MARCHF6-DT

Summary

MARCHF6-DT (MARCHF6 divergent transcript, HGNC:56238) is a long non-coding RNA gene on chromosome 5p15.2. Micropeptide that acts as a regulator of DNA repair both by preventing KLHL15-mediated ubiquitination and degradation of RBBP8/CtIP, and by promoting the poly-ADP-ribosyltransferase activity of PARP1.

Enables poly-ADP-D-ribose binding activity. Involved in negative regulation of protein ubiquitination and positive regulation of DNA repair. Is active in nucleolus and site of DNA damage.

Source: NCBI Gene 101929977 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:56238
Approved symbol	MARCHF6-DT
Name	MARCHF6 divergent transcript
Location	5p15.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	CTD-2256P15.2, PACMP
Ensembl gene	ENSG00000259802
Ensembl biotype	lncRNA
Entrez	101929977
RNAcentral	URS00026A2760 — lncRNA, 1968 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 10 lncRNA

ENST00000561606, ENST00000705515, ENST00000705516, ENST00000705517, ENST00000784828, ENST00000784829, ENST00000784830, ENST00000784831, ENST00000784832, ENST00000784833

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000561606 — 1 exons

Exon	Start	End
ENSE00004159984	10352580	10353634

Expression profiles

Bgee: expression breadth ubiquitous, 158 present calls, max score 92.47.

Top tissues by expression

242 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	92.47	gold quality
bone marrow cell	CL:0002092	74.04	gold quality
right lobe of liver	UBERON:0001114	73.99	gold quality
islet of Langerhans	UBERON:0000006	72.13	gold quality
right adrenal gland	UBERON:0001233	69.39	gold quality
right adrenal gland cortex	UBERON:0035827	68.42	gold quality
adenohypophysis	UBERON:0002196	68.07	gold quality
left adrenal gland	UBERON:0001234	67.82	gold quality
left adrenal gland cortex	UBERON:0035825	67.74	gold quality
gastrocnemius	UBERON:0001388	67.55	gold quality
granulocyte	CL:0000094	67.53	gold quality
muscle of leg	UBERON:0001383	67.23	gold quality
cortical plate	UBERON:0005343	67.19	gold quality
liver	UBERON:0002107	66.93	gold quality
ventricular zone	UBERON:0003053	66.67	gold quality
leukocyte	CL:0000738	66.59	gold quality
pituitary gland	UBERON:0000007	66.56	gold quality
prefrontal cortex	UBERON:0000451	66.51	gold quality
monocyte	CL:0000576	66.47	gold quality
adrenal cortex	UBERON:0001235	65.96	gold quality
adrenal gland	UBERON:0002369	65.85	gold quality
pancreas	UBERON:0001264	64.80	gold quality
left testis	UBERON:0004533	64.66	gold quality
ganglionic eminence	UBERON:0004023	64.37	gold quality
mucosa of transverse colon	UBERON:0004991	63.95	gold quality
right testis	UBERON:0004534	63.67	gold quality
adult mammalian kidney	UBERON:0000082	63.43	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	63.18	gold quality
anterior cingulate cortex	UBERON:0009835	63.17	gold quality
testis	UBERON:0000473	63.06	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.88

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.