MAP1S

Summary

MAP1S (microtubule associated protein 1S, HGNC:15715) is a protein-coding gene on chromosome 19p13.12, encoding Microtubule-associated protein 1S (Q66K74). Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD).

Enables DNA binding activity and cytoskeletal protein binding activity. Involved in metaphase chromosome alignment; microtubule cytoskeleton organization; and neuron projection morphogenesis. Located in several cellular components, including microtubule cytoskeleton; nuclear lumen; and perinuclear region of cytoplasm.

Source: NCBI Gene 55201 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 237 total
• MANE Select transcript: NM_018174

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15715
Approved symbol	MAP1S
Name	microtubule associated protein 1S
Location	19p13.12
Locus type	gene with protein product
Status	Approved
Aliases	FLJ10669, MAP8
Ensembl gene	ENSG00000130479
Ensembl biotype	protein_coding
OMIM	607573
Entrez	55201

Gene structure

Transcript identifiers

Ensembl transcripts: 32 — 17 protein_coding, 8 protein_coding_CDS_not_defined, 5 nonsense_mediated_decay, 2 retained_intron

ENST00000324096, ENST00000544059, ENST00000593593, ENST00000594212, ENST00000594340, ENST00000594365, ENST00000594625, ENST00000595338, ENST00000596637, ENST00000597000, ENST00000597067, ENST00000597681, ENST00000597735, ENST00000598756, ENST00000598769, ENST00000598916, ENST00000599494, ENST00000600186, ENST00000600608, ENST00000601097, ENST00000601544, ENST00000897430, ENST00000897431, ENST00000897432, ENST00000897433, ENST00000897434, ENST00000897435, ENST00000932495, ENST00000932496, ENST00000932497, ENST00000949628, ENST00000949629

RefSeq mRNA: 2 — MANE Select: NM_018174 NM_001308363, NM_018174

CCDS: CCDS32954, CCDS77262

Canonical transcript exons

ENST00000324096 — 7 exons

Exon	Start	End
ENSE00001226844	17725829	17728172
ENSE00003005624	17719480	17719620
ENSE00003467552	17720936	17721037
ENSE00003493424	17734273	17734513
ENSE00003534738	17733193	17733428
ENSE00003643531	17724126	17724208
ENSE00003681346	17725049	17725189

Expression profiles

Bgee: expression breadth ubiquitous, 266 present calls, max score 95.03.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 26.3987 / max 193.3725, expressed in 1807 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
174535	26.0387	1806
174536	0.2433	109
174537	0.1167	40

Top tissues by expression

287 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right testis	UBERON:0004534	95.03	gold quality
left testis	UBERON:0004533	94.96	gold quality
prefrontal cortex	UBERON:0000451	94.41	gold quality
right frontal lobe	UBERON:0002810	94.40	gold quality
Brodmann (1909) area 9	UBERON:0013540	92.87	gold quality
testis	UBERON:0000473	92.51	gold quality
frontal cortex	UBERON:0001870	92.50	gold quality
anterior cingulate cortex	UBERON:0009835	92.37	gold quality
cingulate cortex	UBERON:0003027	92.32	gold quality
stromal cell of endometrium	CL:0002255	92.22	gold quality
hindlimb stylopod muscle	UBERON:0004252	92.21	gold quality
neocortex	UBERON:0001950	92.09	gold quality
cortical plate	UBERON:0005343	91.94	gold quality
putamen	UBERON:0001874	91.45	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	91.10	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	91.10	gold quality
amygdala	UBERON:0001876	91.08	gold quality
ganglionic eminence	UBERON:0004023	91.00	gold quality
caudate nucleus	UBERON:0001873	90.87	gold quality
nucleus accumbens	UBERON:0001882	90.32	gold quality
cerebral cortex	UBERON:0000956	90.20	gold quality
right hemisphere of cerebellum	UBERON:0014890	90.05	gold quality
apex of heart	UBERON:0002098	89.96	gold quality
telencephalon	UBERON:0001893	89.95	gold quality
ventricular zone	UBERON:0003053	89.94	gold quality
gall bladder	UBERON:0002110	89.54	gold quality
forebrain	UBERON:0001890	89.43	gold quality
adenohypophysis	UBERON:0002196	89.34	gold quality
cerebellar cortex	UBERON:0002129	89.26	gold quality
cerebellar hemisphere	UBERON:0002245	89.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.84

