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MAP9

gene
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Also known as ASAPFLJ21159

Summary

MAP9 (microtubule associated protein 9, HGNC:26118) is a protein-coding gene on chromosome 4q32.1, encoding Microtubule-associated protein 9 (Q49MG5). Involved in organization of the bipolar mitotic spindle.

ASAP is a microtubule-associated protein required for spindle function, mitotic progression, and cytokinesis (Saffin et al., 2005 [PubMed 16049101]).

Source: NCBI Gene 79884 — RefSeq curated summary.

At a glance

  • GWAS associations: 4
  • Clinical variants (ClinVar): 101 total
  • MANE Select transcript: NM_001039580

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:26118
Approved symbolMAP9
Namemicrotubule associated protein 9
Location4q32.1
Locus typegene with protein product
StatusApproved
AliasesASAP, FLJ21159
Ensembl geneENSG00000164114
Ensembl biotypeprotein_coding
OMIM610070
Entrez79884

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 12 protein_coding, 1 nonsense_mediated_decay, 1 retained_intron

ENST00000311277, ENST00000379248, ENST00000424373, ENST00000433024, ENST00000450097, ENST00000481250, ENST00000503466, ENST00000515654, ENST00000650955, ENST00000933327, ENST00000933328, ENST00000933329, ENST00000933330, ENST00000933332

RefSeq mRNA: 1 — MANE Select: NM_001039580 NM_001039580

CCDS: CCDS35493

Canonical transcript exons

ENST00000311277 — 14 exons

ExonStartEnd
ENSE00001081572155362048155362141
ENSE00001081575155355716155355884
ENSE00001081577155368586155368812
ENSE00001081579155357449155357519
ENSE00001081582155360168155360415
ENSE00001399390155352596155352728
ENSE00001480276155342658155347905
ENSE00003466322155352912155353057
ENSE00003517187155353179155353340
ENSE00003561743155373136155373456
ENSE00003562281155375776155375914
ENSE00003608922155355071155355160
ENSE00003626892155374937155375021
ENSE00003841678155376771155376965

Expression profiles

Bgee: expression breadth ubiquitous, 265 present calls, max score 97.79.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.7773 / max 588.4982, expressed in 1320 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter IDTPM avgSamples expressed
545363.71771105
545382.04491010
545350.8241389
545370.190683

Top tissues by expression

287 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
lateral nuclear group of thalamusUBERON:000273697.79gold quality
Brodmann (1909) area 23UBERON:001355497.18gold quality
ponsUBERON:000098897.09gold quality
pigmented layer of retinaUBERON:000178296.09gold quality
substantia nigra pars compactaUBERON:000196595.91gold quality
bronchial epithelial cellCL:000232895.82gold quality
endothelial cellCL:000011595.37gold quality
superior vestibular nucleusUBERON:000722795.27gold quality
substantia nigra pars reticulataUBERON:000196695.22gold quality
mucosa of paranasal sinusUBERON:000503094.94gold quality
lateral globus pallidusUBERON:000247694.54gold quality
postcentral gyrusUBERON:000258192.35gold quality
parietal lobeUBERON:000187292.25gold quality
primary visual cortexUBERON:000243691.98gold quality
dorsal root ganglionUBERON:000004491.93gold quality
occipital lobeUBERON:000202191.05gold quality
entorhinal cortexUBERON:000272890.84gold quality
oocyteCL:000002390.79gold quality
ventral tegmental areaUBERON:000269190.78gold quality
caput epididymisUBERON:000435890.42gold quality
middle temporal gyrusUBERON:000277190.19gold quality
superior frontal gyrusUBERON:000266190.03gold quality
globus pallidusUBERON:000187589.25gold quality
trigeminal ganglionUBERON:000167589.20gold quality
medial globus pallidusUBERON:000247788.63gold quality
male germ line stem cell (sensu Vertebrata) in testisCL:0000089 ∩ UBERON:000047388.52gold quality
choroid plexus epitheliumUBERON:000391188.51gold quality
primordial germ cell in gonadCL:0000670 ∩ UBERON:000099188.49gold quality
cerebellar vermisUBERON:000472088.45gold quality
medulla oblongataUBERON:000189688.13gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 3.

