MAPT-AS1

Summary

MAPT-AS1 (MAPT antisense RNA 1, HGNC:43738) is a long non-coding RNA gene on chromosome 17q21.31.

Involved in regulatory ncRNA-mediated gene silencing. Implicated in Parkinson’s disease.

Source: NCBI Gene 100128977 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43738
Approved symbol	MAPT-AS1
Name	MAPT antisense RNA 1
Location	17q21.31
Locus type	RNA, long non-coding
Status	Approved
Aliases	MAPT-AS
Ensembl gene	ENSG00000264589
Ensembl biotype	lncRNA
Entrez	100128977
RNAcentral	URS000075DB76 — lncRNA, 855 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 9 lncRNA

ENST00000579244, ENST00000579599, ENST00000581125, ENST00000634876, ENST00000649665, ENST00000653949, ENST00000793286, ENST00000793287, ENST00000793288

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579244 — 2 exons

Exon	Start	End
ENSE00002697542	45843651	45844161
ENSE00002717058	45895480	45895600

Expression profiles

Bgee: expression breadth ubiquitous, 108 present calls, max score 79.77.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.6217 / max 109.8355, expressed in 159 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
166558	0.4940	143
166559	0.1277	62

Top tissues by expression

108 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right testis	UBERON:0004534	79.77	gold quality
left testis	UBERON:0004533	79.45	gold quality
cerebellum	UBERON:0002037	79.31	gold quality
cerebellar cortex	UBERON:0002129	79.25	gold quality
cerebellar hemisphere	UBERON:0002245	79.25	gold quality
colonic epithelium	UBERON:0000397	78.92	gold quality
right hemisphere of cerebellum	UBERON:0014890	78.85	gold quality
testis	UBERON:0000473	78.63	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	76.55	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	75.69	gold quality
cortical plate	UBERON:0005343	74.83	gold quality
superior frontal gyrus	UBERON:0002661	74.15	gold quality
prefrontal cortex	UBERON:0000451	72.94	gold quality
temporal lobe	UBERON:0001871	72.74	gold quality
amygdala	UBERON:0001876	72.61	gold quality
frontal cortex	UBERON:0001870	72.24	gold quality
hypothalamus	UBERON:0001898	71.89	gold quality
cerebral cortex	UBERON:0000956	71.18	gold quality
right frontal lobe	UBERON:0002810	71.01	gold quality
anterior cingulate cortex	UBERON:0009835	70.96	gold quality
brain	UBERON:0000955	70.85	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	70.51	gold quality
Brodmann (1909) area 9	UBERON:0013540	70.15	gold quality
Ammon’s horn	UBERON:0001954	69.89	gold quality
putamen	UBERON:0001874	68.66	gold quality
primary visual cortex	UBERON:0002436	68.61	gold quality
cortex of kidney	UBERON:0001225	68.29	gold quality
hindlimb stylopod muscle	UBERON:0004252	68.23	gold quality
substantia nigra	UBERON:0002038	68.14	gold quality
caudate nucleus	UBERON:0001873	66.71	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.43

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• MAPT-AS1 and DNMT1 have been identified as potential epigenetic regulators of MAPT expression in PD across four different brain regions. Our data also suggest that increased MAPT expression could be associated with disease state, but not with PD neuropathology severity. (PMID:27336847)
• the level of MAPT-AS1 was correlated with the expression of MAPT, and MAPT was associated with survival time in breast cancer. (PMID:30074401)
• MIR-NATs repress MAPT translation and aid proteostasis in neurodegeneration. (PMID:34012113)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.