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): SPI1

Literature-anchored findings (GeneRIF, showing 14)

• The amino acid sequence of VCY2IP-1 shows 59.3% and 41.9% homology to two human microtubule-associated proteins (MAPs), MAP1B and MAP1A, respectively. VCY2IP-1 has an extensive homology to the N-terminus and C-terminus regions of MAP1B and MAP1A (PMID:14627543)
• is expressed in a wide range of tissues in addition to neurons and represents the non-neuronal counterpart of a cytolinker family (PMID:15528209)
• Deletion mutagenesis indicated that C19ORF5 selectively binds double stranded DNA through its microtubule binding domain. (PMID:15907802)
• These results suggest that the interaction of SOCS3 with MAP1S and the integrity of the microtubule cytoskeleton play an important role in the negative regulation of SOCS3 on IL-6 signaling. (PMID:19027008)
• C19ORF5 distributed broadly across the mitotic spindle and reversibly accumulated during reversible mitotic arrest. (PMID:19759419)
• clarify roles of MAP1S in bridging microtubules and mitochondria with autophagic and mitophagic initiation, maturation, trafficking, and lysosomal clearance. (PMID:21262964)
• The PU.1-regulated MAP1S gene is implicated in neutrophil differentiation and autophagy control. (PMID:25043887)
• Ddata underline the key role of MAP1S as a global regulator of microbutule stability and demonstrate a new primary function of MAP1S to regulate MT dynamics at the onset of cytokinesis. (PMID:25300793)
• results support a role for MAP1 proteins in promoting efficient retrograde trafficking of HIV-1 by stimulating the formation of stable microtubules and mediating the association of HIV-1 cores with microtubules. (PMID:25505242)
• HDAC4 destabilizes MAP1S, suppresses autophagy flux and promotes the accumulation of mHTT aggregates. (PMID:26540094)
• Autophagy defects in the degradation of lipid droplets triggered by the MAP1S deficiency may enhance the initiation and development of ccRCC and reduce the survival of ccRCC patients. (PMID:26701856)
• Results suggested that microtubule associated protein 1S (MAP1S) were up-regulated among Crohn’s disease (CD) patients and MAP1S-related autophagy inhibits apoptosis of intestinal epithelial cells (IECs) through Wnt/beta-catenin signaling pathway which might play a vital role in the protection of intestinal mucosal barrier and inhibition the progression of CD. (PMID:28188784)
• RASSF1A Enhances Chemosensitivity of NSCLC Cells Through Activating Autophagy by Regulating MAP1S to Inactivate Keap1-Nrf2 Pathway. (PMID:33442234)
• Spermidine suppresses the activation of hepatic stellate cells to cure liver fibrosis through autophagy activator MAP1S. (PMID:36892418)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	map1sb	ENSDARG00000060326
danio_rerio	map1sa	ENSDARG00000060805
mus_musculus	Map1s	ENSMUSG00000019261
rattus_norvegicus	Map1s	ENSRNOG00000018781

Paralogs (2): MAP1B (ENSG00000131711), MAP1A (ENSG00000166963)

Protein

Protein identifiers

Microtubule-associated protein 1S — Q66K74 (reviewed: Q66K74)

Alternative names: BPY2-interacting protein 1, Microtubule-associated protein 8, Variable charge Y chromosome 2-interacting protein 1

All UniProt accessions (10): Q66K74, M0QX37, M0QXE8, M0QXK6, M0QXQ9, M0QY41, M0QYI5, M0QZ50, M0R1J2, M0R1M7

UniProt curated annotations — full annotation on UniProt →

Function. Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles.

