MAP7D1

Summary

MAP7D1 (MAP7 domain containing 1, HGNC:25514) is a protein-coding gene on chromosome 1p34.3, encoding MAP7 domain-containing protein 1 (Q3KQU3). Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth.

Predicted to be involved in microtubule cytoskeleton organization. Located in spindle.

Source: NCBI Gene 55700 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 146 total
• MANE Select transcript: NM_001388490

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25514
Approved symbol	MAP7D1
Name	MAP7 domain containing 1
Location	1p34.3
Locus type	gene with protein product
Status	Approved
Aliases	FLJ10350, FLJ39022
Ensembl gene	ENSG00000116871
Ensembl biotype	protein_coding
Entrez	55700

Gene structure

Transcript identifiers

Ensembl transcripts: 30 — 24 protein_coding, 4 retained_intron, 2 protein_coding_CDS_not_defined

ENST00000316156, ENST00000373148, ENST00000373150, ENST00000373151, ENST00000429533, ENST00000462118, ENST00000474796, ENST00000487114, ENST00000487131, ENST00000527764, ENST00000530729, ENST00000530975, ENST00000532131, ENST00000879383, ENST00000879384, ENST00000879385, ENST00000879386, ENST00000879387, ENST00000879388, ENST00000879389, ENST00000879390, ENST00000879391, ENST00000879392, ENST00000879393, ENST00000879394, ENST00000967866, ENST00000967867, ENST00000967868, ENST00000967869, ENST00000967870

RefSeq mRNA: 4 — MANE Select: NM_001388490 NM_001286365, NM_001286366, NM_001388490, NM_018067

CCDS: CCDS30673, CCDS65492, CCDS65493, CCDS90916

Canonical transcript exons

ENST00000474796 — 17 exons

Exon	Start	End
ENSE00000916746	36178921	36179025
ENSE00001037177	36172464	36172627
ENSE00001254526	36171513	36171581
ENSE00001255036	36178419	36178596
ENSE00001255052	36176697	36176842
ENSE00001913730	36180248	36180849
ENSE00003504617	36173364	36173478
ENSE00003504927	36178685	36178823
ENSE00003550018	36179262	36179315
ENSE00003593992	36179666	36179756
ENSE00003599618	36177873	36178201
ENSE00003616813	36170971	36171315
ENSE00003626415	36176199	36176581
ENSE00003627495	36179874	36180067
ENSE00003631911	36179515	36179557
ENSE00003787942	36174898	36175008
ENSE00003922083	36156160	36156463

Expression profiles

Bgee: expression breadth ubiquitous, 288 present calls, max score 99.18.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 76.7413 / max 645.0370, expressed in 1825 samples.

FANTOM5 promoters (15 alternative TSS)

Promoter ID	TPM avg	Samples expressed
2153	67.0857	1823
2154	2.7140	1392
2155	1.6513	1056
2157	1.1433	665
2152	0.9008	400
2156	0.8944	393
2158	0.5515	289
2151	0.4674	243
2160	0.3901	171
2159	0.3226	152

Top tissues by expression

296 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
apex of heart	UBERON:0002098	99.18	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	98.71	gold quality
right atrium auricular region	UBERON:0006631	98.58	gold quality
sural nerve	UBERON:0015488	98.56	gold quality
spinal cord	UBERON:0002240	98.53	gold quality
gastrocnemius	UBERON:0001388	98.42	gold quality
cardiac atrium	UBERON:0002081	98.40	gold quality
right frontal lobe	UBERON:0002810	98.37	gold quality
heart left ventricle	UBERON:0002084	98.34	gold quality
prefrontal cortex	UBERON:0000451	98.21	gold quality
cardiac ventricle	UBERON:0002082	98.18	gold quality
hindlimb stylopod muscle	UBERON:0004252	98.16	gold quality
lower esophagus	UBERON:0013473	98.04	gold quality
lower esophagus muscularis layer	UBERON:0035833	98.04	gold quality
inferior vagus X ganglion	UBERON:0005363	98.01	gold quality
muscle of leg	UBERON:0001383	97.97	gold quality
right hemisphere of cerebellum	UBERON:0014890	97.97	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	97.87	gold quality
muscle layer of sigmoid colon	UBERON:0035805	97.79	gold quality
cingulate cortex	UBERON:0003027	97.77	gold quality
anterior cingulate cortex	UBERON:0009835	97.77	gold quality
cerebellar hemisphere	UBERON:0002245	97.75	gold quality
cerebellar cortex	UBERON:0002129	97.73	gold quality
heart	UBERON:0000948	97.67	gold quality
hypothalamus	UBERON:0001898	97.60	gold quality
right coronary artery	UBERON:0001625	97.56	gold quality
nucleus accumbens	UBERON:0001882	97.56	gold quality
skin of leg	UBERON:0001511	97.49	gold quality
amygdala	UBERON:0001876	97.46	gold quality
Brodmann (1909) area 9	UBERON:0013540	97.40	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	11.16