ExperimentMarker?Max mean expression
E-ANND-3yes8.53
E-GEOD-81608yes5.09
E-GEOD-81547yes4.71

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

211 targeting MAP9, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-5692A100.0074.406850
HSA-MIR-190A-3P100.0080.355520
HSA-MIR-5011-5P100.0083.465820
HSA-MIR-4795-3P100.0074.624024
HSA-MIR-656-3P100.0072.152788
HSA-MIR-3613-3P100.0076.367965
HSA-LET-7A-3P100.0074.033932
HSA-LET-7B-3P100.0074.083913
HSA-LET-7F-1-3P100.0074.023928
HSA-MIR-98-3P100.0074.083907
HSA-MIR-5692B100.0071.322622
HSA-MIR-5692C100.0071.322622
HSA-MIR-4481100.0066.421669
HSA-MIR-3924100.0072.092394
HSA-MIR-3163100.0077.238605
HSA-MIR-126-5P100.0072.713180
HSA-MIR-7110-3P100.0073.182486
HSA-MIR-118499.9968.191458
HSA-MIR-511-3P99.9968.851467
HSA-MIR-428299.9975.366408
HSA-MIR-477599.9875.006394
HSA-MIR-569699.9872.364487
HSA-MIR-433-3P99.9869.371203
HSA-MIR-4789-5P99.9870.762721
HSA-MIR-60799.9773.625593
HSA-MIR-4666A-3P99.9671.713434
HSA-MIR-590-3P99.9674.346478
HSA-MIR-365899.9673.874379
HSA-MIR-548AT-5P99.9670.832666
HSA-MIR-55999.9572.283609

Literature-anchored findings (GeneRIF, showing 12)

  • ASAP is a human microtubule-associated protein required for bipolar spindle assembly and cytokinesis. (PMID:16049101)
  • Study demonstrates that AurA-mediated phosphorylation of ASAP is essential to spindle formation and mitosis. (PMID:17925329)
  • Results highlight dual ASAP regulation by Plk1 and further confirm the importance of ASAP for spindle pole organization, bipolar spindle assembly, and mitosis. (PMID:20615875)
  • ASAP stabilizes p53 both by alleviating MDM2-mediated p53 ubiquitination and by enhancing its p300-dependent acetylation. (PMID:22672907)
  • MAP9 downregulation is associated with colorectal malignancy. (PMID:24876664)
  • MAP9 rs1058992 polymorphism is associated with risk of EBV-associated gastric carcinoma (PMID:30472874)
  • Data suggest miR-320a/microtubule-associated protein 9 (MAP9) as promising targets for the treatment and prevention of postmenopausal osteoporosis (PMO). (PMID:31301305)
  • MAP9 Loss Triggers Chromosomal Instability, Initiates Colorectal Tumorigenesis, and Is Associated with Poor Survival of Patients with Colorectal Cancer. (PMID:31662330)
  • Microtubule associated protein 9 inhibits liver tumorigenesis by suppressing ERCC3. (PMID:32151798)
  • MAP9/ERCC3 signaling cascade: A new insight on understanding the chromosomal instability in hepatocellular carcinoma. (PMID:32268270)
  • Expression of MAP9 in Epstein-Barr virus-associated gastric carcinoma. (PMID:33309912)
  • MAP9/MAPH-9 supports axonemal microtubule doublets and modulates motor movement. (PMID:38159567)

Cross-species orthologs

4 orthologs

OrganismSymbolGene ID
danio_reriomap9ENSDARG00000037276
mus_musculusMap9ENSMUSG00000033900
rattus_norvegicusMap9ENSRNOG00000012982
caenorhabditis_elegansWBGENE00016397

Protein

Protein identifiers

Microtubule-associated protein 9 — Q49MG5 (reviewed: Q49MG5)

Alternative names: Aster-associated protein

All UniProt accessions (7): A0A0C4DG83, A2VCS9, A8MSM7, C9JXH8, Q49MG5, E7ETZ8, H0Y945

UniProt curated annotations — full annotation on UniProt →

Function. Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing interphase microtubules.

Subunit / interactions. Binds to purified microtubules via its C-terminus.

Subcellular location. Cytoplasm. Cytoskeleton. Spindle.