Subunit / interactions. Heterodimer of a heavy and a light chain. Interacts with microtubules and actin. Both MAP1S heavy and light chains interact with microtubules. MAP1S light chain interacts with actin. Interacts (via C-terminus) with GAN (via Kelch domains). Interacts with ESR1, LRPPRC, RASSF1 isoform A and isoform C, microtubules and VCY2. Interacts with WDR47 (via N-terminus of light chain).

Subcellular location. Nucleus. Cytoplasm. Cytosol. Cytoskeleton. Spindle.

Tissue specificity. Expressed in neurons (at protein level). Expressed in spermatocytes, spermatids and spermatozoa. Expressed in the cerebral cortex. Highly expressed in testis. Moderately expressed in the brain, colon, heart, kidney, liver, lung, placenta, small intestine, spleen and stomach. Weakly expressed in muscle.

Domain organisation. The N-terminus of the heavy chain associates with the C-terminus of the light chain to form the heterodimer complex. Its C-terminal part of the heavy chain interacts with ESR1.

Miscellaneous. Depletion of MAP1S by RNAi causes mitotic abnormalities that consist of failure to form a stable metaphase plate, premature sister chromatid separation, lagging chromosomes, and multipolar spindles.

Similarity. Belongs to the MAP1 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q66K74-1	1	yes
Q66K74-2	2

RefSeq proteins (2): NP_001295292, NP_060644* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR026074	MAP1	Family
IPR056617	MAP1B/S_N	Domain
IPR057480	MAP1A/B/S-like_MBL	Domain

Pfam: PF23415, PF25281

UniProt features (42 total): compositionally biased region 11, modified residue 10, region of interest 7, sequence conflict 7, chain 3, sequence variant 3, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q66K74-F1	66.46	0.33

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (10): 321, 472, 582, 638, 640, 655, 657, 731, 759, 809

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 161 (showing top): GOBP_DENDRITE_DEVELOPMENT, GOBP_REGULATION_OF_MICROTUBULE_BASED_PROCESS, GOBP_MICROTUBULE_ANCHORING, GOMF_NUCLEASE_ACTIVITY, GOBP_CHROMOSOME_LOCALIZATION, GOBP_NEUROGENESIS, GOBP_ORGANELLE_TRANSPORT_ALONG_MICROTUBULE, GOCC_MICROTUBULE_ORGANIZING_CENTER, GOBP_MICROTUBULE_DEPOLYMERIZATION, GOCC_CENTROSOME, GOBP_MITOTIC_CELL_CYCLE, GOBP_MICROTUBULE_BUNDLE_FORMATION, BYSTRYKH_HEMATOPOIESIS_STEM_CELL_AND_BRAIN_QTL_TRANS, GOBP_HEAD_DEVELOPMENT, GOBP_PROTEIN_DEPOLYMERIZATION

GO Biological Process (14): microtubule cytoskeleton organization (GO:0000226), microtubule bundle formation (GO:0001578), autophagy (GO:0006914), apoptotic process (GO:0006915), mitotic spindle organization (GO:0007052), nervous system development (GO:0007399), axonogenesis (GO:0007409), brain development (GO:0007420), dendrite development (GO:0016358), regulation of microtubule depolymerization (GO:0031114), microtubule anchoring at centrosome (GO:0034454), mitochondrion transport along microtubule (GO:0047497), neuron projection morphogenesis (GO:0048812), metaphase chromosome alignment (GO:0051310)

GO Molecular Function (9): DNA binding (GO:0003677), actin binding (GO:0003779), microtubule binding (GO:0008017), tubulin binding (GO:0015631), identical protein binding (GO:0042802), beta-tubulin binding (GO:0048487), actin filament binding (GO:0051015), WD40-repeat domain binding (GO:0071987), protein binding (GO:0005515)

