MAPKAPK5-AS1

Summary

MAPKAPK5-AS1 (MAPKAPK5 antisense RNA 1, HGNC:24091) is a long non-coding RNA gene on chromosome 12q24.12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24091
Approved symbol	MAPKAPK5-AS1
Name	MAPKAPK5 antisense RNA 1
Location	12q24.12
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ39616, MAAS, lncRNA-cCSC1
Ensembl gene	ENSG00000234608
Ensembl biotype	lncRNA
Entrez	51275
RNAcentral	URS0000CCDFB5 — lncRNA, 2390 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 23 — 23 lncRNA

ENST00000428207, ENST00000442119, ENST00000443596, ENST00000456429, ENST00000590479, ENST00000609228, ENST00000609983, ENST00000652940, ENST00000656209, ENST00000656227, ENST00000671444, ENST00000688987, ENST00000692189, ENST00000738349, ENST00000738350, ENST00000738351, ENST00000738352, ENST00000738353, ENST00000738354, ENST00000738355, ENST00000738356, ENST00000738357, ENST00000738358

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000428207 — 2 exons

Exon	Start	End
ENSE00004073503	111841327	111842902
ENSE00004073548	111839760	111840477

Expression profiles

Bgee: expression breadth ubiquitous, 257 present calls, max score 95.15.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 14.7092 / max 335.0840, expressed in 1783 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
133314	11.2246	1762
133315	1.8494	1035
133316	0.9369	558
133313	0.6983	409

Top tissues by expression

279 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
mucosa of transverse colon	UBERON:0004991	95.15	gold quality
right lung	UBERON:0002167	93.57	gold quality
rectum	UBERON:0001052	93.17	gold quality
cortical plate	UBERON:0005343	92.41	gold quality
transverse colon	UBERON:0001157	91.99	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	91.94	gold quality
ganglionic eminence	UBERON:0004023	91.93	gold quality
nucleus accumbens	UBERON:0001882	91.90	gold quality
anterior cingulate cortex	UBERON:0009835	91.89	gold quality
cingulate cortex	UBERON:0003027	91.73	gold quality
caudate nucleus	UBERON:0001873	91.31	gold quality
granulocyte	CL:0000094	91.29	gold quality
right frontal lobe	UBERON:0002810	90.83	gold quality
prefrontal cortex	UBERON:0000451	90.81	gold quality
upper lobe of left lung	UBERON:0008952	90.77	gold quality
apex of heart	UBERON:0002098	90.75	gold quality
amygdala	UBERON:0001876	90.66	gold quality
putamen	UBERON:0001874	90.57	gold quality
monocyte	CL:0000576	90.55	gold quality
small intestine Peyer’s patch	UBERON:0003454	90.54	gold quality
leukocyte	CL:0000738	90.46	gold quality
spinal cord	UBERON:0002240	90.36	gold quality
mononuclear cell	CL:0000842	90.26	gold quality
cerebellar hemisphere	UBERON:0002245	90.26	gold quality
cerebellar cortex	UBERON:0002129	90.17	gold quality
muscle layer of sigmoid colon	UBERON:0035805	90.10	gold quality
upper lobe of lung	UBERON:0008948	90.07	gold quality
spleen	UBERON:0002106	90.00	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	89.95	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	89.88	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.61

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• Data show that cyclin-dependent kinase inhibitor 1A protein (p21) is a target of long noncoding RNA MAPKAPK5-AS1. (PMID:30343528)
• lncRNA expression profiles related to apoptosis and autophagy in peripheral blood mononuclear cells of patients with rheumatoid arthritis. (PMID:32569434)
• Long noncoding RNA MAPKAPK5-AS1 promotes colorectal cancer progression by cis-regulating the nearby gene MK5 and acting as a let-7f-1-3p sponge. (PMID:32690100)
• IncRNA MAPKAPK5-AS1 promotes proliferation and migration of thyroid cancer cell lines by targeting miR-519e-5p/YWHAH. (PMID:33272009)
• LncRNA-cCSC1 promotes cell proliferation of colorectal cancer through sponging miR-124-3p and upregulating CD44. (PMID:33887588)
• LncRNA MAPKAPK5_AS1 facilitates cell proliferation in hepatitis B virus -related hepatocellular carcinoma. (PMID:35264707)
• Long noncoding RNA MAPKAPK5-AS1 promotes metastasis through regulation miR-376b-5p/ECT2 axis in hepatocellular carcinoma. (PMID:36567178)
• Upregulation of MAPKAPK5-AS1, PXN-AS1 and URB1-AS1 lncRNAs in non-functioning pituitary adenoma. (PMID:37154079)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.