Isoforms (2)

UniProt IDNamesCanonical?
Q49MG5-11yes
Q49MG5-22

RefSeq proteins (1): NP_001034669* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR026106MAP9Family

UniProt features (31 total): compositionally biased region 8, region of interest 6, sequence variant 4, sequence conflict 4, coiled-coil region 3, modified residue 2, splice variant 2, initiator methionine 1, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q49MG5-F162.530.29

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 2, 12

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 159 (showing top): GOBP_MITOTIC_CYTOKINESIS, GOBP_CHROMOSOME_ORGANIZATION, AGGAAGC_MIR5163P, chr4q32, GOBP_REGULATION_OF_MICROTUBULE_BASED_PROCESS, CMYB_01, GOBP_MITOTIC_SPINDLE_ASSEMBLY, GOBP_ORGANELLE_FISSION, GOBP_CYTOKINESIS, GOBP_REGULATION_OF_SPINDLE_ORGANIZATION, GOBP_REGULATION_OF_CELL_CYCLE, GOBP_MITOTIC_NUCLEAR_DIVISION, GOBP_REGULATION_OF_CYTOKINESIS, GOBP_REGULATION_OF_CELL_DIVISION, GOBP_ORGANELLE_ASSEMBLY

GO Biological Process (7): mitotic cytokinesis (GO:0000281), regulation of mitotic centrosome separation (GO:0046602), regulation of mitotic spindle organization (GO:0060236), mitotic spindle assembly (GO:0090307), regulation of mitotic cytokinesis (GO:1902412), spindle assembly (GO:0051225), cell division (GO:0051301)

GO Molecular Function (1): microtubule binding (GO:0008017)

GO Cellular Component (11): astral microtubule (GO:0000235), cytoplasm (GO:0005737), axon (GO:0030424), spindle midzone (GO:0051233), mitotic spindle (GO:0072686), mitotic spindle midzone (GO:1990023), aster (GO:0005818), spindle (GO:0005819), cytoskeleton (GO:0005856), microtubule (GO:0005874), microtubule cytoskeleton (GO:0015630)

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
spindle3
intracellular membraneless organelle3
mitotic spindle organization2
cellular anatomical structure2
microtubule cytoskeleton2
mitotic cell cycle1
cytoskeleton-dependent cytokinesis1
mitotic cell cycle process1
mitotic centrosome separation1
regulation of cell cycle process1
regulation of spindle organization1
mitotic sister chromatid segregation1
spindle assembly1
mitotic nuclear division1
mitotic cytokinesis1
regulation of cytokinesis1
spindle organization1
chromosome segregation1
membraneless organelle assembly1
cellular process1
tubulin binding1
aster1
spindle microtubule1
cytoplasmic microtubule1
intracellular anatomical structure1
neuron projection1
spindle midzone1
mitotic spindle1
supramolecular complex1
polymeric cytoskeletal fiber1
cytoskeleton1

Protein interactions and networks

STRING

538 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
MAP9TUBA4AP05215722
MAP9AURKAO14965577
MAP9MAP10Q9P2G4479
MAP9NXPE3Q969Y0447
MAP9MAP7D3Q8IWC1407
MAP9MAP7Q14244399
MAP9MMABQ96EY8387
MAP9TMEM82A0PJX8382
MAP9CCDC163A0A0D9SF12376
MAP9RSPH9Q9H1X1371
MAP9NEDD1Q8NHV4363
MAP9ZNF154Q13106350
MAP9CIMAP1BA8MYP8339
MAP9MAP7D1Q3KQU3338
MAP9FAM161BQ96MY7324

IntAct

38 interactions, top by confidence:

