MAP3K20-AS1

Summary

MAP3K20-AS1 (MAP3K20 antisense RNA 1, HGNC:27935) is a long non-coding RNA gene on chromosome 2q31.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27935
Approved symbol	MAP3K20-AS1
Name	MAP3K20 antisense RNA 1
Location	2q31.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000238133
Ensembl biotype	lncRNA
Entrez	339751
RNAcentral	URS000075CC9C — lncRNA, 2551 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000419609, ENST00000422703, ENST00000423106

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000419609 — 3 exons

Exon	Start	End
ENSE00001648049	173207547	173207612
ENSE00001659310	173166446	173166838
ENSE00001760164	173192941	173193056

Expression profiles

Bgee: expression breadth ubiquitous, 147 present calls, max score 79.30.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.5983 / max 122.4084, expressed in 69 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
31825	0.5870	65
31824	0.0113	3

Top tissues by expression

235 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.30	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	75.41	gold quality
bone marrow cell	CL:0002092	75.02	gold quality
colonic epithelium	UBERON:0000397	70.37	gold quality
secondary oocyte	CL:0000655	69.49	gold quality
hindlimb stylopod muscle	UBERON:0004252	66.19	gold quality
gastrocnemius	UBERON:0001388	64.86	gold quality
calcaneal tendon	UBERON:0003701	64.61	gold quality
muscle of leg	UBERON:0001383	64.22	gold quality
mucosa of stomach	UBERON:0001199	62.00	gold quality
popliteal artery	UBERON:0002250	61.51	gold quality
tibial artery	UBERON:0007610	61.46	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	61.30	gold quality
lower esophagus	UBERON:0013473	61.18	gold quality
lower esophagus muscularis layer	UBERON:0035833	61.16	gold quality
ventricular zone	UBERON:0003053	60.08	gold quality
muscle layer of sigmoid colon	UBERON:0035805	58.76	gold quality
monocyte	CL:0000576	58.58	gold quality
ganglionic eminence	UBERON:0004023	58.47	gold quality
right ovary	UBERON:0002118	58.38	gold quality
aorta	UBERON:0000947	58.36	gold quality
apex of heart	UBERON:0002098	58.20	gold quality
body of uterus	UBERON:0009853	57.98	gold quality
left ovary	UBERON:0002119	57.64	gold quality
endocervix	UBERON:0000458	57.43	gold quality
right atrium auricular region	UBERON:0006631	57.16	gold quality
tendon	UBERON:0000043	57.09	gold quality
ectocervix	UBERON:0012249	57.08	gold quality
oviduct epithelium	UBERON:0004804	57.01	silver quality
skin of abdomen	UBERON:0001416	56.87	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.64

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• These findings demonstrate that knockdown of MLK7-AS1 by siRNA inhibits gastric cancer growth by epigenetically regulating miR-375. (PMID:29428732)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.