GO Cellular Component (19): nucleus (GO:0005634), nucleoplasm (GO:0005654), nucleolus (GO:0005730), centrosome (GO:0005813), microtubule organizing center (GO:0005815), spindle (GO:0005819), cytosol (GO:0005829), microtubule (GO:0005874), microtubule associated complex (GO:0005875), dendrite (GO:0030425), cell projection (GO:0042995), neuronal cell body (GO:0043025), synapse (GO:0045202), perinuclear region of cytoplasm (GO:0048471), sperm principal piece (GO:0097228), mitotic spindle microtubule (GO:1990498), cytoplasm (GO:0005737), cytoskeleton (GO:0005856), microtubule cytoskeleton (GO:0015630)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	7
microtubule cytoskeleton	4
intracellular membraneless organelle	3
neuron projection development	2
cytoskeletal protein binding	2
tubulin binding	2
nuclear lumen	2
cytoplasm	2
cytoskeleton organization	1
microtubule-based process	1
microtubule cytoskeleton organization	1
catabolic process	1
transmembrane transport	1
process utilizing autophagic mechanism	1
programmed cell death	1
apoptotic signaling pathway	1
execution phase of apoptosis	1
mitotic cell cycle	1
spindle organization	1
microtubule cytoskeleton organization involved in mitosis	1
system development	1
cell morphogenesis involved in neuron differentiation	1
neuron projection morphogenesis	1
axon development	1
central nervous system development	1
animal organ development	1
head development	1
anatomical structure development	1
microtubule depolymerization	1
regulation of microtubule polymerization or depolymerization	1
regulation of protein depolymerization	1
regulation of supramolecular fiber organization	1
microtubule anchoring at microtubule organizing center	1
establishment of mitochondrion localization, microtubule-mediated	1
organelle transport along microtubule	1
plasma membrane bounded cell projection morphogenesis	1
chromosome localization	1
nuclear chromosome segregation	1
nucleic acid binding	1
protein binding	1

Protein interactions and networks

STRING

1510 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MAP1S	SQSTM1	Q13501	973
MAP1S	LRPPRC	P42704	959
MAP1S	RASSF1	Q9NS23	954
MAP1S	MAP1LC3B	Q9GZQ8	933
MAP1S	ATG12	O94817	923
MAP1S	BECN1	Q14457	911
MAP1S	ATG5	Q9H1Y0	887
MAP1S	MAP1LC3A	Q9H492	886
MAP1S	F5GZY7	F5GZY7	863
MAP1S	HEBP2	Q9Y5Z4	858
MAP1S	GABARAPL2	P60520	855
MAP1S	ATG7	O95352	854
MAP1S	CECR2	Q9BXF3	834
MAP1S	ATG16L1	Q676U5	831
MAP1S	MAP1LC3C	Q9BXW4	819

IntAct

117 interactions, top by confidence:

A	B	Type	Score
VAPB	FAM83G	psi-mi:“MI:0914”(association)	0.730
STK4	MAP1B	psi-mi:“MI:0914”(association)	0.730
STK3	MAP1B	psi-mi:“MI:0914”(association)	0.640
STK4	STRN	psi-mi:“MI:0914”(association)	0.610
STK4	STRN	psi-mi:“MI:2364”(proximity)	0.610
BPY2C	MAP1S	psi-mi:“MI:0915”(physical association)	0.580
MAP1S	BPY2C	psi-mi:“MI:0915”(physical association)	0.580
MAP1S	BPY2C	psi-mi:“MI:0407”(direct interaction)	0.580
Rassf1	VAPB	psi-mi:“MI:0915”(physical association)	0.560
MAP1S	SOCS3	psi-mi:“MI:0915”(physical association)	0.540
SOCS3	MAP1S	psi-mi:“MI:0915”(physical association)	0.540
MAP1S	SOCS3	psi-mi:“MI:0403”(colocalization)	0.540
FAM174A	BLTP3B	psi-mi:“MI:0914”(association)	0.530
LIPH	LRP5	psi-mi:“MI:0914”(association)	0.530
GGA1	CLCN3	psi-mi:“MI:0914”(association)	0.530
KBTBD7	PLD2	psi-mi:“MI:0914”(association)	0.530
TRAPPC1	TRAPPC13	psi-mi:“MI:0914”(association)	0.530
ATG3	MAP1LC3B2	psi-mi:“MI:0914”(association)	0.530
DBF4B	CDC7	psi-mi:“MI:0914”(association)	0.530
LRRC27	HMOX1	psi-mi:“MI:0914”(association)	0.530
RASSF1	MAP1B	psi-mi:“MI:0914”(association)	0.530
STRN	MAP4K4	psi-mi:“MI:0914”(association)	0.530
RASSF5	MAP1B	psi-mi:“MI:0914”(association)	0.530