ABTypeScore
NEURL4APBB1psi-mi:“MI:0914”(association)0.530
EZH1EPOPpsi-mi:“MI:0914”(association)0.530
MAP9AK2psi-mi:“MI:0915”(physical association)0.400
MAP9TPRpsi-mi:“MI:0915”(physical association)0.400
MAP9RPL10Apsi-mi:“MI:0915”(physical association)0.400
NEURL4CCDC85Cpsi-mi:“MI:0914”(association)0.350
ORF4aMPHOSPH10psi-mi:“MI:0914”(association)0.350
CAPZBENAHpsi-mi:“MI:0914”(association)0.350
CSNK2A1RPS3Apsi-mi:“MI:0914”(association)0.350
JPH3PLEKHG3psi-mi:“MI:0914”(association)0.350
IL13PLEKHG3psi-mi:“MI:0914”(association)0.350
ZNF677ZNF320psi-mi:“MI:0914”(association)0.350
AKR7LKIF2Apsi-mi:“MI:0914”(association)0.350
LINC02910MPHOSPH10psi-mi:“MI:0914”(association)0.350
C2CD6ACACBpsi-mi:“MI:0914”(association)0.350
ANKRD50PPP1R12Apsi-mi:“MI:0914”(association)0.350
ANAPC15U2SURPpsi-mi:“MI:0914”(association)0.350
GAGE2EWDR46psi-mi:“MI:0914”(association)0.350
H2AJWDR46psi-mi:“MI:0914”(association)0.350
SERF2WDR46psi-mi:“MI:0914”(association)0.350
NDC80WDR46psi-mi:“MI:0914”(association)0.350
CKAP2WDR46psi-mi:“MI:0914”(association)0.350
GNL2POLR1Gpsi-mi:“MI:0914”(association)0.350
IFI27L1KIF1Cpsi-mi:“MI:0914”(association)0.350
PSENENKIF1Cpsi-mi:“MI:0914”(association)0.350
LBHDHX16psi-mi:“MI:0914”(association)0.350
PEA15CLASP2psi-mi:“MI:0914”(association)0.350
EHHADHKHDRBS3psi-mi:“MI:0914”(association)0.350
EMBRLBP1psi-mi:“MI:0914”(association)0.350
GNPDA2MYH11psi-mi:“MI:0914”(association)0.350

BioGRID (62): MAP9 (Proximity Label-MS), MAP9 (Proximity Label-MS), MAP9 (Proximity Label-MS), MAP9 (Proximity Label-MS), MAP9 (Proximity Label-MS), MAP9 (Proximity Label-MS), MAP9 (Proximity Label-MS), MAP9 (Proximity Label-MS), MAP9 (Affinity Capture-MS), MAP9 (Proximity Label-MS), MAP9 (Proximity Label-MS), MAP9 (Proximity Label-MS), MAP9 (Proximity Label-MS), MAP9 (Proximity Label-MS), MAP9 (Proximity Label-MS)

ESM2 similar proteins: A0A1W2P884, A2RUB6, A7E3D8, A8MT70, B0CM36, B2RX88, E9PV87, F1PZQ5, O95447, Q09JY9, Q0IIM1, Q15398, Q1G7G9, Q2KHM9, Q2T9X8, Q3KQW7, Q3TRR0, Q3V036, Q49MG5, Q4KLH6, Q4R3Q7, Q4R6Q9, Q5NVK0, Q5RBD6, Q5RBY6, Q5SZL2, Q5TB80, Q5TID7, Q5VX52, Q66H16, Q66H34, Q6A000, Q6AYN9, Q6DF94, Q6NS45, Q6ZQ06, Q7ZX27, Q80VP2, Q80ZU5, Q86VQ0

Diamond homologs: Q3TRR0, Q49MG5

SIGNOR signaling

2 interactions.

AEffectBMechanism
AURKAup-regulatesMAP9phosphorylation
PLK1up-regulatesMAP9phosphorylation

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 58 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO termPartnersFoldFDR
cell division87.1×3e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

101 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance83
Likely benign5
Benign0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2194 predictions. Top by Δscore:

VariantEffectΔscore
4:155352591:CCT:Cdonor_loss1.0000
4:155352592:CTACC:Cdonor_loss1.0000
4:155352593:TACC:Tdonor_loss1.0000
4:155352594:A:ACdonor_gain1.0000
4:155352594:A:AGdonor_loss1.0000
4:155352594:ACCAG:Adonor_gain1.0000
4:155352595:C:CCdonor_gain1.0000
4:155352595:C:CGdonor_loss1.0000
4:155352595:CCAG:Cdonor_gain1.0000
4:155352595:CCAGC:Cdonor_gain1.0000
4:155352936:T:Cdonor_gain1.0000
4:155353177:A:ACdonor_gain1.0000
4:155353178:C:CCdonor_gain1.0000
4:155353189:T:TAdonor_gain1.0000
4:155353191:T:TAdonor_gain1.0000
4:155353336:TTTTT:Tacceptor_gain1.0000
4:155353337:TTTT:Tacceptor_gain1.0000
4:155353338:TTT:Tacceptor_gain1.0000
4:155353339:TT:Tacceptor_gain1.0000
4:155353340:TC:Tacceptor_loss1.0000
4:155353341:C:CCacceptor_gain1.0000
4:155353341:CTA:Cacceptor_loss1.0000
4:155353344:CAG:Cacceptor_gain1.0000
4:155353345:A:Tacceptor_gain1.0000
4:155353346:G:Cacceptor_gain1.0000
4:155353346:G:GCacceptor_gain1.0000
4:155360163:AATAC:Adonor_loss1.0000
4:155360164:ATACC:Adonor_loss1.0000
4:155360165:TACC:Tdonor_loss1.0000
4:155360166:ACC:Adonor_loss1.0000

