MAPK1IP1L

Summary

MAPK1IP1L (mitogen-activated protein kinase 1 interacting protein 1 like, HGNC:19840) is a protein-coding gene on chromosome 14q22.3, encoding MAPK-interacting and spindle-stabilizing protein-like (Q8NDC0).

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 46 total
• MANE Select transcript: NM_144578

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19840
Approved symbol	MAPK1IP1L
Name	mitogen-activated protein kinase 1 interacting protein 1 like
Location	14q22.3
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000168175
Ensembl biotype	protein_coding
OMIM	617226
Entrez	93487

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 7 protein_coding, 3 protein_coding_CDS_not_defined

ENST00000395468, ENST00000553976, ENST00000554364, ENST00000556515, ENST00000866725, ENST00000866726, ENST00000969129, ENST00000969130, ENST00000969131, ENST00000969132

RefSeq mRNA: 1 — MANE Select: NM_144578 NM_144578

CCDS: CCDS32085

Canonical transcript exons

ENST00000395468 — 4 exons

Exon	Start	End
ENSE00001147454	55062618	55063325
ENSE00001490330	55064616	55070194
ENSE00001521801	55051647	55051803
ENSE00001646561	55061680	55061701

Expression profiles

Bgee: expression breadth ubiquitous, 295 present calls, max score 99.41.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 180.0837 / max 1732.8054, expressed in 1828 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
139688	173.4523	1826
139689	4.3169	1637
139696	1.1118	629
139694	0.6691	333
139693	0.5336	221

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cauda epididymis	UBERON:0004360	99.41	gold quality
caput epididymis	UBERON:0004358	99.27	gold quality
corpus epididymis	UBERON:0004359	99.12	gold quality
parotid gland	UBERON:0001831	98.96	gold quality
mucosa of sigmoid colon	UBERON:0004993	98.88	gold quality
renal medulla	UBERON:0000362	98.80	gold quality
hair follicle	UBERON:0002073	98.79	gold quality
cartilage tissue	UBERON:0002418	98.68	gold quality
cervix squamous epithelium	UBERON:0006922	98.67	gold quality
nipple	UBERON:0002030	98.63	gold quality
vena cava	UBERON:0004087	98.62	gold quality
nephron tubule	UBERON:0001231	98.60	gold quality
mammary duct	UBERON:0001765	98.60	gold quality
cranial nerve II	UBERON:0000941	98.55	gold quality
pylorus	UBERON:0001166	98.51	gold quality
superior surface of tongue	UBERON:0007371	98.46	gold quality
saphenous vein	UBERON:0007318	98.44	gold quality
epithelium of mammary gland	UBERON:0003244	98.40	gold quality
pharyngeal mucosa	UBERON:0000355	98.35	gold quality
colonic mucosa	UBERON:0000317	98.31	gold quality
heart right ventricle	UBERON:0002080	98.29	gold quality
cardia of stomach	UBERON:0001162	98.17	gold quality
pericardium	UBERON:0002407	98.13	gold quality
amniotic fluid	UBERON:0000173	98.12	gold quality
tongue	UBERON:0001723	98.03	gold quality
trabecular bone tissue	UBERON:0002483	98.03	gold quality
adult organism	UBERON:0007023	98.03	gold quality
tongue squamous epithelium	UBERON:0006919	98.00	gold quality
pigmented layer of retina	UBERON:0001782	97.98	gold quality
renal glomerulus	UBERON:0000074	97.92	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-6075	no	1310.61
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

227 targeting MAPK1IP1L, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-3667-3P	99.99	67.17	1636
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-568	99.98	69.86	2084
HSA-MIR-3065-5P	99.97	71.56	3281

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mapk1ip1l	ENSMUSG00000021840
mus_musculus	Mapk1ip1	ENSMUSG00000041775
rattus_norvegicus	Mapk1ip1	ENSRNOG00000016935
rattus_norvegicus		ENSRNOG00000077396

Protein

Protein identifiers

MAPK-interacting and spindle-stabilizing protein-like — Q8NDC0 (reviewed: Q8NDC0)

Alternative names: Mitogen-activated protein kinase 1-interacting protein 1-like

All UniProt accessions (1): Q8NDC0

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the MISS family.