BioGRID (167): MAP1S (Affinity Capture-MS), RASSF5 (Two-hybrid), MAP1S (Affinity Capture-MS), MAP1S (Affinity Capture-MS), MAP1S (Affinity Capture-MS), MAP1S (Affinity Capture-MS), MAP1S (Affinity Capture-MS), MAP1S (Affinity Capture-MS), ANXA1 (Affinity Capture-MS), ANXA2 (Affinity Capture-MS), B2M (Affinity Capture-MS), GSN (Affinity Capture-MS), MAP1B (Affinity Capture-MS), STK4 (Affinity Capture-MS), STK3 (Affinity Capture-MS)

ESM2 similar proteins: A0JPN4, A1YF56, A2A288, A2A9T0, A2AEV7, A6QQJ8, A7MCY6, A8MVW0, D3ZG83, D3ZZN9, O09039, O15037, O75427, O94983, O95382, O95947, P0C5W1, P98077, Q02779, Q16584, Q2M3V2, Q53LP3, Q5D1E7, Q5D1E8, Q66HA1, Q66K74, Q66L42, Q6DG50, Q6ZUM4, Q6ZW31, Q76KP1, Q7T0L4, Q7TSG2, Q80XI6, Q80Y50, Q8BIY3, Q8BLS7, Q8K120, Q8K1S6, Q8R5G7

Diamond homologs: A6QQ70, P0C5W1, P14400, P14401, P14873, P15205, P34926, P46821, P78559, Q66K74, Q8C052, Q9QYR6, Q9W596

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
CUL3	“down-regulates quantity”	MAP1S	ubiquitination

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 119 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
mitophagy	5	15.3×	8e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

237 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	201
Likely benign	16
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

1503 predictions. Top by Δscore:

Variant	Effect	Δscore
19:17721038:G:GA	donor_loss	1.0000
19:17724121:CACA:C	acceptor_loss	1.0000
19:17724123:CA:C	acceptor_loss	1.0000
19:17724124:A:AG	acceptor_gain	1.0000
19:17724124:AG:A	acceptor_gain	1.0000
19:17724124:AGGCC:A	acceptor_loss	1.0000
19:17724125:G:A	acceptor_loss	1.0000
19:17724125:G:GG	acceptor_gain	1.0000
19:17724125:GG:G	acceptor_gain	1.0000
19:17724125:GGC:G	acceptor_gain	1.0000
19:17724125:GGCC:G	acceptor_gain	1.0000
19:17724125:GGCCA:G	acceptor_gain	1.0000
19:17724208:GGT:G	donor_loss	1.0000
19:17724209:GTAG:G	donor_loss	1.0000
19:17725185:GAGAG:G	donor_gain	1.0000
19:17725187:GAG:G	donor_gain	1.0000
19:17725190:GTAA:G	donor_loss	1.0000
19:17725191:T:A	donor_loss	1.0000
19:17725825:ACAG:A	acceptor_loss	1.0000
19:17725827:A:AG	acceptor_gain	1.0000
19:17725827:A:AT	acceptor_loss	1.0000
19:17725828:G:A	acceptor_loss	1.0000
19:17725828:G:GG	acceptor_gain	1.0000
19:17733188:CGCA:C	acceptor_loss	1.0000
19:17733189:GCA:G	acceptor_loss	1.0000
19:17733190:CAG:C	acceptor_loss	1.0000
19:17733191:A:AG	acceptor_gain	1.0000
19:17733191:A:T	acceptor_loss	1.0000
19:17733191:AG:A	acceptor_gain	1.0000
19:17733192:G:GA	acceptor_gain	1.0000