AlphaMissense

4329 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
4:155355157:A:GW432R0.998
4:155355157:A:TW432R0.998
4:155353295:A:GW476R0.997
4:155353295:A:TW476R0.997
4:155353298:C:GA475P0.997
4:155353293:C:AW476C0.996
4:155353293:C:GW476C0.996
4:155355155:C:AW432C0.996
4:155355155:C:GW432C0.996
4:155353045:A:GW519R0.995
4:155353045:A:TW519R0.995
4:155353316:C:GA469P0.994
4:155353043:C:AW519C0.993
4:155353043:C:GW519C0.993
4:155353289:C:GA478P0.992
4:155353294:C:GW476S0.992
4:155355721:A:CY429D0.992
4:155355731:C:AR425S0.992
4:155355731:C:GR425S0.992
4:155375014:A:GL28P0.992
4:155352913:A:GW563R0.991
4:155352913:A:TW563R0.991
4:155353271:C:GA484P0.991
4:155375779:G:CF24L0.991
4:155375779:G:TF24L0.991
4:155375781:A:GF24L0.991
4:155374997:C:GA34P0.990
4:155353020:A:GL527P0.989
4:155353052:A:CF516L0.989
4:155353052:A:TF516L0.989

dbSNP variants (sampled 300 via entrez): RS1000069207 (4:155357827 G>C), RS10001550 (4:155352284 T>A,G), RS1000162264 (4:155366235 T>C), RS1000209259 (4:155371091 T>C), RS1000213002 (4:155370506 C>T), RS1000263284 (4:155346151 G>A), RS1000339923 (4:155351711 T>A), RS1000411807 (4:155364610 C>T), RS10004913 (4:155353432 T>G), RS10007738 (4:155363044 G>C), RS1000797466 (4:155376695 C>T), RS1000811125 (4:155372454 TTCTA>T), RS10008263 (4:155363760 C>T), RS1001079346 (4:155345105 T>C), RS1001092863 (4:155375432 C>A)

Disease associations

OMIM: gene MIM:610070 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

StudyTraitp-value
GCST007269_230Pulse pressure1.000000e-10
GCST009218_7Lateral ventricle temporal horn volume3.000000e-08
GCST010774_8Essential hypertension (time to event)1.000000e-07
GCST010867_59Coronary artery disease5.000000e-09

EFO canonical traits (2, from GWAS)

EFO IDTrait name
EFO:0005763pulse pressure measurement
EFO:0004918age at diagnosis

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

30 total (human), top 30 by PubMed support.

ChemicalActions (top 5)PubMed papers
Valproic Acidaffects expression, increases expression4
bisphenol Adecreases expression, increases methylation2
trichostatin Aaffects cotreatment, decreases expression2
Benzo(a)pyreneaffects methylation, increases expression2
Particulate Matterdecreases expression, increases abundance, increases expression2
aristolochic acid Idecreases expression1
methylmercuric chloridedecreases expression1
triphenyl phosphateaffects expression1
cypermethrinincreases expression1
monomethylarsonous acidincreases expression1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamideaffects cotreatment, decreases expression1
dorsomorphindecreases expression, affects cotreatment1
jinfukangdecreases expression1
Sunitinibdecreases expression1
Vorinostatincreases expression1
Air Pollutantsdecreases expression, increases abundance1
Vehicle Emissionsincreases abundance, increases expression1
Caffeineincreases phosphorylation1
Carbamazepineaffects expression1
Clorgylineincreases expression1
Leadaffects expression1
Mercuryincreases expression1
Methyl Methanesulfonateincreases expression1
Silicon Dioxideincreases expression1
Dihydrotestosteroneincreases expression1
Thimerosalincreases expression1
Tobacco Smoke Pollutiondecreases expression1
Cyclosporinedecreases expression1
Cadmium Chlorideincreases expression1
Magnetite Nanoparticlesincreases methylation1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

  • Disease cohort memberships (association, not causation — diseases whose associated-gene cohort lists this gene; a subset are also under Associated diseases): essential hypertension

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

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Sources 74

This page pulls from 74 datasets indexed by BioBTree:

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