RefSeq proteins (1): NP_653179* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR031653	MISS	Family

Pfam: PF15822

UniProt features (12 total): compositionally biased region 5, modified residue 4, initiator methionine 1, chain 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NDC0-F1	51.99	0.00

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (4): 6, 15, 2, 2

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 154 (showing top): GSE45365_CTRL_VS_MCMV_INFECTION_NK_CELL_DN, AAGCAAT_MIR137, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, TACAATC_MIR508, CTATGCA_MIR153, GGGCATT_MIR365, WANG_LMO4_TARGETS_DN, AAAGACA_MIR511, TIEN_INTESTINE_PROBIOTICS_24HR_UP, FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN, DOUGLAS_BMI1_TARGETS_UP, ZHENG_GLIOBLASTOMA_PLASTICITY_UP, HSF2_01, LIU_NASOPHARYNGEAL_CARCINOMA, HSF1_01

GO Biological Process (0):

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (0):

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	1

Protein interactions and networks

STRING

1527 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MAPK1IP1L	RAB15	P59190	567
MAPK1IP1L	RAB33B	Q9H082	547
MAPK1IP1L	PM20D2	Q8IYS1	520
MAPK1IP1L	ANAPC16	Q96DE5	477
MAPK1IP1L	BTF3L4	Q96K17	423
MAPK1IP1L	ERVMER34-1	Q9H9K5	407
MAPK1IP1L	MAP7D2	Q96T17	399
MAPK1IP1L	PPP4R4	Q6NUP7	397
MAPK1IP1L	INTS5	Q6P9B9	395
MAPK1IP1L	SPACA1	Q9HBV2	369
MAPK1IP1L	GTF2H3	Q13889	369
MAPK1IP1L	SYNDIG1L	A6NDD5	362
MAPK1IP1L	STARD5	P59094	355
MAPK1IP1L	EOLA1	Q8TE69	349
MAPK1IP1L	ARB2A	Q8WUF8	345

IntAct

120 interactions, top by confidence:

A	B	Type	Score
MAPK1IP1L	C1orf94	psi-mi:“MI:0915”(physical association)	0.750
C1orf94	MAPK1IP1L	psi-mi:“MI:0915”(physical association)	0.750
MAPK1IP1L	EWSR1	psi-mi:“MI:0915”(physical association)	0.740
EWSR1	MAPK1IP1L	psi-mi:“MI:0915”(physical association)	0.740
MAPK1IP1L	VPS37C	psi-mi:“MI:0915”(physical association)	0.720
MAPK1IP1L	HGS	psi-mi:“MI:0915”(physical association)	0.720
UBE2I	MAPK1IP1L	psi-mi:“MI:0915”(physical association)	0.720
TFG	MAPK1IP1L	psi-mi:“MI:0915”(physical association)	0.720
VPS37C	MAPK1IP1L	psi-mi:“MI:0915”(physical association)	0.720
HGS	MAPK1IP1L	psi-mi:“MI:0915”(physical association)	0.720
MAPK1IP1L	UBE2I	psi-mi:“MI:0915”(physical association)	0.720
MAPK1IP1L	TFG	psi-mi:“MI:0915”(physical association)	0.720
LENG8	MAPK1IP1L	psi-mi:“MI:0915”(physical association)	0.700

BioGRID (62): MAPK1IP1L (Two-hybrid), MAPK1IP1L (Two-hybrid), MAPK1IP1L (Two-hybrid), MAPK1IP1L (Two-hybrid), MAPK1IP1L (Two-hybrid), MAPK1IP1L (Two-hybrid), MAPK1IP1L (Two-hybrid), MAPK1IP1L (Two-hybrid), MAPK1IP1L (Two-hybrid), MAPK1IP1L (Two-hybrid), MAPK1IP1L (Two-hybrid), MAPK1IP1L (Two-hybrid), MAPK1IP1L (Two-hybrid), SUMO1P1 (Two-hybrid), MAPK1IP1L (Two-hybrid)

ESM2 similar proteins: A5PJN8, B1AYB6, B2RWS6, B2RYL1, C7EMF5, F4I171, O48582, O55196, O75157, P0CG10, P0CG12, P0CG14, P18583, P45481, P49750, P62500, P62501, Q09472, Q10571, Q14686, Q148B6, Q15428, Q29W20, Q32KG4, Q3HS82, Q4R837, Q5E9L3, Q5ISE2, Q5JT82, Q5PRE5, Q5R623, Q62203, Q66IN2, Q6JHU9, Q6UX39, Q76KD6, Q86XN7, Q8BH93, Q8NDC0, Q91012

Diamond homologs: Q4R837, Q5E9L3, Q5R623, Q8BH93, Q8NDC0, Q9D7G9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

46 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	37
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

982 predictions. Top by Δscore:

