MAPT-IT1

Summary

MAPT-IT1 (MAPT intronic transcript 1, HGNC:43741) is a long non-coding RNA gene on chromosome 17q21.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43741
Approved symbol	MAPT-IT1
Name	MAPT intronic transcript 1
Location	17q21.31
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000279685
Ensembl biotype	lncRNA
Entrez	100130148
RNAcentral	URS000075C819 — lncRNA, 3024 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000624111

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000624111 — 1 exons

Exon	Start	End
ENSE00003759930	45895783	45898798

Expression profiles

Bgee: expression breadth broad, 64 present calls, max score 85.79.

Top tissues by expression

64 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.79	gold quality
cortex of kidney	UBERON:0001225	83.14	gold quality
skeletal muscle tissue	UBERON:0001134	68.32	silver quality
cortical plate	UBERON:0005343	67.42	gold quality
prefrontal cortex	UBERON:0000451	66.31	gold quality
frontal cortex	UBERON:0001870	62.98	gold quality
superior frontal gyrus	UBERON:0002661	61.94	gold quality
hindlimb stylopod muscle	UBERON:0004252	60.75	silver quality
hypothalamus	UBERON:0001898	60.51	gold quality
cerebral cortex	UBERON:0000956	59.71	gold quality
ventricular zone	UBERON:0003053	59.60	silver quality
ganglionic eminence	UBERON:0004023	58.71	gold quality
Brodmann (1909) area 9	UBERON:0013540	58.54	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	58.52	gold quality
anterior cingulate cortex	UBERON:0009835	58.28	gold quality
right frontal lobe	UBERON:0002810	58.17	gold quality
adenohypophysis	UBERON:0002196	56.93	gold quality
pituitary gland	UBERON:0000007	56.69	gold quality
brain	UBERON:0000955	56.49	gold quality
primary visual cortex	UBERON:0002436	56.39	gold quality
temporal lobe	UBERON:0001871	54.69	gold quality
amygdala	UBERON:0001876	54.51	gold quality
substantia nigra	UBERON:0002038	54.21	gold quality
multicellular organism	UBERON:0000468	54.19	gold quality
Ammon’s horn	UBERON:0001954	54.14	gold quality
corpus callosum	UBERON:0002336	53.38	gold quality
cerebellum	UBERON:0002037	53.02	gold quality
putamen	UBERON:0001874	53.01	gold quality
cerebellar cortex	UBERON:0002129	52.99	gold quality
right hemisphere of cerebellum	UBERON:0014890	52.96	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.