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

34 targeting MAP7D1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6758-5P	100.00	66.21	1470
HSA-MIR-6856-5P	100.00	65.47	1298
HSA-MIR-574-5P	100.00	66.01	989
HSA-MIR-6798-5P	100.00	65.77	699
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-MIR-6888-3P	99.97	65.95	1170
HSA-MIR-141-3P	99.94	72.79	2421
HSA-MIR-200A-3P	99.94	72.68	2420
HSA-MIR-144-3P	99.94	73.98	2698
HSA-MIR-3121-3P	99.82	71.96	3630
HSA-MIR-4658	99.77	64.94	514
HSA-MIR-6790-5P	99.77	65.24	505
HSA-MIR-6764-5P	99.75	67.89	2304
HSA-MIR-3659	99.70	67.97	694
HSA-MIR-1915-3P	99.58	66.79	1988
HSA-MIR-3136-3P	99.57	66.59	781
HSA-MIR-7155-3P	99.57	66.48	794
HSA-MIR-516B-5P	99.56	66.33	1495
HSA-MIR-582-5P	99.47	70.79	2635
HSA-MIR-18A-5P	99.29	71.05	806
HSA-MIR-18B-5P	99.29	71.05	806
HSA-MIR-7974	99.24	65.48	1137
HSA-MIR-6739-3P	99.22	68.84	1843
HSA-MIR-4735-3P	99.14	69.85	777
HSA-MIR-935	98.82	69.36	1072
HSA-MIR-423-5P	98.69	67.48	1522

Literature-anchored findings (GeneRIF, showing 3)

• Here we show that in HeLa cells, the paralogous MT-associated proteins Map7 and Map7D1 (Map7/7D1) form an interdependent regulatory loop with Disheveled, the critical signal transducer in Wnt signaling (PMID:29880710)
• MAP7 proteins are microtubule-tethered kinesin-1 activators, with which the motor transiently interacts as it moves along microtubules. (PMID:30770434)
• Genome-wide 5-Hydroxymethylcytosine Profiling Analysis Identifies MAP7D1 as A Novel Regulator of Lymph Node Metastasis in Breast Cancer. (PMID:33716151)

Cross-species orthologs

9 orthologs

Organism	Symbol	Gene ID
danio_rerio	si:ch73-281i18.3	ENSDARG00000089402
danio_rerio	map7d1a	ENSDARG00000098802
danio_rerio	si:ch73-281i18.6	ENSDARG00000101490
danio_rerio	si:ch73-281i18.4	ENSDARG00000102533
danio_rerio	si:ch73-281i18.7	ENSDARG00000103395
danio_rerio	map7d1b	ENSDARG00000104701
mus_musculus	Map7d1	ENSMUSG00000028849
rattus_norvegicus	Map7d1	ENSRNOG00000010237
drosophila_melanogaster	ens	FBGN0264693

Paralogs (3): MAP7D3 (ENSG00000129680), MAP7 (ENSG00000135525), MAP7D2 (ENSG00000184368)

Protein

Protein identifiers

MAP7 domain-containing protein 1 — Q3KQU3 (reviewed: Q3KQU3)

Alternative names: Arginine/proline-rich coiled-coil domain-containing protein 1, Proline/arginine-rich coiled-coil domain-containing protein 1

All UniProt accessions (5): Q3KQU3, C9JIR3, D3DPS3, E9PLH3, H0YF21

UniProt curated annotations — full annotation on UniProt →

Function. Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules.

Subcellular location. Cytoplasm. Cytoskeleton. Spindle. Microtubule organizing center. Centrosome. Midbody.

Similarity. Belongs to the MAP7 family.