AlphaMissense

6703 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:17726210:T:A	W276R	0.998
19:17726210:T:C	W276R	0.998
19:17733404:G:C	K1000N	0.996
19:17733404:G:T	K1000N	0.996
19:17726304:G:C	R307P	0.995
19:17727596:T:C	C738R	0.995
19:17720947:T:A	W44R	0.994
19:17720947:T:C	W44R	0.994
19:17726243:G:C	A287P	0.994
19:17724174:T:C	L90P	0.993
19:17726121:T:C	F246S	0.993
19:17727598:C:G	C738W	0.993
19:17727617:T:C	F745L	0.993
19:17727619:T:A	F745L	0.993
19:17727619:T:G	F745L	0.993
19:17720987:T:C	L57P	0.992
19:17725086:T:C	L114P	0.992
19:17726165:T:C	F261L	0.992
19:17726167:C:A	F261L	0.992
19:17726167:C:G	F261L	0.992
19:17726212:G:C	W276C	0.992
19:17726212:G:T	W276C	0.992
19:17726303:C:A	R307S	0.992
19:17734315:T:A	W1023R	0.992
19:17734315:T:C	W1023R	0.992
19:17720995:T:C	F60L	0.991
19:17720997:T:A	F60L	0.991
19:17720997:T:G	F60L	0.991
19:17724171:T:A	V89D	0.991
19:17726235:G:C	R284P	0.991

dbSNP variants (sampled 300 via entrez): RS1000031049 (19:17732948 A>G), RS1000096095 (19:17733988 G>T), RS1000269953 (19:17718778 C>T), RS1000604272 (19:17717590 C>T), RS1000838586 (19:17727722 G>A), RS1000917375 (19:17726299 GC>G), RS1001504731 (19:17717915 T>C), RS1001549940 (19:17722818 A>G), RS1001551699 (19:17723742 C>G,T), RS1001644974 (19:17723578 C>A,T), RS1001846021 (19:17719696 T>G), RS1001883934 (19:17722713 C>T), RS1001977267 (19:17722371 T>C,G), RS1002228650 (19:17718063 G>A), RS1002270692 (19:17721765 A>G)

Disease associations

OMIM: gene MIM:607573 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST005194_109	Coronary artery disease	6.000000e-13
GCST005195_59	Coronary artery disease	1.000000e-13
GCST008163_287	Height	1.000000e-06
GCST010866_162	Coronary artery disease	4.000000e-15

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

42 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	increases abundance, increases expression, affects binding, increases reaction, decreases expression	5
bisphenol A	decreases expression	2
Acetaminophen	increases expression	2
aristolochic acid I	increases expression	1
FR900359	affects phosphorylation	1
bisphenol F	increases expression	1
triphenyl phosphate	affects expression	1
perfluorooctanoic acid	decreases expression	1
manganese chloride	increases abundance, increases expression	1
coumarin	affects phosphorylation	1
beta-methylcholine	affects expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
monomethylarsonous acid	increases expression	1
abrine	increases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	decreases expression	1
pentabrominated diphenyl ether 100	decreases expression	1
bisphenol S	increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Temozolomide	increases expression	1
Air Pollutants	affects expression, increases abundance	1
Arsenic	increases abundance, increases expression	1
Benzene	increases expression	1
Benzo(a)pyrene	increases methylation	1
Benztropine	increases expression	1
Cadmium	increases abundance, increases expression	1
Caffeine	affects phosphorylation	1
Cisplatin	decreases expression	1
Clozapine	increases expression	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.