MAP3K2-DT

Summary

MAP3K2-DT (MAP3K2 divergent transcript, HGNC:54088) is a long non-coding RNA gene on chromosome 2q14.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:54088
Approved symbol	MAP3K2-DT
Name	MAP3K2 divergent transcript
Location	2q14.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	ENST00000433673
Ensembl gene	ENSG00000236682
Ensembl biotype	lncRNA
Entrez	100506922
RNAcentral	URS00026A1AD0 — lncRNA, 2995 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 35 — 35 lncRNA

ENST00000433673, ENST00000654207, ENST00000654347, ENST00000685004, ENST00000685635, ENST00000688447, ENST00000692574, ENST00000692842, ENST00000693466, ENST00000778703, ENST00000778704, ENST00000778705, ENST00000778706, ENST00000778707, ENST00000778708, ENST00000778709, ENST00000778710, ENST00000778711, ENST00000778712, ENST00000778713, ENST00000778714, ENST00000778715, ENST00000778716, ENST00000778717, ENST00000778718, ENST00000778719, ENST00000778720, ENST00000778721, ENST00000778722, ENST00000778723, ENST00000778724, ENST00000778725, ENST00000778726, ENST00000778727, ENST00000778728

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000433673 — 4 exons

Exon	Start	End
ENSE00001674293	127389111	127389185
ENSE00003862738	127388881	127388998
ENSE00004148415	127397947	127400580
ENSE00004148427	127388181	127388311

Expression profiles

Bgee: expression breadth ubiquitous, 200 present calls, max score 86.61.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.0941 / max 127.0703, expressed in 1218 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
22418	4.0539	1215
22419	0.0253	7
22420	0.0149	1

Top tissues by expression

250 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.61	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	85.16	gold quality
right lobe of liver	UBERON:0001114	84.06	gold quality
putamen	UBERON:0001874	83.41	gold quality
nucleus accumbens	UBERON:0001882	83.39	gold quality
anterior cingulate cortex	UBERON:0009835	83.19	gold quality
right frontal lobe	UBERON:0002810	83.18	gold quality
caudate nucleus	UBERON:0001873	82.94	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.93	gold quality
gastrocnemius	UBERON:0001388	82.87	gold quality
adenohypophysis	UBERON:0002196	82.86	gold quality
muscle of leg	UBERON:0001383	82.61	gold quality
Brodmann (1909) area 9	UBERON:0013540	82.39	gold quality
spinal cord	UBERON:0002240	82.22	gold quality
amygdala	UBERON:0001876	81.99	gold quality
pituitary gland	UBERON:0000007	81.56	gold quality
descending thoracic aorta	UBERON:0002345	81.22	gold quality
hypothalamus	UBERON:0001898	81.18	gold quality
left testis	UBERON:0004533	80.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	80.94	gold quality
ascending aorta	UBERON:0001496	80.58	gold quality
thoracic aorta	UBERON:0001515	80.57	gold quality
right coronary artery	UBERON:0001625	80.48	gold quality
left lobe of thyroid gland	UBERON:0001120	80.25	gold quality
aorta	UBERON:0000947	79.83	gold quality
right adrenal gland cortex	UBERON:0035827	79.80	gold quality
tibial artery	UBERON:0007610	79.69	gold quality
popliteal artery	UBERON:0002250	79.68	gold quality
substantia nigra	UBERON:0002038	79.57	gold quality
testis	UBERON:0000473	79.55	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.62

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.