Isoforms (4)

UniProt ID	Names	Canonical?
Q3KQU3-1	1	yes
Q3KQU3-2	2
Q3KQU3-3	3
Q3KQU3-4	4

RefSeq proteins (4): NP_001273294, NP_001273295, NP_001375419, NP_060537 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR008604	MAP7_fam	Family
IPR051483	MAP7_domain-containing	Family

Pfam: PF05672

UniProt features (61 total): modified residue 32, compositionally biased region 11, splice variant 6, region of interest 3, coiled-coil region 3, sequence variant 2, sequence conflict 2, chain 1, cross-link 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q3KQU3-F1	60.10	0.14

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (33): 47, 51, 70, 86, 93, 97, 113, 116, 118, 123, 125, 254, 273, 313, 366, 399, 442, 446, 452, 454 …

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 162 (showing top): GCACCTT_MIR18A_MIR18B, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GOCC_MICROTUBULE_ORGANIZING_CENTER, BILD_HRAS_ONCOGENIC_SIGNATURE, WEI_MYCN_TARGETS_WITH_E_BOX, RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_DN, GOCC_CENTROSOME, chr1p34, SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN, TGANTCA_AP1_C, TGACATY_UNKNOWN, LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN, RYTTCCTG_ETS2_B, GOCC_SPINDLE, GOCC_MIDBODY

GO Biological Process (1): microtubule cytoskeleton organization (GO:0000226)

GO Molecular Function (0):

GO Cellular Component (6): centrosome (GO:0005813), spindle (GO:0005819), microtubule cytoskeleton (GO:0015630), midbody (GO:0030496), cytoplasm (GO:0005737), cytoskeleton (GO:0005856)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
intracellular membraneless organelle	2
cellular anatomical structure	2
cytoskeleton organization	1
microtubule-based process	1
centriole	1
microtubule organizing center	1
microtubule cytoskeleton	1
cytoskeleton	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

1698 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MAP7D1	MAPK6	Q16659	444
MAP7D1	DNMBP	Q6XZF7	408
MAP7D1	KIF21A	Q7Z4S6	404
MAP7D1	CAMSAP3	Q9P1Y5	401
MAP7D1	CLASP1	Q7Z460	396
MAP7D1	GORASP1	Q9BQQ3	395
MAP7D1	CAMSAP2	Q08AD1	390
MAP7D1	TRIM46	Q7Z4K8	374
MAP7D1	PROSER3	Q2NL68	373
MAP7D1	KCNC3	Q14003	367
MAP7D1	MAP7D3	Q8IWC1	363
MAP7D1	KIF5C	O60282	362
MAP7D1	DYNLT3	P51808	345
MAP7D1	RBM26	Q5T8P6	340
MAP7D1	MAP9	Q49MG5	338

IntAct

217 interactions, top by confidence:

A	B	Type	Score
SPC24	NDC80	psi-mi:“MI:0914”(association)	0.920
YWHAB	PIK3C2A	psi-mi:“MI:0914”(association)	0.800
YWHAG	BLTP3B	psi-mi:“MI:0914”(association)	0.640
YWHAG	BLTP3B	psi-mi:“MI:2364”(proximity)	0.640
YWHAB	BLTP3B	psi-mi:“MI:2364”(proximity)	0.610
YWHAE	PIK3C2A	psi-mi:“MI:0914”(association)	0.570
YWHAH	BLTP3B	psi-mi:“MI:0914”(association)	0.570
YWHAZ	PIK3C2A	psi-mi:“MI:0914”(association)	0.570
YWHAH	BLTP3B	psi-mi:“MI:2364”(proximity)	0.570
TUBB3	POTEF	psi-mi:“MI:0914”(association)	0.530
ORF10	PPT1	psi-mi:“MI:0914”(association)	0.530
N	NOP56	psi-mi:“MI:0914”(association)	0.530
N	RBM47	psi-mi:“MI:0914”(association)	0.530
YWHAZ	BLTP3B	psi-mi:“MI:0914”(association)	0.530
LTBR	ZNF724	psi-mi:“MI:0914”(association)	0.530
MAGEB2	POLRMT	psi-mi:“MI:0914”(association)	0.530
CLEC11A	VWA8	psi-mi:“MI:0914”(association)	0.530
MAGEB2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
ZNRD2	MYO9A	psi-mi:“MI:0914”(association)	0.530
KIAA0753	OFD1	psi-mi:“MI:2364”(proximity)	0.480
CFTR	CNOT1	psi-mi:“MI:0914”(association)	0.480
DDX21	MED19	psi-mi:“MI:2364”(proximity)	0.480
H3C1	SMCHD1	psi-mi:“MI:2364”(proximity)	0.410
MAP7D1	CCDC47	psi-mi:“MI:0915”(physical association)	0.400
MAP7D1	SNRPB2	psi-mi:“MI:0915”(physical association)	0.400
Tubb4b	MGST3	psi-mi:“MI:0915”(physical association)	0.400
Cep170	NEURL4	psi-mi:“MI:0914”(association)	0.350
FOXL1	IFRD1	psi-mi:“MI:0914”(association)	0.350
JUN	TPM3	psi-mi:“MI:0914”(association)	0.350

