MAP3K9-DT

Summary

MAP3K9-DT (MAP3K9 divergent transcript, HGNC:53189) is a long non-coding RNA gene on chromosome 14q24.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53189
Approved symbol	MAP3K9-DT
Name	MAP3K9 divergent transcript
Location	14q24.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	lincNMR
Ensembl gene	ENSG00000259153
Ensembl biotype	lncRNA
Entrez	100506411
RNAcentral	URS00026A289A — lncRNA, 1653 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 27 — 26 lncRNA, 1 retained_intron

ENST00000554032, ENST00000557691, ENST00000653562, ENST00000661317, ENST00000685546, ENST00000697755, ENST00000697756, ENST00000697757, ENST00000697758, ENST00000697759, ENST00000697760, ENST00000697761, ENST00000697762, ENST00000697763, ENST00000697764, ENST00000697765, ENST00000697766, ENST00000697767, ENST00000697768, ENST00000697769, ENST00000697772, ENST00000697773, ENST00000697774, ENST00000697775, ENST00000697776, ENST00000817031, ENST00000817032

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000554032 — 3 exons

Exon	Start	End
ENSE00003938108	70809885	70809939
ENSE00003971607	70815111	70815396
ENSE00003971620	70810081	70810291

Expression profiles

Bgee: expression breadth ubiquitous, 132 present calls, max score 94.65.

FANTOM5 (CAGE): breadth broad, TPM avg 2.6312 / max 385.0674, expressed in 666 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
140414	2.2651	619
140413	0.3661	215

Top tissues by expression

132 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	94.65	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.79	gold quality
esophagus mucosa	UBERON:0002469	87.48	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.82	gold quality
cortical plate	UBERON:0005343	81.78	gold quality
superior frontal gyrus	UBERON:0002661	80.92	gold quality
prefrontal cortex	UBERON:0000451	80.85	gold quality
primary visual cortex	UBERON:0002436	79.37	gold quality
frontal cortex	UBERON:0001870	78.98	gold quality
nucleus accumbens	UBERON:0001882	78.98	gold quality
Brodmann (1909) area 9	UBERON:0013540	78.89	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	78.23	gold quality
cerebral cortex	UBERON:0000956	77.67	gold quality
caudate nucleus	UBERON:0001873	77.36	gold quality
putamen	UBERON:0001874	77.05	gold quality
anterior cingulate cortex	UBERON:0009835	76.81	gold quality
colonic epithelium	UBERON:0000397	76.76	gold quality
brain	UBERON:0000955	76.67	gold quality
cerebellar hemisphere	UBERON:0002245	76.31	gold quality
cerebellar cortex	UBERON:0002129	76.30	gold quality
cerebellum	UBERON:0002037	76.23	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	76.20	gold quality
right frontal lobe	UBERON:0002810	75.99	gold quality
islet of Langerhans	UBERON:0000006	75.89	gold quality
skin of leg	UBERON:0001511	75.82	gold quality
pituitary gland	UBERON:0000007	75.76	gold quality
ganglionic eminence	UBERON:0004023	75.50	gold quality
right hemisphere of cerebellum	UBERON:0014890	75.50	gold quality
adenohypophysis	UBERON:0002196	75.40	gold quality
hypothalamus	UBERON:0001898	75.37	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.86

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• The lncRNA lincNMR regulates nucleotide metabolism via a YBX1 - RRM2 axis in cancer. (PMID:32587247)
• APOBEC3B expression is promoted by lincNMR collaborating with TGF-beta-Smad pathway. (PMID:36335471)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.