellular membraneless organelle	1

Protein interactions and networks

STRING

272 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MAP10	TRAPPC14	Q8WVR3	618
MAP10	ZNF133	P52736	532
MAP10	RASGEF1C	Q8N431	491
MAP10	ZNF584	Q8IVC4	479
MAP10	MAP9	Q49MG5	479
MAP10	ZSCAN2	Q7Z7L9	437
MAP10	C3orf38	Q5JPI3	433
MAP10	FOXD4L3	Q6VB84	419
MAP10	FOXD4L4	Q8WXT5	417
MAP10	KIAA0408	Q6ZU52	395
MAP10	TEDC1	Q86SX3	392
MAP10	LRRC61	Q9BV99	391
MAP10	A6NDT3	A6NDT3	380
MAP10	MTCL3	Q5TF21	374
MAP10	BRINP1	O60477	351

IntAct

3 interactions, top by confidence:

A	B	Type	Score
MAP10	HNRNPU	psi-mi:“MI:0915”(physical association)	0.400
MAP10	WDR62	psi-mi:“MI:0914”(association)	0.350

BioGRID (31): LOC100158003 (Reconstituted Complex), TUBB2A (Reconstituted Complex), MAP10 (Proximity Label-MS), AMER1 (Affinity Capture-MS), PRKACB (Affinity Capture-MS), WDR62 (Affinity Capture-MS), VPRBP (Affinity Capture-MS), MIB1 (Affinity Capture-MS), PRKAR1B (Affinity Capture-MS), CEP76 (Affinity Capture-MS), PPP1R15B (Affinity Capture-MS), CENPB (Affinity Capture-MS), CAMK2D (Affinity Capture-MS), KIAA0232 (Affinity Capture-MS), CWC22 (Affinity Capture-MS)

ESM2 similar proteins: A0A1L8EYB2, A0JMF7, A2AHC3, A3KMW7, A5D8S0, A5WUN7, B0S6S9, D3Z8E6, D3Z987, F1M5M3, F1MJR8, F1QB81, P70347, P97412, Q0P5X5, Q0VET5, Q15468, Q2M2Z5, Q2T9I9, Q3UEN2, Q3V0M2, Q49A88, Q49AJ0, Q5CZC0, Q5RA75, Q5RHB5, Q5SW75, Q5T5Y3, Q60664, Q6JPI3, Q6NRK3, Q6PUR7, Q71F56, Q76I76, Q7M6U3, Q7TSH4, Q8C753, Q8CCC3, Q8IWB6, Q8K2J4

Diamond homologs: A3KMW7, D3ZAP3, Q8BJS7, Q9P2G4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

179 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	155
Likely benign	22
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

9 predictions. Top by Δscore:

Variant	Effect	Δscore
1:232806137:GCTGA:G	donor_gain	0.3900
1:232806368:A:AG	acceptor_gain	0.3900
1:232806198:TTAA:T	donor_gain	0.3300
1:232806266:TG:T	acceptor_gain	0.3200
1:232805561:G:GT	donor_gain	0.3000
1:232806267:G:GT	acceptor_gain	0.2400
1:232806268:T:TT	acceptor_gain	0.2400
1:232806269:T:TT	acceptor_gain	0.2400
1:232806070:C:A	donor_gain	0.2000

AlphaMissense

6847 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000027515 (1:232803635 C>T), RS1001961203 (1:232809834 G>A), RS1002863802 (1:232805391 C>A,G,T), RS1003084684 (1:232808796 G>C), RS1003378542 (1:232808364 T>C), RS1003893187 (1:232810182 T>C), RS1004003932 (1:232810405 G>A), RS1004906704 (1:232808830 A>C), RS1004929316 (1:232809078 T>C), RS1007314972 (1:232806942 G>A,T), RS1008827128 (1:232809465 A>G,T), RS1009113810 (1:232803568 G>A), RS1009400552 (1:232808680 G>A), RS1009417011 (1:232803676 T>C), RS1009975622 (1:232805335 G>A,T)

Disease associations

OMIM: gene MIM:618551 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST003472_12	Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder	5.000000e-07
GCST003472_13	Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder	4.000000e-07
GCST003472_14	Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder	3.000000e-07
GCST009391_1351	Metabolite levels	5.000000e-06

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0007679	oppositional defiant disorder measurement
EFO:0010365	lysophosphatidylcholine 22:6 measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

11 total (human), top 11 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
GSK-J4	decreases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	decreases expression	1
cypermethrin	increases expression	1
abrine	increases expression	1
Benzo(a)pyrene	affects methylation, decreases methylation	1
Tobacco Smoke Pollution	decreases expression	1
Valproic Acid	decreases methylation	1
Aflatoxin B1	increases methylation	1
Okadaic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.