BioGRID (211): MAP7D1 (Affinity Capture-MS), MAP7D1 (Affinity Capture-MS), MAP7D1 (Affinity Capture-MS), MAP7D1 (Biochemical Activity), MAP7D1 (Proximity Label-MS), MAP7D1 (Proximity Label-MS), MAP7D1 (Proximity Label-MS), MAP7D1 (Proximity Label-MS), MAP7D1 (Proximity Label-MS), MAP7D1 (Proximity Label-MS), MAP7D1 (Proximity Label-MS), MAP7D1 (Affinity Capture-MS), MAP7D1 (Affinity Capture-MS), MAP7D1 (Affinity Capture-MS), MAP7D1 (Affinity Capture-MS)

ESM2 similar proteins: A0A8I5ZM56, A2AG50, A2AI08, A2AJI0, A5D7K1, D4A4L4, E1C2Q8, F1LR10, O00515, O14529, O75128, O88573, O88735, P51825, P57016, Q14244, Q32LQ1, Q3KQU3, Q3U2K0, Q5JTD0, Q5NBX1, Q5PR69, Q5R7F9, Q5XHX2, Q5ZIA2, Q5ZJJ1, Q68DK7, Q6IPM2, Q6NV74, Q6NZF1, Q6PDH0, Q6PDM1, Q6PG95, Q6ZU35, Q86UU1, Q8CCJ4, Q8K124, Q8N7J2, Q8TD55, Q96PV7

Diamond homologs: A0A8I5ZM56, A2AG50, A2AJI0, D4A4L4, O88735, Q14244, Q3KQU3, Q5R7F9, Q5ZIA2, Q96T17

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 206 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Activation of BAD and translocation to mitochondria	7	42.6×	1e-08
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	7	37.6×	3e-08
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	7	37.6×	3e-08
Activation of BH3-only proteins	7	27.8×	2e-07
Intrinsic Pathway for Apoptosis	8	18.7×	3e-07
RHO GTPases activate PKNs	7	17.8×	3e-06
SARS-CoV-1-host interactions	12	16.9×	1e-09
Translocation of SLC2A4 (GLUT4) to the plasma membrane	13	16.1×	4e-10

GO biological processes:

GO term	Partners	Fold	FDR
cytoplasmic translation	11	12.0×	2e-06
mitotic spindle organization	7	11.2×	1e-03
negative regulation of translation	7	8.1×	6e-03
response to endoplasmic reticulum stress	8	7.8×	2e-03
translation	11	6.7×	5e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

146 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	119
Likely benign	6
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

1976 predictions. Top by Δscore:

Variant	Effect	Δscore
1:36170957:T:TA	acceptor_gain	1.0000
1:36170960:T:A	acceptor_gain	1.0000
1:36170966:TTCA:T	acceptor_loss	1.0000
1:36170967:TCA:T	acceptor_loss	1.0000
1:36170969:A:AG	acceptor_gain	1.0000
1:36170969:AG:A	acceptor_loss	1.0000
1:36170969:AGCT:A	acceptor_gain	1.0000
1:36170970:G:GG	acceptor_gain	1.0000
1:36170970:G:GT	acceptor_loss	1.0000
1:36170970:GCT:G	acceptor_gain	1.0000
1:36170970:GCTG:G	acceptor_gain	1.0000
1:36170970:GCTGT:G	acceptor_gain	1.0000
1:36171506:T:A	acceptor_gain	1.0000
1:36171510:CAGA:C	acceptor_loss	1.0000
1:36171511:A:AG	acceptor_gain	1.0000
1:36171511:AGAG:A	acceptor_gain	1.0000
1:36171512:G:GT	acceptor_gain	1.0000
1:36171512:GA:G	acceptor_gain	1.0000
1:36171512:GAGG:G	acceptor_gain	1.0000
1:36171512:GAGGT:G	acceptor_gain	1.0000
1:36171580:GG:G	donor_gain	1.0000
1:36171581:GG:G	donor_gain	1.0000
1:36171582:G:GG	donor_gain	1.0000
1:36171582:GTG:G	donor_loss	1.0000
1:36171583:T:A	donor_loss	1.0000
1:36171594:G:GT	donor_gain	1.0000
1:36172459:CACAG:C	acceptor_loss	1.0000
1:36172460:ACAGC:A	acceptor_gain	1.0000
1:36172462:A:AC	acceptor_loss	1.0000
1:36172462:A:AG	acceptor_gain	1.0000

