MBNL1-AS1
gene geneOn this page
Also known as LOC401093
Summary
MBNL1-AS1 (MBNL1 antisense RNA 1, HGNC:44584) is a long non-coding RNA gene on chromosome 3q25.1.
At a glance
- Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).
Identifiers
Gene identifiers
| Field | Value |
|---|---|
| HGNC ID | HGNC:44584 |
| Approved symbol | MBNL1-AS1 |
| Name | MBNL1 antisense RNA 1 |
| Location | 3q25.1 |
| Locus type | RNA, long non-coding |
| Status | Approved |
| Aliases | LOC401093 |
| Ensembl gene | ENSG00000229619 |
| Ensembl biotype | lncRNA |
| Entrez | 401093 |
| RNAcentral | URS000075BBFA — lncRNA, 6658 nt, 1 organism(s) |
Gene structure
Transcript identifiers
Ensembl transcripts: 4 — 4 lncRNA
ENST00000445466, ENST00000608395, ENST00000665663, ENST00000669594
RefSeq mRNA: 0 — MANE Select: None
Canonical transcript exons
ENST00000445466 — 2 exons
| Exon | Start | End |
|---|---|---|
| ENSE00001750588 | 152269439 | 152269546 |
| ENSE00001758248 | 152268184 | 152269072 |
Expression profiles
Bgee: expression breadth ubiquitous, 216 present calls, max score 99.15.
FANTOM5 (CAGE): breadth ubiquitous, TPM avg 3.4465 / max 187.9417, expressed in 1234 samples.
FANTOM5 promoters (7 alternative TSS)
| Promoter ID | TPM avg | Samples expressed |
|---|---|---|
| 45185 | 2.4786 | 973 |
| 45183 | 0.3299 | 154 |
| 45187 | 0.2438 | 99 |
| 45186 | 0.2233 | 107 |
| 45184 | 0.0641 | 19 |
| 45182 | 0.0570 | 20 |
| 45181 | 0.0498 | 25 |
Top tissues by expression
236 total, by Bgee expression score (0-100, higher = more expressed):
| Tissue | Anatomy ID | Expression score | Quality |
|---|---|---|---|
| tibialis anterior | UBERON:0001385 | 99.15 | gold quality |
| vastus lateralis | UBERON:0001379 | 99.14 | gold quality |
| quadriceps femoris | UBERON:0001377 | 99.01 | gold quality |
| skeletal muscle tissue of rectus abdominis | UBERON:0004511 | 98.81 | gold quality |
| biceps brachii | UBERON:0001507 | 98.58 | gold quality |
| skeletal muscle tissue of biceps brachii | UBERON:0004502 | 98.40 | gold quality |
| deltoid | UBERON:0001476 | 98.33 | gold quality |
| saphenous vein | UBERON:0007318 | 97.64 | gold quality |
| skeletal muscle tissue | UBERON:0001134 | 97.57 | gold quality |
| gastrocnemius | UBERON:0001388 | 96.87 | gold quality |
| muscle of leg | UBERON:0001383 | 96.62 | gold quality |
| muscle tissue | UBERON:0002385 | 95.48 | gold quality |
| right coronary artery | UBERON:0001625 | 93.60 | gold quality |
| popliteal artery | UBERON:0002250 | 93.49 | gold quality |
| tibial artery | UBERON:0007610 | 93.47 | gold quality |
| smooth muscle tissue | UBERON:0001135 | 93.36 | gold quality |
| hindlimb stylopod muscle | UBERON:0004252 | 93.32 | gold quality |
| calcaneal tendon | UBERON:0003701 | 92.93 | gold quality |
| aorta | UBERON:0000947 | 92.81 | gold quality |
| cauda epididymis | UBERON:0004360 | 92.17 | gold quality |
| thoracic aorta | UBERON:0001515 | 92.07 | gold quality |
| ascending aorta | UBERON:0001496 | 91.99 | gold quality |
| heart right ventricle | UBERON:0002080 | 91.92 | gold quality |
| tendon | UBERON:0000043 | 90.61 | gold quality |
| lower esophagus muscularis layer | UBERON:0035833 | 90.47 | gold quality |
| descending thoracic aorta | UBERON:0002345 | 90.34 | gold quality |
| lower esophagus | UBERON:0013473 | 90.34 | gold quality |
| left coronary artery | UBERON:0001626 | 89.75 | gold quality |
| coronary artery | UBERON:0001621 | 89.29 | gold quality |
| superficial temporal artery | UBERON:0001614 | 89.25 | gold quality |
Single-cell (SCXA)
Detected in 2 experiment(s), a significant marker in 2.
| Experiment | Marker? | Max mean expression |
|---|---|---|
| E-MTAB-9543 | yes | 28.21 |
| E-ANND-3 | yes | 7.02 |
Regulation
Is transcription factor: no
Literature-anchored findings (GeneRIF, showing 10)
- the present study suggests an inhibitory role of lncRNA MBNL1-AS1 in CSC drug resistance of Non-small cell lung cancer (NSCLC) by upregulating miR-301b-3p-targeted TGFBR2. (PMID:31113460)
- LncRNA MBNL1-AS1 represses cell proliferation and enhances cell apoptosis via targeting miR-135a-5p/PHLPP2/FOXO1 axis in bladder cancer. (PMID:31769229)
- Muscleblind-like 1 antisense RNA 1 inhibits cell proliferation, invasion, and migration of prostate cancer by sponging miR-181a-5p and regulating PTEN/PI3K/AKT/mTOR signaling. (PMID:33648424)
- The Regulatory Role of Both MBNL1 and MBNL1-AS1 in Several Common Cancers. (PMID:34459372)
- Up-regulation of long noncoding RNA MBNL1-AS1 suppresses breast cancer progression by modulating miR-423-5p/CREBZF axis. (PMID:35094653)
- Tumour-suppressing functions of the lncRNA MBNL1-AS1/miR-889-3p/KLF9 axis in human breast cancer cells. (PMID:35112997)
- LncRNA MBNL1-AS1 represses gastric cancer progression via the TGF-beta pathway by modulating miR-424-5p/Smad7 axis. (PMID:35311623)
- MBNL1-AS1 Promotes Hypoxia-Induced Myocardial Infarction via the miR-132-3p/RAB14/CAMTA1 Axis. (PMID:36785792)
- LncRNA MBNL1-AS1 Suppresses Cell Proliferation and Metastasis of Pancreatic Adenocarcinoma through Targeting Carcinogenic miR-301b-3p. (PMID:36908851)
- MBNL1-AS1 attenuates tumor cell proliferation by regulating the miR-29c-3p/BVES signal in colorectal cancer. (PMID:37711058)
Cross-species orthologs
0 orthologs
Protein
Non-coding RNA — no protein product; not a drug target.
Function
No curated pathway, Gene-Ontology, or interaction data.
Disease & clinical
No curated disease, variant, or cancer-driver associations.
Drugs & pharmacology
No drug or pharmacology data — not an established drug target.
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.