Variant	Effect	Δscore
14:55062616:A:AG	acceptor_gain	1.0000
14:55062617:G:GG	acceptor_gain	1.0000
14:55064789:T:TA	donor_gain	1.0000
14:55064790:A:AA	donor_gain	1.0000
14:55051799:GCCGG:G	donor_gain	0.9900
14:55051802:GG:G	donor_gain	0.9900
14:55051803:GG:G	donor_gain	0.9900
14:55061700:CGGTA:C	donor_loss	0.9900
14:55061701:GGT:G	donor_loss	0.9900
14:55061702:G:GG	donor_gain	0.9900
14:55061702:GTAA:G	donor_loss	0.9900
14:55061703:T:A	donor_loss	0.9900
14:55062614:CCA:C	acceptor_loss	0.9900
14:55062616:AGTT:A	acceptor_gain	0.9900
14:55062617:GTT:G	acceptor_gain	0.9900
14:55062617:GTTG:G	acceptor_gain	0.9900
14:55062808:G:GT	donor_gain	0.9900
14:55062809:A:T	donor_gain	0.9900
14:55062897:G:GA	donor_gain	0.9900
14:55063326:G:GG	donor_gain	0.9900
14:55064614:A:AG	acceptor_gain	0.9900
14:55064615:G:GG	acceptor_gain	0.9900
14:55064664:G:GT	donor_gain	0.9900
14:55064763:A:G	donor_gain	0.9900
14:55064825:G:GT	donor_gain	0.9900
14:55051804:G:GG	donor_gain	0.9800
14:55051804:GT:G	donor_loss	0.9800
14:55051827:G:GT	donor_gain	0.9800
14:55051960:GAC:G	donor_gain	0.9800
14:55053811:G:GT	donor_gain	0.9800

AlphaMissense

1517 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
14:55061696:T:C	F5L	0.990
14:55061698:T:A	F5L	0.990
14:55061698:T:G	F5L	0.990
14:55063194:T:A	W199R	0.975
14:55063194:T:C	W199R	0.975
14:55063196:G:C	W199C	0.961
14:55063196:G:T	W199C	0.961
14:55062619:T:C	L7S	0.957
14:55061697:T:C	F5S	0.951
14:55062789:T:C	F64L	0.950
14:55062791:T:A	F64L	0.950
14:55062791:T:G	F64L	0.950
14:55061697:T:G	F5C	0.949
14:55063272:T:C	F225L	0.942
14:55063274:C:A	F225L	0.942
14:55063274:C:G	F225L	0.942
14:55063056:T:A	W153R	0.941
14:55063056:T:C	W153R	0.941
14:55063180:T:A	V194D	0.937
14:55063058:G:C	W153C	0.926
14:55063058:G:T	W153C	0.926
14:55063172:G:C	W191C	0.919
14:55063172:G:T	W191C	0.919
14:55062861:T:C	F88L	0.906
14:55062863:T:A	F88L	0.906
14:55062863:T:G	F88L	0.906
14:55062959:T:A	N120K	0.899
14:55062959:T:G	N120K	0.899
14:55063034:G:C	W145C	0.897
14:55063034:G:T	W145C	0.897

dbSNP variants (sampled 300 via entrez): RS1000195504 (14:55053163 A>G), RS1000926357 (14:55051870 C>T), RS1001051329 (14:55068125 T>C), RS1001069852 (14:55052109 C>T), RS1001126252 (14:55062029 A>G), RS1001408403 (14:55051170 T>C), RS1001533331 (14:55057307 G>T), RS1001663983 (14:55061154 C>CA), RS1001913667 (14:55054854 T>C), RS1001976862 (14:55056035 C>A,T), RS1002054 (14:55062195 A>C,T), RS1002239076 (14:55051457 G>A,C,T), RS1002398005 (14:55056809 A>G), RS1002414990 (14:55062319 A>C,G), RS1002578125 (14:55050037 T>C)

Disease associations

OMIM: gene MIM:617226 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST008595_84	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy)	3.000000e-08
GCST010676_4	Leukoderma in response to rhododendrol	9.000000e-06

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004337	intelligence
EFO:0004784	self reported educational attainment

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

29 total (human), top 29 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cisplatin	increases expression, affects cotreatment, decreases expression	3
bisphenol A	decreases expression, affects cotreatment, decreases methylation	2
Cadmium Chloride	decreases expression, increases abundance	2
aristolochic acid I	decreases expression	1
FR900359	decreases phosphorylation	1
dicrotophos	increases expression	1
triphenyl phosphate	affects expression	1
diethyl maleate	increases expression	1
sodium arsenite	increases abundance, affects cotreatment, decreases expression	1
deguelin	increases expression	1
jinfukang	affects cotreatment, decreases expression	1
Fulvestrant	affects cotreatment, decreases methylation	1
Acetaminophen	increases expression	1
Arsenic	affects cotreatment, decreases expression, increases abundance	1
Cadmium	decreases expression, increases abundance	1
Caffeine	increases phosphorylation	1
Hydrogen Peroxide	affects cotreatment, increases expression	1
Ivermectin	decreases expression	1
Smoke	decreases expression	1
Dronabinol	increases expression	1
Theophylline	affects cotreatment, increases expression	1
Tobacco Smoke Pollution	increases expression	1
Tretinoin	increases expression	1
Urethane	increases expression	1
Valproic Acid	decreases expression	1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	increases expression	1
Cyclosporine	increases expression	1
Aflatoxin B1	increases methylation	1
Antirheumatic Agents	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.