AlphaMissense

5364 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:36176247:T:C	L300P	1.000
1:36172560:G:C	R186P	0.999
1:36172578:G:C	R192P	0.999
1:36172581:G:C	R193P	0.999
1:36176226:A:T	E293V	0.999
1:36176235:T:A	I296N	0.999
1:36176247:T:A	L300Q	0.999
1:36179266:T:C	L712P	0.999
1:36179275:T:C	I715T	0.999
1:36179275:T:G	I715S	0.999
1:36171555:G:C	R145P	0.998
1:36172471:G:C	K156N	0.998
1:36172471:G:T	K156N	0.998
1:36172536:G:C	R178P	0.998
1:36172580:C:A	R193S	0.998
1:36172599:G:C	R199P	0.998
1:36172605:G:C	R201P	0.998
1:36173376:G:C	A213P	0.998
1:36173379:G:C	A214P	0.998
1:36173430:T:A	W231R	0.998
1:36173430:T:C	W231R	0.998
1:36173436:T:A	W233R	0.998
1:36173436:T:C	W233R	0.998
1:36173438:G:C	W233C	0.998
1:36173438:G:T	W233C	0.998
1:36176222:T:A	W292R	0.998
1:36176222:T:C	W292R	0.998
1:36176225:G:A	E293K	0.998
1:36176244:G:C	R299P	0.998
1:36176267:T:C	F307L	0.998

dbSNP variants (sampled 300 via entrez): RS1000002845 (1:36170627 G>T), RS1000081836 (1:36158613 C>A,T), RS1000167327 (1:36159891 T>C,G), RS1000190762 (1:36176090 T>C,G), RS1000597378 (1:36179638 G>A,T), RS1000682116 (1:36167113 T>C), RS1000845680 (1:36164631 G>A), RS1000897490 (1:36158099 T>C), RS1000996551 (1:36171800 G>A), RS1001151592 (1:36171958 A>C), RS1001225164 (1:36157985 C>G), RS1001347571 (1:36164100 A>G), RS1001361744 (1:36164985 T>C), RS1001399765 (1:36159059 T>C), RS1001447547 (1:36157639 C>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST010320_34	PR interval	1.000000e-08
GCST010321_172	PR interval	2.000000e-08

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004462	PR interval

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

54 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases expression	3
bisphenol S	affects cotreatment, increases methylation, increases expression	2
Benzo(a)pyrene	affects methylation, increases expression	2
Cyclosporine	decreases expression, increases expression	2
aristolochic acid I	increases expression	1
FR900359	affects phosphorylation	1
TAK-243	increases sumoylation	1
dicrotophos	increases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	increases expression	1
lead acetate	increases expression	1
pyrogallol 1,3-dimethyl ether	affects cotreatment, decreases expression, affects localization, increases expression	1
methylparaben	increases expression	1
cobaltous chloride	increases expression	1
cupric chloride	increases expression	1
coumarin	decreases phosphorylation	1
isobutyl alcohol	affects cotreatment, increases abundance, increases expression	1
CGP 52608	affects binding, increases reaction	1
chloropicrin	decreases expression	1
perfluoro-n-nonanoic acid	decreases expression	1
K 7174	increases expression	1
nutlin 3	affects cotreatment, increases secretion	1
abrine	increases expression	1
Grape Seed Proanthocyanidins	affects cotreatment, decreases expression	1
bisphenol AF	increases expression	1
Temozolomide	decreases expression	1
Fulvestrant	affects cotreatment, increases methylation, decreases methylation	1
Acetaminophen	affects response to substance	1
Air Pollutants	affects expression, increases abundance	1
Ethanol	affects cotreatment, increases abundance, increases expression	1

Cellosaurus cell lines

2 cell lines: 1 transformed cell line, 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B3AM	Abcam HEK293T MAP7D1 KO	Transformed cell line	Female
CVCL_E2BU	HAP1 MAP7D1 (-)	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.